Ndrg2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ndrg2
Entrez Gene ID	171114
Full Name	NDRG family member 2
General protein information	Preferred Names NDRG family member 2 Names protein NDRG2 N-myc downstream regulated gene 2 N-myc downstream-regulated gene 2 protein NDRG1-related protein antidepressant-related protein ADRG123
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 15 Map Location: 15p14
Summary	may play a significant role in mineralocorticoid signaling [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001270864.1	NP_001257793.1	protein NDRG2 isoform b
NM_001270862.1	NP_001257791.1	protein NDRG2 isoform a
NM_001270863.1	NP_001257792.1	protein NDRG2 isoform a
NM_133583.2	NP_598267.2	protein NDRG2 isoform b

Pathways from BioSystems

Homologies

Homo sapiens (human)	NDRG2	NP_963834.1
Pan troglodytes (chimpanzee)	NDRG2	NP_001182082.1
Canis lupus familiaris (dog)	NDRG2	XP_851185.1
Arabidopsis thaliana (thale cress)	NDL2	NP_568251.1
Mus musculus (house mouse)	Ndrg2	NP_038892.1
Danio rerio (zebrafish)	ndrg2	NP_001008593.1
Rattus norvegicus (Norway rat)	Ndrg2	NP_001257791.1
Xenopus tropicalis (tropical clawed frog)	ndrg2	NP_001007898.1
Bos taurus (cattle)	NDRG2	NP_001030381.1

Gene Ontology
Bibliography

Related articles in PubMed

The pathological roles of NDRG2 in Alzheimer's disease, a study using animal models and APPwt-overexpressed cells.
Rong XF, Sun YN, Liu DM, Yin HJ, Peng Y, Xu SF, Wang L, Wang XL
CNS neuroscience & therapeutics23(8)667-679(2017 Aug)

2-Arachidonylglycerol Protects Primary Astrocytes Exposed to Oxygen-Glucose Deprivation Through a Blockade of NDRG2 Signaling and STAT3 Phosphorylation.
Wang F, Li M, Li X, Kinden R, Zhou H, Guo F, Wang Q, Xiong L
Rejuvenation research19(3)215-22(2016 Jun)

NDRG2 promoted secreted miR-375 in microvesicles shed from M1 microglia, which induced neuron damage.
Tang LL, Wu YB, Fang CQ, Qu P, Gao ZL
Biochemical and biophysical research communications469(3)392-8(2016 Jan)

Retrograde ductal administration of the adenovirus-mediated NDRG2 gene leads to improved sialaden hypofunction in estrogen-deficient rats.
Li Y, Liu C, Hou W, Li Y, Ma J, Lin K, Situ Z, Xiong L, Li S, Yao L
Molecular therapy : the journal of the American Society of Gene Therapy22(5)908-18(2014 May)

NDRG2 is involved in anti-apoptosis induced by electroacupuncture pretreatment after focal cerebral ischemia in rats.
Wang F, Gao Z, Li X, Li Y, Li X, Zhong H, Xu N, Cao F, Wang Q, Xiong L
Neurological research35(4)406-14(2013 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

2-arachidonylglycerol protects primary astrocytes exposed to oxygen-glucose deprivation through a blockade of NDRG2 signaling and STAT3 phosphorylation.
Title: 2-Arachidonylglycerol Protects Primary Astrocytes Exposed to Oxygen-Glucose Deprivation Through a Blockade of NDRG2 Signaling and STAT3 Phosphorylation.

Our results demonstrated that NDRG2 promoted secreted miR-375 in microvesicles shed from M1 microglia, which induced neuron damage.
Title: NDRG2 promoted secreted miR-375 in microvesicles shed from M1 microglia, which induced neuron damage.

We further showed that the localized delivery of NDRG2 improved the dysfunction of Na(+) and Cl(-) reabsorption
Title: Retrograde ductal administration of the adenovirus-mediated NDRG2 gene leads to improved sialaden hypofunction in estrogen-deficient rats.

Our results indicated that NDRG2 is involved in anti-apoptosis induced by electroacupuncture pretreatment after focal cerebral ischemia in rats
Title: NDRG2 is involved in anti-apoptosis induced by electroacupuncture pretreatment after focal cerebral ischemia in rats.

