Adra2b cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Adra2b
Entrez Gene ID	24174
Full Name	adrenoceptor alpha 2B
General protein information	Preferred Names adrenoceptor alpha 2B Names alpha-2B adrenergic receptor Adrenergic alpha2B- receptor class III Adrenergic, alpha2B-, receptor class III adrenergic receptor, alpha 2b adrenergic, alpha-2B-, receptor alpha-2B adrenoceptor alpha-2B adrenoreceptor alpha-2BAR
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 3 Map Location: 3q36

mRNA and Protein(s)

mRNA	Protein	Name
NM_138505.2	NP_612514.2	alpha-2B adrenergic receptor

Pathways from BioSystems

Homologies

	ADRA2B	XP_001082230.1
Danio rerio (zebrafish)	adra2b	NP_997521.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP000606	XP_565734.4
Bos taurus (cattle)	ADRA2B	NP_001193557.1
Danio rerio (zebrafish)	LOC100330650	XP_002663705.3
Caenorhabditis elegans (roundworm)	dop-1	NP_001024579.1
Pan troglodytes (chimpanzee)	ADRA2B	XP_003309176.1
Canis lupus familiaris (dog)	ADRA2B	XP_005642499.1
Mus musculus (house mouse)	Adra2b	NP_033763.2
Homo sapiens (human)	ADRA2B	NP_000673.2
Rattus norvegicus (Norway rat)	Adra2b	NP_612514.2
Gallus gallus (chicken)	LOC101751513	XP_004951007.1
Xenopus tropicalis (tropical clawed frog)	adra2b	XP_002932610.1

Gene Ontology
Bibliography

Related articles in PubMed

Regulation of ?
Zhang M, Huang W, Gao J, Terry AV, Wu G
Scientific reports637921(2016 Nov)

Adrenal ?2-adrenergic receptors in the aging normotensive and spontaneously hypertensive rat.
Moura E, Pinto CE, Serr?o MP, Afonso J, Vieira-Coelho MA
Neurobiology of aging33(5)969-78(2012 May)

Alpha2B-adrenergic receptor interaction with tubulin controls its transport from the endoplasmic reticulum to the cell surface.
Duvernay MT, Wang H, Dong C, Guidry JJ, Sackett DL, Wu G
The Journal of biological chemistry286(16)14080-9(2011 Apr)

[The effect of the ARC 239 on the myometrial and cervical action in the rat, in vitro].
G?l A, Kolarovszki-Sipiczki Z, G?lik M, Ducza E, Minorics R, Klukovits A, Falkay G, G?sp?r R
Acta pharmaceutica Hungarica79(2)75-80(2009)

alpha 2B-adrenergic receptor activates MAPK via a pathway involving arachidonic acid metabolism, matrix metalloproteinases, and epidermal growth factor receptor transactivation.
Cussac D, Schaak S, Denis C, Paris H
The Journal of biological chemistry277(22)19882-8(2002 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Report specific roles of alpha2A - and alpha2B -, but not alpha2C -, adrenoceptor subtypes in the inhibition of the vasopressor sympathetic out-flow in diabetic pithed rats.
Title: Specific role of ?2A - and ?2B -, but not ?2C -, adrenoceptor subtypes in the inhibition of the vasopressor sympathetic out-flow in diabetic pithed rats.

In aging, the alpha-2B receptor mediated feedback inhibition of epinephrine release from the adrenal medulla is preserved in control rats but compromised in hypertensive rats, resulting in increased epinephrine release.
Title: Adrenal ?2-adrenergic receptors in the aging normotensive and spontaneously hypertensive rat.

Alpha2B-adrenergic receptor interaction with tubulin controls its transport from the endoplasmic reticulum to the cell surface
Title: Alpha2B-adrenergic receptor interaction with tubulin controls its transport from the endoplasmic reticulum to the cell surface.

These data demonstrate that Rab2 and Rab6 differentially influence anterograde transport and signaling of GPCRs.
Title: Regulation of anterograde transport of adrenergic and angiotensin II receptors by Rab2 and Rab6 GTPases.

alpha2-adrenoceptors are inhibitory after nerve injury, not excitatory
Title: alpha2-adrenoceptors inhibit the intracellular Ca2+ response to electrical stimulation in normal and injured sensory neurons, with increased inhibition of calcitonin gene-related peptide expressing neurons after injury.

The following Adra2b gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Adra2b cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa42854	NM_138505.2 Latest version!	Rattus norvegicus adrenoceptor alpha 2B (Adra2b), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Adra2b ( NM_138505.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_612514.2 Rattus norvegicus adrenoceptor alpha 2B (Adra2b), mRNA.

