Mtnr1b cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Mtnr1b
Entrez Gene ID	192646
Full Name	melatonin receptor 1B
Synonyms	Mel1b-r
General protein information	Preferred Names melatonin receptor 1B Names melatonin receptor type 1B mel-1B-R mel1b melatonin receptor mel1b receptor
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 8 Map Location: 8q12
Summary	G protein-coupled receptor for the hormone melatonin [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001100641.1	NP_001094111.1	melatonin receptor type 1B precursor

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	MTNR1B	XP_417201.2
Danio rerio (zebrafish)	mtnr1bb	NP_571469.1
Homo sapiens (human)	MTNR1B	NP_005950.1
Pan troglodytes (chimpanzee)	MTNR1B	XP_522146.2
Xenopus tropicalis (tropical clawed frog)	mtnr1b	XP_002945491.2
Xenopus tropicalis (tropical clawed frog)	LOC100493509	XP_004920801.1
	MTNR1B	XP_001084265.1
Canis lupus familiaris (dog)	MTNR1B	XP_849722.2
Rattus norvegicus (Norway rat)	Mtnr1b	NP_001094111.1
Bos taurus (cattle)	MTNR1B	NP_001193836.1
Mus musculus (house mouse)	Mtnr1b	NP_663758.2

Gene Ontology
Bibliography

Related articles in PubMed

Brain injury results in lower levels of melatonin receptors subtypes MT1 and MT2.
Osier ND, Pham L, Pugh BJ, Puccio A, Ren D, Conley YP, Alexander S, Dixon CE
Neuroscience letters65018-24(2017 May)

The role of melatonin membrane receptors in melatonin-dependent oxytocin secretion from the rat hypothalamo-neurohypophysial system - an in vitro and in vivo approach.
Juszczak M, Wolak M, Bojanowska E, Piera L, Roszczyk M
Endokrynologia Polska67(5)507-514(2016)

Antinociceptive properties of selective MT(2) melatonin receptor partial agonists.
L?pez-Canul M, Comai S, Dom?nguez-L?pez S, Granados-Soto V, Gobbi G
European journal of pharmacology764424-32(2015 Oct)

Co-expression of two subtypes of melatonin receptor on rat M1-type intrinsically photosensitive retinal ganglion cells.
Sheng WL, Chen WY, Yang XL, Zhong YM, Weng SJ
PloS one10(2)e0117967(2015)

Promotion of non-rapid eye movement sleep and activation of reticular thalamic neurons by a novel MT2 melatonin receptor ligand.
Ochoa-Sanchez R, Comai S, Lacoste B, Bambico FR, Dominguez-Lopez S, Spadoni G, Rivara S, Bedini A, Angeloni D, Fraschini F, Mor M, Tarzia G, Descarries L, Gobbi G
The Journal of neuroscience : the official journal of the Society for Neuroscience31(50)18439-52(2011 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

An inhibitory effect of melatonin on oxytocin secretion from the rat hypothalamo-neurohypophysial system is mediated through a subtype MT1 membrane receptor and its action is independent of subtype MT2 receptor. However, for the stimulatory effect of pharmacological concentration of the pineal hormone on oxytocin release, probably mechanisms other than membrane MT1/MT2 receptor(s)-dependent are involved.
Title: The role of melatonin membrane receptors in melatonin-dependent oxytocin secretion from the rat hypothalamo-neurohypophysial system - an in vitro and in vivo approach.

Suggest MT2 melatonin receptor may be a novel target for analgesic drug development.
Title: Antinociceptive properties of selective MT(2) melatonin receptor partial agonists.

We demonstrated the co-existence of MT1 and MT2 receptors in all melanopsin-positive M1 ipRGCs, and the expression of MT1 and MT2 receptors in these cells could be seen as early as the day of birth (P0).
Title: Co-expression of two subtypes of melatonin receptor on rat M1-type intrinsically photosensitive retinal ganglion cells.

The present study demonstrates, for the first time, that MT1b receptors are localized and expressed in rat vestibular nuclei. This study provides additional insight into the role of melatonin receptors during vestibular signal processing.
Title: Immunohistochemical and biomolecular identification of melatonin 1a and 1b receptors in rat vestibular nuclei.

melatonin MT receptor was expressed in somata, dendrites and axon terminals of rat rod-dominant ON type bipolar cells
Title: Melatonin inhibits tetraethylammonium-sensitive potassium channels of rod ON type bipolar cells via MT2 receptors in rat retina.

