Alb cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Alb
Entrez Gene ID	24186
Full Name	albumin
Synonyms	Alb1,Albza
General protein information	Preferred Names albumin Names serum albumin
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 14 Map Location: 14p22
Summary	may play a role in nitric oxide signaling; may mediate formation of S-nitrosothiols [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_134326.2	NP_599153.2	serum albumin precursor

Pathways from BioSystems

Homologies

	ALB	XP_001103956.1
Bos taurus (cattle)	ALB	NP_851335.1
Xenopus tropicalis (tropical clawed frog)	cars2	NP_001004887.2
Pan troglodytes (chimpanzee)	ALB	XP_517233.3
Homo sapiens (human)	ALB	NP_000468.1
Mus musculus (house mouse)	Alb	NP_033784.2
Rattus norvegicus (Norway rat)	Alb	NP_599153.2
Gallus gallus (chicken)	ALB	NP_990592.1
Canis lupus familiaris (dog)	ALB	NP_001003026.1

Gene Ontology
Bibliography

Related articles in PubMed

Endocytosis of Albumin Induces Matrix Metalloproteinase-9 by Activating the ERK Signaling Pathway in Renal Tubule Epithelial Cells.
Chen X, Cobbs A, George J, Chima A, Tuyishime F, Zhao X
International journal of molecular sciences18(8)(2017 Aug)

Transient cerebral ischemia induces albumin expression in microglia only in the CA1 region of the gerbil hippocampus.
Park JH, Park JA, Ahn JH, Kim YH, Kang IJ, Won MH, Lee CH
Molecular medicine reports16(1)661-665(2017 Jul)

Hepatocarcinogenesis Is Associated with Serum Albumin Levels after Sustained Virological Responses with Interferon-Based Therapy in Patients with Hepatitis C.
Umehara Y, Hagiwara S, Nishida N, Sakurai T, Ida H, Minami Y, Takita M, Minami T, Chishina H, Ueshima K, Komeda Y, Arizumi T, Watanabe T, Kudo M
Digestive diseases (Basel, Switzerland)35(6)548-555(2017)

Hepatoprotective effect of apple polyphenols against concanavalin A-induced immunological liver injury in mice.
Wang F, Xue Y, Yang J, Lin F, Sun Y, Li T, Wu C
Chemico-biological interactions258159-65(2016 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

significant structural changes occur to albumin with glycation, particularly in the FcRn-binding region, which could explain the reduced affinity to FcRn
Title: Mechanism of increased clearance of glycated albumin by proximal tubule cells.

Physiological Levels of Pentraxin 3 and Albumin Attenuate Vascular Endothelial Cell Damage Induced by Histone H3
Title: Physiological Levels of Pentraxin 3 and Albumin Attenuate Vascular Endothelial Cell Damage Induced by Histone H3 In Vitro.

Megalin/cubilin and lysosome rupture is involved in albumin-triggered tubular injury and tubulointerstitial inflammation.
Title: Megalin/Cubulin-Lysosome-mediated Albumin Reabsorption Is Involved in the Tubular Cell Activation of NLRP3 Inflammasome and Tubulointerstitial Inflammation.

Both insulin and high glucose concentrations enhance the permeability of podocytes to albumin by stimulating oxygen free radical production, primarily by NAD(P)H oxidase-4 (NOX4), and by activating protein kinase G, isoform Ialpha.
Title: Combined effect of insulin and high glucose concentration on albumin permeability in cultured rat podocytes.

albumin prevents 6-hydroxydopamine-induced loss of tyrosine hydroxylase
Title: Human albumin prevents 6-hydroxydopamine-induced loss of tyrosine hydroxylase in in vitro and in vivo.

The following Alb gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Alb cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa01100	NM_134326.2 Latest version!	Rattus norvegicus albumin (Alb), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$307.30 $439.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Alb ( NM_134326.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_599153.2 Rattus norvegicus albumin (Alb), mRNA.