Price & Availability↑

CloneID	ORa42854
Clone ID Related Accession (Same CDS sequence)	NM_138505.2
Accession Version	NM_138505.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1362bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Rattus norvegicus(Norway rat)
Product	alpha-2B adrenergic receptor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AABR07053673.1. On Aug 25, 2010 this sequence version replaced NM_138505.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.

ATGTCCGGCC CCACCATGGA CCATCAGGAG CCCTACTCGG TGCAGGCCAC CGCCGCCATC 
GCGTCGGCCA TCACCTTTCT CATCCTTTTC ACCATTTTCG GCAATGCGCT GGTCATTCTG 
GCTGTGTTGA CCAGCCGCTC ACTCCGTGCA CCACAAAACC TGTTCCTGGT GTCACTGGCA 
GCAGCCGACA TCCTAGTGGC TACTCTCATC ATCCCTTTCT CTCTGGCCAA CGAGCTGCTG 
GGCTACTGGT ACTTCTGGCG TGCGTGGTGC GAGGTCTACC TGGCGCTAGA CGTGCTCTTC 
TGTACCTCCT CCATCGTGCA CCTGTGTGCC ATCAGCCTGG ACAGGTACTG GGCAGTGAGC 
CGAGCATTGG AGTACAACTC CAAGCGCACT CCGCGCCGCA TCAAGTGCAT CATCCTCACT 
GTGTGGCTCA TTGCAGCTGT CATTTCTCTA CCGCCCCTCA TCTACAAGGG CGACCAACGC 
CCCGAGCCCC GCGGGCTCCC CCAGTGTGAG CTCAACCAGG AGGCCTGGTA CATCTTGGCT 
TCCAGCATCG GATCTTTTTT TGCTCCCTGC CTCATCATGA TCCTCGTCTA CCTGCGAATC 
TACGTGATTG CCAAACGCAG CCACTGCAGA GGTCTCGGAG CCAAGAGGGG CTCTGGAGAA 
GGTGAGTCCA AGAAGCCCCA GCCGGTTGCT GGGGGAGTGC CAACCTCAGC TAAGGTGCCC 
ACCCTGGTCT CTCCTCTATC TTCTGTTGGA GAGGCCAATG GACACCCCAA GCCTCCAAGA 
GAGAAGGAGG AGGGGGAGAC CCCTGAAGAT CCTGAGGCCA GGGCTTTGCC CCCAACTTGG 
TCTGCCCTTC CCAGATCAGG CCAAGGCCAG AAGAAGGGGA CTAGTGGGGC GACTGCAGAG 
GAGGGAGATG AAGAGGATGA GGAAGAGGTG GAAGAATGTG AACCCCAAAC ACTGCCAGCA 
TCTCCTGCCT CGGTATGCAA CCCACCCTTG CAGCAGCCTC AGACTTCTCG GGTACTGGCC 
ACACTTCGTG GCCAGGTGCT TCTGGGCAAG AATGTGGGAG TTGCCAGTGG GCAGTGGTGG 
CGCAGACGGA CACAGCTGAG CCGGGAGAAG AGGTTCACCT TTGTGCTGGC CGTGGTCATT 
GGAGTTTTCG TGGTCTGCTG GTTTCCTTTC TTCTTCAGCT ACAGCCTGGG GGCCATCTGC 
CCACAGCACT GCAAGGTACC GCATGGCCTC TTCCAGTTCT TCTTCTGGAT CGGCTACTGC 
AACAGCTCTT TGAACCCTGT CATCTACACC GTCTTCAACC AGGACTTCCG CCGTGCCTTT 
CGAAGGATCC TTTGCCGGCC GTGGACCCAG ACTGGCTGGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_612514.2
CDS	369..1730
Translation	MSGPTMDHQEPYSVQATAAIASAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELLGYWYFWRAWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNSKRTPRRIKCIILTVWLIAAVISLPPLIYKGDQRPEPRGLPQCELNQEAWYILASSIGSFFAPCLIMILVYLRIYVIAKRSHCRGLGAKRGSGEGESKKPQPVAGGVPTSAKVPTLVSPLSSVGEANGHPKPPREKEEGETPEDPEARALPPTWSALPRSGQGQKKGTSGATAEEGDEEDEEEVEECEPQTLPASPASVCNPPLQQPQTSRVLATLRGQVLLGKNVGVASGQWWRRRTQLSREKRFTFVLAVVIGVFVVCWFPFFFSYSLGAICPQHCKVPHGLFQFFFWIGYCNSSLNPVIYTVFNQDFRRAFRRILCRPWTQTGW

Target ORF information:

RefSeq Version	NM_138505.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus adrenoceptor alpha 2B (Adra2b), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_138505.2

