Clstn3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Clstn3
Entrez Gene ID	171393
Full Name	calsyntenin 3
Synonyms	Cs3,Cstn3
General protein information	Preferred Names calsyntenin 3 Names calsyntenin-3 alc-beta alcadein-beta
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 4 Map Location: 4q42
Summary	postsynaptic membrane protein involved in excitatory synaptic transmission [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_134376.1	NP_599203.1	calsyntenin-3 precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	CLSTN3	XP_508982.4
Bos taurus (cattle)	CLSTN3	NP_001068893.2
Rattus norvegicus (Norway rat)	Clstn3	NP_599203.1
Homo sapiens (human)	CLSTN3	NP_055533.2
Gallus gallus (chicken)	CLSTN3	XP_416520.4
Danio rerio (zebrafish)	clstn3	XP_683286.4
	CLSTN3	XP_001112325.1
Canis lupus familiaris (dog)	CLSTN3	XP_543838.2
Mus musculus (house mouse)	Clstn3	NP_705728.1
Xenopus tropicalis (tropical clawed frog)	LOC100036725	NP_001090739.1

Gene Ontology
Bibliography

Related articles in PubMed

Calsyntenins function as synaptogenic adhesion molecules in concert with neurexins.
Um JW, Pramanik G, Ko JS, Song MY, Lee D, Kim H, Park KS, S?dhof TC, Tabuchi K, Ko J
Cell reports6(6)1096-1109(2014 Mar)

The specific ?-neurexin interactor calsyntenin-3 promotes excitatory and inhibitory synapse development.
Pettem KL, Yokomaku D, Luo L, Linhoff MW, Prasad T, Connor SA, Siddiqui TJ, Kawabe H, Chen F, Zhang L, Rudenko G, Wang YT, Brose N, Craig AM
Neuron80(1)113-28(2013 Oct)

Calsyntenins are secretory granule proteins in anterior pituitary gland and pancreatic islet alpha cells.
Rindler MJ, Xu CF, Gumper I, Cen C, Sonderegger P, Neubert TA
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society56(4)381-8(2008 Apr)

The calsyntenins--a family of postsynaptic membrane proteins with distinct neuronal expression patterns.
Hintsch G, Zurlinden A, Meskenaite V, Steuble M, Fink-Widmer K, Kinter J, Sonderegger P
Molecular and cellular neurosciences21(3)393-409(2002 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The transmembrane form of calsyntenin-3 can trigger excitatory and inhibitory presynapse differentiation in contacting axons.
Title: The specific ?-neurexin interactor calsyntenin-3 promotes excitatory and inhibitory synapse development.

Results indicate that calsyntenins function outside the nervous system and potentially are modulators of endocrine function.
Title: Calsyntenins are secretory granule proteins in anterior pituitary gland and pancreatic islet alpha cells.

The following Clstn3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Clstn3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa01234	NM_134376.1 Latest version!	Rattus norvegicus calsyntenin 3 (Clstn3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$475.30 $679.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Clstn3 ( NM_134376.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_599203.1 Rattus norvegicus calsyntenin 3 (Clstn3), mRNA.

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CloneID	ORa01234
Clone ID Related Accession (Same CDS sequence)	NM_134376.1
Accession Version	NM_134376.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2874bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-15
Organism	Rattus norvegicus(Norway rat)
Product	calsyntenin-3 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AJ431642.1. On Jan 12, 2005 this sequence version replaced XM_346720.1. ##Evidence-Data-START## Transcript exon combination :: AJ431642.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296 [ECO:0000348] ##Evidence-Data-END##

