Eml2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Eml2
Entrez Gene ID	192360
Full Name	echinoderm microtubule associated protein like 2
Synonyms	Emap,Emap-2,Eml1
General protein information	Preferred Names echinoderm microtubule associated protein like 2 Names echinoderm microtubule-associated protein-like 2
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q21
Summary	microtubule-associated protein that binds to the delta2 glutamate receptor [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_138921.1	NP_620276.1	echinoderm microtubule-associated protein-like 2

Pathways from BioSystems

Homologies

Bos taurus (cattle)	EML2	XP_003587322.1
Mus musculus (house mouse)	Eml2	NP_001156468.1
Caenorhabditis elegans (roundworm)	elp-1	NP_001256951.1
Homo sapiens (human)	EML2	NP_001180197.1
	EML2	XP_001110928.2
Rattus norvegicus (Norway rat)	Eml2	NP_620276.1
Danio rerio (zebrafish)	eml2	NP_001025406.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP012350	XP_320204.4
Canis lupus familiaris (dog)	EML2	XP_003432617.1

Gene Ontology
Bibliography

Related articles in PubMed

Crystal structure of EML1 reveals the basis for Hsp90 dependence of oncogenic EML4-ALK by disruption of an atypical ?-propeller domain.
Richards MW, Law EW, Rennalls LP, Busacca S, O'Regan L, Fry AM, Fennell DA, Bayliss R
Proceedings of the National Academy of Sciences of the United States of America111(14)5195-200(2014 Apr)

Role of RhoA/ROCK signaling in endothelial-monocyte-activating polypeptide II opening of the blood-tumor barrier: role of RhoA/ROCK signaling in EMAP II opening of the BTB.
Xie H, Xue YX, Liu LB, Liu YH, Wang P
Journal of molecular neuroscience : MN46(3)666-76(2012 Mar)

Identification of rat EMAP, a delta-glutamate receptor binding protein.
Ly CD, Roche KW, Lee HK, Wenthold RJ
Biochemical and biophysical research communications291(1)85-90(2002 Feb)

The human EMAP-like protein-70 (ELP70) is a microtubule destabilizer that localizes to the mitotic apparatus.
Eichenmuller B, Everley P, Palange J, Lepley D, Suprenant KA
The Journal of biological chemistry277(2)1301-9(2002 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

RhoA/ROCK signaling plays a role in endothelial-monocyte-activating polypeptide (EMAP) II-induced increase in blood-tumor barrier (BTB) permeability in rat brain microvascular endothelial cells.
Title: Role of RhoA/ROCK signaling in endothelial-monocyte-activating polypeptide II opening of the blood-tumor barrier: role of RhoA/ROCK signaling in EMAP II opening of the BTB.

The following Eml2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Eml2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa02039	NM_138921.1 Latest version!	Rattus norvegicus EMAP like 2 (Eml2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Eml2 ( NM_138921.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_620276.1 Rattus norvegicus EMAP like 2 (Eml2), mRNA.

