Elovl6 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Elovl6
Entrez Gene ID	171402
Full Name	ELOVL fatty acid elongase 6
Synonyms	Lce2,rELO2
General protein information	Preferred Names ELOVL fatty acid elongase 6 Names elongation of very long chain fatty acids protein 6 3-keto acyl-CoA synthase Elovl6 ELOVL FA elongase 6 ELOVL family member 6, elongation of long chain fatty acids fatty acid elongase 2 fatty acyl-CoA elongase long-chain fatty-acyl elongase very long chain 3-ketoacyl-CoA synthase 6 very long chain 3-oxoacyl-CoA synthase 6
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 2 Map Location: 2q42
Summary	mouse homolog is a long chain fatty acyl elongase [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_134383.2	NP_599210.1	elongation of very long chain fatty acids protein 6
XM_017596899.1	XP_017452388.1	elongation of very long chain fatty acids protein 6 isoform X1

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	ELOVL6	NP_001026710.1
Danio rerio (zebrafish)	elovl6	NP_955826.1
Drosophila melanogaster (fruit fly)	Baldspot	NP_648909.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP006520	XP_001237830.2
Caenorhabditis elegans (roundworm)	elo-3	NP_001255291.1
	ELOVL6	XP_001089527.1
Bos taurus (cattle)	ELOVL6	NP_001095625.1
Rattus norvegicus (Norway rat)	Elovl6	NP_599210.1
Homo sapiens (human)	ELOVL6	NP_001124193.1
Pan troglodytes (chimpanzee)	ELOVL6	XP_517396.1
Canis lupus familiaris (dog)	ELOVL6	XP_005639328.1
Mus musculus (house mouse)	Elovl6	NP_569717.1
Xenopus tropicalis (tropical clawed frog)	elovl6	NP_001017257.2
Rattus norvegicus (Norway rat)	LOC102549542	XP_006233363.1

Gene Ontology
Bibliography

Related articles in PubMed

Elongation of Long-Chain Fatty Acid Family Member 6 (Elovl6)-Driven Fatty Acid Metabolism Regulates Vascular Smooth Muscle Cell Phenotype Through AMP-Activated Protein Kinase/Kr?ppel-Like Factor 4 (AMPK/KLF4) Signaling.
Sunaga H, Matsui H, Anjo S, Syamsunarno MR, Koitabashi N, Iso T, Matsuzaka T, Shimano H, Yokoyama T, Kurabayashi M
Journal of the American Heart Association5(12)(2016 Nov)

Brown Adipose Tissue Thermogenic Capacity Is Regulated by Elovl6.
Tan CY, Virtue S, Bidault G, Dale M, Hagen R, Griffin JL, Vidal-Puig A
Cell reports13(10)2039-47(2015 Dec)

The metabolic cascade leading to eicosanoid precursors--desaturases, elongases, and phospholipases A2--is altered in Zucker fatty rats.
F?vre C, Bellenger S, Pierre AS, Minville M, Bellenger J, Gresti J, Rialland M, Narce M, Tessier C
Biochimica et biophysica acta1811(6)409-17(2011 Jun)

Modulation of palmitate-induced endoplasmic reticulum stress and apoptosis in pancreatic ?-cells by stearoyl-CoA desaturase and Elovl6.
Green CD, Olson LK
American journal of physiology. Endocrinology and metabolism300(4)E640-9(2011 Apr)

ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid synthesis.
Ohno Y, Suto S, Yamanaka M, Mizutani Y, Mitsutake S, Igarashi Y, Sassa T, Kihara A
Proceedings of the National Academy of Sciences of the United States of America107(43)18439-44(2010 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

dysregulation of Elovl6-driven long-chain fatty acid metabolism induces phenotypic switching of VSMC via ROS production and AMPK/KLF4 signaling that leads to growth arrest and downregulation of VSMC marker expression.
Title: Elongation of Long-Chain Fatty Acid Family Member 6 (Elovl6)-Driven Fatty Acid Metabolism Regulates Vascular Smooth Muscle Cell Phenotype Through AMP-Activated Protein Kinase/Kr?ppel-Like Factor 4 (AMPK/KLF4) Signaling.

Results show that delta-6 desaturase as well as elongase-6 expressions were upregulated in 3-month-old Zucker fatty rats as compared to lean littermates.
Title: The metabolic cascade leading to eicosanoid precursors--desaturases, elongases, and phospholipases A2--is altered in Zucker fatty rats.