ATGACCCTCC TGCTGGTGTC CCTCTTGCTG GCCTCTCTGC TTCAGATCAG CTCTGGCAAC 
AAAGCGAACA AGCATAAGCC ATGGATCGAG GCCGAGTACC AGGGCATCGT CATGGAGAAT 
GACAACACGG TCCTGTTGAA TCCGCCACTC TTTGCCTTGG ACAAAGATGC TCCGCTGCGC 
TATGCAGGTG AGATCTGTGG CTTCCGGCTC CATGGGTCTG GGGTACCCTT TAAGGCTGTG 
ATCCTGGACA AGGCAACAGG TGAAGGGCTG ATCCGGGCCA AGGAGCCTGT GGACTGCGAG 
GCCCAGAAGG AGCACACCTT TACCACCCAG GCTTATGACT GTGTAGATGG GCCCGATGGT 
GCCAATACCA AGAAGTCTCA CAAGGCGACC GTGCATGTTC GGGTCAACGA TGTGAATGAG 
TTTGCCCCAG TCTTTGTGGA GCGTCTCTAC CGTGCTGCAG TGACTGAGGG GAAGCTGTAT 
GATCGCATCT TACGTGTGGA AGCCATTGAT GGTGACTGCT CCCCTCAGTA CAGCCAGATC 
TGCTACTATG AGATCCTTAC ACCCAACACC CCTTTCCTCA TTGACAATGA TGGCAACATT 
GAGAACACAG AGAAGTTACA GTACAGTGGT GAGAAGCTCT ATAAGTTCAC AGTGACAGCA 
TATGACTGTG GGAAGAAGCG AGCAGCAGAT GATGCTGAGG TGGAAATCCA GGTGAAGCCC 
ACCTGCAAAC CCAGCTGGCA AGGCTGGAAC AAAAGGATTG AATATGCCCC AGGAGCGGGG 
AGCTTGGCTT TGTTCCCTGG CATCCGCCTG GAGACCTGTG ATGAGCCACT GTGGAACATT 
CAGGCCACCA TAGAGCTGCA GACCAGCCAT GTGGCCAAGG GCTGTGACCG AGACAACTAC 
TCAGAGAGGG CTCTGCGGAA GCTCTGTGGT GCTGCTACTG GGGAGGTGGA CCTGTTGCCC 
ATGCCTGGCC CCAATGCCAA CTGGACAGCG GGGCTCTCGG TACACTACAG CCAGGACAGC 
AGCCTCATCT ACTGGTTCAA TGGCACACAA GCTGTGCAAG TTCCCCTGGG TGGTCCAGCA 
GGGCTGGGCT CTGGGCCGCA GGATGGCCTC AGTGACCACT TTACCCTGTC TTTCTGGATG 
AAGCATAGTG TGACTCCTAG CAAGGGGAAG AAGGAGGAGG AGACCATTGT ATGTAACACC 
ATTCAGAACG AGGACGGCTA CTCTCACTAC TCATTGACTG TCCACGGCTG CAGAATCGCC 
TTTCTCTACT GGCCGTTGCT TGAGAGTGCA CGCCCGGTCA AGTTCCTCTG GAAGCTGGAG 
CAGGTATGTG ACGATGAGTG GCATCACTAC GCCCTGAACC TCGAGTTCCC CACAGTCACG 
CTCTATACTG ATGGCATCTC CTTCGACCCA GCTCTCATCC ACGACAATGG TCTCATCCAC 
CCACCCAGGA GGGAACCTGC GCTCATGATC GGGGCCTGCT GGTCTGAAGA GAAGAACAAA 
GAGAAGGAGA AGGGGGGAGA GAACAGTACA GACACGACCT CAGGAGACCC CTTGCCGATC 
CACCATTACT TCCATGGCTA CCTAGCTGGT TTCAGCGTGC GCTCAGGTCG CCTGGAGAGC 
CGTGAGGTCA TCGAGTGCCT CTATGCATGT CGGGAGGGGC TGGACTATAG GGATTTCGAG 
AGCCTGGGCA AAGGCATGAA GGTGCACGTG AACCCCTCGC AGTCCCTGCT CACCTTGGAG 
GGGGATGATG TGGAGACCTT CAACCATGCC CTGCAGCACG TGGCTTACAT GAACACTCTG 
CGCTTTGCCA CGCCCGGCGT CAGGCCCCTT CGCCTCACCA CCGCTGTCAA GTGCTTTAGT 
GAAGAGTCCT GTGTCTCCAT CCCTGAAGTG GAGGGCTATG TGGTGGTTCT TCAGCCCGAT 
