Spon2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Spon2
Entrez Gene ID	171569
Full Name	spondin 2
General protein information	Preferred Names spondin 2 Names spondin-2 F-spondin mindin spondin 2, extracellular matrix protein spondin-2-like
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 14 Map Location: 14q21
Summary	promotes cell adhesion and outgrowth of embryonic hippocampal neurons [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_017599062.1	XP_017454551.1	spondin-2 isoform X1
NM_138533.3	NP_612542.1	spondin-2 precursor
XM_017599063.1	XP_017454552.1	spondin-2 isoform X1

Pathways from BioSystems

Homologies

	SPON2	XP_001092523.1
Mus musculus (house mouse)	Spon2	NP_598664.3
Danio rerio (zebrafish)	spon2b	NP_571083.4
Drosophila melanogaster (fruit fly)	mspo	NP_725407.1
Homo sapiens (human)	SPON2	NP_036577.1
Bos taurus (cattle)	SPON2	NP_001039622.1
Canis lupus familiaris (dog)	LOC102155429	XP_005618808.1
Xenopus tropicalis (tropical clawed frog)	spon2	NP_001072560.1
Rattus norvegicus (Norway rat)	Spon2	NP_612542.1
Gallus gallus (chicken)	SPON2	XP_420847.3
Pan troglodytes (chimpanzee)	SPON2	XP_001141954.1

Gene Ontology
Bibliography

Related articles in PubMed

Mindin regulates vascular smooth muscle cell phenotype and prevents neointima formation.
Zhu LH, Huang L, Zhang X, Zhang P, Zhang SM, Guan H, Zhang Y, Zhu XY, Tian S, Deng K, Li H
Clinical science (London, England : 1979)129(2)129-45(2015 Jul)

Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c.
Abonnenc M, Nabeebaccus AA, Mayr U, Barallobre-Barreiro J, Dong X, Cuello F, Sur S, Drozdov I, Langley SR, Lu R, Stathopoulou K, Didangelos A, Yin X, Zimmermann WH, Shah AM, Zampetaki A, Mayr M
Circulation research113(10)1138-47(2013 Oct)

3'poly-G-tailed ODNs inhibit F-spondin to induce cell death and neurite retraction in rat embryonic neurons.
Cheng YC, Chen TA, Chen CY, Liang CM, Liang SM
Molecular neurobiology45(3)536-49(2012 Jun)

Positive regulation of spondin 2 by thyroid hormone is associated with cell migration and invasion.
Liao CH, Yeh SC, Huang YH, Chen RN, Tsai MM, Chen WJ, Chi HC, Tai PJ, Liao CJ, Wu SM, Cheng WL, Pai LM, Lin KH
Endocrine-related cancer17(1)99-111(2010 Mar)

Large-scale proteomics and phosphoproteomics of urinary exosomes.
Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal of the American Society of Nephrology : JASN20(2)363-79(2009 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Mindin protects against vascular hyperplasia by suppression of abnormal VSMC proliferation, migration and phenotypic switching in an AKT-dependent manner.
Title: Mindin regulates vascular smooth muscle cell phenotype and prevents neointima formation.

3'G-oligodeoxyribonucleotides enhance nucleus YB-1 to inhibit F-spondin leading to cell death and neurite retraction of embryonic neuron cells.
Title: 3'poly-G-tailed ODNs inhibit F-spondin to induce cell death and neurite retraction in rat embryonic neurons.

Spon2 protein was 9.2-fold & mRNA 16.5-fold higher in the T3-treated thyroidectomized (Tx)rats compared with the Tx group.
Title: Positive regulation of spondin 2 by thyroid hormone is associated with cell migration and invasion.

These studies identify F-spondin as a novel protein in osteoarthritis cartilage, where it may act in situ at lesional areas to activate latent TGF-beta and induce cartilage degradation.
Title: F-spondin, a neuroregulatory protein, is up-regulated in osteoarthritis and regulates cartilage metabolism via TGF-beta activation.

NMR solution structures of TSR domains of F-spondin showed that they have an unusual fold that is characterized by a long, nonglobular shape, consisting of two beta-strands and one irregular extended strand.
Title: Solution structures of the first and fourth TSR domains of F-spondin.