The following Mtnr1b gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Mtnr1b cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa11325	NM_001100641.1 Latest version!	Rattus norvegicus melatonin receptor 1B (Mtnr1b), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
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5 or more Clone	50% OFF
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*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Mtnr1b ( NM_001100641.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001094111.1 Rattus norvegicus melatonin receptor 1B (Mtnr1b), mRNA.

Price & Availability↑

CloneID	ORa11325
Clone ID Related Accession (Same CDS sequence)	NM_001100641.1
Accession Version	NM_001100641.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1095bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Rattus norvegicus(Norway rat)
Product	melatonin receptor type 1B precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB377275.1. On or before Jan 5, 2009 this sequence version replaced XM_345899.3, XM_001074702.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB377275.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN02642615, SAMN02642675 [ECO:0000350] ##Evidence-Data-END##

ATGCCTGACA ACAGCTCCAT CGCCAACTGC TGTGCGGCCA GCGGGCTGGC AGCGCGCCCT 
AGTTGGCCCG GGTCAGCGGA GGCGGAGCCC CCTGAGACTC CCCGGGCACC CTGGGTGGCT 
CCCATGCTAT CTACAGTAGT CATTGTCACC ACAGCTGTGG ACTTCGTGGG GAACCTGCTT 
GTGATCCTCT CGGTGCTCAG GAACCGCAAG CTGCGGAACG CAGGTAATTT ATTTGTGGTG 
AATCTGGCCT TGGCTGACCT GGTGGTAGCC CTGTACCCTT ACCCACTCAT CCTTGTGGCC 
ATTCTCCATG ACGGTTGGGT ACTTGGGGAG ATCCACTGTA AGGCCAGTGC CTTTGTGATG 
GGCCTGAGTG TCATTGGCTC TGTCTTCAAC ATCACAGCCA TTGCCATCAA CCGCTACTGG 
TGCATCTGTC ACAGTGCGAC CTACCACCGA GCCTGCAGTC AGTGGCATGC TCCCCTCTAC 
ATCAGCCTCA TCTGGCTTCT CACTCTGGTG GCCTTGGTGC CCAATTTCTT TGTGGGGTCT 
CTAGAATATG ACCCGCGAAT CTATTCCTGC ACCTTCATCC AGACAGCCAG CACCCAATAC 
ACTATGGCTG TGGTGGCCAT CCACTTCCTC CTTCCAATTG CTGTGGTGTC CTTTTGCTAC 
CTGCGAATAT GGATACTGGT GCTCCAGGCC CGAAGGAAGG CAAAGGCTGA GAGAAAGCTA 
CGCCTGAGAC CCAGTGACCT GCGCAGTTTC CTAACCATGT TCGCAGTGTT TGTGGTTTTC 
GCCATATGCT GGGCCCCCCT CAACTGTATT GGCCTTGCAG TGGCCATCAA TCCAGAGGCA 
ATGGCTCTTC AGATCCCAGA AGGGCTTTTT GTCACCAGTT ACTTCCTAGC TTACTTCAAC 
AGCTGCCTTA ATGCTATTGT TTATGGGCTT CTGAACCAGA ACTTCCGCAG GGAGTACAAG 
AGGATCCTCT CGGCCCTCTG GAGCACTGGG CGCTGCTTCC ATGATGCTTC CAAATGCCAC 
CTGACTGAGG ATTTGCAGGG CCCAGTGCCA CCTGCTGCCA TGGCCACCAT ACCTGTCCAG 
GAAGGTGCTC TCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001094111.1
CDS	116..1210
Translation	MPDNSSIANCCAASGLAARPSWPGSAEAEPPETPRAPWVAPMLSTVVIVTTAVDFVGNLLVILSVLRNRKLRNAGNLFVVNLALADLVVALYPYPLILVAILHDGWVLGEIHCKASAFVMGLSVIGSVFNITAIAINRYWCICHSATYHRACSQWHAPLYISLIWLLTLVALVPNFFVGSLEYDPRIYSCTFIQTASTQYTMAVVAIHFLLPIAVVSFCYLRIWILVLQARRKAKAERKLRLRPSDLRSFLTMFAVFVVFAICWAPLNCIGLAVAINPEAMALQIPEGLFVTSYFLAYFNSCLNAIVYGLLNQNFRREYKRILSALWSTGRCFHDASKCHLTEDLQGPVPPAAMATIPVQEGAL