ORF Insert Sequence:

ATGTCCGGCC CCACCATGGA CCATCAGGAG CCCTACTCGG TGCAGGCCAC CGCCGCCATC 
GCGTCGGCCA TCACCTTTCT CATCCTTTTC ACCATTTTCG GCAATGCGCT GGTCATTCTG 
GCTGTGTTGA CCAGCCGCTC ACTCCGTGCA CCACAAAACC TGTTCCTGGT GTCACTGGCA 
GCAGCCGACA TCCTAGTGGC TACTCTCATC ATCCCTTTCT CTCTGGCCAA CGAGCTGCTG 
GGCTACTGGT ACTTCTGGCG TGCGTGGTGC GAGGTCTACC TGGCGCTAGA CGTGCTCTTC 
TGTACCTCCT CCATCGTGCA CCTGTGTGCC ATCAGCCTGG ACAGGTACTG GGCAGTGAGC 
CGAGCATTGG AGTACAACTC CAAGCGCACT CCGCGCCGCA TCAAGTGCAT CATCCTCACT 
GTGTGGCTCA TTGCAGCTGT CATTTCTCTA CCGCCCCTCA TCTACAAGGG CGACCAACGC 
CCCGAGCCCC GCGGGCTCCC CCAGTGTGAG CTCAACCAGG AGGCCTGGTA CATCTTGGCT 
TCCAGCATCG GATCTTTTTT TGCTCCCTGC CTCATCATGA TCCTCGTCTA CCTGCGAATC 
TACGTGATTG CCAAACGCAG CCACTGCAGA GGTCTCGGAG CCAAGAGGGG CTCTGGAGAA 
GGTGAGTCCA AGAAGCCCCA GCCGGTTGCT GGGGGAGTGC CAACCTCAGC TAAGGTGCCC 
ACCCTGGTCT CTCCTCTATC TTCTGTTGGA GAGGCCAATG GACACCCCAA GCCTCCAAGA 
GAGAAGGAGG AGGGGGAGAC CCCTGAAGAT CCTGAGGCCA GGGCTTTGCC CCCAACTTGG 
TCTGCCCTTC CCAGATCAGG CCAAGGCCAG AAGAAGGGGA CTAGTGGGGC GACTGCAGAG 
GAGGGAGATG AAGAGGATGA GGAAGAGGTG GAAGAATGTG AACCCCAAAC ACTGCCAGCA 
TCTCCTGCCT CGGTATGCAA CCCACCCTTG CAGCAGCCTC AGACTTCTCG GGTACTGGCC 
ACACTTCGTG GCCAGGTGCT TCTGGGCAAG AATGTGGGAG TTGCCAGTGG GCAGTGGTGG 
CGCAGACGGA CACAGCTGAG CCGGGAGAAG AGGTTCACCT TTGTGCTGGC CGTGGTCATT 
GGAGTTTTCG TGGTCTGCTG GTTTCCTTTC TTCTTCAGCT ACAGCCTGGG GGCCATCTGC 
CCACAGCACT GCAAGGTACC GCATGGCCTC TTCCAGTTCT TCTTCTGGAT CGGCTACTGC 
AACAGCTCTT TGAACCCTGT CATCTACACC GTCTTCAACC AGGACTTCCG CCGTGCCTTT 
CGAAGGATCC TTTGCCGGCC GTGGACCCAG ACTGGCTGGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Regulation of ?
Scientific reports637921(2016 Nov)
Zhang M,Huang W,Gao J,Terry AV,Wu G

Adrenal ?2-adrenergic receptors in the aging normotensive and spontaneously hypertensive rat.
Neurobiology of aging33(5)969-78(2012 May)
Moura E,Pinto CE,Serr?o MP,Afonso J,Vieira-Coelho MA

Alpha2B-adrenergic receptor interaction with tubulin controls its transport from the endoplasmic reticulum to the cell surface.
The Journal of biological chemistry286(16)14080-9(2011 Apr)
Duvernay MT,Wang H,Dong C,Guidry JJ,Sackett DL,Wu G

[The effect of the ARC 239 on the myometrial and cervical action in the rat, in vitro].
Acta pharmaceutica Hungarica79(2)75-80(2009)
G?l A,Kolarovszki-Sipiczki Z,G?lik M,Ducza E,Minorics R,Klukovits A,Falkay G,G?sp?r R

alpha 2B-adrenergic receptor activates MAPK via a pathway involving arachidonic acid metabolism, matrix metalloproteinases, and epidermal growth factor receptor transactivation.
The Journal of biological chemistry277(22)19882-8(2002 May)
Cussac D,Schaak S,Denis C,Paris H

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Adra2b cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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