Cx3cr1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cx3cr1
Entrez Gene ID	171056
Full Name	C-X3-C motif chemokine receptor 1
Synonyms	Rbs11
General protein information	Preferred Names C-X3-C motif chemokine receptor 1 Names CX3C chemokine receptor 1 C-X3-C CKR-1 chemokine (C-X3-C motif) receptor 1 chemokine (C-X3-C) receptor 1 fractalkine receptor
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 8 Map Location: 8q32
Summary	member of the rhodopsin family of G-protein coupled receptors; may act as a receptor for a chemokine peptide ligand [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_133534.1	NP_598218.1	CX3C chemokine receptor 1

Pathways from BioSystems

Homologies

Homo sapiens (human)	CX3CR1	NP_001328.1
Gallus gallus (chicken)	CX3CR1	XP_004939539.1
Pan troglodytes (chimpanzee)	CX3CR1	NP_001139725.1
Canis lupus familiaris (dog)	CX3CR1	XP_005634322.1
	CX3CR1	XP_001084169.1
Bos taurus (cattle)	CX3CR1	NP_001096028.1
Mus musculus (house mouse)	Cx3cr1	NP_034117.3
Rattus norvegicus (Norway rat)	Cx3cr1	NP_598218.1

Gene Ontology
Bibliography

Related articles in PubMed

Decreased post-synaptic density-95 protein expression on dendrites of newborn neurons following CX3CR1 modulation in the epileptogenic adult rodent brain.
Ali I, Avdic U, Chugh D, Ekdahl CT
Cellular & molecular immunology(2017 Oct)

Involvement of NF-?B and the CX3CR1 Signaling Network in Mechanical Allodynia Induced by Tetanic Sciatic Stimulation.
Wang ZC, Li LH, Bian C, Yang L, Lv N, Zhang YQ
Neuroscience bulletin(2017 Jun)

TGF-?1 Downregulates the Expression of CX
Regis S, Caliendo F, Dondero A, Casu B, Romano F, Loiacono F, Moretta A, Bottino C, Castriconi R
Frontiers in immunology8868(2017)

CX3CR1 Mediates Nicotine Withdrawal-Induced Hyperalgesia via Microglial P38 MAPK Signaling.
Ding Y, Shi W, Xie G, Yu A, Wang Q, Zhang Z
Neurochemical research40(11)2252-61(2015 Nov)

Involvement of CX3CL1/CX3CR1 signaling in spinal long term potentiation.
Bian C, Zhao ZQ, Zhang YQ, L? N
PloS one10(3)e0118842(2015)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

microglial CX3CR1/p38MAPK pathway is critical for the development of pain hypersensitivity after nicotine withdrawal
Title: CX3CR1 Mediates Nicotine Withdrawal-Induced Hyperalgesia via Microglial P38 MAPK Signaling.

Results suggest fractalkine-CX3CR1 signaling pathway role in limbic seizure-induced hippocampal pathologies including microglial activation, neurodegeneration and neuroblast production
Title: Role of fractalkine-CX3CR1 pathway in seizure-induced microglial activation, neurodegeneration, and neuroblast production in the adult rat brain.

CX3CL1/CX3CR1 signaling is involved in LTP of C-fiber-evoked field potentials in the rodent spinal dorsal horn
Title: Involvement of CX3CL1/CX3CR1 signaling in spinal long term potentiation.

Results suggest that CX3C chemokine receptor 1 (CX3CR1) activation of pancreatic stellate cells (PSCs) could be important in their effects in pancreatitis, especially to PSCs proliferation in pancreatitis where CX3CL1 levels are elevated.
Title: Pancreatic stellate cells and CX3CR1: occurrence in normal pancreas and acute and chronic pancreatitis and effect of their activation by a CX3CR1 agonist.

This is the first study to identify CX3CL1 signaling through CX3CR1 via the DRG/SC anatomical connection that represents a critical pathway involved in NPP induction in an EAE model of MS.
Title: Elevated expression of fractalkine (CX3CL1) and fractalkine receptor (CX3CR1) in the dorsal root ganglia and spinal cord in experimental autoimmune encephalomyelitis: implications in multiple sclerosis-induced neuropathic pain.