Results suggest a novel role of PI3K/Akt/NDRG2 signaling in the cardioprotective effect of insulin.
Title: NDRG2: a newly identified mediator of insulin cardioprotection against myocardial ischemia-reperfusion injury.

The following Ndrg2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ndrg2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa01003	NM_001270864.1 Latest version!	Rattus norvegicus NDRG family member 2 (Ndrg2), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00
ORa01003	NM_133583.2 Latest version!	Rattus norvegicus NDRG family member 2 (Ndrg2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00
ORa09916	NM_001270863.1 Latest version!	Rattus norvegicus NDRG family member 2 (Ndrg2), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
ORa09916	NM_001270862.1 Latest version!	Rattus norvegicus NDRG family member 2 (Ndrg2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ndrg2 ( NM_001270864.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001257793.1 Rattus norvegicus NDRG family member 2 (Ndrg2), transcript variant 4, mRNA.

Price & Availability↑

CloneID	ORa01003
Clone ID Related Accession (Same CDS sequence)	NM_001270864.1 , NM_133583.2
Accession Version	NM_001270864.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1074bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-24
Organism	Rattus norvegicus(Norway rat)
Product	protein NDRG2 isoform b
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from FM057759.1 and AF334106.1. Transcript Variant: This variant (4) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 2 and 4 both encode the same isoform (b). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ426427.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCAGAGC TTCAGGAGGT GCAGATCACT GAGGAGAAGC CACTGTTGCC AGGACAGACG 
CCTGAGGCTG CCAAGACTCA TTCTGTGGAG ACACCTTATG GCTCCGTCAC TTTTACCGTG 
TATGGCACCC CCAAACCCAA ACGTCCAGCG ATATTCACCT ACCATGATGT AGGACTCAAC 
TATAAATCTT GCTTCCAGCC ACTGTTTCAG TTCGGGGATA TGCAAGAGAT CATACAGAAC 
TTCGTGCGGG TCCATGTGGA TGCCCCTGGA ATGGAAGAGG GGGCACCTGT GTTTCCTCTG 
GGGTACCAGT ACCCATCTCT GGACCAGCTT GCAGACATGA TTCCTTGCAT CCTGCAGTAC 
TTAAATTTCT CTACGATAAT TGGAGTTGGC GTTGGAGCTG GAGCATACAT TCTGTCACGA 
TACGCTCTGA ACCACCCGGA CACCGTTGAA GGTCTTGTTC TCATCAACAT TGATCCCAAC 
GCCAAGGGCT GGATGGATTG GGCAGCCCAC AAGTTAACCG GCCTTACGTC TTCCATTCCG 
GAGATGATTC TTGGGCACCT TTTCAGCCAG GAAGAGCTTT CTGGAAATTC TGAATTGATA 
CAGAAGTATA GAAGTCTCAT CACACACGCG CCCAACCTGG AGAACATCGA ACTGTATTGG 
AACAGTTACA ACAACCGCCG AGACCTGAAC TTTGAGCGAG GTGGTGAGAT GACCCTCAAG 
TGCCCCGTGA TGCTGGTGGT AGGAGACCAA GCACCTCATG AAGATGCCGT GGTGGAATGT 
AATTCAAAAC TGGACCCCAC ACAGACCTCA TTCCTCAAGA TGGCGGACTC TGGAGGTCAG 
CCGCAGCTGA CTCAGCCAGG CAAGCTGACA GAAGCTTTCA AGTACTTCGT GCAAGGCATG 
GGCTACATGG CCTCATCCTG TATGACTCGC CTGTCTCGGT CTCGCACAGC ATCTCTGACC 
AGTGCGGCAT CCATCGATGG CAGTCGGTCC CGATCCCGCA CCCTGTCGCA GAGTAGCGAG 
TCTGGGACTC TCCCTTCTGG ACCCCCGGGG CACACCATGG AAGTCTCCTG TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001257793.1
CDS	57..1130
Translation	MAELQEVQITEEKPLLPGQTPEAAKTHSVETPYGSVTFTVYGTPKPKRPAIFTYHDVGLNYKSCFQPLFQFGDMQEIIQNFVRVHVDAPGMEEGAPVFPLGYQYPSLDQLADMIPCILQYLNFSTIIGVGVGAGAYILSRYALNHPDTVEGLVLINIDPNAKGWMDWAAHKLTGLTSSIPEMILGHLFSQEELSGNSELIQKYRSLITHAPNLENIELYWNSYNNRRDLNFERGGEMTLKCPVMLVVGDQAPHEDAVVECNSKLDPTQTSFLKMADSGGQPQLTQPGKLTEAFKYFVQGMGYMASSCMTRLSRSRTASLTSAASIDGSRSRSRTLSQSSESGTLPSGPPGHTMEVSC