GCCCCCCAGA TCCTTCTGAG TGGCACAGCT CATTTTGCCC GCCCAGCTGT GGACTTTGAG 
GGACCCGAGG GAGTCCCCTT GTTCCCTGAT CTTCAGATCA CCTGCTCCAT TTCTCACCAG 
GTGGAGGCCA AAGCAGATGA GAGTTGGCAG GGCACAGTGA CAGACACACG CATGTCAGAT 
GAGATTGTAC ACAACTTGGA CGGCTGTGAG ATTTCTCTGG TGGGGGATGA CCTAGACCCT 
GAACGAGAGA GCCTGCTCTT GGACATGGCT TCCCTGCAGC AGCGAGGCCT GGAACTCACC 
AACAGATCTG CCTACCTCAC CATTGCTGGG GTGGAGACCA TCACTGTGTA TGAAGAGATC 
CTGAGGCAGG CTCGTTATCA GCTTCGGCAT GGAGCTGCCC TTTATGCCAG GAAATTCCGG 
CTTTCTTGCT CGGAGATGAA CGGCCGATAC TCCAGCAACG AATTCATTGT GGAGGTCAAC 
GTCCTGCACA GCATGAACCG GGTGGCCCAT CCCAGCCACG TGCTCAGTTC ACAGCAGTTC 
CTGCACCGGG GTCACCAGCC TCCTCCTGAG ATGGCTGGAC ACAGCCTGGC CAGCTCCCAC 
CGGAACTCCA TGGTCCCCAG TGCTGCGACT CTCATCATTG TGGTATGCGT GGGCTTTCTG 
GTGCTTATGG TCATCCTCGG CCTCGTGCGG ATCCACTCCC TTCATCGCCG TGTCTCAGGA 
ACTGGTGGAC CCTCAGGGGC TTCCGCTGAC CCGAAAGACC CTGACCTCTT CTGGGATGAC 
TCTGCTCTCA CCATTATCGT GAATCCCATG GAGTCCTACC AGAACCAGCA GACTGGTGTG 
GCAGGGGTTG CTGGTGGCCA GCAAGAGGAA GAGGACAGCA GTGATTCCGA AGCAGCTGAC 
TCCCCCAGCA GCGATGAAAG ACGCATCATT GAGAGCCCCC CACACCGCTA TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_599203.1
CDS	142..3015
Translation	MTLLLVSLLLASLLQISSGNKANKHKPWIEAEYQGIVMENDNTVLLNPPLFALDKDAPLRYAGEICGFRLHGSGVPFKAVILDKATGEGLIRAKEPVDCEAQKEHTFTTQAYDCVDGPDGANTKKSHKATVHVRVNDVNEFAPVFVERLYRAAVTEGKLYDRILRVEAIDGDCSPQYSQICYYEILTPNTPFLIDNDGNIENTEKLQYSGEKLYKFTVTAYDCGKKRAADDAEVEIQVKPTCKPSWQGWNKRIEYAPGAGSLALFPGIRLETCDEPLWNIQATIELQTSHVAKGCDRDNYSERALRKLCGAATGEVDLLPMPGPNANWTAGLSVHYSQDSSLIYWFNGTQAVQVPLGGPAGLGSGPQDGLSDHFTLSFWMKHSVTPSKGKKEEETIVCNTIQNEDGYSHYSLTVHGCRIAFLYWPLLESARPVKFLWKLEQVCDDEWHHYALNLEFPTVTLYTDGISFDPALIHDNGLIHPPRREPALMIGACWSEEKNKEKEKGGENSTDTTSGDPLPIHHYFHGYLAGFSVRSGRLESREVIECLYACREGLDYRDFESLGKGMKVHVNPSQSLLTLEGDDVETFNHALQHVAYMNTLRFATPGVRPLRLTTAVKCFSEESCVSIPEVEGYVVVLQPDAPQILLSGTAHFARPAVDFEGPEGVPLFPDLQITCSISHQVEAKADESWQGTVTDTRMSDEIVHNLDGCEISLVGDDLDPERESLLLDMASLQQRGLELTNRSAYLTIAGVETITVYEEILRQARYQLRHGAALYARKFRLSCSEMNGRYSSNEFIVEVNVLHSMNRVAHPSHVLSSQQFLHRGHQPPPEMAGHSLASSHRNSMVPSAATLIIVVCVGFLVLMVILGLVRIHSLHRRVSGTGGPSGASADPKDPDLFWDDSALTIIVNPMESYQNQQTGVAGVAGGQQEEEDSSDSEAADSPSSDERRIIESPPHRY

