Ccr4 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ccr4
Entrez Gene ID	171054
Full Name	C-C motif chemokine receptor 4
Synonyms	Cmkbr4
General protein information	Preferred Names C-C motif chemokine receptor 4 Names C-C chemokine receptor type 4 C-C chemokine receptor 4 chemokine (C-C motif) receptor 4 chemokine (C-C) receptor 4
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 8 Map Location: 8q32
Summary	mouse homolog is a chemokine receptor that binds both macrophage inflammatory protein-1 alpha and RANTES [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_006243915.3	XP_006243977.1	C-C chemokine receptor type 4 isoform X1
NM_133532.2	NP_598216.2	C-C chemokine receptor type 4

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	CCR4	XP_001168244.1
Canis lupus familiaris (dog)	CCR4	NP_001003020.1
Homo sapiens (human)	CCR4	NP_005499.1
Bos taurus (cattle)	CCR4	NP_001093763.1
Mus musculus (house mouse)	Ccr4	NP_034046.2
Rattus norvegicus (Norway rat)	Ccr4	NP_598216.2
Danio rerio (zebrafish)	LOC100329837	XP_005173521.1
Gallus gallus (chicken)	CCR4	XP_004939540.1
	CCR4	XP_001098807.1

Gene Ontology
Bibliography

Related articles in PubMed

Synthesis of some CC chemokines and their receptors in the synovium in rheumatoid arthritis.
Zhebrun DA, Totolyan AA, Maslyanskii AL, Titov AG, Patrukhin AP, Kostareva AA, Gol'tseva IS
Bulletin of experimental biology and medicine158(2)192-6(2014 Dec)

Differential requirement for CCR4 in the maintenance but not establishment of the invariant V?5(+) dendritic epidermal T-cell pool.
Nakamura K, White AJ, Parnell SM, Lane PJ, Jenkinson EJ, Jenkinson WE, Anderson G
PloS one8(9)e74019(2013)

Differing requirements for CCR4, E-selectin, and ?4?1 for the migration of memory CD4 and activated T cells to dermal inflammation.
Gehad A, Al-Banna NA, Vaci M, Issekutz AC, Mohan K, Latta M, Issekutz TB
Journal of immunology (Baltimore, Md. : 1950)189(1)337-46(2012 Jul)

Expression of MDC/CCL22 and its receptor CCR4 in rheumatoid arthritis, psoriatic arthritis and osteoarthritis.
Flytlie HA, Hvid M, Lindgreen E, Kofod-Olsen E, Petersen EL, J?rgensen A, Deleuran M, Vestergaard C, Deleuran B
Cytokine49(1)24-9(2010 Jan)

Th1- and Th2-related chemokine and chemokine receptor expression on the ocular surface in endotoxin-induced uveitis.
Trinh L, Brignole-Baudouin F, Pauly A, Liang H, Houssier M, Baudouin C
Molecular vision142428-34(2008)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

There is no strict relationship between CCR4 and E-selectin for skin homing of CD4 cells, because activation state and inflammatory stimulus are the critical determinants.
Title: Differing requirements for CCR4, E-selectin, and ?4?1 for the migration of memory CD4 and activated T cells to dermal inflammation.

The following Ccr4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ccr4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa41996	NM_133532.2 Latest version!	Rattus norvegicus C-C motif chemokine receptor 4 (Ccr4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
ORa31664	XM_006243915.3 Latest version!	Rattus norvegicus C-C motif chemokine receptor 4 (Ccr4), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ccr4 ( NM_133532.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_598216.2 Rattus norvegicus C-C motif chemokine receptor 4 (Ccr4), mRNA.