Price & Availability↑

CloneID	ORa02039
Clone ID Related Accession (Same CDS sequence)	NM_138921.1
Accession Version	NM_138921.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1905bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-12-12
Organism	Rattus norvegicus(Norway rat)
Product	echinoderm microtubule-associated protein-like 2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF335571.1. On Jun 25, 2006 this sequence version replaced XM_001075500.1. ##Evidence-Data-START## Transcript exon combination :: AF335571.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGAGGAGG GATCCGTGAA GATGTTTCTG CGGGGACGCC CTGTGCCCAT GCTGATCCCA 
GACGAGCTGG CGCCCACCTA TAGCCTGGAC ACTCGTTCTG AGCTGCCTTC CAGCCGGCTA 
AAGCTAGATT GGGTCTATGG CTATCGAGGC CGGGACTGCA GGGCCAACCT TTACCTCCTG 
CCCACCGGGG AGGTGGTGTA CTTCGTGGCC TCTGTGGCTG TACTGTACAG CGTAGAGGAG 
CAGAGACAAC GACACTACCT GGGACACAAT GATGACATCA AATGTCTGGC TGTCCATCCG 
GATATGGTCA CCATCGCCAC GGGACAGGTG GCAGGAACCA CAAAGGAAGG CAAGCCTCTG 
CCACCCCATG TGCGTGTGTG GGACTCAGTT TCCCTTTCCA CCTTACACGT CCTGGGCCTG 
GGGGTGTTTG ACAGAGCTGT GTGCTGTGTG GCCTTCTCCA AATCCAATGG GGGCAACCTG 
CTATGTGCAG TGGACGAATC CAACGATCAT GTGCTCTCTG TGTGGGACTG GGCCAAGGAG 
AGCAAAGTGG TGGATAGCAA GTGTTCTAAT GAGGCCGTGC TGGTGGCTAC CTTCCACCCC 
ACTGATCCCA ACCTGCTGAT AACCTGTGGC AAATCCCACA TCTACTTCTG GAGCCTGGAA 
GGAGGCAACC TGAGCAAGCG GCAGGGCCTG TTTGAGAAAC ACGAGAAGCC AAAGTATGTG 
CTGTGTGTGA CCTTCTTGGA AGGTGGCGAC GTGGTCACTG GAGACTCTGG GGGGAACCTC 
TATGTCTGGG GCAAAGGTGG AAACCGCATC ACCCAGGAAG TTCTAGGAGC CCATGATGGT 
GGCGTGTTTG CGCTCTGCGC CCTGCGGGAC GGGACGCTGG TGTCTGTTTG GGGCCGTGAT 
CGTCGGGTGG TCCTCTGGGG TTCAGACTAC AGCAAGGTGC AAGAGGTGGA GGTCCCAGAG 
GACTTCGGCC CTGTACGCAC CGTGGCAGAG GGCAGGGGAG ACACACTGTA CGTGGGGACC 