The following Cx3cr1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cx3cr1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa12678	NM_133534.1 Latest version!	Rattus norvegicus C-X3-C motif chemokine receptor 1 (Cx3cr1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cx3cr1 ( NM_133534.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_598218.1 Rattus norvegicus C-X3-C motif chemokine receptor 1 (Cx3cr1), mRNA.

Price & Availability↑

CloneID	ORa12678
Clone ID Related Accession (Same CDS sequence)	NM_133534.1
Accession Version	NM_133534.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1065bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	CX3C chemokine receptor 1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U04808.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U04808.1, DN956036.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGCCTACCT CCTTCCCGGA ATTGGATCTA GAGAACTTTG AGTATGATGA CTCTGCTGAG 
GCCTGTTATT TGGGTGACAT CGTGGCCTTT GGGACCATCT TCCTATCTAT TTTCTACTCC 
CTTGTCTTCA CGTTCGGTCT GGTGGGGAAT CTGTTGGTGG TCCTCGCCCT CACCAACAGC 
CGGAAGTCCA AGAGCATCAC TGACATCTAC CTCCTGAACC TGGCCTTGAG CGACCTGCTC 
TTTGTGGCCA CTTTGCCCTT CTGGACTCAC TACCTCATCA GCCATGAGGG CCTCCACAAC 
GCCATGTGCA AGCTCACGAC TGCTTTCTTC TTCATTGGCT TCTTTGGGGG CATATTCTTC 
ATCACCGTCA TCAGCATCGA CCGGTACCTC GCCATCGTCC TGGCCGCCAA CTCCATGAAC 
AACCGGACAG TGCAACACGG CGTCACCATC AGTCTGGGCG TCTGGGCGGC GGCCATCTTA 
GTGGCGTCGC CCCAGTTCAT GTTCACAAAG AGAAAGGACA ACGAATGTTT GGGTGATTAC 
CCCGAGGTCC TGCAGGAAAT CTGGCCCGTG CTCCGCAACT CGGAGGTCAA CATCCTGGGC 
TTCGTCCTGC CCTTGCTTAT CATGAGCTTT TGCTACTTCC GCATCGTCCG GACGCTGTTT 
TCCTGCAAGA ACCGGAAGAA GGCCAGAGCC ATTAGGCTCA TCCTCTTGGT GGTTGTTGTC 
TTCTTCCTCT TCTGGACGCC TTACAACATC GTGATTTTCC TGGAGACTCT CAAATTCTAC 
AACTTCTTCC CTAGTTGTGG CATGAAGAGG GACCTGAGGT GGGCCCTTAG TGTGACGGAG 
ACAGTGGCGT TTAGCCACTG CTGCCTCAAC CCCTTTATCT ACGCTTTCGC TGGGGAAAAG 
TTCAGAAGGT ACCTGAGACA CCTGTACAAC AAGTGCCTGG CCGTCCTGTG CGGTCGTCCT 
GTCCACGCCG GCTTCTCAAC AGAGTCCCAG AGGAGCAGGC AGGACAGCAT TCTGAGCAGC 
TTGACTCACT ACACAAGCGA GGGAGAGGGA TCTCTCCTGC TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_598218.1
CDS	68..1132
Translation	MPTSFPELDLENFEYDDSAEACYLGDIVAFGTIFLSIFYSLVFTFGLVGNLLVVLALTNSRKSKSITDIYLLNLALSDLLFVATLPFWTHYLISHEGLHNAMCKLTTAFFFIGFFGGIFFITVISIDRYLAIVLAANSMNNRTVQHGVTISLGVWAAAILVASPQFMFTKRKDNECLGDYPEVLQEIWPVLRNSEVNILGFVLPLLIMSFCYFRIVRTLFSCKNRKKARAIRLILLVVVVFFLFWTPYNIVIFLETLKFYNFFPSCGMKRDLRWALSVTETVAFSHCCLNPFIYAFAGEKFRRYLRHLYNKCLAVLCGRPVHAGFSTESQRSRQDSILSSLTHYTSEGEGSLLL