The following Spon2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Spon2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa01596	NM_138533.3 Latest version!	Rattus norvegicus spondin 2 (Spon2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00
ORa01596	XM_017599063.1 Latest version!	Rattus norvegicus spondin 2 (Spon2), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00
ORa01596	XM_017599062.1 Latest version!	Rattus norvegicus spondin 2 (Spon2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Spon2 ( NM_138533.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_612542.1 Rattus norvegicus spondin 2 (Spon2), mRNA.

Price & Availability↑

CloneID	ORa01596
Clone ID Related Accession (Same CDS sequence)	XM_017599062.1 , NM_138533.3 , XM_017599063.1
Accession Version	NM_138533.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 993bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-20
Organism	Rattus norvegicus(Norway rat)
Product	spondin-2 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC078734.1. On Jun 10, 2007 this sequence version replaced NM_138533.2. ##Evidence-Data-START## Transcript exon combination :: BC078734.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGAAAACG TGAGTTTTTC CCTGGACAGA ACTCTTTGGG TCTTCCTCCT GGCCATGCTA 
GGCTCCACCG CAGGCCAGCC GCTGGGGGGA GAATCTGTCT GCACAGCCCG GCCTCTGGCT 
AGATACAGCA TCACTTTCAC TGGCAAGTGG AGCCAGACAG CATTTCCCAA GCAGTATCCT 
CTGTTCCGGC CCCCTGCACA GTGGTCCTCT CTGCTGGGGG CAGCACACAG CTCTGACTAC 
AGCATGTGGC GGAAGAATGA GTACGTCAGC AATGGGCTGA GGGACTTCGC TGAGCGTGGT 
GAGGCCTGGG CACTGATGAA AGAGATCGAA GCAGCAGGAG AGAAGCTCCA GAGTGTGCAC 
GCGGTATTCT CGGCTCCCGC CGTGCCTAGT GGTACCGGGC AGACTTCTGC AGAGTTAGAG 
GTGCACCCTA GGCACTCGCT GGTGTCCTTC GTGGTACGCA TTGTCCCCAG TCCGGACTGG 
TTTGTGGGCA TCGACAGTCT GGACCTGTGC GAGGGAGGCC GCTGGAAGGA GCAGGTGGTC 
CTTGATCTTT ACCCACACGA TGCAGGGACA GACAGTGGCT TCACCTTCTC CTCCCCCAAC 
TTTGCAACCA TCCCACAAGA CACAGTGACT GAGATAACCG CCTCATCGCC CAGTCACCCA 
GCCAACTCAT TCTACTACCC ACGCCTCAAG TCCTTGCCAC CCATTGCCAA AGTGACCTTC 
GTGCGGCTAC GGCAGAGTCC CAGAGCCTTT GCCCCACCTT CCCTGGACCT GGCCAGCAGA 
GGAAATGAAA TCGTTGACAG CCTCTCAGTT CCAGAGACAC CGCTGGACTG TGAAGTTTCC 
CTGTGGTCAT CCTGGGGACT GTGCGGAGGG CCATGTGGAA AGTTGGGAGC CAAGAGCAGA 
ACTCGCTATG TGCGTGTTCA GCCTGCTAAC AATGGGACTC CCTGTCCCGA GCTTGAAGAA 
GAGGCTGAGT GTGCCCCAGA TAACTGTGTC TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_612542.1
CDS	203..1195
Translation	MENVSFSLDRTLWVFLLAMLGSTAGQPLGGESVCTARPLARYSITFTGKWSQTAFPKQYPLFRPPAQWSSLLGAAHSSDYSMWRKNEYVSNGLRDFAERGEAWALMKEIEAAGEKLQSVHAVFSAPAVPSGTGQTSAELEVHPRHSLVSFVVRIVPSPDWFVGIDSLDLCEGGRWKEQVVLDLYPHDAGTDSGFTFSSPNFATIPQDTVTEITASSPSHPANSFYYPRLKSLPPIAKVTFVRLRQSPRAFAPPSLDLASRGNEIVDSLSVPETPLDCEVSLWSSWGLCGGPCGKLGAKSRTRYVRVQPANNGTPCPELEEEAECAPDNCV