ACCCGTAACT CCATCTTGCT TGGCTCGGTG CACACAGGTT TCTCTCTGCT TGTCCAGGGA 
CATGTGGAAG AACTGTGGGG CCTGGCCACA CATCCTAGCA GGGCACAGTT TGTGAGCTGT 
GGGCAGGATA AGCTGGTGCA TCTGTGGAGC TCGGAGACCC ACCAGCCAGT GTGGAGCAGG 
AGCATTGAGG ACCCTGCCCG TTCGGCTGGC TTCCACCCCA GTGGCTCTGT CCTAGCGGTG 
GGCACAGTGA CCGGCAGGTG GCTGCTACTG GACACAGACA CCCGTGACCT GGTGGCTATC 
CACACAGATG GCAATGAGCA GATCTCTGTG GTCAGCTTTT CACCAGACGG GGCGTACCTG 
GCTGTGGGCT CCCACGACAA CTTGGTGTAC GTGTACACGG TGGACCATTG TGGCCGCAAG 
GTCAGCCGCC TGGGCAAGTG CTCGGGCCAT TCCAGTTTTA TCACTCACCT GGATTGGGCC 
CAGGACAGCA CCTGCTTTGT CACCAACTCT GGAGACTACG AAATTCTGTA CTGGGACGCT 
GCCACCTGTA AGCAGATCAC CAGTGCAGAC ACCGTGAGAA ATGTGCAATG GGCTACTGCT 
ACTTGTGTGT TGGGTTTTGG AGTTTTTGGG ATCTGGCCTG AGGGGGCAGA CGGCACAGAC 
ATCAATGCTG TGGCCCGCTC TCACGATGGG AACTTGCTGG TTTCTGCTGA CGACTTCGGC 
AAAGTGCACC TGTTCAGCTA CCCCTGCTGT CAGCCGAGAG CTCTCAGCCA CAAATATGGT 
GGACACAGCA GCCATGTGAC TAATGTGGCC TTCTTGTGGG ATGACAGCAT GGTCCTAACC 
ACTGGGGGCA AAGACACGAG CGTGCTGCAG TGGCGGGTAG CCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_620276.1
CDS	526..2430
Translation	MEEGSVKMFLRGRPVPMLIPDELAPTYSLDTRSELPSSRLKLDWVYGYRGRDCRANLYLLPTGEVVYFVASVAVLYSVEEQRQRHYLGHNDDIKCLAVHPDMVTIATGQVAGTTKEGKPLPPHVRVWDSVSLSTLHVLGLGVFDRAVCCVAFSKSNGGNLLCAVDESNDHVLSVWDWAKESKVVDSKCSNEAVLVATFHPTDPNLLITCGKSHIYFWSLEGGNLSKRQGLFEKHEKPKYVLCVTFLEGGDVVTGDSGGNLYVWGKGGNRITQEVLGAHDGGVFALCALRDGTLVSVWGRDRRVVLWGSDYSKVQEVEVPEDFGPVRTVAEGRGDTLYVGTTRNSILLGSVHTGFSLLVQGHVEELWGLATHPSRAQFVSCGQDKLVHLWSSETHQPVWSRSIEDPARSAGFHPSGSVLAVGTVTGRWLLLDTDTRDLVAIHTDGNEQISVVSFSPDGAYLAVGSHDNLVYVYTVDHCGRKVSRLGKCSGHSSFITHLDWAQDSTCFVTNSGDYEILYWDAATCKQITSADTVRNVQWATATCVLGFGVFGIWPEGADGTDINAVARSHDGNLLVSADDFGKVHLFSYPCCQPRALSHKYGGHSSHVTNVAFLWDDSMVLTTGGKDTSVLQWRVA