Overt type 2 diabetes is associated with diminished islet expression of SCD and Elovl6, and this can disrupt desaturation of saturated FAs to MUFAs, rendering beta-cells more susceptible to saturated FA-induced ER stress and apoptosis.
Title: Modulation of palmitate-induced endoplasmic reticulum stress and apoptosis in pancreatic ?-cells by stearoyl-CoA desaturase and Elovl6.

increased expression genes encoding Scd1, Elovl6, and other key lipogenic enzymes may favor fat storage after chronic food restriction/refeeding and may be part of the molecular mechanism by which food restriction/refeeding increases body weight
Title: Up-regulation of stearoyl-CoA desaturase 1 and elongase 6 genes expression in rat lipogenic tissues by chronic food restriction and chronic food restriction/refeeding.

These findings demonstrate that coordinated induction of fatty acid elongases Elovl5 and 6 and desaturase activity is required for balanced synthesis of specific n-7 versus n-9 MUFA species.
Title: Role of fatty acid elongases in determination of de novo synthesized monounsaturated fatty acid species.

The following Elovl6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Elovl6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa25259	NM_134383.2 Latest version!	Rattus norvegicus ELOVL fatty acid elongase 6 (Elovl6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
ORa25259	XM_017596899.1 Latest version!	Rattus norvegicus ELOVL fatty acid elongase 6 (Elovl6), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Elovl6 ( NM_134383.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_599210.1 Rattus norvegicus ELOVL fatty acid elongase 6 (Elovl6), mRNA.

Price & Availability↑

CloneID	ORa25259
Clone ID Related Accession (Same CDS sequence)	NM_134383.2 , XM_017596899.1
Accession Version	NM_134383.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 804bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-15
Organism	Rattus norvegicus(Norway rat)
Product	elongation of very long chain fatty acids protein 6
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB071986.1. On May 25, 2007 this sequence version replaced NM_134383.1. ##Evidence-Data-START## Transcript exon combination :: FM039661.1, FM039632.1 [ECO:0000332] ##Evidence-Data-END##

ATGAACATGT CAGTGTTGAC TTTACAAGAA TATGAATTCG AGAAGCAGTT CAACGAGAAT 
GAAGCCATCC AATGGATGCA GGAAAACTGG AAGAAATCTT TCCTGTTTTC TGCGCTGTAC 
GCTGCCTTTA TATTTGGTGG TCGGCATCTG ATGAACAAGC GGGCCAAGTT TGAACTGCGG 
AAGCCGCTCG TGCTCTGGTC ACTGACTCTT GCGGTCTTCA GTATATTCGG TGCTCTTCGA 
ACTGGTGCTT ACATGCTGTA CATTTTGATG ACCAAAGGCC TGAAGCAGTC AGTTTGTGAC 
CAGAGTTTTT ACAACGGACC TGTCAGCAAA TTCTGGGCTT ACGCGTTTGT GCTCAGCAAA 
GCACCCGAAC TAGGTGATAC GATATTCATC ATTCTGAGGA AGCAGAAGCT GATCTTCCTG 
CACTGGTACC ACCACATCAC TGTGCTCCTG TACTCTTGGT ACTCCTACAA AGACATGGTA 
GCTGGGGGTG GTTGGTTCAT GACTATGAAC TATGGCGTAC ACGCCGTCAT GTACTCTTAC 
TACGCCTTGC GGGCTGCGGG TTTCCGGGTC TCCCGGAAGT TTGCCATGTT CATCACGTTG 
TCCCAGATCA CTCAGATGCT GATGGGCTGT GTCATTAACT ACCTGGTCTT CAACTGGATG 
CAGCATGACA ATGACCAGTG CTACTCCCAC TTTCAGAACA TCTTCTGGTC CTCACTCATG 
TACCTCAGCT ACCTTCTGCT CTTCTGCCAT TTCTTCTTTG AGGCCTACAT CGGCAAAGTG 
AAGAAAGCGA CGAAGGCCGA GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_599210.1
CDS	90..893
Translation	MNMSVLTLQEYEFEKQFNENEAIQWMQENWKKSFLFSALYAAFIFGGRHLMNKRAKFELRKPLVLWSLTLAVFSIFGALRTGAYMLYILMTKGLKQSVCDQSFYNGPVSKFWAYAFVLSKAPELGDTIFIILRKQKLIFLHWYHHITVLLYSWYSYKDMVAGGGWFMTMNYGVHAVMYSYYALRAAGFRVSRKFAMFITLSQITQMLMGCVINYLVFNWMQHDNDQCYSHFQNIFWSSLMYLSYLLLFCHFFFEAYIGKVKKATKAE