Target ORF information:

RefSeq Version	NM_133534.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus C-X3-C motif chemokine receptor 1 (Cx3cr1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_133534.1

ORF Insert Sequence:

ATGCCTACCT CCTTCCCGGA ATTGGATCTA GAGAACTTTG AGTATGATGA CTCTGCTGAG 
GCCTGTTATT TGGGTGACAT CGTGGCCTTT GGGACCATCT TCCTATCTAT TTTCTACTCC 
CTTGTCTTCA CGTTCGGTCT GGTGGGGAAT CTGTTGGTGG TCCTCGCCCT CACCAACAGC 
CGGAAGTCCA AGAGCATCAC TGACATCTAC CTCCTGAACC TGGCCTTGAG CGACCTGCTC 
TTTGTGGCCA CTTTGCCCTT CTGGACTCAC TACCTCATCA GCCATGAGGG CCTCCACAAC 
GCCATGTGCA AGCTCACGAC TGCTTTCTTC TTCATTGGCT TCTTTGGGGG CATATTCTTC 
ATCACCGTCA TCAGCATCGA CCGGTACCTC GCCATCGTCC TGGCCGCCAA CTCCATGAAC 
AACCGGACAG TGCAACACGG CGTCACCATC AGTCTGGGCG TCTGGGCGGC GGCCATCTTA 
GTGGCGTCGC CCCAGTTCAT GTTCACAAAG AGAAAGGACA ACGAATGTTT GGGTGATTAC 
CCCGAGGTCC TGCAGGAAAT CTGGCCCGTG CTCCGCAACT CGGAGGTCAA CATCCTGGGC 
TTCGTCCTGC CCTTGCTTAT CATGAGCTTT TGCTACTTCC GCATCGTCCG GACGCTGTTT 
TCCTGCAAGA ACCGGAAGAA GGCCAGAGCC ATTAGGCTCA TCCTCTTGGT GGTTGTTGTC 
TTCTTCCTCT TCTGGACGCC TTACAACATC GTGATTTTCC TGGAGACTCT CAAATTCTAC 
AACTTCTTCC CTAGTTGTGG CATGAAGAGG GACCTGAGGT GGGCCCTTAG TGTGACGGAG 
ACAGTGGCGT TTAGCCACTG CTGCCTCAAC CCCTTTATCT ACGCTTTCGC TGGGGAAAAG 
TTCAGAAGGT ACCTGAGACA CCTGTACAAC AAGTGCCTGG CCGTCCTGTG CGGTCGTCCT 
GTCCACGCCG GCTTCTCAAC AGAGTCCCAG AGGAGCAGGC AGGACAGCAT TCTGAGCAGC 
TTGACTCACT ACACAAGCGA GGGAGAGGGA TCTCTCCTGC TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Decreased post-synaptic density-95 protein expression on dendrites of newborn neurons following CX3CR1 modulation in the epileptogenic adult rodent brain.
Cellular & molecular immunology(2017 Oct)
Ali I,Avdic U,Chugh D,Ekdahl CT

Involvement of NF-?B and the CX3CR1 Signaling Network in Mechanical Allodynia Induced by Tetanic Sciatic Stimulation.
Neuroscience bulletin(2017 Jun)
Wang ZC,Li LH,Bian C,Yang L,Lv N,Zhang YQ

TGF-?1 Downregulates the Expression of CX
Frontiers in immunology8868(2017)
Regis S,Caliendo F,Dondero A,Casu B,Romano F,Loiacono F,Moretta A,Bottino C,Castriconi R

CX3CR1 Mediates Nicotine Withdrawal-Induced Hyperalgesia via Microglial P38 MAPK Signaling.
Neurochemical research40(11)2252-61(2015 Nov)
Ding Y,Shi W,Xie G,Yu A,Wang Q,Zhang Z

Involvement of CX3CL1/CX3CR1 signaling in spinal long term potentiation.
PloS one10(3)e0118842(2015)
Bian C,Zhao ZQ,Zhang YQ,L? N