Target ORF information:

RefSeq Version	NM_001270864.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus NDRG family member 2 (Ndrg2), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001270864.1

ORF Insert Sequence:

ATGGCAGAGC TTCAGGAGGT GCAGATCACT GAGGAGAAGC CACTGTTGCC AGGACAGACG 
CCTGAGGCTG CCAAGACTCA TTCTGTGGAG ACACCTTATG GCTCCGTCAC TTTTACCGTG 
TATGGCACCC CCAAACCCAA ACGTCCAGCG ATATTCACCT ACCATGATGT AGGACTCAAC 
TATAAATCTT GCTTCCAGCC ACTGTTTCAG TTCGGGGATA TGCAAGAGAT CATACAGAAC 
TTCGTGCGGG TCCATGTGGA TGCCCCTGGA ATGGAAGAGG GGGCACCTGT GTTTCCTCTG 
GGGTACCAGT ACCCATCTCT GGACCAGCTT GCAGACATGA TTCCTTGCAT CCTGCAGTAC 
TTAAATTTCT CTACGATAAT TGGAGTTGGC GTTGGAGCTG GAGCATACAT TCTGTCACGA 
TACGCTCTGA ACCACCCGGA CACCGTTGAA GGTCTTGTTC TCATCAACAT TGATCCCAAC 
GCCAAGGGCT GGATGGATTG GGCAGCCCAC AAGTTAACCG GCCTTACGTC TTCCATTCCG 
GAGATGATTC TTGGGCACCT TTTCAGCCAG GAAGAGCTTT CTGGAAATTC TGAATTGATA 
CAGAAGTATA GAAGTCTCAT CACACACGCG CCCAACCTGG AGAACATCGA ACTGTATTGG 
AACAGTTACA ACAACCGCCG AGACCTGAAC TTTGAGCGAG GTGGTGAGAT GACCCTCAAG 
TGCCCCGTGA TGCTGGTGGT AGGAGACCAA GCACCTCATG AAGATGCCGT GGTGGAATGT 
AATTCAAAAC TGGACCCCAC ACAGACCTCA TTCCTCAAGA TGGCGGACTC TGGAGGTCAG 
CCGCAGCTGA CTCAGCCAGG CAAGCTGACA GAAGCTTTCA AGTACTTCGT GCAAGGCATG 
GGCTACATGG CCTCATCCTG TATGACTCGC CTGTCTCGGT CTCGCACAGC ATCTCTGACC 
AGTGCGGCAT CCATCGATGG CAGTCGGTCC CGATCCCGCA CCCTGTCGCA GAGTAGCGAG 
TCTGGGACTC TCCCTTCTGG ACCCCCGGGG CACACCATGG AAGTCTCCTG TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Ndrg2 ( NM_133583.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_598267.2 Rattus norvegicus NDRG family member 2 (Ndrg2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	ORa01003
Clone ID Related Accession (Same CDS sequence)	NM_001270864.1 , NM_133583.2
Accession Version	NM_133583.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1074bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-24
Organism	Rattus norvegicus(Norway rat)
Product	protein NDRG2 isoform b
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from FM045410.1 and AF334106.1. On Aug 4, 2012 this sequence version replaced NM_133583.1. Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 2 and 4 both encode the same isoform (b). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ426425.1, AF334106.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCAGAGC TTCAGGAGGT GCAGATCACT GAGGAGAAGC CACTGTTGCC AGGACAGACG 
CCTGAGGCTG CCAAGACTCA TTCTGTGGAG ACACCTTATG GCTCCGTCAC TTTTACCGTG 
TATGGCACCC CCAAACCCAA ACGTCCAGCG ATATTCACCT ACCATGATGT AGGACTCAAC 
TATAAATCTT GCTTCCAGCC ACTGTTTCAG TTCGGGGATA TGCAAGAGAT CATACAGAAC 
TTCGTGCGGG TCCATGTGGA TGCCCCTGGA ATGGAAGAGG GGGCACCTGT GTTTCCTCTG 
GGGTACCAGT ACCCATCTCT GGACCAGCTT GCAGACATGA TTCCTTGCAT CCTGCAGTAC 
TTAAATTTCT CTACGATAAT TGGAGTTGGC GTTGGAGCTG GAGCATACAT TCTGTCACGA 
TACGCTCTGA ACCACCCGGA CACCGTTGAA GGTCTTGTTC TCATCAACAT TGATCCCAAC 
GCCAAGGGCT GGATGGATTG GGCAGCCCAC AAGTTAACCG GCCTTACGTC TTCCATTCCG 
GAGATGATTC TTGGGCACCT TTTCAGCCAG GAAGAGCTTT CTGGAAATTC TGAATTGATA 
CAGAAGTATA GAAGTCTCAT CACACACGCG CCCAACCTGG AGAACATCGA ACTGTATTGG 
AACAGTTACA ACAACCGCCG AGACCTGAAC TTTGAGCGAG GTGGTGAGAT GACCCTCAAG 
TGCCCCGTGA TGCTGGTGGT AGGAGACCAA GCACCTCATG AAGATGCCGT GGTGGAATGT 
AATTCAAAAC TGGACCCCAC ACAGACCTCA TTCCTCAAGA TGGCGGACTC TGGAGGTCAG 
CCGCAGCTGA CTCAGCCAGG CAAGCTGACA GAAGCTTTCA AGTACTTCGT GCAAGGCATG 
GGCTACATGG CCTCATCCTG TATGACTCGC CTGTCTCGGT CTCGCACAGC ATCTCTGACC 
AGTGCGGCAT CCATCGATGG CAGTCGGTCC CGATCCCGCA CCCTGTCGCA GAGTAGCGAG 
TCTGGGACTC TCCCTTCTGG ACCCCCGGGG CACACCATGG AAGTCTCCTG TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_598267.2
CDS	75..1148
Translation	MAELQEVQITEEKPLLPGQTPEAAKTHSVETPYGSVTFTVYGTPKPKRPAIFTYHDVGLNYKSCFQPLFQFGDMQEIIQNFVRVHVDAPGMEEGAPVFPLGYQYPSLDQLADMIPCILQYLNFSTIIGVGVGAGAYILSRYALNHPDTVEGLVLINIDPNAKGWMDWAAHKLTGLTSSIPEMILGHLFSQEELSGNSELIQKYRSLITHAPNLENIELYWNSYNNRRDLNFERGGEMTLKCPVMLVVGDQAPHEDAVVECNSKLDPTQTSFLKMADSGGQPQLTQPGKLTEAFKYFVQGMGYMASSCMTRLSRSRTASLTSAASIDGSRSRSRTLSQSSESGTLPSGPPGHTMEVSC

