Rph3al cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Rph3al
Entrez Gene ID	171123
Full Name	rabphilin 3A-like (without C2 domains)
Synonyms	Noc2
General protein information	Preferred Names rabphilin 3A-like (without C2 domains) Names rab effector Noc2 no C2 domains protein rabphilin-3A-like protein
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 10 Map Location: 10q24
Summary	zinc finger protein; may be involved in regulated exocytosis in endocrine cells [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_008767944.2	XP_008766166.1	rab effector Noc2 isoform X3
NM_133591.2	NP_598275.1	rab effector Noc2
XM_008767941.2	XP_008766163.1	rab effector Noc2 isoform X1
XM_008767942.2	XP_008766164.1	rab effector Noc2 isoform X1
XM_008767943.2	XP_008766165.1	rab effector Noc2 isoform X2

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Rph3al	NP_598275.1
Danio rerio (zebrafish)	LOC101884118	XP_005168682.1
Mus musculus (house mouse)	Rph3al	NP_083824.1
Gallus gallus (chicken)	RPH3AL	XP_004946759.1
Homo sapiens (human)	RPH3AL	NP_008918.1
Xenopus tropicalis (tropical clawed frog)	rph3al	NP_001011007.1
Canis lupus familiaris (dog)	RPH3AL	XP_005624975.1
Bos taurus (cattle)	RPH3AL	NP_001030571.1

Gene Ontology
Bibliography

Related articles in PubMed

Insulin regulates Rab3-Noc2 complex dissociation to promote GLUT4 translocation in rat adipocytes.
Koumanov F, Pereira VJ, Richardson JD, Sargent SL, Fazakerley DJ, Holman GD
Diabetologia58(8)1877-86(2015 Aug)

The Rab27 effector Rabphilin, unlike Granuphilin and Noc2, rapidly exchanges between secretory granules and cytosol in PC12 cells.
Handley MT, Burgoyne RD
Biochemical and biophysical research communications373(2)275-81(2008 Aug)

Functional involvement of Noc2, a Rab27 effector, in rat parotid acinar cells.
Imai A, Yoshie S, Nashida T, Shimomura H, Fukuda M
Archives of biochemistry and biophysics455(2)127-35(2006 Nov)

Noc2 is essential in normal regulation of exocytosis in endocrine and exocrine cells.
Matsumoto M, Miki T, Shibasaki T, Kawaguchi M, Shinozaki H, Nio J, Saraya A, Koseki H, Miyazaki M, Iwanaga T, Seino S
Proceedings of the National Academy of Sciences of the United States of America101(22)8313-8(2004 Jun)

Rabphilin and Noc2 are recruited to dense-core vesicles through specific interaction with Rab27A in PC12 cells.
Fukuda M, Kanno E, Yamamoto A
The Journal of biological chemistry279(13)13065-75(2004 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

discovery of the involvement of Rab3 and Noc2 in an insulin-regulated step in GLUT4 translocation suggests that the control of this translocation process is unexpectedly similar to regulated secretion and particularly pancreatic insulin-vesicle release.
Title: Insulin regulates Rab3-Noc2 complex dissociation to promote GLUT4 translocation in rat adipocytes.

Three Rab3/27 effectors, Granuphilin, Noc2, and Rabphilin, in PC12 cells using fluorescence recovery after photobleaching of EGFP-tagged proteins.
Title: The Rab27 effector Rabphilin, unlike Granuphilin and Noc2, rapidly exchanges between secretory granules and cytosol in PC12 cells.

Our results suggest that the Noc2/Rab27 complex is an important constituent of the early stages of IPR-stimulated amylase release.
Title: Functional involvement of Noc2, a Rab27 effector, in rat parotid acinar cells.

Rabphilin and Noc2 are recruited to dense-core vesicles through specific interaction with Rab27A in rat cells
Title: Rabphilin and Noc2 are recruited to dense-core vesicles through specific interaction with Rab27A in PC12 cells.

Noc2 is a potential partner of Munc13, a component of the machinery that controls vesicle priming and insulin exocytosis
Title: The Rab-binding protein Noc2 is associated with insulin-containing secretory granules and is essential for pancreatic beta-cell exocytosis.