Target ORF information:

RefSeq Version	NM_134383.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus ELOVL fatty acid elongase 6 (Elovl6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_134383.2

ORF Insert Sequence:

ATGAACATGT CAGTGTTGAC TTTACAAGAA TATGAATTCG AGAAGCAGTT CAACGAGAAT 
GAAGCCATCC AATGGATGCA GGAAAACTGG AAGAAATCTT TCCTGTTTTC TGCGCTGTAC 
GCTGCCTTTA TATTTGGTGG TCGGCATCTG ATGAACAAGC GGGCCAAGTT TGAACTGCGG 
AAGCCGCTCG TGCTCTGGTC ACTGACTCTT GCGGTCTTCA GTATATTCGG TGCTCTTCGA 
ACTGGTGCTT ACATGCTGTA CATTTTGATG ACCAAAGGCC TGAAGCAGTC AGTTTGTGAC 
CAGAGTTTTT ACAACGGACC TGTCAGCAAA TTCTGGGCTT ACGCGTTTGT GCTCAGCAAA 
GCACCCGAAC TAGGTGATAC GATATTCATC ATTCTGAGGA AGCAGAAGCT GATCTTCCTG 
CACTGGTACC ACCACATCAC TGTGCTCCTG TACTCTTGGT ACTCCTACAA AGACATGGTA 
GCTGGGGGTG GTTGGTTCAT GACTATGAAC TATGGCGTAC ACGCCGTCAT GTACTCTTAC 
TACGCCTTGC GGGCTGCGGG TTTCCGGGTC TCCCGGAAGT TTGCCATGTT CATCACGTTG 
TCCCAGATCA CTCAGATGCT GATGGGCTGT GTCATTAACT ACCTGGTCTT CAACTGGATG 
CAGCATGACA ATGACCAGTG CTACTCCCAC TTTCAGAACA TCTTCTGGTC CTCACTCATG 
TACCTCAGCT ACCTTCTGCT CTTCTGCCAT TTCTTCTTTG AGGCCTACAT CGGCAAAGTG 
AAGAAAGCGA CGAAGGCCGA GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Elovl6 ( XM_017596899.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017452388.1 Rattus norvegicus ELOVL fatty acid elongase 6 (Elovl6), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa25259
Clone ID Related Accession (Same CDS sequence)	NM_134383.2 , XM_017596899.1
Accession Version	XM_017596899.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 804bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	elongation of very long chain fatty acids protein 6 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (AC_000070.1) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAACATGT CAGTGTTGAC TTTACAAGAA TATGAATTCG AGAAGCAGTT CAACGAGAAT 
GAAGCCATCC AATGGATGCA GGAAAACTGG AAGAAATCTT TCCTGTTTTC TGCGCTGTAC 
GCTGCCTTTA TATTTGGTGG TCGGCATCTG ATGAACAAGC GGGCCAAGTT TGAACTGCGG 
AAGCCGCTCG TGCTCTGGTC ACTGACTCTT GCGGTCTTCA GTATATTCGG TGCTCTTCGA 
ACTGGTGCTT ACATGCTGTA CATTTTGATG ACCAAAGGCC TGAAGCAGTC AGTTTGTGAC 
CAGAGTTTTT ACAACGGACC TGTCAGCAAA TTCTGGGCTT ACGCGTTTGT GCTCAGCAAA 
GCACCCGAAC TAGGTGATAC GATATTCATC ATTCTGAGGA AGCAGAAGCT GATCTTCCTG 
CACTGGTACC ACCACATCAC TGTGCTCCTG TACTCTTGGT ACTCCTACAA AGACATGGTA 
GCTGGGGGTG GTTGGTTCAT GACTATGAAC TATGGCGTAC ACGCCGTCAT GTACTCTTAC 
TACGCCTTGC GGGCTGCGGG TTTCCGGGTC TCCCGGAAGT TTGCCATGTT CATCACGTTG 
TCCCAGATCA CTCAGATGCT GATGGGCTGT GTCATTAACT ACCTGGTCTT CAACTGGATG 
CAGCATGACA ATGACCAGTG CTACTCCCAC TTTCAGAACA TCTTCTGGTC CTCACTCATG 
TACCTCAGCT ACCTTCTGCT CTTCTGCCAT TTCTTCTTTG AGGCCTACAT CGGCAAAGTG 
AAGAAAGCGA CGAAGGCCGA GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017452388.1
CDS	231..1034
Translation	MNMSVLTLQEYEFEKQFNENEAIQWMQENWKKSFLFSALYAAFIFGGRHLMNKRAKFELRKPLVLWSLTLAVFSIFGALRTGAYMLYILMTKGLKQSVCDQSFYNGPVSKFWAYAFVLSKAPELGDTIFIILRKQKLIFLHWYHHITVLLYSWYSYKDMVAGGGWFMTMNYGVHAVMYSYYALRAAGFRVSRKFAMFITLSQITQMLMGCVINYLVFNWMQHDNDQCYSHFQNIFWSSLMYLSYLLLFCHFFFEAYIGKVKKATKAE

