Reg3a cDNA ORF clone, Rattus norvegicus(Norway rat)

The pancreas responds to remote damage and systemic stress by secretion of the pancreatic secretory proteins PSP/regI and PAP/regIII.
Reding T, Palmiere C, Pazhepurackel C, Schiesser M, Bimmler D, Schlegel A, S?ss U, Steiner S, Mancina L, Seleznik G, Graf R
Oncotarget8(18)30162-30174(2017 May)

Microarray analysis of rat pancreas reveals altered expression of Alox15 and regenerating islet-derived genes in response to iron deficiency and overload.
Coffey R, Nam H, Knutson MD
PloS one9(1)e86019(2014)

Islet neogenesis-associated protein (INGAP)-positive cell mass, ?-cell mass, and insulin secretion: their relationship during the fetal and neonatal periods.
Madrid V, Borelli MI, Maiztegui B, Flores LE, Gagliardino JJ, Zotto HD
Pancreas42(3)422-8(2013 Apr)

Intestinal adaptation and Reg gene expression induced by antidiabetic duodenal-jejunal bypass surgery in Zucker fatty rats.
Li B, Lu Y, Srikant CB, Gao ZH, Liu JL
American journal of physiology. Gastrointestinal and liver physiology304(7)G635-45(2013 Apr)

The antimicrobial protein REG3A regulates keratinocyte proliferation and differentiation after skin injury.
Lai Y, Li D, Li C, Muehleisen B, Radek KA, Park HJ, Jiang Z, Li Z, Lei H, Quan Y, Zhang T, Wu Y, Kotol P, Morizane S, Hata TR, Iwatsuki K, Tang C, Gallo RL
Immunity37(1)74-84(2012 Jul)

Alox15 mRNA levels were 4 times higher in iron-deficient than in iron-adequate pancreas and that Reg1a, Reg3a, and Reg3b mRNA levels were 17-36 times higher in iron-overloaded pancreas.
Title: Microarray analysis of rat pancreas reveals altered expression of Alox15 and regenerating islet-derived genes in response to iron deficiency and overload.

Findings suggest that islet neogenesis-associated protein (INGAP) exerts a positive modulatory effect on beta-cell mass and its secretory function in fetal and neonatal rats, thus becoming a new component in the multifactorial regulation of such processes.
Title: Islet neogenesis-associated protein (INGAP)-positive cell mass, ?-cell mass, and insulin secretion: their relationship during the fetal and neonatal periods.

After duodenal-jejunal bypass, the level of Reg3alpha and -3beta were not changed in bypassed duodenum in morbidly obese Zucker fatty rats.
Title: Intestinal adaptation and Reg gene expression induced by antidiabetic duodenal-jejunal bypass surgery in Zucker fatty rats.

Letter: aggregation status of PAP1 and PAP2 could change their role in regulating the inflammation in acute pancreatitis.
Title: Pancreatitis-associated proteins' regulation of inflammation is correlated with their ability to aggregate.

preincubation with select rPAP2 mutant proteins affect translocation of this transcription factor into the nucleus
Title: Mutational characterization of pancreatitis-associated protein 2 domains involved in mediating cytokine secretion in macrophages and the NF-kappaB pathway.