Mfn1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Mfn1
Entrez Gene ID	192647
Full Name	mitofusin 1
Synonyms	Fzo1b
General protein information	Preferred Names mitofusin 1 Names mitofusin-1 mitochondrial transmembrane GTPase FZO1B transmembrane GTPase MFN1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 2 Map Location: 2q24
Summary	mouse homolog is involved in regulation of mitochondrial fusion and is essential for embryonic development [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_138976.1	NP_620432.1	mitofusin-1

Pathways from BioSystems

Homologies

	MFN1	XP_001108853.1
Pan troglodytes (chimpanzee)	MFN1	XP_516887.2
Canis lupus familiaris (dog)	MFN1	XP_545210.2
Bos taurus (cattle)	MFN1	NP_001193437.1
Rattus norvegicus (Norway rat)	Mfn1	NP_620432.1
Gallus gallus (chicken)	MFN1	NP_001012949.1
Danio rerio (zebrafish)	mfn1b	NP_956941.1
Homo sapiens (human)	MFN1	NP_284941.2
Mus musculus (house mouse)	Mfn1	NP_077162.2
Xenopus tropicalis (tropical clawed frog)	mfn1	NP_001016189.1

Gene Ontology
Bibliography

Related articles in PubMed

MiR-125a regulates mitochondrial homeostasis through targeting mitofusin 1 to control hypoxic pulmonary vascular remodeling.
Ma C, Zhang C, Ma M, Zhang L, Zhang L, Zhang F, Chen Y, Cao F, Li M, Wang G, Shen T, Yao H, Liu Y, Pan Z, Song S, Zhu D
Journal of molecular medicine (Berlin, Germany)95(9)977-993(2017 Sep)

Calcium sensing receptor protects high glucose-induced energy metabolism disorder via blocking gp78-ubiquitin proteasome pathway.
Wang Y, Gao P, Wei C, Li H, Zhang L, Zhao Y, Wu B, Tian Y, Zhang W, Wu L, Wang R, Xu C
Cell death & disease8(5)e2799(2017 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data identify MFN1 as an ERK target to modulate mitochondrial shape and apoptosis.
Title: Extracellular regulated kinase phosphorylates mitofusin 1 to control mitochondrial morphology and apoptosis.

In the renal tissues of rats with chronic fluorosis, expression of both Mfn1 protein and mRNA was clearly reduced, whereas that of Fis1 was elevated.
Title: The decreased expression of mitofusin-1 and increased fission-1 together with alterations in mitochondrial morphology in the kidney of rats with chronic fluorosis may involve elevated oxidative stress.

Mfn1 and miR-140 are integrated into the program of cardiomyocyte apoptosis.
Title: Mitofusin 1 is negatively regulated by microRNA 140 in cardiomyocyte apoptosis.

Physical exercise is identified as a preventive measure to promote mitochondrial function and expressions of mitofusin, BDNF and antioxidant in brain, so as to protect brain energy metabolism against chronic mild stress.
Title: Corticosterone reduces brain mitochondrial function and expression of mitofusin, BDNF in depression-like rodents regardless of exercise preconditioning.

The Mfn 1 could inhibit the activation of caspase-3 and caspase-9, which are necessary for endonuclease G translocation to the nucleus.
Title: Mitochondrial fission controls DNA fragmentation by regulating endonuclease G.

The following Mfn1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Mfn1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa42509	NM_138976.1 Latest version!	Rattus norvegicus mitofusin 1 (Mfn1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$433.30 $619.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Mfn1 ( NM_138976.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_620432.1 Rattus norvegicus mitofusin 1 (Mfn1), mRNA.

Price & Availability↑

CloneID	ORa42509
Clone ID Related Accession (Same CDS sequence)	NM_138976.1
Accession Version	NM_138976.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2226bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-09
Organism	Rattus norvegicus(Norway rat)
Product	mitofusin-1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB084166.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB084166.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END##