Target ORF information:

RefSeq Version	NM_001100641.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus melatonin receptor 1B (Mtnr1b), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001100641.1

ORF Insert Sequence:

ATGCCTGACA ACAGCTCCAT CGCCAACTGC TGTGCGGCCA GCGGGCTGGC AGCGCGCCCT 
AGTTGGCCCG GGTCAGCGGA GGCGGAGCCC CCTGAGACTC CCCGGGCACC CTGGGTGGCT 
CCCATGCTAT CTACAGTAGT CATTGTCACC ACAGCTGTGG ACTTCGTGGG GAACCTGCTT 
GTGATCCTCT CGGTGCTCAG GAACCGCAAG CTGCGGAACG CAGGTAATTT ATTTGTGGTG 
AATCTGGCCT TGGCTGACCT GGTGGTAGCC CTGTACCCTT ACCCACTCAT CCTTGTGGCC 
ATTCTCCATG ACGGTTGGGT ACTTGGGGAG ATCCACTGTA AGGCCAGTGC CTTTGTGATG 
GGCCTGAGTG TCATTGGCTC TGTCTTCAAC ATCACAGCCA TTGCCATCAA CCGCTACTGG 
TGCATCTGTC ACAGTGCGAC CTACCACCGA GCCTGCAGTC AGTGGCATGC TCCCCTCTAC 
ATCAGCCTCA TCTGGCTTCT CACTCTGGTG GCCTTGGTGC CCAATTTCTT TGTGGGGTCT 
CTAGAATATG ACCCGCGAAT CTATTCCTGC ACCTTCATCC AGACAGCCAG CACCCAATAC 
ACTATGGCTG TGGTGGCCAT CCACTTCCTC CTTCCAATTG CTGTGGTGTC CTTTTGCTAC 
CTGCGAATAT GGATACTGGT GCTCCAGGCC CGAAGGAAGG CAAAGGCTGA GAGAAAGCTA 
CGCCTGAGAC CCAGTGACCT GCGCAGTTTC CTAACCATGT TCGCAGTGTT TGTGGTTTTC 
GCCATATGCT GGGCCCCCCT CAACTGTATT GGCCTTGCAG TGGCCATCAA TCCAGAGGCA 
ATGGCTCTTC AGATCCCAGA AGGGCTTTTT GTCACCAGTT ACTTCCTAGC TTACTTCAAC 
AGCTGCCTTA ATGCTATTGT TTATGGGCTT CTGAACCAGA ACTTCCGCAG GGAGTACAAG 
AGGATCCTCT CGGCCCTCTG GAGCACTGGG CGCTGCTTCC ATGATGCTTC CAAATGCCAC 
CTGACTGAGG ATTTGCAGGG CCCAGTGCCA CCTGCTGCCA TGGCCACCAT ACCTGTCCAG 
GAAGGTGCTC TCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Brain injury results in lower levels of melatonin receptors subtypes MT1 and MT2.
Neuroscience letters65018-24(2017 May)
Osier ND,Pham L,Pugh BJ,Puccio A,Ren D,Conley YP,Alexander S,Dixon CE

The role of melatonin membrane receptors in melatonin-dependent oxytocin secretion from the rat hypothalamo-neurohypophysial system - an in vitro and in vivo approach.
Endokrynologia Polska67(5)507-514(2016)
Juszczak M,Wolak M,Bojanowska E,Piera L,Roszczyk M

Antinociceptive properties of selective MT(2) melatonin receptor partial agonists.
European journal of pharmacology764424-32(2015 Oct)
L?pez-Canul M,Comai S,Dom?nguez-L?pez S,Granados-Soto V,Gobbi G

Co-expression of two subtypes of melatonin receptor on rat M1-type intrinsically photosensitive retinal ganglion cells.
PloS one10(2)e0117967(2015)
Sheng WL,Chen WY,Yang XL,Zhong YM,Weng SJ

Promotion of non-rapid eye movement sleep and activation of reticular thalamic neurons by a novel MT2 melatonin receptor ligand.
The Journal of neuroscience : the official journal of the Society for Neuroscience31(50)18439-52(2011 Dec)
Ochoa-Sanchez R,Comai S,Lacoste B,Bambico FR,Dominguez-Lopez S,Spadoni G,Rivara S,Bedini A,Angeloni D,Fraschini F,Mor M,Tarzia G,Descarries L,Gobbi G

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Mtnr1b cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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