Target ORF information:

RefSeq Version	NM_133583.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus NDRG family member 2 (Ndrg2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_133583.2

ORF Insert Sequence:

ATGGCAGAGC TTCAGGAGGT GCAGATCACT GAGGAGAAGC CACTGTTGCC AGGACAGACG 
CCTGAGGCTG CCAAGACTCA TTCTGTGGAG ACACCTTATG GCTCCGTCAC TTTTACCGTG 
TATGGCACCC CCAAACCCAA ACGTCCAGCG ATATTCACCT ACCATGATGT AGGACTCAAC 
TATAAATCTT GCTTCCAGCC ACTGTTTCAG TTCGGGGATA TGCAAGAGAT CATACAGAAC 
TTCGTGCGGG TCCATGTGGA TGCCCCTGGA ATGGAAGAGG GGGCACCTGT GTTTCCTCTG 
GGGTACCAGT ACCCATCTCT GGACCAGCTT GCAGACATGA TTCCTTGCAT CCTGCAGTAC 
TTAAATTTCT CTACGATAAT TGGAGTTGGC GTTGGAGCTG GAGCATACAT TCTGTCACGA 
TACGCTCTGA ACCACCCGGA CACCGTTGAA GGTCTTGTTC TCATCAACAT TGATCCCAAC 
GCCAAGGGCT GGATGGATTG GGCAGCCCAC AAGTTAACCG GCCTTACGTC TTCCATTCCG 
GAGATGATTC TTGGGCACCT TTTCAGCCAG GAAGAGCTTT CTGGAAATTC TGAATTGATA 
CAGAAGTATA GAAGTCTCAT CACACACGCG CCCAACCTGG AGAACATCGA ACTGTATTGG 
AACAGTTACA ACAACCGCCG AGACCTGAAC TTTGAGCGAG GTGGTGAGAT GACCCTCAAG 
TGCCCCGTGA TGCTGGTGGT AGGAGACCAA GCACCTCATG AAGATGCCGT GGTGGAATGT 
AATTCAAAAC TGGACCCCAC ACAGACCTCA TTCCTCAAGA TGGCGGACTC TGGAGGTCAG 
CCGCAGCTGA CTCAGCCAGG CAAGCTGACA GAAGCTTTCA AGTACTTCGT GCAAGGCATG 
GGCTACATGG CCTCATCCTG TATGACTCGC CTGTCTCGGT CTCGCACAGC ATCTCTGACC 
AGTGCGGCAT CCATCGATGG CAGTCGGTCC CGATCCCGCA CCCTGTCGCA GAGTAGCGAG 
TCTGGGACTC TCCCTTCTGG ACCCCCGGGG CACACCATGG AAGTCTCCTG TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Ndrg2 ( NM_001270862.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001257791.1 Rattus norvegicus NDRG family member 2 (Ndrg2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	ORa09916
Clone ID Related Accession (Same CDS sequence)	NM_001270862.1 , NM_001270863.1
Accession Version	NM_001270862.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1116bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Rattus norvegicus(Norway rat)
Product	protein NDRG2 isoform a