ATGGCAGAAA CGGTATCTCC ACTGAAGCAC TTCGTGCTGG CAAAGAAGGC CATCACTGCG 
ATCTTCGGCC AGTTACTGGA GTTTGTTACT GAGGGCTCAC ATTTTGTTGA AGCAACATAC 
AGGAACCCGG AACTTGATCG GATAGCAACC GAGGATGATC TGGTGGAGAT ACAGGGCTAC 
AGAAACAAGC TCGCTGTCAT TGGGGAGGTG CTGTCTCGGA GGCATATGAA AGTGGCATTT 
TTTGGCAGGA CAAGTAGTGG CAAGAGCTCT GTCATCAACG CAATGCTGTG GGATAAAGTC 
CTCCCCAGCG GGATTGGTCA CACAACCAAC TGCTTCCTGA GTGTGGAGGG AACTGATGGA 
GATAAAGCCT ACCTTATGAC CGAAGGGTCA GATGAGAAGA AAAGCGTGAA GACTGTTAAT 
CAGCTGGCCC ATGCCCTCCA TATGGATAAA GACTTGAAAG CTGGTTGTCT TGTGCACGTA 
TTTTGGCCCA AAGCAAAATG TGCCCTCTTG AGAGATGACC TGGTTTTAGT AGACAGCCCA 
GGTACAGATG TCACCACAGA GCTGGACATC TGGATTGATA AGTTCTGCCT TGATGCTGAT 
GTTTTTGTTT TGGTGGCAAA CTCGGAATCA ACGCTGATGA ACACGGAGAA ACATTTTTTC 
CATAAGGTGA ATGAGCGGCT CTCCAAGCCA AACATTTTTA TCCTGAATAA TCGTTGGGAT 
GCTTCTGCTT CAGAGCCAGA ATATATGGAG GATGTGCGCA GACAGCACAT GGAAAGATGT 
CTTCACTTCT TGGTAGAAGA GCTCAAGGTT GTGAGTCCTT TAGAAGCTCG GAATCGGATC 
TTTTTTGTTT CAGCCAAGGA AGTTCTCAAC TCCAGAATGA ATAAAGCCCA GGGGATGCCA 
GAAGGTGGAG GGGCACTTGC AGAAGGATTT CAGGCAAGAT TACAGGAGTT TCAAAATTTT 
GAACAAACTT TTGAGGAGTG TATCTCGCAG TCAGCAGTGA AAACAAAGTT TGAACAGCAC 
ACTATCAGAG CTAAACAGAT ACTAGACACT GTGAAAAACA TACTGGACTC AGTAAACGTG 
GCAGCAGCAG AGAAGAGGGT TTATTCAATG GAAGAGAGGG AAGACCAAAT CGACAGACTG 
GACTTTATTC GAAACCAGAT GAACCTTTTA ACAATGGATG TTAAGAAGAA GATCAAGGAG 
GTCACGGAGG AGGTGGCAAA CAAGGTTTCT TGTGCAATGA CAGATGAGAT TTGTCGCCTG 
TCTGTTTTGG TTGATGAGTT TTGTTCTGAG TTTCATCCTA CCCCCAGTGT GCTGAAAGTG 
TATAAGAGTG AATTAAATAA GCACATAGAA GATGGCATGG GAAGAAATTT GGCTGATCGG 
TGCACCAGTG AAGTCAATGC CTCCATTCTT CAATCTCAGC AAGAAATCAT TGAAAATTTG 
AAGCCACTAC TTCCAGCTGG TATACAGAAT AAACTTCATA CATTAATCCC TTGCAAAAAG 