Price & Availability↑

CloneID	ORa01100
Clone ID Related Accession (Same CDS sequence)	NM_134326.2
Accession Version	NM_134326.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1827bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	serum albumin precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC085359.1. On Oct 11, 2007 this sequence version replaced NM_134326.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC085359.1, V01222.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01906347, SAMN01906348 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END##

ATGAAGTGGG TAACCTTTCT CCTCCTCCTC TTCATCTCCG GTTCTGCCTT TTCCAGGGGT 
GTGTTTCGCC GAGAAGCACA CAAGAGTGAG ATCGCCCATC GGTTTAAGGA CTTGGGAGAA 
CAGCATTTCA AAGGCCTAGT CCTGATTGCC TTTTCCCAGT ATCTCCAGAA ATGCCCATAT 
GAAGAGCATA TCAAATTGGT GCAGGAAGTA ACAGACTTTG CAAAAACATG TGTCGCTGAT 
GAGAATGCCG AAAACTGTGA CAAGTCCATT CACACTCTCT TCGGAGACAA GTTATGCGCC 
ATTCCAAAGC TTCGCGACAA CTACGGTGAA CTGGCTGACT GCTGTGCAAA ACAAGAGCCC 
GAAAGAAACG AGTGTTTCCT GCAGCACAAG GATGACAACC CCAACCTGCC ACCCTTCCAG 
AGGCCGGAGG CTGAGGCCAT GTGCACCTCC TTCCAGGAGA ACCCTACCAG CTTTCTGGGA 
CACTATTTGC ATGAAGTTGC CAGGAGACAT CCTTATTTCT ATGCCCCAGA ACTCCTTTAC 
TATGCTGAGA AATACAATGA GGTTCTGACC CAGTGCTGCA CAGAGTCTGA CAAAGCAGCC 
TGCCTGACAC CGAAGCTTGA TGCCGTGAAA GAGAAAGCAC TGGTCGCAGC TGTCCGTCAG 
AGGATGAAGT GCTCCAGTAT GCAGAGATTT GGAGAGAGAG CCTTCAAAGC CTGGGCAGTA 
GCTCGTATGA GCCAGCGATT CCCCAATGCT GAGTTCGCAG AAATCACCAA ATTGGCAACA 
GACCTCACCA AAATCAACAA GGAGTGCTGT CACGGCGACC TGTTGGAATG CGCGGATGAC 
AGGGCGGAAC TTGCCAAGTA CATGTGTGAG AACCAGGCCA CTATCTCCAG CAAACTGCAG 
GCTTGCTGTG ATAAGCCAGT GCTGCAGAAA TCCCAGTGTC TCGCTGAGAT AGAACATGAC 
