Akr1c3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Akr1c3
Entrez Gene ID	171516
Full Name	aldo-keto reductase family 1, member C3
Synonyms	Akr1c18
General protein information	Preferred Names aldo-keto reductase family 1, member C3 Names aldo-keto reductase family 1 member C18 20-alpha-HSD 20-alpha-hydroxysteroid dehydrogenase 20alpha-hydroxysteroid dehydrogenase HSD1 aldo-keto reductase family 1, member C18 aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 17 Map Location: 17q12.2
Summary	catalyses the convariant of progesterone into 20 alpha-dihydroprogesterone (20 alpha-OHP); activity is regulated by prolactin [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_138510.1	NP_612519.1	aldo-keto reductase family 1 member C18

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	AKR1C3	NP_001012344.1
Bos taurus (cattle)	AKR1C3	XP_002692230.1
Bos taurus (cattle)	LOC100337056	XP_002692229.1
Bos taurus (cattle)	LOC782922	NP_001159696.1
Bos taurus (cattle)	LOC527068	NP_001030444.1
Mus musculus (house mouse)	Akr1c18	NP_598827.1
Bos taurus (cattle)	LOC784927	XP_005214488.1
Rattus norvegicus (Norway rat)	Akr1c3	NP_612519.1
Pan troglodytes (chimpanzee)	AKR1C3	XP_003951631.1
Bos taurus (cattle)	AKR1C4	NP_851370.1
Bos taurus (cattle)	20ALPHA-HSD	NP_001161132.1
Homo sapiens (human)	AKR1C3	NP_001240837.1
Bos taurus (cattle)	LOC506594	XP_002692251.3
Bos taurus (cattle)	LOC782061	NP_001159695.1
Bos taurus (cattle)	LOC785762	NP_001159697.1
Bos taurus (cattle)	LOC538060	NP_001193716.1

Gene Ontology
Bibliography

Related articles in PubMed

AKR1C3 is a biomarker of sensitivity to PR-104 in preclinical models of T-cell acute lymphoblastic leukemia.
Moradi Manesh D, El-Hoss J, Evans K, Richmond J, Toscan CE, Bracken LS, Hedrick A, Sutton R, Marshall GM, Wilson WR, Kurmasheva RT, Billups C, Houghton PJ, Smith MA, Carol H, Lock RB
Blood126(10)1193-202(2015 Sep)

[Effects of AKR1C3 on kidney damage of preeclamptic rats].
Jin Y, Sun C, Zhang W
Zhonghua yi xue za zhi95(1)30-3(2015 Jan)

AKR1C3 overexpression may serve as a promising biomarker for prostate cancer progression.
Tian Y, Zhao L, Zhang H, Liu X, Zhao L, Zhao X, Li Y, Li J
Diagnostic pathology942(2014 Feb)

Aldo-keto reductase family 1 member C3 (AKR1C3) is a biomarker and therapeutic target for castration-resistant prostate cancer.
Hamid AR, Pfeiffer MJ, Verhaegh GW, Schaafsma E, Brandt A, Sweep FC, Sedelaar JP, Schalken JA
Molecular medicine (Cambridge, Mass.)181449-55(2013 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data found that FP localizes in neuronal somata and dendrites but not in ependymal cells, tanycytes, or endothelial cells. Immunohistochemical analysis of serial sections showed the colocalization of FP and PGFS I.
Title: Colocalization of prostaglandin F(2alpha) receptor FP and prostaglandin F synthase-I in the spinal cord.

A strong immunoreactivity was detected not only in classically hormone-associated tissues such as prostate and testis but also in non-hormone-associated tissues such as kidney and bladder in humans and rats.
Title: Tissue distribution of human AKR1C3 and rat homolog in the adult genitourinary system.