The following Rph3al gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Rph3al cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa01021	NM_133591.2 Latest version!	Rattus norvegicus rabphilin 3A-like (without C2 domains) (Rph3al), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
ORa01021	XM_008767942.2 Latest version!	Rattus norvegicus rabphilin 3A-like (without C2 domains) (Rph3al), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
ORa01021	XM_008767941.2 Latest version!	Rattus norvegicus rabphilin 3A-like (without C2 domains) (Rph3al), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
ORa44276	XM_008767943.2 Latest version!	Rattus norvegicus rabphilin 3A-like (without C2 domains) (Rph3al), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
ORa44277	XM_008767944.2 Latest version!	Rattus norvegicus rabphilin 3A-like (without C2 domains) (Rph3al), transcript variant X4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Rph3al ( NM_133591.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_598275.1 Rattus norvegicus rabphilin 3A-like (without C2 domains) (Rph3al), mRNA.

Price & Availability↑

CloneID	ORa01021
Clone ID Related Accession (Same CDS sequence)	NM_133591.2 , XM_008767941.2 , XM_008767942.2
Accession Version	NM_133591.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 909bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	rab effector Noc2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC091126.1. On Mar 27, 2005 this sequence version replaced NM_133591.1. ##Evidence-Data-START## Transcript exon combination :: BC091126.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGGCTGACA CCATCTTCAG CAGTGGAAAT GATCAGTGGG TGTGCCCCAA CGATCGGCAG 
CTTGCTCTGA GAGCCAAGCT GCAGACAGGC TGGTCTGTGC ACACATACCA GACGGAGAAG 
CAGAGGAGGA CTCAATGCCT GAGCCCTGGA GAGGTGGAGG TCATCCTTCA GGTCATCCAG 
AGAGCAGAGC GGCTGGACAT CCTGGAGCAG CAGAGGATTG GGCGGCTGGT GGAGCGGCTG 
GAGACGATGC AGAAGAACGT GATGGGCAAT GGTGTCTCCC AGTGTCTGCT CTGCGGGGAG 
ATGTTGGGAT TCCTGGGCAG CTCCTCTGTA TTCTGCAAAG ACTGCCGGAA GAAAGTCTGC 
ACCAAGTGTG GGATCGAGGC TTCCCCCGGC CAGAAGCGGC CCCTGTGGCT GTGTAAGATC 
TGCAGTGAGC AGAGAGAGGT CTGGAAGAGG TCAGGGGCCT GGTTCTACAA AGGGCTCCCC 
AAGTACATCT TGCCCCTGAA AACCCCTGGC CGGGCTGATG ATCCCCACTT CCGACCTCTG 
CCTGTGGAGC CCACAGAACC ACAGCCTCAG AGTGCTGAAG TCAGCCGTGT CTACACATGG 
GCCCGAGGGA GAGTGGTTTC TAGTGACAGT GACAGTGACT CAGATCTCAG CTCCTCCAGC 
CTGGAGGACA GACCTATGCC CTCTGGGATC AAGGGCACAA AATATGACAA GCCTAGAGGG 
GACTCAGGTG GCAGCATGGA GTCACCCAGG ATGGGGCCTG CCCGACCGCC CAGCCATCTT 
TCTGGCAGCC AGAGCAGCCT GGGCAGTGAG ACGGGGGCAG GTGCTACAGA TCCACAGGGA 
GGCACCCTAC CCCGGCCTGA GCCCAGGGTA TCCGGCAAAA GGCATACCTG GGCAACTACC 
CATTACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_598275.1
CDS	116..1024
Translation	MADTIFSSGNDQWVCPNDRQLALRAKLQTGWSVHTYQTEKQRRTQCLSPGEVEVILQVIQRAERLDILEQQRIGRLVERLETMQKNVMGNGVSQCLLCGEMLGFLGSSSVFCKDCRKKVCTKCGIEASPGQKRPLWLCKICSEQREVWKRSGAWFYKGLPKYILPLKTPGRADDPHFRPLPVEPTEPQPQSAEVSRVYTWARGRVVSSDSDSDSDLSSSSLEDRPMPSGIKGTKYDKPRGDSGGSMESPRMGPARPPSHLSGSQSSLGSETGAGATDPQGGTLPRPEPRVSGKRHTWATTHY

Target ORF information:

RefSeq Version	NM_133591.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus rabphilin 3A-like (without C2 domains) (Rph3al), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_133591.2