Target ORF information:

RefSeq Version	NM_134376.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus calsyntenin 3 (Clstn3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_134376.1

ORF Insert Sequence:

ATGACCCTCC TGCTGGTGTC CCTCTTGCTG GCCTCTCTGC TTCAGATCAG CTCTGGCAAC 
AAAGCGAACA AGCATAAGCC ATGGATCGAG GCCGAGTACC AGGGCATCGT CATGGAGAAT 
GACAACACGG TCCTGTTGAA TCCGCCACTC TTTGCCTTGG ACAAAGATGC TCCGCTGCGC 
TATGCAGGTG AGATCTGTGG CTTCCGGCTC CATGGGTCTG GGGTACCCTT TAAGGCTGTG 
ATCCTGGACA AGGCAACAGG TGAAGGGCTG ATCCGGGCCA AGGAGCCTGT GGACTGCGAG 
GCCCAGAAGG AGCACACCTT TACCACCCAG GCTTATGACT GTGTAGATGG GCCCGATGGT 
GCCAATACCA AGAAGTCTCA CAAGGCGACC GTGCATGTTC GGGTCAACGA TGTGAATGAG 
TTTGCCCCAG TCTTTGTGGA GCGTCTCTAC CGTGCTGCAG TGACTGAGGG GAAGCTGTAT 
GATCGCATCT TACGTGTGGA AGCCATTGAT GGTGACTGCT CCCCTCAGTA CAGCCAGATC 
TGCTACTATG AGATCCTTAC ACCCAACACC CCTTTCCTCA TTGACAATGA TGGCAACATT 
GAGAACACAG AGAAGTTACA GTACAGTGGT GAGAAGCTCT ATAAGTTCAC AGTGACAGCA 
TATGACTGTG GGAAGAAGCG AGCAGCAGAT GATGCTGAGG TGGAAATCCA GGTGAAGCCC 
ACCTGCAAAC CCAGCTGGCA AGGCTGGAAC AAAAGGATTG AATATGCCCC AGGAGCGGGG 
AGCTTGGCTT TGTTCCCTGG CATCCGCCTG GAGACCTGTG ATGAGCCACT GTGGAACATT 
CAGGCCACCA TAGAGCTGCA GACCAGCCAT GTGGCCAAGG GCTGTGACCG AGACAACTAC 
TCAGAGAGGG CTCTGCGGAA GCTCTGTGGT GCTGCTACTG GGGAGGTGGA CCTGTTGCCC 
ATGCCTGGCC CCAATGCCAA CTGGACAGCG GGGCTCTCGG TACACTACAG CCAGGACAGC 
AGCCTCATCT ACTGGTTCAA TGGCACACAA GCTGTGCAAG TTCCCCTGGG TGGTCCAGCA 
GGGCTGGGCT CTGGGCCGCA GGATGGCCTC AGTGACCACT TTACCCTGTC TTTCTGGATG 
AAGCATAGTG TGACTCCTAG CAAGGGGAAG AAGGAGGAGG AGACCATTGT ATGTAACACC 
ATTCAGAACG AGGACGGCTA CTCTCACTAC TCATTGACTG TCCACGGCTG CAGAATCGCC 
TTTCTCTACT GGCCGTTGCT TGAGAGTGCA CGCCCGGTCA AGTTCCTCTG GAAGCTGGAG 
CAGGTATGTG ACGATGAGTG GCATCACTAC GCCCTGAACC TCGAGTTCCC CACAGTCACG 
CTCTATACTG ATGGCATCTC CTTCGACCCA GCTCTCATCC ACGACAATGG TCTCATCCAC 
CCACCCAGGA GGGAACCTGC GCTCATGATC GGGGCCTGCT GGTCTGAAGA GAAGAACAAA 
GAGAAGGAGA AGGGGGGAGA GAACAGTACA GACACGACCT CAGGAGACCC CTTGCCGATC 
CACCATTACT TCCATGGCTA CCTAGCTGGT TTCAGCGTGC GCTCAGGTCG CCTGGAGAGC 
CGTGAGGTCA TCGAGTGCCT CTATGCATGT CGGGAGGGGC TGGACTATAG GGATTTCGAG 
AGCCTGGGCA AAGGCATGAA GGTGCACGTG AACCCCTCGC AGTCCCTGCT CACCTTGGAG 
GGGGATGATG TGGAGACCTT CAACCATGCC CTGCAGCACG TGGCTTACAT GAACACTCTG 
CGCTTTGCCA CGCCCGGCGT CAGGCCCCTT CGCCTCACCA CCGCTGTCAA GTGCTTTAGT 