20alpha-HSD expression and enzymatic activity is closely correlated with the presence of the X-zone.
Title: Adrenal 20alpha-hydroxysteroid dehydrogenase in the mouse catabolizes progesterone and 11-deoxycorticosterone and is restricted to the X-zone.

effect of the deciduoma reaction on 20alpha-hydroxysteroid dehydrogenase activities in the rat corpus luteum of pseudopregnancy
Title: Luteal 3beta-hydroxysteroid dehydrogenase and 20alpha-hydroxysteroid dehydrogenase activities in the rat corpus luteum of pseudopregnancy: effect of the deciduoma reaction.

The following Akr1c3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Akr1c3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa01493	NM_138510.1 Latest version!	Rattus norvegicus aldo-keto reductase family 1, member C3 (Akr1c3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Akr1c3 ( NM_138510.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_612519.1 Rattus norvegicus aldo-keto reductase family 1, member C3 (Akr1c3), mRNA.

Price & Availability↑

CloneID	ORa01493
Clone ID Related Accession (Same CDS sequence)	NM_138510.1
Accession Version	NM_138510.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 972bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-18
Organism	Rattus norvegicus(Norway rat)
Product	aldo-keto reductase family 1 member C18
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from L32601.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: L32601.1, BC086579.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689601, SAMEA2689602 [ECO:0000348] ##Evidence-Data-END##

ATGAATTCCA AAATTCAGAA GATGGAGTTA AACGATGGTC ACTCCATCCC TGTACTGGGC 
TTTGGCACCT ATGCAACCGA AGAGAATCTC AGAAAAAAGT CTATGGAGTC CACGAAAATA 
GCTATAGATG TTGGGTTCCG CCATATTGAT TGTTCTCACT TGTACCAGAA TGAAGAAGAG 
ATAGGTCAGG CCATTGTAAG CAAGATTGAA GATGGCACTG TGAAAAGGGA AGATATATTC 
TATACTTCAA AGCTTTGGTC AACTTCCCAT CGTCCAGAGT TGGTCAGACC CAGCTTGGAA 
AATTCACTGA GGAAACTTAA TTTGGACTAT GTAGACCTCT ATCTCATTCA TTTCCCGGTA 
TCTCTGAAGC CAGGGGATGA GCTTTTACCT CAAGATGAGC ATGGAAACTT AATACTTGAC 
ACAGTGGATC TCTGCGACAC CTGGGAGGCC ATGGAGAAGT GTAAGGATGC AGGATTGGCC 
AAGTCCATCG GGGTGTCCAA CTTTAACCGC AGGCAGCTGG AGAAGATCCT GAATAAGCCG 
GGGCTCAAGC ACAGGCCTGT GTGCAACCAG GTAGAATGCC ATCTTTATCT CAACCAGAGC 
AAGCTGCTCG CTTACTGCAA GATGAATGAC ATCGTTCTGG TTGCCTATGG TGCCCTGGGA 
ACTCAGAGAT ACAAATACTG TATTAATGAA GATACCCCAG TTCTCTTGGA TGATCCCATT 
CTTTGTACCA TGGCAAAGAA GTACAAGCGG ACTCCAGCCC TGATTGCCCT TCGCTACCAG 
CTGGAGCGTG GGATTGTGAC CCTAGTCAAG AGTTTCAATG AGGAGAGAAT CAGAGAGAAC 
CTGCAGGTCT TTGATTTCCA GTTGGCTTCA GATGACATGG AAATTTTAGA TAACCTGGAC 
AGAAATCTTC GGTACTTTCC TGCTAATATG TTTAAGGCTC ACCCTAACTT TCCATTCTCT 
GATGAATACT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_612519.1
CDS	46..1017
Translation	MNSKIQKMELNDGHSIPVLGFGTYATEENLRKKSMESTKIAIDVGFRHIDCSHLYQNEEEIGQAIVSKIEDGTVKREDIFYTSKLWSTSHRPELVRPSLENSLRKLNLDYVDLYLIHFPVSLKPGDELLPQDEHGNLILDTVDLCDTWEAMEKCKDAGLAKSIGVSNFNRRQLEKILNKPGLKHRPVCNQVECHLYLNQSKLLAYCKMNDIVLVAYGALGTQRYKYCINEDTPVLLDDPILCTMAKKYKRTPALIALRYQLERGIVTLVKSFNEERIRENLQVFDFQLASDDMEILDNLDRNLRYFPANMFKAHPNFPFSDEY