Price & Availability↑

CloneID	ORa41996
Clone ID Related Accession (Same CDS sequence)	NM_133532.2
Accession Version	NM_133532.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1083bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-05-26
Organism	Rattus norvegicus(Norway rat)
Product	C-C chemokine receptor type 4
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF432872.2. On Dec 11, 2002 this sequence version replaced NM_133532.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF432872.2 [ECO:0000332] ##Evidence-Data-END##

ATGAATGCCA CAGATGTCAC AGACACCACC CAGGATGAAG CCGCGTACAA TAGTTACTAC 
TTCGACGAGA GCTTGCCAAA GCCTTGCACC AAGGAAGGCA TCAAGGCGTT CGGCGAGGTC 
TTCCTGCCTC CTCTCTACTC CTTGGTCTTT CTGTTGGGTC TGTTTGGGAA TTCTGTTGTG 
GTTCTGGTGC TGTTCAAGTA CAAGAGGCTC AAGTCCATGA CTGACGTGTA CCTGCTGAAC 
CTAGCCATCT CGGATTTACT GTTTGTGCTG TCTCTCCCGT TCTGGGGCTA CTATGCTGCT 
GACCAGTGGG TTTTTGGTCT AGGTCTGTGT AAGATTATCT CATGGATGTA CCTGGTGGGC 
TTCTACAGCG GGATCTTCTT CATCATGCTC ATGAGTATAG ACAGATACCT GGCCATCGTG 
CACGCAGTGT TTTCCTTGAG AGCGAGGACT CTGACCTATG GGGTCATCAC CAGCCTCATC 
ACGTGGTCTG TGGCTGTGTT TGCCTCCCTA CCAGGCCTCT TGTTCAGCAC CTGCGACACA 
GAGAACAACC ACACATACTG CAAAACCCAG TACTCGGTCA ACTCGACCAC GTGGAAAGTC 
CTCAGCTCCC TGGAGATCAA TGTCTTGGGG CTGGTCATCC CCCTGGGGAT CATGTTGTTC 
TGCTATTCCA TGATCATCAG GACCCTGAGA CACTGCAAGA ATGAGAAGAA GAACAGAGCA 
GTTCGGATGA TCTTCGCCGT GGTGGTCCTC TTCCTCGGCT TCTGGACGCC GTACAACGTG 
GTGCTTTTCC TGGAGACCTT GGTGGAGCTC GAAGTCCTTC AGGACTGCAC CTTGGAGAGG 
TACCTAGACT ATGCCATCCA GGCCACAGAA ACCCTGGCCT TCATTCACTG CTGCCTTAAC 
CCTGTCATTT ACTTCTTCCT TGGGGAGAAA TTCCGCAAGT ACATCGCCCA ACTCTTCAGA 
ACGTGCCGGG GTCCTCCTGT GCTCTGCCAA CACTGTGACT TCCTTCAGAT CTCCTCGGCC 
GACACTTCCA GCTCCTCTTA CACTCAGTCC ACTGTGGATC ATGACTTCCG TGACGCTTTG 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_598216.2
CDS	1..1083
Translation	MNATDVTDTTQDEAAYNSYYFDESLPKPCTKEGIKAFGEVFLPPLYSLVFLLGLFGNSVVVLVLFKYKRLKSMTDVYLLNLAISDLLFVLSLPFWGYYAADQWVFGLGLCKIISWMYLVGFYSGIFFIMLMSIDRYLAIVHAVFSLRARTLTYGVITSLITWSVAVFASLPGLLFSTCDTENNHTYCKTQYSVNSTTWKVLSSLEINVLGLVIPLGIMLFCYSMIIRTLRHCKNEKKNRAVRMIFAVVVLFLGFWTPYNVVLFLETLVELEVLQDCTLERYLDYAIQATETLAFIHCCLNPVIYFFLGEKFRKYIAQLFRTCRGPPVLCQHCDFLQISSADTSSSSYTQSTVDHDFRDAL

Target ORF information:

RefSeq Version	NM_133532.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus C-C motif chemokine receptor 4 (Ccr4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_133532.2

ORF Insert Sequence:

ATGAATGCCA CAGATGTCAC AGACACCACC CAGGATGAAG CCGCGTACAA TAGTTACTAC 
TTCGACGAGA GCTTGCCAAA GCCTTGCACC AAGGAAGGCA TCAAGGCGTT CGGCGAGGTC 
TTCCTGCCTC CTCTCTACTC CTTGGTCTTT CTGTTGGGTC TGTTTGGGAA TTCTGTTGTG 
GTTCTGGTGC TGTTCAAGTA CAAGAGGCTC AAGTCCATGA CTGACGTGTA CCTGCTGAAC 
CTAGCCATCT CGGATTTACT GTTTGTGCTG TCTCTCCCGT TCTGGGGCTA CTATGCTGCT 
GACCAGTGGG TTTTTGGTCT AGGTCTGTGT AAGATTATCT CATGGATGTA CCTGGTGGGC 
TTCTACAGCG GGATCTTCTT CATCATGCTC ATGAGTATAG ACAGATACCT GGCCATCGTG 
CACGCAGTGT TTTCCTTGAG AGCGAGGACT CTGACCTATG GGGTCATCAC CAGCCTCATC 
ACGTGGTCTG TGGCTGTGTT TGCCTCCCTA CCAGGCCTCT TGTTCAGCAC CTGCGACACA 
GAGAACAACC ACACATACTG CAAAACCCAG TACTCGGTCA ACTCGACCAC GTGGAAAGTC 
CTCAGCTCCC TGGAGATCAA TGTCTTGGGG CTGGTCATCC CCCTGGGGAT CATGTTGTTC 
TGCTATTCCA TGATCATCAG GACCCTGAGA CACTGCAAGA ATGAGAAGAA GAACAGAGCA 
GTTCGGATGA TCTTCGCCGT GGTGGTCCTC TTCCTCGGCT TCTGGACGCC GTACAACGTG 
GTGCTTTTCC TGGAGACCTT GGTGGAGCTC GAAGTCCTTC AGGACTGCAC CTTGGAGAGG 
TACCTAGACT ATGCCATCCA GGCCACAGAA ACCCTGGCCT TCATTCACTG CTGCCTTAAC 
CCTGTCATTT ACTTCTTCCT TGGGGAGAAA TTCCGCAAGT ACATCGCCCA ACTCTTCAGA 
ACGTGCCGGG GTCCTCCTGT GCTCTGCCAA CACTGTGACT TCCTTCAGAT CTCCTCGGCC 
GACACTTCCA GCTCCTCTTA CACTCAGTCC ACTGTGGATC ATGACTTCCG TGACGCTTTG 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Ccr4 ( XM_006243915.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006243977.1 Rattus norvegicus C-C motif chemokine receptor 4 (Ccr4), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa31664
Clone ID Related Accession (Same CDS sequence)	XM_006243915.3
Accession Version	XM_006243915.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1248bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	C-C chemokine receptor type 4 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005107.4) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006243915.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCCCAGT GTCACAGGAA GTCACCCTTC AAAGCACCTG TGCTGCTTCT AGGATCCTGG 