Target ORF information:

RefSeq Version	NM_138533.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus spondin 2 (Spon2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_138533.3

ORF Insert Sequence:

ATGGAAAACG TGAGTTTTTC CCTGGACAGA ACTCTTTGGG TCTTCCTCCT GGCCATGCTA 
GGCTCCACCG CAGGCCAGCC GCTGGGGGGA GAATCTGTCT GCACAGCCCG GCCTCTGGCT 
AGATACAGCA TCACTTTCAC TGGCAAGTGG AGCCAGACAG CATTTCCCAA GCAGTATCCT 
CTGTTCCGGC CCCCTGCACA GTGGTCCTCT CTGCTGGGGG CAGCACACAG CTCTGACTAC 
AGCATGTGGC GGAAGAATGA GTACGTCAGC AATGGGCTGA GGGACTTCGC TGAGCGTGGT 
GAGGCCTGGG CACTGATGAA AGAGATCGAA GCAGCAGGAG AGAAGCTCCA GAGTGTGCAC 
GCGGTATTCT CGGCTCCCGC CGTGCCTAGT GGTACCGGGC AGACTTCTGC AGAGTTAGAG 
GTGCACCCTA GGCACTCGCT GGTGTCCTTC GTGGTACGCA TTGTCCCCAG TCCGGACTGG 
TTTGTGGGCA TCGACAGTCT GGACCTGTGC GAGGGAGGCC GCTGGAAGGA GCAGGTGGTC 
CTTGATCTTT ACCCACACGA TGCAGGGACA GACAGTGGCT TCACCTTCTC CTCCCCCAAC 
TTTGCAACCA TCCCACAAGA CACAGTGACT GAGATAACCG CCTCATCGCC CAGTCACCCA 
GCCAACTCAT TCTACTACCC ACGCCTCAAG TCCTTGCCAC CCATTGCCAA AGTGACCTTC 
GTGCGGCTAC GGCAGAGTCC CAGAGCCTTT GCCCCACCTT CCCTGGACCT GGCCAGCAGA 
GGAAATGAAA TCGTTGACAG CCTCTCAGTT CCAGAGACAC CGCTGGACTG TGAAGTTTCC 
CTGTGGTCAT CCTGGGGACT GTGCGGAGGG CCATGTGGAA AGTTGGGAGC CAAGAGCAGA 
ACTCGCTATG TGCGTGTTCA GCCTGCTAAC AATGGGACTC CCTGTCCCGA GCTTGAAGAA 
GAGGCTGAGT GTGCCCCAGA TAACTGTGTC TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Spon2 ( XM_017599062.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017454551.1 Rattus norvegicus spondin 2 (Spon2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa01596
Clone ID Related Accession (Same CDS sequence)	XM_017599062.1 , NM_138533.3 , XM_017599063.1
Accession Version	XM_017599062.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 993bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	spondin-2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005113.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAAAACG TGAGTTTTTC CCTGGACAGA ACTCTTTGGG TCTTCCTCCT GGCCATGCTA 
GGCTCCACCG CAGGCCAGCC GCTGGGGGGA GAATCTGTCT GCACAGCCCG GCCTCTGGCT 
AGATACAGCA TCACTTTCAC TGGCAAGTGG AGCCAGACAG CATTTCCCAA GCAGTATCCT 
CTGTTCCGGC CCCCTGCACA GTGGTCCTCT CTGCTGGGGG CAGCACACAG CTCTGACTAC 
AGCATGTGGC GGAAGAATGA GTACGTCAGC AATGGGCTGA GGGACTTCGC TGAGCGTGGT 
GAGGCCTGGG CACTGATGAA AGAGATCGAA GCAGCAGGAG AGAAGCTCCA GAGTGTGCAC 
GCGGTATTCT CGGCTCCCGC CGTGCCTAGT GGTACCGGGC AGACTTCTGC AGAGTTAGAG 
GTGCACCCTA GGCACTCGCT GGTGTCCTTC GTGGTACGCA TTGTCCCCAG TCCGGACTGG 
TTTGTGGGCA TCGACAGTCT GGACCTGTGC GAGGGAGGCC GCTGGAAGGA GCAGGTGGTC 
CTTGATCTTT ACCCACACGA TGCAGGGACA GACAGTGGCT TCACCTTCTC CTCCCCCAAC 
TTTGCAACCA TCCCACAAGA CACAGTGACT GAGATAACCG CCTCATCGCC CAGTCACCCA 
GCCAACTCAT TCTACTACCC ACGCCTCAAG TCCTTGCCAC CCATTGCCAA AGTGACCTTC 
GTGCGGCTAC GGCAGAGTCC CAGAGCCTTT GCCCCACCTT CCCTGGACCT GGCCAGCAGA 
GGAAATGAAA TCGTTGACAG CCTCTCAGTT CCAGAGACAC CGCTGGACTG TGAAGTTTCC 
CTGTGGTCAT CCTGGGGACT GTGCGGAGGG CCATGTGGAA AGTTGGGAGC CAAGAGCAGA 
ACTCGCTATG TGCGTGTTCA GCCTGCTAAC AATGGGACTC CCTGTCCCGA GCTTGAAGAA 
GAGGCTGAGT GTGCCCCAGA TAACTGTGTC TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017454551.1
CDS	2215..3207
Translation	MENVSFSLDRTLWVFLLAMLGSTAGQPLGGESVCTARPLARYSITFTGKWSQTAFPKQYPLFRPPAQWSSLLGAAHSSDYSMWRKNEYVSNGLRDFAERGEAWALMKEIEAAGEKLQSVHAVFSAPAVPSGTGQTSAELEVHPRHSLVSFVVRIVPSPDWFVGIDSLDLCEGGRWKEQVVLDLYPHDAGTDSGFTFSSPNFATIPQDTVTEITASSPSHPANSFYYPRLKSLPPIAKVTFVRLRQSPRAFAPPSLDLASRGNEIVDSLSVPETPLDCEVSLWSSWGLCGGPCGKLGAKSRTRYVRVQPANNGTPCPELEEEAECAPDNCV

