Adra1b cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Adra1b
Entrez Gene ID	24173
Full Name	adrenoceptor alpha 1B
General protein information	Preferred Names adrenoceptor alpha 1B Names alpha-1B adrenergic receptor Adrenergic alpha 1B- receptor adrenergic receptor, alpha 1b adrenergic, alpha-1B-, receptor alpha-1B adrenoceptor alpha-1B adrenoreceptor
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 10 Map Location: 10q21
Summary	couples with G alpha(h) (transglutaminase II) to activate phospholipase C; facilitates Ca2+ release and capacitative Ca2+ entry [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_016991.2	NP_058687.2	alpha-1B adrenergic receptor

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Adra1b	NP_058687.2
Danio rerio (zebrafish)	LOC100149100	XP_001922013.3
Pan troglodytes (chimpanzee)	ADRA1B	XP_003311001.1
	ADRA1B	XP_001083528.1
Mus musculus (house mouse)	Adra1b	NP_001271309.1
Canis lupus familiaris (dog)	ADRA1B	NP_001183964.1
Homo sapiens (human)	ADRA1B	NP_000670.1
Bos taurus (cattle)	ADRA1B	NP_001178068.1
Gallus gallus (chicken)	ADRA1B	XP_414483.2
Danio rerio (zebrafish)	adra1bb	NP_001007359.1
Xenopus tropicalis (tropical clawed frog)	LOC100488806	XP_002943114.2

Gene Ontology
Bibliography

Related articles in PubMed

?1b-Adrenergic Receptor Localization and Relationship to the D1-Dopamine Receptor in the Rat Nucleus Accumbens.
Mitrano DA, Jackson K, Finley S, Seeley A
Neuroscience371126-137(2017 Dec)

Type of supplemented simple sugar, not merely calorie intake, determines adverse effects on metabolism and aortic function in female rats.
Sang?esa G, Shaligram S, Akther F, Roglans N, Laguna JC, Rahimian R, Alegret M
American journal of physiology. Heart and circulatory physiology312(2)H289-H304(2017 Feb)

Up-regulation of cutaneous ?1-adrenoceptors after a burn.
Drummond PD, Dawson LF, Finch PM, Drummond ES, Wood FM, Fear MW
Burns : journal of the International Society for Burn Injuries41(6)1227-34(2015 Sep)

Heteromerization of chemokine (C-X-C motif) receptor 4 with ?1A/B-adrenergic receptors controls ?1-adrenergic receptor function.
Tripathi A, Vana PG, Chavan TS, Brueggemann LI, Byron KL, Tarasova NI, Volkman BF, Gaponenko V, Majetschak M
Proceedings of the National Academy of Sciences of the United States of America112(13)E1659-68(2015 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Within 2 weeks of a burn, Adra1 expression increased in the re-forming epidermis, in dense bands of spindle-shaped cells in the upper dermis and on nerve fibres in the deep dermis. Adra1 expression in the upper dermis decreased contralateral to the burn.
Title: Up-regulation of cutaneous ?1-adrenoceptors after a burn.

heteromeric receptor complexes between alpha1A-AR and CXCR4 and between alpha1B-AR and CXCR4 are constitutively expressed in rat and human vascular smooth muscle cells; the quaternary structure of the receptor complex is important for signaling and contraction
Title: Heteromerization of chemokine (C-X-C motif) receptor 4 with ?1A/B-adrenergic receptors controls ?1-adrenergic receptor function.

NA promotes HSC-T6 cell activation, proliferation and secretion of ECM in vitro via activation of Galpha-coupled alpha1B-AR and alpha1D-AR and the PKC-PI3K-AKT signaling pathway.
Title: Selective ?1B- and ?1D-adrenoceptor antagonists suppress noradrenaline-induced activation, proliferation and ECM secretion of rat hepatic stellate cells in vitro.

alpha- and beta-adrenergic signalling has a role in epinephrine-dependent control of glucose metabolism in white adipose tissue
Title: Epinephrine-dependent control of glucose metabolism in white adipose tissue: the role of ?- and ?-adrenergic signalling.

NOX2 activated by alpha1-adrenoceptors modulates hepatic metabolic routes stimulated by beta-adrenoceptors
Title: NOX2 activated by ?1-adrenoceptors modulates hepatic metabolic routes stimulated by ?-adrenoceptors.

The following Adra1b gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Adra1b cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa02416	NM_016991.2 Latest version!	Rattus norvegicus adrenoceptor alpha 1B (Adra1b), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$300.30 $429.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Adra1b ( NM_016991.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_058687.2 Rattus norvegicus adrenoceptor alpha 1B (Adra1b), mRNA.