ORF Insert Sequence:

ATGGCTGACA CCATCTTCAG CAGTGGAAAT GATCAGTGGG TGTGCCCCAA CGATCGGCAG 
CTTGCTCTGA GAGCCAAGCT GCAGACAGGC TGGTCTGTGC ACACATACCA GACGGAGAAG 
CAGAGGAGGA CTCAATGCCT GAGCCCTGGA GAGGTGGAGG TCATCCTTCA GGTCATCCAG 
AGAGCAGAGC GGCTGGACAT CCTGGAGCAG CAGAGGATTG GGCGGCTGGT GGAGCGGCTG 
GAGACGATGC AGAAGAACGT GATGGGCAAT GGTGTCTCCC AGTGTCTGCT CTGCGGGGAG 
ATGTTGGGAT TCCTGGGCAG CTCCTCTGTA TTCTGCAAAG ACTGCCGGAA GAAAGTCTGC 
ACCAAGTGTG GGATCGAGGC TTCCCCCGGC CAGAAGCGGC CCCTGTGGCT GTGTAAGATC 
TGCAGTGAGC AGAGAGAGGT CTGGAAGAGG TCAGGGGCCT GGTTCTACAA AGGGCTCCCC 
AAGTACATCT TGCCCCTGAA AACCCCTGGC CGGGCTGATG ATCCCCACTT CCGACCTCTG 
CCTGTGGAGC CCACAGAACC ACAGCCTCAG AGTGCTGAAG TCAGCCGTGT CTACACATGG 
GCCCGAGGGA GAGTGGTTTC TAGTGACAGT GACAGTGACT CAGATCTCAG CTCCTCCAGC 
CTGGAGGACA GACCTATGCC CTCTGGGATC AAGGGCACAA AATATGACAA GCCTAGAGGG 
GACTCAGGTG GCAGCATGGA GTCACCCAGG ATGGGGCCTG CCCGACCGCC CAGCCATCTT 
TCTGGCAGCC AGAGCAGCCT GGGCAGTGAG ACGGGGGCAG GTGCTACAGA TCCACAGGGA 
GGCACCCTAC CCCGGCCTGA GCCCAGGGTA TCCGGCAAAA GGCATACCTG GGCAACTACC 
CATTACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Rph3al ( XM_008767941.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008766163.1 Rattus norvegicus rabphilin 3A-like (without C2 domains) (Rph3al), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa01021
Clone ID Related Accession (Same CDS sequence)	NM_133591.2 , XM_008767941.2 , XM_008767942.2
Accession Version	XM_008767941.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 909bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	rab effector Noc2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005109.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008767941.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCTGACA CCATCTTCAG CAGTGGAAAT GATCAGTGGG TGTGCCCCAA CGATCGGCAG 
CTTGCTCTGA GAGCCAAGCT GCAGACAGGC TGGTCTGTGC ACACATACCA GACGGAGAAG 
CAGAGGAGGA CTCAATGCCT GAGCCCTGGA GAGGTGGAGG TCATCCTTCA GGTCATCCAG 
AGAGCAGAGC GGCTGGACAT CCTGGAGCAG CAGAGGATTG GGCGGCTGGT GGAGCGGCTG 
GAGACGATGC AGAAGAACGT GATGGGCAAT GGTGTCTCCC AGTGTCTGCT CTGCGGGGAG 
ATGTTGGGAT TCCTGGGCAG CTCCTCTGTA TTCTGCAAAG ACTGCCGGAA GAAAGTCTGC 
ACCAAGTGTG GGATCGAGGC TTCCCCCGGC CAGAAGCGGC CCCTGTGGCT GTGTAAGATC 
TGCAGTGAGC AGAGAGAGGT CTGGAAGAGG TCAGGGGCCT GGTTCTACAA AGGGCTCCCC 
AAGTACATCT TGCCCCTGAA AACCCCTGGC CGGGCTGATG ATCCCCACTT CCGACCTCTG 
CCTGTGGAGC CCACAGAACC ACAGCCTCAG AGTGCTGAAG TCAGCCGTGT CTACACATGG 
GCCCGAGGGA GAGTGGTTTC TAGTGACAGT GACAGTGACT CAGATCTCAG CTCCTCCAGC 
CTGGAGGACA GACCTATGCC CTCTGGGATC AAGGGCACAA AATATGACAA GCCTAGAGGG 
GACTCAGGTG GCAGCATGGA GTCACCCAGG ATGGGGCCTG CCCGACCGCC CAGCCATCTT 
TCTGGCAGCC AGAGCAGCCT GGGCAGTGAG ACGGGGGCAG GTGCTACAGA TCCACAGGGA 
GGCACCCTAC CCCGGCCTGA GCCCAGGGTA TCCGGCAAAA GGCATACCTG GGCAACTACC 
CATTACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008766163.1
CDS	1299..2207
Translation	MADTIFSSGNDQWVCPNDRQLALRAKLQTGWSVHTYQTEKQRRTQCLSPGEVEVILQVIQRAERLDILEQQRIGRLVERLETMQKNVMGNGVSQCLLCGEMLGFLGSSSVFCKDCRKKVCTKCGIEASPGQKRPLWLCKICSEQREVWKRSGAWFYKGLPKYILPLKTPGRADDPHFRPLPVEPTEPQPQSAEVSRVYTWARGRVVSSDSDSDSDLSSSSLEDRPMPSGIKGTKYDKPRGDSGGSMESPRMGPARPPSHLSGSQSSLGSETGAGATDPQGGTLPRPEPRVSGKRHTWATTHY