TTTGATCTCA GCTATGATCT CAATTGCCAC AAGCTGTGTT CGGATTTTCA AGAAGACATT 
GTGTTTCGGT TTTCCCTGGG CTGGTCTTCC CTTGTACATC GATTCCTGGG TTCTACGAAT 
GCACAGAGGG TGCTGCTTGG GCTGTCAGAG CCTATCTTTC AGGTCCCTAG ATCTTTAGCT 
TCAACTCCTA CTGCTCCTTC TAACCCAGCA GCACCAGATA ATGCAGCCCA GGAAGAGCTC 
ATGATCACAC TGATCACAGG ATTGGCATCC CTCACGTCTA GAACCTCCAT GGGCATCATA 
GTTGTTGGGG GCGTGATTTG GAAAACAGTG GGCTGGAAAC TCATCTCTGT CACCTTAAGT 
ATGTATGGAG CTTTGTACCT TTATGAAAGA CTGACTTGGA CTACTCGTGC GAAAGAGAGA 
GCGTTTAAGC AGCAGTTTGT AAACTATGCA ACTGAAAAAC TGCAGATGAT TGTGAAGTTC 
ACAAGTGCAA ACTGCAGCCA CCAAGTCCAG CAAGAAATGG CCACCACTTT TGCTCGACTG 
TGCCAACAAG TTGATGTTAC TCAGAAACAT CTGGAAGAAG AAATTGCTAG ATTATCCAAA 
GAGATTGACC AACTGGAGAA AATACAAAAC AATTCAAAGC TCTTAAGAAA TAAAGCTGTT 
CAACTTGAAC GTGAGCTGGA AAATTTTTCG AAGCAGTTTC TCCACCCGAG CAGTGGAGAA 
TCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_620432.1
CDS	1..2226
Translation	MAETVSPLKHFVLAKKAITAIFGQLLEFVTEGSHFVEATYRNPELDRIATEDDLVEIQGYRNKLAVIGEVLSRRHMKVAFFGRTSSGKSSVINAMLWDKVLPSGIGHTTNCFLSVEGTDGDKAYLMTEGSDEKKSVKTVNQLAHALHMDKDLKAGCLVHVFWPKAKCALLRDDLVLVDSPGTDVTTELDIWIDKFCLDADVFVLVANSESTLMNTEKHFFHKVNERLSKPNIFILNNRWDASASEPEYMEDVRRQHMERCLHFLVEELKVVSPLEARNRIFFVSAKEVLNSRMNKAQGMPEGGGALAEGFQARLQEFQNFEQTFEECISQSAVKTKFEQHTIRAKQILDTVKNILDSVNVAAAEKRVYSMEEREDQIDRLDFIRNQMNLLTMDVKKKIKEVTEEVANKVSCAMTDEICRLSVLVDEFCSEFHPTPSVLKVYKSELNKHIEDGMGRNLADRCTSEVNASILQSQQEIIENLKPLLPAGIQNKLHTLIPCKKFDLSYDLNCHKLCSDFQEDIVFRFSLGWSSLVHRFLGSTNAQRVLLGLSEPIFQVPRSLASTPTAPSNPAAPDNAAQEELMITLITGLASLTSRTSMGIIVVGGVIWKTVGWKLISVTLSMYGALYLYERLTWTTRAKERAFKQQFVNYATEKLQMIVKFTSANCSHQVQQEMATTFARLCQQVDVTQKHLEEEIARLSKEIDQLEKIQNNSKLLRNKAVQLERELENFSKQFLHPSSGES