Target ORF information:

RefSeq Version	NM_138510.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus aldo-keto reductase family 1, member C3 (Akr1c3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_138510.1

ORF Insert Sequence:

ATGAATTCCA AAATTCAGAA GATGGAGTTA AACGATGGTC ACTCCATCCC TGTACTGGGC 
TTTGGCACCT ATGCAACCGA AGAGAATCTC AGAAAAAAGT CTATGGAGTC CACGAAAATA 
GCTATAGATG TTGGGTTCCG CCATATTGAT TGTTCTCACT TGTACCAGAA TGAAGAAGAG 
ATAGGTCAGG CCATTGTAAG CAAGATTGAA GATGGCACTG TGAAAAGGGA AGATATATTC 
TATACTTCAA AGCTTTGGTC AACTTCCCAT CGTCCAGAGT TGGTCAGACC CAGCTTGGAA 
AATTCACTGA GGAAACTTAA TTTGGACTAT GTAGACCTCT ATCTCATTCA TTTCCCGGTA 
TCTCTGAAGC CAGGGGATGA GCTTTTACCT CAAGATGAGC ATGGAAACTT AATACTTGAC 
ACAGTGGATC TCTGCGACAC CTGGGAGGCC ATGGAGAAGT GTAAGGATGC AGGATTGGCC 
AAGTCCATCG GGGTGTCCAA CTTTAACCGC AGGCAGCTGG AGAAGATCCT GAATAAGCCG 
GGGCTCAAGC ACAGGCCTGT GTGCAACCAG GTAGAATGCC ATCTTTATCT CAACCAGAGC 
AAGCTGCTCG CTTACTGCAA GATGAATGAC ATCGTTCTGG TTGCCTATGG TGCCCTGGGA 
ACTCAGAGAT ACAAATACTG TATTAATGAA GATACCCCAG TTCTCTTGGA TGATCCCATT 
CTTTGTACCA TGGCAAAGAA GTACAAGCGG ACTCCAGCCC TGATTGCCCT TCGCTACCAG 
CTGGAGCGTG GGATTGTGAC CCTAGTCAAG AGTTTCAATG AGGAGAGAAT CAGAGAGAAC 
CTGCAGGTCT TTGATTTCCA GTTGGCTTCA GATGACATGG AAATTTTAGA TAACCTGGAC 
AGAAATCTTC GGTACTTTCC TGCTAATATG TTTAAGGCTC ACCCTAACTT TCCATTCTCT 
GATGAATACT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

AKR1C3 is a biomarker of sensitivity to PR-104 in preclinical models of T-cell acute lymphoblastic leukemia.
Blood126(10)1193-202(2015 Sep)
Moradi Manesh D,El-Hoss J,Evans K,Richmond J,Toscan CE,Bracken LS,Hedrick A,Sutton R,Marshall GM,Wilson WR,Kurmasheva RT,Billups C,Houghton PJ,Smith MA,Carol H,Lock RB

[Effects of AKR1C3 on kidney damage of preeclamptic rats].
Zhonghua yi xue za zhi95(1)30-3(2015 Jan)
Jin Y,Sun C,Zhang W

AKR1C3 overexpression may serve as a promising biomarker for prostate cancer progression.
Diagnostic pathology942(2014 Feb)
Tian Y,Zhao L,Zhang H,Liu X,Zhao L,Zhao X,Li Y,Li J

Aldo-keto reductase family 1 member C3 (AKR1C3) is a biomarker and therapeutic target for castration-resistant prostate cancer.
Molecular medicine (Cambridge, Mass.)181449-55(2013 Jan)
Hamid AR,Pfeiffer MJ,Verhaegh GW,Schaafsma E,Brandt A,Sweep FC,Sedelaar JP,Schalken JA

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Akr1c3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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