Target ORF information:

RefSeq Version	XM_008767941.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus rabphilin 3A-like (without C2 domains) (Rph3al), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008767941.2

ORF Insert Sequence:

ATGGCTGACA CCATCTTCAG CAGTGGAAAT GATCAGTGGG TGTGCCCCAA CGATCGGCAG 
CTTGCTCTGA GAGCCAAGCT GCAGACAGGC TGGTCTGTGC ACACATACCA GACGGAGAAG 
CAGAGGAGGA CTCAATGCCT GAGCCCTGGA GAGGTGGAGG TCATCCTTCA GGTCATCCAG 
AGAGCAGAGC GGCTGGACAT CCTGGAGCAG CAGAGGATTG GGCGGCTGGT GGAGCGGCTG 
GAGACGATGC AGAAGAACGT GATGGGCAAT GGTGTCTCCC AGTGTCTGCT CTGCGGGGAG 
ATGTTGGGAT TCCTGGGCAG CTCCTCTGTA TTCTGCAAAG ACTGCCGGAA GAAAGTCTGC 
ACCAAGTGTG GGATCGAGGC TTCCCCCGGC CAGAAGCGGC CCCTGTGGCT GTGTAAGATC 
TGCAGTGAGC AGAGAGAGGT CTGGAAGAGG TCAGGGGCCT GGTTCTACAA AGGGCTCCCC 
AAGTACATCT TGCCCCTGAA AACCCCTGGC CGGGCTGATG ATCCCCACTT CCGACCTCTG 
CCTGTGGAGC CCACAGAACC ACAGCCTCAG AGTGCTGAAG TCAGCCGTGT CTACACATGG 
GCCCGAGGGA GAGTGGTTTC TAGTGACAGT GACAGTGACT CAGATCTCAG CTCCTCCAGC 
CTGGAGGACA GACCTATGCC CTCTGGGATC AAGGGCACAA AATATGACAA GCCTAGAGGG 
GACTCAGGTG GCAGCATGGA GTCACCCAGG ATGGGGCCTG CCCGACCGCC CAGCCATCTT 
TCTGGCAGCC AGAGCAGCCT GGGCAGTGAG ACGGGGGCAG GTGCTACAGA TCCACAGGGA 
GGCACCCTAC CCCGGCCTGA GCCCAGGGTA TCCGGCAAAA GGCATACCTG GGCAACTACC 
CATTACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Rph3al ( XM_008767942.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008766164.1 Rattus norvegicus rabphilin 3A-like (without C2 domains) (Rph3al), transcript variant X2, mRNA.