Price & Availability↑

CloneID	ORa02416
Clone ID Related Accession (Same CDS sequence)	NM_016991.2
Accession Version	NM_016991.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1548bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Rattus norvegicus(Norway rat)
Product	alpha-1B adrenergic receptor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC070920.1. On May 24, 2004 this sequence version replaced NM_016991.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC070920.1, X51585.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGAATCCCG ATCTGGACAC CGGCCACAAC ACATCAGCAC CTGCCCACTG GGGAGAGTTG 
AAAGATGACA ACTTCACTGG CCCCAACCAG ACCTCGAGCA ACTCCACACT GCCCCAGCTG 
GACGTCACCA GGGCCATCTC TGTGGGCCTG GTGCTGGGCG CCTTCATCCT CTTTGCCATC 
GTGGGCAACA TCTTGGTCAT CCTGTCGGTG GCCTGCAACC GGCACCTGCG GACGCCCACC 
AACTACTTTA TCGTCAACCT GGCCATTGCT GACCTGCTGT TGAGTTTCAC AGTACTGCCC 
TTCTCCGCTA CCCTAGAAGT GCTTGGCTAC TGGGTGCTGG GGCGCATCTT CTGTGACATC 
TGGGCAGCGG TAGATGTCCT GTGCTGTACG GCCTCCATCC TGAGCCTATG TGCCATCTCC 
ATTGACCGCT ACATTGGGGT GCGATACTCT CTGCAGTACC CCACGCTGGT CACCCGCAGG 
AAGGCCATCT TGGCGCTCCT CAGTGTGTGG GTCTTGTCCA CGGTCATCTC CATCGGGCCT 
CTCCTTGGAT GGAAAGAACC TGCGCCCAAT GATGACAAAG AATGTGGGGT CACCGAAGAA 
CCCTTCTACG CCCTCTTTTC CTCCCTGGGC TCCTTCTACA TCCCGCTCGC GGTCATCCTG 
GTCATGTACT GCCGGGTCTA CATCGTGGCC AAGAGGACCA CCAAGAATCT GGAGGCGGGA 
GTCATGAAGG AAATGTCCAA CTCCAAGGAG CTGACCCTGA GGATCCACTC CAAGAACTTT 
CATGAGGACA CCCTCAGCAG TACCAAGGCC AAGGGCCACA ACCCCAGGAG TTCCATAGCT 
GTCAAACTTT TTAAGTTCTC CAGGGAAAAG AAAGCAGCCA AAACCTTGGG CATTGTAGTC 
GGAATGTTCA TCTTATGTTG GCTCCCCTTC TTCATCGCTC TCCCGCTTGG CTCCCTGTTC 
TCCACCCTAA AGCCCCCGGA CGCCGTGTTC AAGGTGGTGT TCTGGCTGGG CTACTTCAAC 
AGCTGCCTCA ATCCCATCAT CTACCCGTGC TCCAGCAAGG AGTTCAAGCG CGCCTTCATG 
CGTATCCTTG GGTGCCAGTG CCGCGGTGGC CGCCGCCGCC GCCGCCGTCG CCGTCTAGGC 
GGCTGCGCTT ACACCTACCG GCCGTGGACC CGCGGCGGCT CGCTGGAGAG ATCACAGTCG 
CGGAAGGACT CTCTGGATGA CAGCGGCAGC TGCATGAGCG GCAGCCAGAG GACCCTGCCC 
TCGGCGTCGC CCAGCCCGGG CTACCTGGGT CGAGGAACGC AGCCACCCGT GGAGCTGTGC 
GCCTTCCCCG AGTGGAAACC CGGGGCGCTG CTCAGCTTGC CAGAGCCTCC TGGCCGCCGC 
GGCCGTCTCG ACTCTGGGCC ACTCTTCACC TTCAAGCTCC TGGGCGATCC TGAGAGCCCG 
GGAACCGAAG GCGACACCAG CAACGGGGGC TGCGACACCA CGACCGACCT GGCCAACGGG 
CAGCCCGGCT TCAAGAGCAA CATGCCCCTG GCGCCCGGGC ACTTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_058687.2
CDS	390..1937
Translation	MNPDLDTGHNTSAPAHWGELKDDNFTGPNQTSSNSTLPQLDVTRAISVGLVLGAFILFAIVGNILVILSVACNRHLRTPTNYFIVNLAIADLLLSFTVLPFSATLEVLGYWVLGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGPLLGWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAGVMKEMSNSKELTLRIHSKNFHEDTLSSTKAKGHNPRSSIAVKLFKFSREKKAAKTLGIVVGMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAFMRILGCQCRGGRRRRRRRRLGGCAYTYRPWTRGGSLERSQSRKDSLDDSGSCMSGSQRTLPSASPSPGYLGRGTQPPVELCAFPEWKPGALLSLPEPPGRRGRLDSGPLFTFKLLGDPESPGTEGDTSNGGCDTTTDLANGQPGFKSNMPLAPGHF

Target ORF information:

RefSeq Version	NM_016991.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus adrenoceptor alpha 1B (Adra1b), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016991.2

ORF Insert Sequence:

ATGAATCCCG ATCTGGACAC CGGCCACAAC ACATCAGCAC CTGCCCACTG GGGAGAGTTG 
AAAGATGACA ACTTCACTGG CCCCAACCAG ACCTCGAGCA ACTCCACACT GCCCCAGCTG 
GACGTCACCA GGGCCATCTC TGTGGGCCTG GTGCTGGGCG CCTTCATCCT CTTTGCCATC 
GTGGGCAACA TCTTGGTCAT CCTGTCGGTG GCCTGCAACC GGCACCTGCG GACGCCCACC 
AACTACTTTA TCGTCAACCT GGCCATTGCT GACCTGCTGT TGAGTTTCAC AGTACTGCCC 
TTCTCCGCTA CCCTAGAAGT GCTTGGCTAC TGGGTGCTGG GGCGCATCTT CTGTGACATC 
TGGGCAGCGG TAGATGTCCT GTGCTGTACG GCCTCCATCC TGAGCCTATG TGCCATCTCC 
ATTGACCGCT ACATTGGGGT GCGATACTCT CTGCAGTACC CCACGCTGGT CACCCGCAGG 
AAGGCCATCT TGGCGCTCCT CAGTGTGTGG GTCTTGTCCA CGGTCATCTC CATCGGGCCT 
CTCCTTGGAT GGAAAGAACC TGCGCCCAAT GATGACAAAG AATGTGGGGT CACCGAAGAA 
CCCTTCTACG CCCTCTTTTC CTCCCTGGGC TCCTTCTACA TCCCGCTCGC GGTCATCCTG 
GTCATGTACT GCCGGGTCTA CATCGTGGCC AAGAGGACCA CCAAGAATCT GGAGGCGGGA 
GTCATGAAGG AAATGTCCAA CTCCAAGGAG CTGACCCTGA GGATCCACTC CAAGAACTTT 
CATGAGGACA CCCTCAGCAG TACCAAGGCC AAGGGCCACA ACCCCAGGAG TTCCATAGCT 
GTCAAACTTT TTAAGTTCTC CAGGGAAAAG AAAGCAGCCA AAACCTTGGG CATTGTAGTC 
GGAATGTTCA TCTTATGTTG GCTCCCCTTC TTCATCGCTC TCCCGCTTGG CTCCCTGTTC 
TCCACCCTAA AGCCCCCGGA CGCCGTGTTC AAGGTGGTGT TCTGGCTGGG CTACTTCAAC 
AGCTGCCTCA ATCCCATCAT CTACCCGTGC TCCAGCAAGG AGTTCAAGCG CGCCTTCATG 
CGTATCCTTG GGTGCCAGTG CCGCGGTGGC CGCCGCCGCC GCCGCCGTCG CCGTCTAGGC 
GGCTGCGCTT ACACCTACCG GCCGTGGACC CGCGGCGGCT CGCTGGAGAG ATCACAGTCG 
CGGAAGGACT CTCTGGATGA CAGCGGCAGC TGCATGAGCG GCAGCCAGAG GACCCTGCCC 
TCGGCGTCGC CCAGCCCGGG CTACCTGGGT CGAGGAACGC AGCCACCCGT GGAGCTGTGC 
GCCTTCCCCG AGTGGAAACC CGGGGCGCTG CTCAGCTTGC CAGAGCCTCC TGGCCGCCGC 
GGCCGTCTCG ACTCTGGGCC ACTCTTCACC TTCAAGCTCC TGGGCGATCC TGAGAGCCCG 
GGAACCGAAG GCGACACCAG CAACGGGGGC TGCGACACCA CGACCGACCT GGCCAACGGG 
CAGCCCGGCT TCAAGAGCAA CATGCCCCTG GCGCCCGGGC ACTTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

?1b-Adrenergic Receptor Localization and Relationship to the D1-Dopamine Receptor in the Rat Nucleus Accumbens.
Neuroscience371126-137(2017 Dec)
Mitrano DA,Jackson K,Finley S,Seeley A

Type of supplemented simple sugar, not merely calorie intake, determines adverse effects on metabolism and aortic function in female rats.
American journal of physiology. Heart and circulatory physiology312(2)H289-H304(2017 Feb)
Sang?esa G,Shaligram S,Akther F,Roglans N,Laguna JC,Rahimian R,Alegret M

Up-regulation of cutaneous ?1-adrenoceptors after a burn.
Burns : journal of the International Society for Burn Injuries41(6)1227-34(2015 Sep)
Drummond PD,Dawson LF,Finch PM,Drummond ES,Wood FM,Fear MW

Heteromerization of chemokine (C-X-C motif) receptor 4 with ?1A/B-adrenergic receptors controls ?1-adrenergic receptor function.
Proceedings of the National Academy of Sciences of the United States of America112(13)E1659-68(2015 Mar)
Tripathi A,Vana PG,Chavan TS,Brueggemann LI,Byron KL,Tarasova NI,Volkman BF,Gaponenko V,Majetschak M

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Adra1b cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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