Target ORF information:

RefSeq Version	NM_138976.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus mitofusin 1 (Mfn1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_138976.1

ORF Insert Sequence:

ATGGCAGAAA CGGTATCTCC ACTGAAGCAC TTCGTGCTGG CAAAGAAGGC CATCACTGCG 
ATCTTCGGCC AGTTACTGGA GTTTGTTACT GAGGGCTCAC ATTTTGTTGA AGCAACATAC 
AGGAACCCGG AACTTGATCG GATAGCAACC GAGGATGATC TGGTGGAGAT ACAGGGCTAC 
AGAAACAAGC TCGCTGTCAT TGGGGAGGTG CTGTCTCGGA GGCATATGAA AGTGGCATTT 
TTTGGCAGGA CAAGTAGTGG CAAGAGCTCT GTCATCAACG CAATGCTGTG GGATAAAGTC 
CTCCCCAGCG GGATTGGTCA CACAACCAAC TGCTTCCTGA GTGTGGAGGG AACTGATGGA 
GATAAAGCCT ACCTTATGAC CGAAGGGTCA GATGAGAAGA AAAGCGTGAA GACTGTTAAT 
CAGCTGGCCC ATGCCCTCCA TATGGATAAA GACTTGAAAG CTGGTTGTCT TGTGCACGTA 
TTTTGGCCCA AAGCAAAATG TGCCCTCTTG AGAGATGACC TGGTTTTAGT AGACAGCCCA 
GGTACAGATG TCACCACAGA GCTGGACATC TGGATTGATA AGTTCTGCCT TGATGCTGAT 
GTTTTTGTTT TGGTGGCAAA CTCGGAATCA ACGCTGATGA ACACGGAGAA ACATTTTTTC 
CATAAGGTGA ATGAGCGGCT CTCCAAGCCA AACATTTTTA TCCTGAATAA TCGTTGGGAT 
GCTTCTGCTT CAGAGCCAGA ATATATGGAG GATGTGCGCA GACAGCACAT GGAAAGATGT 
CTTCACTTCT TGGTAGAAGA GCTCAAGGTT GTGAGTCCTT TAGAAGCTCG GAATCGGATC 
TTTTTTGTTT CAGCCAAGGA AGTTCTCAAC TCCAGAATGA ATAAAGCCCA GGGGATGCCA 
GAAGGTGGAG GGGCACTTGC AGAAGGATTT CAGGCAAGAT TACAGGAGTT TCAAAATTTT 
GAACAAACTT TTGAGGAGTG TATCTCGCAG TCAGCAGTGA AAACAAAGTT TGAACAGCAC 
ACTATCAGAG CTAAACAGAT ACTAGACACT GTGAAAAACA TACTGGACTC AGTAAACGTG 
GCAGCAGCAG AGAAGAGGGT TTATTCAATG GAAGAGAGGG AAGACCAAAT CGACAGACTG 
GACTTTATTC GAAACCAGAT GAACCTTTTA ACAATGGATG TTAAGAAGAA GATCAAGGAG 
GTCACGGAGG AGGTGGCAAA CAAGGTTTCT TGTGCAATGA CAGATGAGAT TTGTCGCCTG 
TCTGTTTTGG TTGATGAGTT TTGTTCTGAG TTTCATCCTA CCCCCAGTGT GCTGAAAGTG 
TATAAGAGTG AATTAAATAA GCACATAGAA GATGGCATGG GAAGAAATTT GGCTGATCGG 
TGCACCAGTG AAGTCAATGC CTCCATTCTT CAATCTCAGC AAGAAATCAT TGAAAATTTG 
AAGCCACTAC TTCCAGCTGG TATACAGAAT AAACTTCATA CATTAATCCC TTGCAAAAAG 
TTTGATCTCA GCTATGATCT CAATTGCCAC AAGCTGTGTT CGGATTTTCA AGAAGACATT 
GTGTTTCGGT TTTCCCTGGG CTGGTCTTCC CTTGTACATC GATTCCTGGG TTCTACGAAT 
GCACAGAGGG TGCTGCTTGG GCTGTCAGAG CCTATCTTTC AGGTCCCTAG ATCTTTAGCT 
TCAACTCCTA CTGCTCCTTC TAACCCAGCA GCACCAGATA ATGCAGCCCA GGAAGAGCTC 
ATGATCACAC TGATCACAGG ATTGGCATCC CTCACGTCTA GAACCTCCAT GGGCATCATA 
GTTGTTGGGG GCGTGATTTG GAAAACAGTG GGCTGGAAAC TCATCTCTGT CACCTTAAGT 
ATGTATGGAG CTTTGTACCT TTATGAAAGA CTGACTTGGA CTACTCGTGC GAAAGAGAGA 
GCGTTTAAGC AGCAGTTTGT AAACTATGCA ACTGAAAAAC TGCAGATGAT TGTGAAGTTC 
ACAAGTGCAA ACTGCAGCCA CCAAGTCCAG CAAGAAATGG CCACCACTTT TGCTCGACTG 
TGCCAACAAG TTGATGTTAC TCAGAAACAT CTGGAAGAAG AAATTGCTAG ATTATCCAAA 
GAGATTGACC AACTGGAGAA AATACAAAAC AATTCAAAGC TCTTAAGAAA TAAAGCTGTT 
CAACTTGAAC GTGAGCTGGA AAATTTTTCG AAGCAGTTTC TCCACCCGAG CAGTGGAGAA 
TCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

MiR-125a regulates mitochondrial homeostasis through targeting mitofusin 1 to control hypoxic pulmonary vascular remodeling.
Journal of molecular medicine (Berlin, Germany)95(9)977-993(2017 Sep)
Ma C,Zhang C,Ma M,Zhang L,Zhang L,Zhang F,Chen Y,Cao F,Li M,Wang G,Shen T,Yao H,Liu Y,Pan Z,Song S,Zhu D

Calcium sensing receptor protects high glucose-induced energy metabolism disorder via blocking gp78-ubiquitin proteasome pathway.
Cell death & disease8(5)e2799(2017 May)
Wang Y,Gao P,Wei C,Li H,Zhang L,Zhao Y,Wu B,Tian Y,Zhang W,Wu L,Wang R,Xu C

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Mfn1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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