Price & Availability↑

CloneID	ORa01021
Clone ID Related Accession (Same CDS sequence)	NM_133591.2 , XM_008767941.2 , XM_008767942.2
Accession Version	XM_008767942.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 909bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	rab effector Noc2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005109.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008767942.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCTGACA CCATCTTCAG CAGTGGAAAT GATCAGTGGG TGTGCCCCAA CGATCGGCAG 
CTTGCTCTGA GAGCCAAGCT GCAGACAGGC TGGTCTGTGC ACACATACCA GACGGAGAAG 
CAGAGGAGGA CTCAATGCCT GAGCCCTGGA GAGGTGGAGG TCATCCTTCA GGTCATCCAG 
AGAGCAGAGC GGCTGGACAT CCTGGAGCAG CAGAGGATTG GGCGGCTGGT GGAGCGGCTG 
GAGACGATGC AGAAGAACGT GATGGGCAAT GGTGTCTCCC AGTGTCTGCT CTGCGGGGAG 
ATGTTGGGAT TCCTGGGCAG CTCCTCTGTA TTCTGCAAAG ACTGCCGGAA GAAAGTCTGC 
ACCAAGTGTG GGATCGAGGC TTCCCCCGGC CAGAAGCGGC CCCTGTGGCT GTGTAAGATC 
TGCAGTGAGC AGAGAGAGGT CTGGAAGAGG TCAGGGGCCT GGTTCTACAA AGGGCTCCCC 
AAGTACATCT TGCCCCTGAA AACCCCTGGC CGGGCTGATG ATCCCCACTT CCGACCTCTG 
CCTGTGGAGC CCACAGAACC ACAGCCTCAG AGTGCTGAAG TCAGCCGTGT CTACACATGG 
GCCCGAGGGA GAGTGGTTTC TAGTGACAGT GACAGTGACT CAGATCTCAG CTCCTCCAGC 
CTGGAGGACA GACCTATGCC CTCTGGGATC AAGGGCACAA AATATGACAA GCCTAGAGGG 
GACTCAGGTG GCAGCATGGA GTCACCCAGG ATGGGGCCTG CCCGACCGCC CAGCCATCTT 
TCTGGCAGCC AGAGCAGCCT GGGCAGTGAG ACGGGGGCAG GTGCTACAGA TCCACAGGGA 
GGCACCCTAC CCCGGCCTGA GCCCAGGGTA TCCGGCAAAA GGCATACCTG GGCAACTACC 
CATTACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008766164.1
CDS	417..1325
Translation	MADTIFSSGNDQWVCPNDRQLALRAKLQTGWSVHTYQTEKQRRTQCLSPGEVEVILQVIQRAERLDILEQQRIGRLVERLETMQKNVMGNGVSQCLLCGEMLGFLGSSSVFCKDCRKKVCTKCGIEASPGQKRPLWLCKICSEQREVWKRSGAWFYKGLPKYILPLKTPGRADDPHFRPLPVEPTEPQPQSAEVSRVYTWARGRVVSSDSDSDSDLSSSSLEDRPMPSGIKGTKYDKPRGDSGGSMESPRMGPARPPSHLSGSQSSLGSETGAGATDPQGGTLPRPEPRVSGKRHTWATTHY

Target ORF information:

RefSeq Version	XM_008767942.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus rabphilin 3A-like (without C2 domains) (Rph3al), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008767942.2

ORF Insert Sequence:

ATGGCTGACA CCATCTTCAG CAGTGGAAAT GATCAGTGGG TGTGCCCCAA CGATCGGCAG 
CTTGCTCTGA GAGCCAAGCT GCAGACAGGC TGGTCTGTGC ACACATACCA GACGGAGAAG 
CAGAGGAGGA CTCAATGCCT GAGCCCTGGA GAGGTGGAGG TCATCCTTCA GGTCATCCAG 
AGAGCAGAGC GGCTGGACAT CCTGGAGCAG CAGAGGATTG GGCGGCTGGT GGAGCGGCTG 
GAGACGATGC AGAAGAACGT GATGGGCAAT GGTGTCTCCC AGTGTCTGCT CTGCGGGGAG 
ATGTTGGGAT TCCTGGGCAG CTCCTCTGTA TTCTGCAAAG ACTGCCGGAA GAAAGTCTGC 
ACCAAGTGTG GGATCGAGGC TTCCCCCGGC CAGAAGCGGC CCCTGTGGCT GTGTAAGATC 
TGCAGTGAGC AGAGAGAGGT CTGGAAGAGG TCAGGGGCCT GGTTCTACAA AGGGCTCCCC 
AAGTACATCT TGCCCCTGAA AACCCCTGGC CGGGCTGATG ATCCCCACTT CCGACCTCTG 
CCTGTGGAGC CCACAGAACC ACAGCCTCAG AGTGCTGAAG TCAGCCGTGT CTACACATGG 
GCCCGAGGGA GAGTGGTTTC TAGTGACAGT GACAGTGACT CAGATCTCAG CTCCTCCAGC 
CTGGAGGACA GACCTATGCC CTCTGGGATC AAGGGCACAA AATATGACAA GCCTAGAGGG 
GACTCAGGTG GCAGCATGGA GTCACCCAGG ATGGGGCCTG CCCGACCGCC CAGCCATCTT 
TCTGGCAGCC AGAGCAGCCT GGGCAGTGAG ACGGGGGCAG GTGCTACAGA TCCACAGGGA 
GGCACCCTAC CCCGGCCTGA GCCCAGGGTA TCCGGCAAAA GGCATACCTG GGCAACTACC 
CATTACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Rph3al ( XM_008767943.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008766165.1 Rattus norvegicus rabphilin 3A-like (without C2 domains) (Rph3al), transcript variant X3, mRNA.