CATTTCTTCA CAGACTGTCC TCAGGACCAC TTTCAGAAGA GCAAGGCTGC TCCATCCTTT 
TTATTGGCTT CTTCTGCTGC CACCCAGAAC CTGTGGATTC CAGAAATGAA TGCCACAGAT 
GTCACAGACA CCACCCAGGA TGAAGCCGCG TACAATAGTT ACTACTTCGA CGAGAGCTTG 
CCAAAGCCTT GCACCAAGGA AGGCATCAAG GCATTCGGCG AGGTCTTCCT GCCTCCTCTC 
TACTCCTTGG TCTTTCTGTT GGGTCTGTTT GGGAATTCTG TTGTGGTTCT GGTGCTGTTC 
AAGTACAAGA GGCTCAAGTC CATGACTGAC GTGTACCTGC TGAACCTAGC CATCTCGGAT 
TTACTGTTTG TGCTGTCTCT CCCGTTCTGG GGCTACTATG CTGCTGACCA GTGGGTTTTT 
GGTCTAGGTC TGTGTAAGAT TATCTCATGG ATGTACCTGG TGGGCTTCTA CAGCGGGATC 
TTCTTCATCA TGCTCATGAG TATAGACAGA TACCTGGCCA TCGTGCACGC AGTGTTTTCC 
TTGAGAGCGA GGACTCTGAC CTATGGGGTC ATCACCAGCC TCATCACGTG GTCTGTGGCT 
GTGTTTGCCT CCCTACCAGG CCTCTTGTTC AGCACCTGCG ACACAGAGAA CAACCACACA 
TACTGCAAAA CCCAGTACTC GGTCAACTCG ACCACGTGGA AAGTCCTCAG CTCCCTGGAG 
ATCAATGTCT TGGGGCTGGT CATCCCCCTG GGGATCATGT TGTTCTGCTA TTCCATGATC 
ATCAGGACCC TGAGACACTG CAAGAATGAG AAGAAGAACA GAGCAGTTCG GATGATCTTC 
GCCGTGGTGG TCCTCTTCCT CGGCTTCTGG ACGCCGTACA ACGTGGTGCT TTTCCTGGAG 
ACCTTGGTGG AGCTCGAAGT CCTTCAGGAC TGCACCTTGG AGAGGTACCT AGACTATGCC 
ATCCAGGCCA CAGAAACCCT GGCCTTCATT CACTGCTGCC TTAACCCTGT CATTTACTTC 
TTCCTTGGGG AGAAATTCCG CAAGTACATC GCCCAACTCT TCAGAACGTG CCGGGGTCCT 
CTTGTGCTCT GCCAACACTG TGACTTCCTT CAGATCTCCT CGGCCGACAC TTCCAGCTCC 
TCTTACACTC AGTCCACTGT GGATCATGAC TTCCGTGACG CTTTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006243977.1
CDS	23..1270
Translation	MSQCHRKSPFKAPVLLLGSWHFFTDCPQDHFQKSKAAPSFLLASSAATQNLWIPEMNATDVTDTTQDEAAYNSYYFDESLPKPCTKEGIKAFGEVFLPPLYSLVFLLGLFGNSVVVLVLFKYKRLKSMTDVYLLNLAISDLLFVLSLPFWGYYAADQWVFGLGLCKIISWMYLVGFYSGIFFIMLMSIDRYLAIVHAVFSLRARTLTYGVITSLITWSVAVFASLPGLLFSTCDTENNHTYCKTQYSVNSTTWKVLSSLEINVLGLVIPLGIMLFCYSMIIRTLRHCKNEKKNRAVRMIFAVVVLFLGFWTPYNVVLFLETLVELEVLQDCTLERYLDYAIQATETLAFIHCCLNPVIYFFLGEKFRKYIAQLFRTCRGPLVLCQHCDFLQISSADTSSSSYTQSTVDHDFRDAL