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from FM045410.1 and AF334105.1. Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 3 both encode the same isoform (a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ426424.1, AF334105.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCAGAGC TTCAGGAGGT GCAGATCACT GAGGAGAAGC CACTGTTGCC AGGACAGACG 
CCTGAGGCTG CCAAGGAGGC TGAGTTAGCT GCCCGAATCC TCCTGGACCA GGGACAGACT 
CATTCTGTGG AGACACCTTA TGGCTCCGTC ACTTTTACCG TGTATGGCAC CCCCAAACCC 
AAACGTCCAG CGATATTCAC CTACCATGAT GTAGGACTCA ACTATAAATC TTGCTTCCAG 
CCACTGTTTC AGTTCGGGGA TATGCAAGAG ATCATACAGA ACTTCGTGCG GGTCCATGTG 
GATGCCCCTG GAATGGAAGA GGGGGCACCT GTGTTTCCTC TGGGGTACCA GTACCCATCT 
CTGGACCAGC TTGCAGACAT GATTCCTTGC ATCCTGCAGT ACTTAAATTT CTCTACGATA 
ATTGGAGTTG GCGTTGGAGC TGGAGCATAC ATTCTGTCAC GATACGCTCT GAACCACCCG 
GACACCGTTG AAGGTCTTGT TCTCATCAAC ATTGATCCCA ACGCCAAGGG CTGGATGGAT 
TGGGCAGCCC ACAAGTTAAC CGGCCTTACG TCTTCCATTC CGGAGATGAT TCTTGGGCAC 
CTTTTCAGCC AGGAAGAGCT TTCTGGAAAT TCTGAATTGA TACAGAAGTA TAGAAGTCTC 
ATCACACACG CGCCCAACCT GGAGAACATC GAACTGTATT GGAACAGTTA CAACAACCGC 
CGAGACCTGA ACTTTGAGCG AGGTGGTGAG ATGACCCTCA AGTGCCCCGT GATGCTGGTG 
GTAGGAGACC AAGCACCTCA TGAAGATGCC GTGGTGGAAT GTAATTCAAA ACTGGACCCC 
ACACAGACCT CATTCCTCAA GATGGCGGAC TCTGGAGGTC AGCCGCAGCT GACTCAGCCA 
GGCAAGCTGA CAGAAGCTTT CAAGTACTTC GTGCAAGGCA TGGGCTACAT GGCCTCATCC 
TGTATGACTC GCCTGTCTCG GTCTCGCACA GCATCTCTGA CCAGTGCGGC ATCCATCGAT 
GGCAGTCGGT CCCGATCCCG CACCCTGTCG CAGAGTAGCG AGTCTGGGAC TCTCCCTTCT 
GGACCCCCGG GGCACACCAT GGAAGTCTCC TGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001257791.1
CDS	75..1190
Translation	MAELQEVQITEEKPLLPGQTPEAAKEAELAARILLDQGQTHSVETPYGSVTFTVYGTPKPKRPAIFTYHDVGLNYKSCFQPLFQFGDMQEIIQNFVRVHVDAPGMEEGAPVFPLGYQYPSLDQLADMIPCILQYLNFSTIIGVGVGAGAYILSRYALNHPDTVEGLVLINIDPNAKGWMDWAAHKLTGLTSSIPEMILGHLFSQEELSGNSELIQKYRSLITHAPNLENIELYWNSYNNRRDLNFERGGEMTLKCPVMLVVGDQAPHEDAVVECNSKLDPTQTSFLKMADSGGQPQLTQPGKLTEAFKYFVQGMGYMASSCMTRLSRSRTASLTSAASIDGSRSRSRTLSQSSESGTLPSGPPGHTMEVSC