Price & Availability↑

CloneID	ORa44276
Clone ID Related Accession (Same CDS sequence)	XM_008767943.2
Accession Version	XM_008767943.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 822bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	rab effector Noc2 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005109.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008767943.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCTGACA CCATCTTCAG CAGTGGAAAT GATCAGTGGG TGTGCCCCAA CGATCGGCAG 
CTTGCTCTGA GAGCCAAGCT GCAGACAGGC TGGTCTGTGC ACACATACCA GACGGAGAAG 
CAGAGGAGGA CTCAATGCCT GAGCCCTGGA GAGGTGGAGG TCATCCTTCA GGTCATCCAG 
AGAGCAGAGC GGCTGGACAT CCTGGAGCAG CAGAGGATTG GGCGGCTGGT GGAGCGGCTG 
GAGACGATGC AGAAGAACGT GATGGGCAAT GGTGTCTCCC AGTGTCTGCT CTGCGGGGAG 
ATGTTGGGAT TCCTGGGCAG CTCCTCTGTA TTCTGCAAAG ACTGCCGGAA GGTCTGGAAG 
AGGTCAGGGG CCTGGTTCTA CAAAGGGCTC CCCAAGTACA TCTTGCCCCT GAAAACCCCT 
GGCCGGGCTG ATGATCCCCA CTTCCGACCT CTGCCTGTGG AGCCCACAGA ACCACAGCCT 
CAGAGTGCTG AAGTCAGCCG TGTCTACACA TGGGCCCGAG GGAGAGTGGT TTCTAGTGAC 
AGTGACAGTG ACTCAGATCT CAGCTCCTCC AGCCTGGAGG ACAGACCTAT GCCCTCTGGG 
ATCAAGGGCA CAAAATATGA CAAGCCTAGA GGGGACTCAG GTGGCAGCAT GGAGTCACCC 
AGGATGGGGC CTGCCCGACC GCCCAGCCAT CTTTCTGGCA GCCAGAGCAG CCTGGGCAGT 
GAGACGGGGG CAGGTGCTAC AGATCCACAG GGAGGCACCC TACCCCGGCC TGAGCCCAGG 
GTATCCGGCA AAAGGCATAC CTGGGCAACT ACCCATTACT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008766165.1
CDS	1299..2120
Translation	MADTIFSSGNDQWVCPNDRQLALRAKLQTGWSVHTYQTEKQRRTQCLSPGEVEVILQVIQRAERLDILEQQRIGRLVERLETMQKNVMGNGVSQCLLCGEMLGFLGSSSVFCKDCRKVWKRSGAWFYKGLPKYILPLKTPGRADDPHFRPLPVEPTEPQPQSAEVSRVYTWARGRVVSSDSDSDSDLSSSSLEDRPMPSGIKGTKYDKPRGDSGGSMESPRMGPARPPSHLSGSQSSLGSETGAGATDPQGGTLPRPEPRVSGKRHTWATTHY

Target ORF information:

RefSeq Version	XM_008767943.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus rabphilin 3A-like (without C2 domains) (Rph3al), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008767943.2

ORF Insert Sequence:

ATGGCTGACA CCATCTTCAG CAGTGGAAAT GATCAGTGGG TGTGCCCCAA CGATCGGCAG 
CTTGCTCTGA GAGCCAAGCT GCAGACAGGC TGGTCTGTGC ACACATACCA GACGGAGAAG 
CAGAGGAGGA CTCAATGCCT GAGCCCTGGA GAGGTGGAGG TCATCCTTCA GGTCATCCAG 
AGAGCAGAGC GGCTGGACAT CCTGGAGCAG CAGAGGATTG GGCGGCTGGT GGAGCGGCTG 
GAGACGATGC AGAAGAACGT GATGGGCAAT GGTGTCTCCC AGTGTCTGCT CTGCGGGGAG 
ATGTTGGGAT TCCTGGGCAG CTCCTCTGTA TTCTGCAAAG ACTGCCGGAA GGTCTGGAAG 
AGGTCAGGGG CCTGGTTCTA CAAAGGGCTC CCCAAGTACA TCTTGCCCCT GAAAACCCCT 
GGCCGGGCTG ATGATCCCCA CTTCCGACCT CTGCCTGTGG AGCCCACAGA ACCACAGCCT 
CAGAGTGCTG AAGTCAGCCG TGTCTACACA TGGGCCCGAG GGAGAGTGGT TTCTAGTGAC 
AGTGACAGTG ACTCAGATCT CAGCTCCTCC AGCCTGGAGG ACAGACCTAT GCCCTCTGGG 
ATCAAGGGCA CAAAATATGA CAAGCCTAGA GGGGACTCAG GTGGCAGCAT GGAGTCACCC 
AGGATGGGGC CTGCCCGACC GCCCAGCCAT CTTTCTGGCA GCCAGAGCAG CCTGGGCAGT 
GAGACGGGGG CAGGTGCTAC AGATCCACAG GGAGGCACCC TACCCCGGCC TGAGCCCAGG 
GTATCCGGCA AAAGGCATAC CTGGGCAACT ACCCATTACT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Rph3al ( XM_008767944.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008766166.1 Rattus norvegicus rabphilin 3A-like (without C2 domains) (Rph3al), transcript variant X4, mRNA.

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CloneID	ORa44277
Clone ID Related Accession (Same CDS sequence)	XM_008767944.2
Accession Version	XM_008767944.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 795bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	rab effector Noc2 isoform X3
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005109.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008767944.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCTGACA CCATCTTCAG CAGTGGAAAT GATCAGTGGG TGTGCCCCAA CGATCGGCAG 
CTTGCTCTGA GAGCCAAGCT GCAGACAGGC TGGTCTGTGC ACACATACCA GACGGAGAAG 
CAGAGGAGGA CTCAATGCCT GAGCCCTGGA GAGGTGGAGG TCATCCTTCA GGTCATCCAG 
AGAGCAGAGC GGCTGGACAT CCTGGAGCAG CAGAGGATTG GGCGGCTGGT GGAGCGGCTG 
GAGACGATGC AGAAGAACGT GATGGGCAAT GGTGTCTCCC AGTGTCTGCT CTGCGGGGAG 
ATGTTGGGAT TCCTGGGCAG CTCCTCTGTA TTCTGCAAAG ACTGCCGGAA GAAAGTCTGC 
ACCAAGTGTG GGATCGAGGC TTCCCCCGGC CAGAAGCGGC CCCTGTGGCT GTGTAAGATC 
TGCAGTGAGC AGAGAGAGGT CTGGAAGAGG TCAGGGGCCT GGTTCTACAA AGGGCTCCCC 
AAGTACATCT TGCCCCTGAA AACCCCTGGC CGGGCTGATG ATCCCCACTT CCGACCTCTG 
CCTGTGGAGC CCACAGAACC ACAGCCTCAG AGTGCTGAAG TCAGCCGTGT CTACACATGG 
GCCCGAGGGA GAGTGCTGAG GATGGAACCC CGGTCCTTGC ACATACTAGG ACCTCATACA 
AGCATCTCAC CGGTAAGCTA TCCCCAGCCC TTAGTCAGTT GGCAGGGGTT TTCAGATCGT 
CTGTCTCAAG CAGGCCCATG GCACGCTTTA CCTCGCCTGT TTTATTTCTC AGGAAAGGGA 
GACCCTGGGC CCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008766166.1
CDS	1299..2093
Translation	MADTIFSSGNDQWVCPNDRQLALRAKLQTGWSVHTYQTEKQRRTQCLSPGEVEVILQVIQRAERLDILEQQRIGRLVERLETMQKNVMGNGVSQCLLCGEMLGFLGSSSVFCKDCRKKVCTKCGIEASPGQKRPLWLCKICSEQREVWKRSGAWFYKGLPKYILPLKTPGRADDPHFRPLPVEPTEPQPQSAEVSRVYTWARGRVLRMEPRSLHILGPHTSISPVSYPQPLVSWQGFSDRLSQAGPWHALPRLFYFSGKGDPGP