Target ORF information:

RefSeq Version	XM_017596899.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus ELOVL fatty acid elongase 6 (Elovl6), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017596899.1

ORF Insert Sequence:

ATGAACATGT CAGTGTTGAC TTTACAAGAA TATGAATTCG AGAAGCAGTT CAACGAGAAT 
GAAGCCATCC AATGGATGCA GGAAAACTGG AAGAAATCTT TCCTGTTTTC TGCGCTGTAC 
GCTGCCTTTA TATTTGGTGG TCGGCATCTG ATGAACAAGC GGGCCAAGTT TGAACTGCGG 
AAGCCGCTCG TGCTCTGGTC ACTGACTCTT GCGGTCTTCA GTATATTCGG TGCTCTTCGA 
ACTGGTGCTT ACATGCTGTA CATTTTGATG ACCAAAGGCC TGAAGCAGTC AGTTTGTGAC 
CAGAGTTTTT ACAACGGACC TGTCAGCAAA TTCTGGGCTT ACGCGTTTGT GCTCAGCAAA 
GCACCCGAAC TAGGTGATAC GATATTCATC ATTCTGAGGA AGCAGAAGCT GATCTTCCTG 
CACTGGTACC ACCACATCAC TGTGCTCCTG TACTCTTGGT ACTCCTACAA AGACATGGTA 
GCTGGGGGTG GTTGGTTCAT GACTATGAAC TATGGCGTAC ACGCCGTCAT GTACTCTTAC 
TACGCCTTGC GGGCTGCGGG TTTCCGGGTC TCCCGGAAGT TTGCCATGTT CATCACGTTG 
TCCCAGATCA CTCAGATGCT GATGGGCTGT GTCATTAACT ACCTGGTCTT CAACTGGATG 
CAGCATGACA ATGACCAGTG CTACTCCCAC TTTCAGAACA TCTTCTGGTC CTCACTCATG 
TACCTCAGCT ACCTTCTGCT CTTCTGCCAT TTCTTCTTTG AGGCCTACAT CGGCAAAGTG 
AAGAAAGCGA CGAAGGCCGA GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Elongation of Long-Chain Fatty Acid Family Member 6 (Elovl6)-Driven Fatty Acid Metabolism Regulates Vascular Smooth Muscle Cell Phenotype Through AMP-Activated Protein Kinase/Kr?ppel-Like Factor 4 (AMPK/KLF4) Signaling.
Journal of the American Heart Association5(12)(2016 Nov)
Sunaga H,Matsui H,Anjo S,Syamsunarno MR,Koitabashi N,Iso T,Matsuzaka T,Shimano H,Yokoyama T,Kurabayashi M

Brown Adipose Tissue Thermogenic Capacity Is Regulated by Elovl6.
Cell reports13(10)2039-47(2015 Dec)
Tan CY,Virtue S,Bidault G,Dale M,Hagen R,Griffin JL,Vidal-Puig A

The metabolic cascade leading to eicosanoid precursors--desaturases, elongases, and phospholipases A2--is altered in Zucker fatty rats.
Biochimica et biophysica acta1811(6)409-17(2011 Jun)
F?vre C,Bellenger S,Pierre AS,Minville M,Bellenger J,Gresti J,Rialland M,Narce M,Tessier C

Modulation of palmitate-induced endoplasmic reticulum stress and apoptosis in pancreatic ?-cells by stearoyl-CoA desaturase and Elovl6.
American journal of physiology. Endocrinology and metabolism300(4)E640-9(2011 Apr)
Green CD,Olson LK

ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid synthesis.
Proceedings of the National Academy of Sciences of the United States of America107(43)18439-44(2010 Oct)
Ohno Y,Suto S,Yamanaka M,Mizutani Y,Mitsutake S,Igarashi Y,Sassa T,Kihara A

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Elovl6 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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