Target ORF information:

RefSeq Version	NM_001270862.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus NDRG family member 2 (Ndrg2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001270862.1

ORF Insert Sequence:

ATGGCAGAGC TTCAGGAGGT GCAGATCACT GAGGAGAAGC CACTGTTGCC AGGACAGACG 
CCTGAGGCTG CCAAGGAGGC TGAGTTAGCT GCCCGAATCC TCCTGGACCA GGGACAGACT 
CATTCTGTGG AGACACCTTA TGGCTCCGTC ACTTTTACCG TGTATGGCAC CCCCAAACCC 
AAACGTCCAG CGATATTCAC CTACCATGAT GTAGGACTCA ACTATAAATC TTGCTTCCAG 
CCACTGTTTC AGTTCGGGGA TATGCAAGAG ATCATACAGA ACTTCGTGCG GGTCCATGTG 
GATGCCCCTG GAATGGAAGA GGGGGCACCT GTGTTTCCTC TGGGGTACCA GTACCCATCT 
CTGGACCAGC TTGCAGACAT GATTCCTTGC ATCCTGCAGT ACTTAAATTT CTCTACGATA 
ATTGGAGTTG GCGTTGGAGC TGGAGCATAC ATTCTGTCAC GATACGCTCT GAACCACCCG 
GACACCGTTG AAGGTCTTGT TCTCATCAAC ATTGATCCCA ACGCCAAGGG CTGGATGGAT 
TGGGCAGCCC ACAAGTTAAC CGGCCTTACG TCTTCCATTC CGGAGATGAT TCTTGGGCAC 
CTTTTCAGCC AGGAAGAGCT TTCTGGAAAT TCTGAATTGA TACAGAAGTA TAGAAGTCTC 
ATCACACACG CGCCCAACCT GGAGAACATC GAACTGTATT GGAACAGTTA CAACAACCGC 
CGAGACCTGA ACTTTGAGCG AGGTGGTGAG ATGACCCTCA AGTGCCCCGT GATGCTGGTG 
GTAGGAGACC AAGCACCTCA TGAAGATGCC GTGGTGGAAT GTAATTCAAA ACTGGACCCC 
ACACAGACCT CATTCCTCAA GATGGCGGAC TCTGGAGGTC AGCCGCAGCT GACTCAGCCA 
GGCAAGCTGA CAGAAGCTTT CAAGTACTTC GTGCAAGGCA TGGGCTACAT GGCCTCATCC 
TGTATGACTC GCCTGTCTCG GTCTCGCACA GCATCTCTGA CCAGTGCGGC ATCCATCGAT 
GGCAGTCGGT CCCGATCCCG CACCCTGTCG CAGAGTAGCG AGTCTGGGAC TCTCCCTTCT 
GGACCCCCGG GGCACACCAT GGAAGTCTCC TGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Ndrg2 ( NM_001270863.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001257792.1 Rattus norvegicus NDRG family member 2 (Ndrg2), transcript variant 3, mRNA.