Target ORF information:

RefSeq Version	XM_006243915.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus C-C motif chemokine receptor 4 (Ccr4), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006243915.3

ORF Insert Sequence:

ATGTCCCAGT GTCACAGGAA GTCACCCTTC AAAGCACCTG TGCTGCTTCT AGGATCCTGG 
CATTTCTTCA CAGACTGTCC TCAGGACCAC TTTCAGAAGA GCAAGGCTGC TCCATCCTTT 
TTATTGGCTT CTTCTGCTGC CACCCAGAAC CTGTGGATTC CAGAAATGAA TGCCACAGAT 
GTCACAGACA CCACCCAGGA TGAAGCCGCG TACAATAGTT ACTACTTCGA CGAGAGCTTG 
CCAAAGCCTT GCACCAAGGA AGGCATCAAG GCATTCGGCG AGGTCTTCCT GCCTCCTCTC 
TACTCCTTGG TCTTTCTGTT GGGTCTGTTT GGGAATTCTG TTGTGGTTCT GGTGCTGTTC 
AAGTACAAGA GGCTCAAGTC CATGACTGAC GTGTACCTGC TGAACCTAGC CATCTCGGAT 
TTACTGTTTG TGCTGTCTCT CCCGTTCTGG GGCTACTATG CTGCTGACCA GTGGGTTTTT 
GGTCTAGGTC TGTGTAAGAT TATCTCATGG ATGTACCTGG TGGGCTTCTA CAGCGGGATC 
TTCTTCATCA TGCTCATGAG TATAGACAGA TACCTGGCCA TCGTGCACGC AGTGTTTTCC 
TTGAGAGCGA GGACTCTGAC CTATGGGGTC ATCACCAGCC TCATCACGTG GTCTGTGGCT 
GTGTTTGCCT CCCTACCAGG CCTCTTGTTC AGCACCTGCG ACACAGAGAA CAACCACACA 
TACTGCAAAA CCCAGTACTC GGTCAACTCG ACCACGTGGA AAGTCCTCAG CTCCCTGGAG 
ATCAATGTCT TGGGGCTGGT CATCCCCCTG GGGATCATGT TGTTCTGCTA TTCCATGATC 
ATCAGGACCC TGAGACACTG CAAGAATGAG AAGAAGAACA GAGCAGTTCG GATGATCTTC 
GCCGTGGTGG TCCTCTTCCT CGGCTTCTGG ACGCCGTACA ACGTGGTGCT TTTCCTGGAG 
ACCTTGGTGG AGCTCGAAGT CCTTCAGGAC TGCACCTTGG AGAGGTACCT AGACTATGCC 
ATCCAGGCCA CAGAAACCCT GGCCTTCATT CACTGCTGCC TTAACCCTGT CATTTACTTC 
TTCCTTGGGG AGAAATTCCG CAAGTACATC GCCCAACTCT TCAGAACGTG CCGGGGTCCT 
CTTGTGCTCT GCCAACACTG TGACTTCCTT CAGATCTCCT CGGCCGACAC TTCCAGCTCC 
TCTTACACTC AGTCCACTGT GGATCATGAC TTCCGTGACG CTTTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Synthesis of some CC chemokines and their receptors in the synovium in rheumatoid arthritis.
Bulletin of experimental biology and medicine158(2)192-6(2014 Dec)
Zhebrun DA,Totolyan AA,Maslyanskii AL,Titov AG,Patrukhin AP,Kostareva AA,Gol'tseva IS

Differential requirement for CCR4 in the maintenance but not establishment of the invariant V?5(+) dendritic epidermal T-cell pool.
PloS one8(9)e74019(2013)
Nakamura K,White AJ,Parnell SM,Lane PJ,Jenkinson EJ,Jenkinson WE,Anderson G

Differing requirements for CCR4, E-selectin, and ?4?1 for the migration of memory CD4 and activated T cells to dermal inflammation.
Journal of immunology (Baltimore, Md. : 1950)189(1)337-46(2012 Jul)
Gehad A,Al-Banna NA,Vaci M,Issekutz AC,Mohan K,Latta M,Issekutz TB

Expression of MDC/CCL22 and its receptor CCR4 in rheumatoid arthritis, psoriatic arthritis and osteoarthritis.
Cytokine49(1)24-9(2010 Jan)
Flytlie HA,Hvid M,Lindgreen E,Kofod-Olsen E,Petersen EL,J?rgensen A,Deleuran M,Vestergaard C,Deleuran B

Th1- and Th2-related chemokine and chemokine receptor expression on the ocular surface in endotoxin-induced uveitis.
Molecular vision142428-34(2008)
Trinh L,Brignole-Baudouin F,Pauly A,Liang H,Houssier M,Baudouin C

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Ccr4 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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