Target ORF information:

RefSeq Version	NM_138921.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus EMAP like 2 (Eml2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_138921.1

ORF Insert Sequence:

ATGGAGGAGG GATCCGTGAA GATGTTTCTG CGGGGACGCC CTGTGCCCAT GCTGATCCCA 
GACGAGCTGG CGCCCACCTA TAGCCTGGAC ACTCGTTCTG AGCTGCCTTC CAGCCGGCTA 
AAGCTAGATT GGGTCTATGG CTATCGAGGC CGGGACTGCA GGGCCAACCT TTACCTCCTG 
CCCACCGGGG AGGTGGTGTA CTTCGTGGCC TCTGTGGCTG TACTGTACAG CGTAGAGGAG 
CAGAGACAAC GACACTACCT GGGACACAAT GATGACATCA AATGTCTGGC TGTCCATCCG 
GATATGGTCA CCATCGCCAC GGGACAGGTG GCAGGAACCA CAAAGGAAGG CAAGCCTCTG 
CCACCCCATG TGCGTGTGTG GGACTCAGTT TCCCTTTCCA CCTTACACGT CCTGGGCCTG 
GGGGTGTTTG ACAGAGCTGT GTGCTGTGTG GCCTTCTCCA AATCCAATGG GGGCAACCTG 
CTATGTGCAG TGGACGAATC CAACGATCAT GTGCTCTCTG TGTGGGACTG GGCCAAGGAG 
AGCAAAGTGG TGGATAGCAA GTGTTCTAAT GAGGCCGTGC TGGTGGCTAC CTTCCACCCC 
ACTGATCCCA ACCTGCTGAT AACCTGTGGC AAATCCCACA TCTACTTCTG GAGCCTGGAA 
GGAGGCAACC TGAGCAAGCG GCAGGGCCTG TTTGAGAAAC ACGAGAAGCC AAAGTATGTG 
CTGTGTGTGA CCTTCTTGGA AGGTGGCGAC GTGGTCACTG GAGACTCTGG GGGGAACCTC 
TATGTCTGGG GCAAAGGTGG AAACCGCATC ACCCAGGAAG TTCTAGGAGC CCATGATGGT 
GGCGTGTTTG CGCTCTGCGC CCTGCGGGAC GGGACGCTGG TGTCTGTTTG GGGCCGTGAT 
CGTCGGGTGG TCCTCTGGGG TTCAGACTAC AGCAAGGTGC AAGAGGTGGA GGTCCCAGAG 
GACTTCGGCC CTGTACGCAC CGTGGCAGAG GGCAGGGGAG ACACACTGTA CGTGGGGACC 
ACCCGTAACT CCATCTTGCT TGGCTCGGTG CACACAGGTT TCTCTCTGCT TGTCCAGGGA 
CATGTGGAAG AACTGTGGGG CCTGGCCACA CATCCTAGCA GGGCACAGTT TGTGAGCTGT 
GGGCAGGATA AGCTGGTGCA TCTGTGGAGC TCGGAGACCC ACCAGCCAGT GTGGAGCAGG 
AGCATTGAGG ACCCTGCCCG TTCGGCTGGC TTCCACCCCA GTGGCTCTGT CCTAGCGGTG 
GGCACAGTGA CCGGCAGGTG GCTGCTACTG GACACAGACA CCCGTGACCT GGTGGCTATC 
CACACAGATG GCAATGAGCA GATCTCTGTG GTCAGCTTTT CACCAGACGG GGCGTACCTG 
GCTGTGGGCT CCCACGACAA CTTGGTGTAC GTGTACACGG TGGACCATTG TGGCCGCAAG 
GTCAGCCGCC TGGGCAAGTG CTCGGGCCAT TCCAGTTTTA TCACTCACCT GGATTGGGCC 
CAGGACAGCA CCTGCTTTGT CACCAACTCT GGAGACTACG AAATTCTGTA CTGGGACGCT 
GCCACCTGTA AGCAGATCAC CAGTGCAGAC ACCGTGAGAA ATGTGCAATG GGCTACTGCT 
ACTTGTGTGT TGGGTTTTGG AGTTTTTGGG ATCTGGCCTG AGGGGGCAGA CGGCACAGAC 
ATCAATGCTG TGGCCCGCTC TCACGATGGG AACTTGCTGG TTTCTGCTGA CGACTTCGGC 
AAAGTGCACC TGTTCAGCTA CCCCTGCTGT CAGCCGAGAG CTCTCAGCCA CAAATATGGT 
GGACACAGCA GCCATGTGAC TAATGTGGCC TTCTTGTGGG ATGACAGCAT GGTCCTAACC 
ACTGGGGGCA AAGACACGAG CGTGCTGCAG TGGCGGGTAG CCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Crystal structure of EML1 reveals the basis for Hsp90 dependence of oncogenic EML4-ALK by disruption of an atypical ?-propeller domain.
Proceedings of the National Academy of Sciences of the United States of America111(14)5195-200(2014 Apr)
Richards MW,Law EW,Rennalls LP,Busacca S,O'Regan L,Fry AM,Fennell DA,Bayliss R

Role of RhoA/ROCK signaling in endothelial-monocyte-activating polypeptide II opening of the blood-tumor barrier: role of RhoA/ROCK signaling in EMAP II opening of the BTB.
Journal of molecular neuroscience : MN46(3)666-76(2012 Mar)
Xie H,Xue YX,Liu LB,Liu YH,Wang P

Identification of rat EMAP, a delta-glutamate receptor binding protein.
Biochemical and biophysical research communications291(1)85-90(2002 Feb)
Ly CD,Roche KW,Lee HK,Wenthold RJ

The human EMAP-like protein-70 (ELP70) is a microtubule destabilizer that localizes to the mitotic apparatus.
The Journal of biological chemistry277(2)1301-9(2002 Jan)
Eichenmuller B,Everley P,Palange J,Lepley D,Suprenant KA

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Eml2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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