Price & Availability↑

CloneID	ORa09916
Clone ID Related Accession (Same CDS sequence)	NM_001270862.1 , NM_001270863.1
Accession Version	NM_001270863.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1116bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-24
Organism	Rattus norvegicus(Norway rat)
Product	protein NDRG2 isoform a
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from FM057759.1 and AF334105.1. Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 and 3 both encode the same isoform (a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ426426.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCAGAGC TTCAGGAGGT GCAGATCACT GAGGAGAAGC CACTGTTGCC AGGACAGACG 
CCTGAGGCTG CCAAGGAGGC TGAGTTAGCT GCCCGAATCC TCCTGGACCA GGGACAGACT 
CATTCTGTGG AGACACCTTA TGGCTCCGTC ACTTTTACCG TGTATGGCAC CCCCAAACCC 
AAACGTCCAG CGATATTCAC CTACCATGAT GTAGGACTCA ACTATAAATC TTGCTTCCAG 
CCACTGTTTC AGTTCGGGGA TATGCAAGAG ATCATACAGA ACTTCGTGCG GGTCCATGTG 
GATGCCCCTG GAATGGAAGA GGGGGCACCT GTGTTTCCTC TGGGGTACCA GTACCCATCT 
CTGGACCAGC TTGCAGACAT GATTCCTTGC ATCCTGCAGT ACTTAAATTT CTCTACGATA 
ATTGGAGTTG GCGTTGGAGC TGGAGCATAC ATTCTGTCAC GATACGCTCT GAACCACCCG 
GACACCGTTG AAGGTCTTGT TCTCATCAAC ATTGATCCCA ACGCCAAGGG CTGGATGGAT 
TGGGCAGCCC ACAAGTTAAC CGGCCTTACG TCTTCCATTC CGGAGATGAT TCTTGGGCAC 
CTTTTCAGCC AGGAAGAGCT TTCTGGAAAT TCTGAATTGA TACAGAAGTA TAGAAGTCTC 
ATCACACACG CGCCCAACCT GGAGAACATC GAACTGTATT GGAACAGTTA CAACAACCGC 
CGAGACCTGA ACTTTGAGCG AGGTGGTGAG ATGACCCTCA AGTGCCCCGT GATGCTGGTG 
GTAGGAGACC AAGCACCTCA TGAAGATGCC GTGGTGGAAT GTAATTCAAA ACTGGACCCC 
ACACAGACCT CATTCCTCAA GATGGCGGAC TCTGGAGGTC AGCCGCAGCT GACTCAGCCA 
GGCAAGCTGA CAGAAGCTTT CAAGTACTTC GTGCAAGGCA TGGGCTACAT GGCCTCATCC 
TGTATGACTC GCCTGTCTCG GTCTCGCACA GCATCTCTGA CCAGTGCGGC ATCCATCGAT 
GGCAGTCGGT CCCGATCCCG CACCCTGTCG CAGAGTAGCG AGTCTGGGAC TCTCCCTTCT 
GGACCCCCGG GGCACACCAT GGAAGTCTCC TGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001257792.1
CDS	57..1172
Translation	MAELQEVQITEEKPLLPGQTPEAAKEAELAARILLDQGQTHSVETPYGSVTFTVYGTPKPKRPAIFTYHDVGLNYKSCFQPLFQFGDMQEIIQNFVRVHVDAPGMEEGAPVFPLGYQYPSLDQLADMIPCILQYLNFSTIIGVGVGAGAYILSRYALNHPDTVEGLVLINIDPNAKGWMDWAAHKLTGLTSSIPEMILGHLFSQEELSGNSELIQKYRSLITHAPNLENIELYWNSYNNRRDLNFERGGEMTLKCPVMLVVGDQAPHEDAVVECNSKLDPTQTSFLKMADSGGQPQLTQPGKLTEAFKYFVQGMGYMASSCMTRLSRSRTASLTSAASIDGSRSRSRTLSQSSESGTLPSGPPGHTMEVSC

Target ORF information:

RefSeq Version	NM_001270863.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus NDRG family member 2 (Ndrg2), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001270863.1

ORF Insert Sequence:

ATGGCAGAGC TTCAGGAGGT GCAGATCACT GAGGAGAAGC CACTGTTGCC AGGACAGACG 
CCTGAGGCTG CCAAGGAGGC TGAGTTAGCT GCCCGAATCC TCCTGGACCA GGGACAGACT 
CATTCTGTGG AGACACCTTA TGGCTCCGTC ACTTTTACCG TGTATGGCAC CCCCAAACCC 
AAACGTCCAG CGATATTCAC CTACCATGAT GTAGGACTCA ACTATAAATC TTGCTTCCAG 
CCACTGTTTC AGTTCGGGGA TATGCAAGAG ATCATACAGA ACTTCGTGCG GGTCCATGTG 
GATGCCCCTG GAATGGAAGA GGGGGCACCT GTGTTTCCTC TGGGGTACCA GTACCCATCT 
CTGGACCAGC TTGCAGACAT GATTCCTTGC ATCCTGCAGT ACTTAAATTT CTCTACGATA 
ATTGGAGTTG GCGTTGGAGC TGGAGCATAC ATTCTGTCAC GATACGCTCT GAACCACCCG 
GACACCGTTG AAGGTCTTGT TCTCATCAAC ATTGATCCCA ACGCCAAGGG CTGGATGGAT 
TGGGCAGCCC ACAAGTTAAC CGGCCTTACG TCTTCCATTC CGGAGATGAT TCTTGGGCAC 
CTTTTCAGCC AGGAAGAGCT TTCTGGAAAT TCTGAATTGA TACAGAAGTA TAGAAGTCTC 
ATCACACACG CGCCCAACCT GGAGAACATC GAACTGTATT GGAACAGTTA CAACAACCGC 
CGAGACCTGA ACTTTGAGCG AGGTGGTGAG ATGACCCTCA AGTGCCCCGT GATGCTGGTG 
GTAGGAGACC AAGCACCTCA TGAAGATGCC GTGGTGGAAT GTAATTCAAA ACTGGACCCC 
ACACAGACCT CATTCCTCAA GATGGCGGAC TCTGGAGGTC AGCCGCAGCT GACTCAGCCA 
GGCAAGCTGA CAGAAGCTTT CAAGTACTTC GTGCAAGGCA TGGGCTACAT GGCCTCATCC 
TGTATGACTC GCCTGTCTCG GTCTCGCACA GCATCTCTGA CCAGTGCGGC ATCCATCGAT 
GGCAGTCGGT CCCGATCCCG CACCCTGTCG CAGAGTAGCG AGTCTGGGAC TCTCCCTTCT 
GGACCCCCGG GGCACACCAT GGAAGTCTCC TGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The pathological roles of NDRG2 in Alzheimer's disease, a study using animal models and APPwt-overexpressed cells.
CNS neuroscience & therapeutics23(8)667-679(2017 Aug)
Rong XF,Sun YN,Liu DM,Yin HJ,Peng Y,Xu SF,Wang L,Wang XL

2-Arachidonylglycerol Protects Primary Astrocytes Exposed to Oxygen-Glucose Deprivation Through a Blockade of NDRG2 Signaling and STAT3 Phosphorylation.
Rejuvenation research19(3)215-22(2016 Jun)
Wang F,Li M,Li X,Kinden R,Zhou H,Guo F,Wang Q,Xiong L

NDRG2 promoted secreted miR-375 in microvesicles shed from M1 microglia, which induced neuron damage.
Biochemical and biophysical research communications469(3)392-8(2016 Jan)
Tang LL,Wu YB,Fang CQ,Qu P,Gao ZL

Retrograde ductal administration of the adenovirus-mediated NDRG2 gene leads to improved sialaden hypofunction in estrogen-deficient rats.
Molecular therapy : the journal of the American Society of Gene Therapy22(5)908-18(2014 May)
Li Y,Liu C,Hou W,Li Y,Ma J,Lin K,Situ Z,Xiong L,Li S,Yao L

NDRG2 is involved in anti-apoptosis induced by electroacupuncture pretreatment after focal cerebral ischemia in rats.
Neurological research35(4)406-14(2013 May)
Wang F,Gao Z,Li X,Li Y,Li X,Zhong H,Xu N,Cao F,Wang Q,Xiong L

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Ndrg2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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