Target ORF information:

RefSeq Version	XM_017599062.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus spondin 2 (Spon2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017599062.1

ORF Insert Sequence:

ATGGAAAACG TGAGTTTTTC CCTGGACAGA ACTCTTTGGG TCTTCCTCCT GGCCATGCTA 
GGCTCCACCG CAGGCCAGCC GCTGGGGGGA GAATCTGTCT GCACAGCCCG GCCTCTGGCT 
AGATACAGCA TCACTTTCAC TGGCAAGTGG AGCCAGACAG CATTTCCCAA GCAGTATCCT 
CTGTTCCGGC CCCCTGCACA GTGGTCCTCT CTGCTGGGGG CAGCACACAG CTCTGACTAC 
AGCATGTGGC GGAAGAATGA GTACGTCAGC AATGGGCTGA GGGACTTCGC TGAGCGTGGT 
GAGGCCTGGG CACTGATGAA AGAGATCGAA GCAGCAGGAG AGAAGCTCCA GAGTGTGCAC 
GCGGTATTCT CGGCTCCCGC CGTGCCTAGT GGTACCGGGC AGACTTCTGC AGAGTTAGAG 
GTGCACCCTA GGCACTCGCT GGTGTCCTTC GTGGTACGCA TTGTCCCCAG TCCGGACTGG 
TTTGTGGGCA TCGACAGTCT GGACCTGTGC GAGGGAGGCC GCTGGAAGGA GCAGGTGGTC 
CTTGATCTTT ACCCACACGA TGCAGGGACA GACAGTGGCT TCACCTTCTC CTCCCCCAAC 
TTTGCAACCA TCCCACAAGA CACAGTGACT GAGATAACCG CCTCATCGCC CAGTCACCCA 
GCCAACTCAT TCTACTACCC ACGCCTCAAG TCCTTGCCAC CCATTGCCAA AGTGACCTTC 
GTGCGGCTAC GGCAGAGTCC CAGAGCCTTT GCCCCACCTT CCCTGGACCT GGCCAGCAGA 
GGAAATGAAA TCGTTGACAG CCTCTCAGTT CCAGAGACAC CGCTGGACTG TGAAGTTTCC 
CTGTGGTCAT CCTGGGGACT GTGCGGAGGG CCATGTGGAA AGTTGGGAGC CAAGAGCAGA 
ACTCGCTATG TGCGTGTTCA GCCTGCTAAC AATGGGACTC CCTGTCCCGA GCTTGAAGAA 
GAGGCTGAGT GTGCCCCAGA TAACTGTGTC TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Spon2 ( XM_017599063.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017454552.1 Rattus norvegicus spondin 2 (Spon2), transcript variant X2, mRNA.