AACATTCCTG CCGATCTGCC CTCAATAGCT GCTGACTTTG TTGAGGATAA GGAAGTGTGT 
AAGAACTATG CTGAGGCCAA GGATGTCTTC CTGGGCACGT TTTTGTATGA ATATTCAAGA 
AGGCACCCCG ATTACTCCGT GTCCCTGCTG CTGAGACTTG CTAAGAAATA TGAAGCCACA 
CTGGAGAAGT GCTGTGCTGA AGGCGATCCT CCTGCCTGCT ACGGCACAGT GCTTGCAGAA 
TTTCAGCCTC TTGTAGAAGA ACCTAAGAAC TTGGTCAAAA CTAACTGTGA GCTTTACGAG 
AAGCTTGGAG AGTATGGATT CCAAAACGCC ATTCTGGTTC GATACACCCA GAAAGCACCT 
CAGGTGTCGA CCCCAACTCT CGTGGAGGCA GCAAGAAACC TGGGAAGAGT GGGCACCAAG 
TGTTGTACCC TTCCTGAAGC TCAGAGACTG CCCTGTGTGG AAGACTATCT GTCTGCCATC 
CTGAACCGTC TGTGTGTGCT GCATGAGAAG ACCCCAGTGA GCGAGAAGGT CACCAAGTGC 
TGTAGTGGGT CCCTGGTGGA AAGACGGCCA TGTTTCTCTG CTCTGACAGT TGACGAGACA 
TATGTCCCCA AAGAGTTTAA AGCTGAGACC TTCACCTTCC ACTCTGATAT CTGCACACTC 
CCAGACAAGG AGAAGCAGAT AAAGAAGCAA ACGGCTCTCG CTGAGCTGGT GAAACACAAG 
CCCAAGGCCA CAGAAGATCA GCTGAAGACG GTGATGGGTG ACTTCGCACA ATTCGTGGAC 
AAGTGTTGCA AGGCTGCCGA CAAGGATAAC TGCTTCGCCA CTGAGGGGCC AAACCTTGTT 
GCTAGAAGCA AAGAAGCCTT AGCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_599153.2
CDS	16..1842
Translation	MKWVTFLLLLFISGSAFSRGVFRREAHKSEIAHRFKDLGEQHFKGLVLIAFSQYLQKCPYEEHIKLVQEVTDFAKTCVADENAENCDKSIHTLFGDKLCAIPKLRDNYGELADCCAKQEPERNECFLQHKDDNPNLPPFQRPEAEAMCTSFQENPTSFLGHYLHEVARRHPYFYAPELLYYAEKYNEVLTQCCTESDKAACLTPKLDAVKEKALVAAVRQRMKCSSMQRFGERAFKAWAVARMSQRFPNAEFAEITKLATDLTKINKECCHGDLLECADDRAELAKYMCENQATISSKLQACCDKPVLQKSQCLAEIEHDNIPADLPSIAADFVEDKEVCKNYAEAKDVFLGTFLYEYSRRHPDYSVSLLLRLAKKYEATLEKCCAEGDPPACYGTVLAEFQPLVEEPKNLVKTNCELYEKLGEYGFQNAILVRYTQKAPQVSTPTLVEAARNLGRVGTKCCTLPEAQRLPCVEDYLSAILNRLCVLHEKTPVSEKVTKCCSGSLVERRPCFSALTVDETYVPKEFKAETFTFHSDICTLPDKEKQIKKQTALAELVKHKPKATEDQLKTVMGDFAQFVDKCCKAADKDNCFATEGPNLVARSKEALA