GAAGAGTCCT GTGTCTCCAT CCCTGAAGTG GAGGGCTATG TGGTGGTTCT TCAGCCCGAT 
GCCCCCCAGA TCCTTCTGAG TGGCACAGCT CATTTTGCCC GCCCAGCTGT GGACTTTGAG 
GGACCCGAGG GAGTCCCCTT GTTCCCTGAT CTTCAGATCA CCTGCTCCAT TTCTCACCAG 
GTGGAGGCCA AAGCAGATGA GAGTTGGCAG GGCACAGTGA CAGACACACG CATGTCAGAT 
GAGATTGTAC ACAACTTGGA CGGCTGTGAG ATTTCTCTGG TGGGGGATGA CCTAGACCCT 
GAACGAGAGA GCCTGCTCTT GGACATGGCT TCCCTGCAGC AGCGAGGCCT GGAACTCACC 
AACAGATCTG CCTACCTCAC CATTGCTGGG GTGGAGACCA TCACTGTGTA TGAAGAGATC 
CTGAGGCAGG CTCGTTATCA GCTTCGGCAT GGAGCTGCCC TTTATGCCAG GAAATTCCGG 
CTTTCTTGCT CGGAGATGAA CGGCCGATAC TCCAGCAACG AATTCATTGT GGAGGTCAAC 
GTCCTGCACA GCATGAACCG GGTGGCCCAT CCCAGCCACG TGCTCAGTTC ACAGCAGTTC 
CTGCACCGGG GTCACCAGCC TCCTCCTGAG ATGGCTGGAC ACAGCCTGGC CAGCTCCCAC 
CGGAACTCCA TGGTCCCCAG TGCTGCGACT CTCATCATTG TGGTATGCGT GGGCTTTCTG 
GTGCTTATGG TCATCCTCGG CCTCGTGCGG ATCCACTCCC TTCATCGCCG TGTCTCAGGA 
ACTGGTGGAC CCTCAGGGGC TTCCGCTGAC CCGAAAGACC CTGACCTCTT CTGGGATGAC 
TCTGCTCTCA CCATTATCGT GAATCCCATG GAGTCCTACC AGAACCAGCA GACTGGTGTG 
GCAGGGGTTG CTGGTGGCCA GCAAGAGGAA GAGGACAGCA GTGATTCCGA AGCAGCTGAC 
TCCCCCAGCA GCGATGAAAG ACGCATCATT GAGAGCCCCC CACACCGCTA TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Calsyntenins function as synaptogenic adhesion molecules in concert with neurexins.
Cell reports6(6)1096-1109(2014 Mar)
Um JW,Pramanik G,Ko JS,Song MY,Lee D,Kim H,Park KS,S?dhof TC,Tabuchi K,Ko J

The specific ?-neurexin interactor calsyntenin-3 promotes excitatory and inhibitory synapse development.
Neuron80(1)113-28(2013 Oct)
Pettem KL,Yokomaku D,Luo L,Linhoff MW,Prasad T,Connor SA,Siddiqui TJ,Kawabe H,Chen F,Zhang L,Rudenko G,Wang YT,Brose N,Craig AM

Calsyntenins are secretory granule proteins in anterior pituitary gland and pancreatic islet alpha cells.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society56(4)381-8(2008 Apr)
Rindler MJ,Xu CF,Gumper I,Cen C,Sonderegger P,Neubert TA

The calsyntenins--a family of postsynaptic membrane proteins with distinct neuronal expression patterns.
Molecular and cellular neurosciences21(3)393-409(2002 Nov)
Hintsch G,Zurlinden A,Meskenaite V,Steuble M,Fink-Widmer K,Kinter J,Sonderegger P

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Clstn3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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