Price & Availability↑

CloneID	ORa01596
Clone ID Related Accession (Same CDS sequence)	XM_017599062.1 , NM_138533.3 , XM_017599063.1
Accession Version	XM_017599063.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 993bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	spondin-2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005113.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAAAACG TGAGTTTTTC CCTGGACAGA ACTCTTTGGG TCTTCCTCCT GGCCATGCTA 
GGCTCCACCG CAGGCCAGCC GCTGGGGGGA GAATCTGTCT GCACAGCCCG GCCTCTGGCT 
AGATACAGCA TCACTTTCAC TGGCAAGTGG AGCCAGACAG CATTTCCCAA GCAGTATCCT 
CTGTTCCGGC CCCCTGCACA GTGGTCCTCT CTGCTGGGGG CAGCACACAG CTCTGACTAC 
AGCATGTGGC GGAAGAATGA GTACGTCAGC AATGGGCTGA GGGACTTCGC TGAGCGTGGT 
GAGGCCTGGG CACTGATGAA AGAGATCGAA GCAGCAGGAG AGAAGCTCCA GAGTGTGCAC 
GCGGTATTCT CGGCTCCCGC CGTGCCTAGT GGTACCGGGC AGACTTCTGC AGAGTTAGAG 
GTGCACCCTA GGCACTCGCT GGTGTCCTTC GTGGTACGCA TTGTCCCCAG TCCGGACTGG 
TTTGTGGGCA TCGACAGTCT GGACCTGTGC GAGGGAGGCC GCTGGAAGGA GCAGGTGGTC 
CTTGATCTTT ACCCACACGA TGCAGGGACA GACAGTGGCT TCACCTTCTC CTCCCCCAAC 
TTTGCAACCA TCCCACAAGA CACAGTGACT GAGATAACCG CCTCATCGCC CAGTCACCCA 
GCCAACTCAT TCTACTACCC ACGCCTCAAG TCCTTGCCAC CCATTGCCAA AGTGACCTTC 
GTGCGGCTAC GGCAGAGTCC CAGAGCCTTT GCCCCACCTT CCCTGGACCT GGCCAGCAGA 
GGAAATGAAA TCGTTGACAG CCTCTCAGTT CCAGAGACAC CGCTGGACTG TGAAGTTTCC 
CTGTGGTCAT CCTGGGGACT GTGCGGAGGG CCATGTGGAA AGTTGGGAGC CAAGAGCAGA 
ACTCGCTATG TGCGTGTTCA GCCTGCTAAC AATGGGACTC CCTGTCCCGA GCTTGAAGAA 
GAGGCTGAGT GTGCCCCAGA TAACTGTGTC TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017454552.1
CDS	528..1520
Translation	MENVSFSLDRTLWVFLLAMLGSTAGQPLGGESVCTARPLARYSITFTGKWSQTAFPKQYPLFRPPAQWSSLLGAAHSSDYSMWRKNEYVSNGLRDFAERGEAWALMKEIEAAGEKLQSVHAVFSAPAVPSGTGQTSAELEVHPRHSLVSFVVRIVPSPDWFVGIDSLDLCEGGRWKEQVVLDLYPHDAGTDSGFTFSSPNFATIPQDTVTEITASSPSHPANSFYYPRLKSLPPIAKVTFVRLRQSPRAFAPPSLDLASRGNEIVDSLSVPETPLDCEVSLWSSWGLCGGPCGKLGAKSRTRYVRVQPANNGTPCPELEEEAECAPDNCV

Target ORF information:

RefSeq Version	XM_017599063.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus spondin 2 (Spon2), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017599063.1

ORF Insert Sequence:

ATGGAAAACG TGAGTTTTTC CCTGGACAGA ACTCTTTGGG TCTTCCTCCT GGCCATGCTA 
GGCTCCACCG CAGGCCAGCC GCTGGGGGGA GAATCTGTCT GCACAGCCCG GCCTCTGGCT 
AGATACAGCA TCACTTTCAC TGGCAAGTGG AGCCAGACAG CATTTCCCAA GCAGTATCCT 
CTGTTCCGGC CCCCTGCACA GTGGTCCTCT CTGCTGGGGG CAGCACACAG CTCTGACTAC 
AGCATGTGGC GGAAGAATGA GTACGTCAGC AATGGGCTGA GGGACTTCGC TGAGCGTGGT 
GAGGCCTGGG CACTGATGAA AGAGATCGAA GCAGCAGGAG AGAAGCTCCA GAGTGTGCAC 
GCGGTATTCT CGGCTCCCGC CGTGCCTAGT GGTACCGGGC AGACTTCTGC AGAGTTAGAG 
GTGCACCCTA GGCACTCGCT GGTGTCCTTC GTGGTACGCA TTGTCCCCAG TCCGGACTGG 
TTTGTGGGCA TCGACAGTCT GGACCTGTGC GAGGGAGGCC GCTGGAAGGA GCAGGTGGTC 
CTTGATCTTT ACCCACACGA TGCAGGGACA GACAGTGGCT TCACCTTCTC CTCCCCCAAC 
TTTGCAACCA TCCCACAAGA CACAGTGACT GAGATAACCG CCTCATCGCC CAGTCACCCA 
GCCAACTCAT TCTACTACCC ACGCCTCAAG TCCTTGCCAC CCATTGCCAA AGTGACCTTC 
GTGCGGCTAC GGCAGAGTCC CAGAGCCTTT GCCCCACCTT CCCTGGACCT GGCCAGCAGA 
GGAAATGAAA TCGTTGACAG CCTCTCAGTT CCAGAGACAC CGCTGGACTG TGAAGTTTCC 
CTGTGGTCAT CCTGGGGACT GTGCGGAGGG CCATGTGGAA AGTTGGGAGC CAAGAGCAGA 
ACTCGCTATG TGCGTGTTCA GCCTGCTAAC AATGGGACTC CCTGTCCCGA GCTTGAAGAA 
GAGGCTGAGT GTGCCCCAGA TAACTGTGTC TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Mindin regulates vascular smooth muscle cell phenotype and prevents neointima formation.
Clinical science (London, England : 1979)129(2)129-45(2015 Jul)
Zhu LH,Huang L,Zhang X,Zhang P,Zhang SM,Guan H,Zhang Y,Zhu XY,Tian S,Deng K,Li H

Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c.
Circulation research113(10)1138-47(2013 Oct)
Abonnenc M,Nabeebaccus AA,Mayr U,Barallobre-Barreiro J,Dong X,Cuello F,Sur S,Drozdov I,Langley SR,Lu R,Stathopoulou K,Didangelos A,Yin X,Zimmermann WH,Shah AM,Zampetaki A,Mayr M

3'poly-G-tailed ODNs inhibit F-spondin to induce cell death and neurite retraction in rat embryonic neurons.
Molecular neurobiology45(3)536-49(2012 Jun)
Cheng YC,Chen TA,Chen CY,Liang CM,Liang SM

Positive regulation of spondin 2 by thyroid hormone is associated with cell migration and invasion.
Endocrine-related cancer17(1)99-111(2010 Mar)
Liao CH,Yeh SC,Huang YH,Chen RN,Tsai MM,Chen WJ,Chi HC,Tai PJ,Liao CJ,Wu SM,Cheng WL,Pai LM,Lin KH

Large-scale proteomics and phosphoproteomics of urinary exosomes.
Journal of the American Society of Nephrology : JASN20(2)363-79(2009 Feb)
Gonzales PA,Pisitkun T,Hoffert JD,Tchapyjnikov D,Star RA,Kleta R,Wang NS,Knepper MA

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Spon2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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