Target ORF information:

RefSeq Version	NM_134326.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus albumin (Alb), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_134326.2

ORF Insert Sequence:

ATGAAGTGGG TAACCTTTCT CCTCCTCCTC TTCATCTCCG GTTCTGCCTT TTCCAGGGGT 
GTGTTTCGCC GAGAAGCACA CAAGAGTGAG ATCGCCCATC GGTTTAAGGA CTTGGGAGAA 
CAGCATTTCA AAGGCCTAGT CCTGATTGCC TTTTCCCAGT ATCTCCAGAA ATGCCCATAT 
GAAGAGCATA TCAAATTGGT GCAGGAAGTA ACAGACTTTG CAAAAACATG TGTCGCTGAT 
GAGAATGCCG AAAACTGTGA CAAGTCCATT CACACTCTCT TCGGAGACAA GTTATGCGCC 
ATTCCAAAGC TTCGCGACAA CTACGGTGAA CTGGCTGACT GCTGTGCAAA ACAAGAGCCC 
GAAAGAAACG AGTGTTTCCT GCAGCACAAG GATGACAACC CCAACCTGCC ACCCTTCCAG 
AGGCCGGAGG CTGAGGCCAT GTGCACCTCC TTCCAGGAGA ACCCTACCAG CTTTCTGGGA 
CACTATTTGC ATGAAGTTGC CAGGAGACAT CCTTATTTCT ATGCCCCAGA ACTCCTTTAC 
TATGCTGAGA AATACAATGA GGTTCTGACC CAGTGCTGCA CAGAGTCTGA CAAAGCAGCC 
TGCCTGACAC CGAAGCTTGA TGCCGTGAAA GAGAAAGCAC TGGTCGCAGC TGTCCGTCAG 
AGGATGAAGT GCTCCAGTAT GCAGAGATTT GGAGAGAGAG CCTTCAAAGC CTGGGCAGTA 
GCTCGTATGA GCCAGCGATT CCCCAATGCT GAGTTCGCAG AAATCACCAA ATTGGCAACA 
GACCTCACCA AAATCAACAA GGAGTGCTGT CACGGCGACC TGTTGGAATG CGCGGATGAC 
AGGGCGGAAC TTGCCAAGTA CATGTGTGAG AACCAGGCCA CTATCTCCAG CAAACTGCAG 
GCTTGCTGTG ATAAGCCAGT GCTGCAGAAA TCCCAGTGTC TCGCTGAGAT AGAACATGAC 
AACATTCCTG CCGATCTGCC CTCAATAGCT GCTGACTTTG TTGAGGATAA GGAAGTGTGT 
AAGAACTATG CTGAGGCCAA GGATGTCTTC CTGGGCACGT TTTTGTATGA ATATTCAAGA 
AGGCACCCCG ATTACTCCGT GTCCCTGCTG CTGAGACTTG CTAAGAAATA TGAAGCCACA 
CTGGAGAAGT GCTGTGCTGA AGGCGATCCT CCTGCCTGCT ACGGCACAGT GCTTGCAGAA 
TTTCAGCCTC TTGTAGAAGA ACCTAAGAAC TTGGTCAAAA CTAACTGTGA GCTTTACGAG 
AAGCTTGGAG AGTATGGATT CCAAAACGCC ATTCTGGTTC GATACACCCA GAAAGCACCT 
CAGGTGTCGA CCCCAACTCT CGTGGAGGCA GCAAGAAACC TGGGAAGAGT GGGCACCAAG 
TGTTGTACCC TTCCTGAAGC TCAGAGACTG CCCTGTGTGG AAGACTATCT GTCTGCCATC 
CTGAACCGTC TGTGTGTGCT GCATGAGAAG ACCCCAGTGA GCGAGAAGGT CACCAAGTGC 
TGTAGTGGGT CCCTGGTGGA AAGACGGCCA TGTTTCTCTG CTCTGACAGT TGACGAGACA 
TATGTCCCCA AAGAGTTTAA AGCTGAGACC TTCACCTTCC ACTCTGATAT CTGCACACTC 
CCAGACAAGG AGAAGCAGAT AAAGAAGCAA ACGGCTCTCG CTGAGCTGGT GAAACACAAG 
CCCAAGGCCA CAGAAGATCA GCTGAAGACG GTGATGGGTG ACTTCGCACA ATTCGTGGAC 
AAGTGTTGCA AGGCTGCCGA CAAGGATAAC TGCTTCGCCA CTGAGGGGCC AAACCTTGTT 
GCTAGAAGCA AAGAAGCCTT AGCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Endocytosis of Albumin Induces Matrix Metalloproteinase-9 by Activating the ERK Signaling Pathway in Renal Tubule Epithelial Cells.
International journal of molecular sciences18(8)(2017 Aug)
Chen X,Cobbs A,George J,Chima A,Tuyishime F,Zhao X

Transient cerebral ischemia induces albumin expression in microglia only in the CA1 region of the gerbil hippocampus.
Molecular medicine reports16(1)661-665(2017 Jul)
Park JH,Park JA,Ahn JH,Kim YH,Kang IJ,Won MH,Lee CH

Hepatocarcinogenesis Is Associated with Serum Albumin Levels after Sustained Virological Responses with Interferon-Based Therapy in Patients with Hepatitis C.
Digestive diseases (Basel, Switzerland)35(6)548-555(2017)
Umehara Y,Hagiwara S,Nishida N,Sakurai T,Ida H,Minami Y,Takita M,Minami T,Chishina H,Ueshima K,Komeda Y,Arizumi T,Watanabe T,Kudo M

Hepatoprotective effect of apple polyphenols against concanavalin A-induced immunological liver injury in mice.
Chemico-biological interactions258159-65(2016 Oct)
Wang F,Xue Y,Yang J,Lin F,Sun Y,Li T,Wu C

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Alb cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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