Target ORF information:

RefSeq Version	XM_008767944.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus rabphilin 3A-like (without C2 domains) (Rph3al), transcript variant X4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008767944.2

ORF Insert Sequence:

ATGGCTGACA CCATCTTCAG CAGTGGAAAT GATCAGTGGG TGTGCCCCAA CGATCGGCAG 
CTTGCTCTGA GAGCCAAGCT GCAGACAGGC TGGTCTGTGC ACACATACCA GACGGAGAAG 
CAGAGGAGGA CTCAATGCCT GAGCCCTGGA GAGGTGGAGG TCATCCTTCA GGTCATCCAG 
AGAGCAGAGC GGCTGGACAT CCTGGAGCAG CAGAGGATTG GGCGGCTGGT GGAGCGGCTG 
GAGACGATGC AGAAGAACGT GATGGGCAAT GGTGTCTCCC AGTGTCTGCT CTGCGGGGAG 
ATGTTGGGAT TCCTGGGCAG CTCCTCTGTA TTCTGCAAAG ACTGCCGGAA GAAAGTCTGC 
ACCAAGTGTG GGATCGAGGC TTCCCCCGGC CAGAAGCGGC CCCTGTGGCT GTGTAAGATC 
TGCAGTGAGC AGAGAGAGGT CTGGAAGAGG TCAGGGGCCT GGTTCTACAA AGGGCTCCCC 
AAGTACATCT TGCCCCTGAA AACCCCTGGC CGGGCTGATG ATCCCCACTT CCGACCTCTG 
CCTGTGGAGC CCACAGAACC ACAGCCTCAG AGTGCTGAAG TCAGCCGTGT CTACACATGG 
GCCCGAGGGA GAGTGCTGAG GATGGAACCC CGGTCCTTGC ACATACTAGG ACCTCATACA 
AGCATCTCAC CGGTAAGCTA TCCCCAGCCC TTAGTCAGTT GGCAGGGGTT TTCAGATCGT 
CTGTCTCAAG CAGGCCCATG GCACGCTTTA CCTCGCCTGT TTTATTTCTC AGGAAAGGGA 
GACCCTGGGC CCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Insulin regulates Rab3-Noc2 complex dissociation to promote GLUT4 translocation in rat adipocytes.
Diabetologia58(8)1877-86(2015 Aug)
Koumanov F,Pereira VJ,Richardson JD,Sargent SL,Fazakerley DJ,Holman GD

The Rab27 effector Rabphilin, unlike Granuphilin and Noc2, rapidly exchanges between secretory granules and cytosol in PC12 cells.
Biochemical and biophysical research communications373(2)275-81(2008 Aug)
Handley MT,Burgoyne RD

Functional involvement of Noc2, a Rab27 effector, in rat parotid acinar cells.
Archives of biochemistry and biophysics455(2)127-35(2006 Nov)
Imai A,Yoshie S,Nashida T,Shimomura H,Fukuda M

Noc2 is essential in normal regulation of exocytosis in endocrine and exocrine cells.
Proceedings of the National Academy of Sciences of the United States of America101(22)8313-8(2004 Jun)
Matsumoto M,Miki T,Shibasaki T,Kawaguchi M,Shinozaki H,Nio J,Saraya A,Koseki H,Miyazaki M,Iwanaga T,Seino S

Rabphilin and Noc2 are recruited to dense-core vesicles through specific interaction with Rab27A in PC12 cells.
The Journal of biological chemistry279(13)13065-75(2004 Mar)
Fukuda M,Kanno E,Yamamoto A

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Rph3al cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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