Tcf3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Tcf3
Entrez Gene ID	171046
Full Name	transcription factor 3
Synonyms	Pan2,Tcfe2a
General protein information	Preferred Names transcription factor 3 Names transcription factor E2-alpha TCF-3 immunoglobulin enhancer-binding factor E12/E47 pancreas specific transcription factor 1c transcription factor E2a transcription factor E2a-like transcription regulator Pan
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 7 Map Location: 7q11
Summary	transcriptional regulator; binds enhancer motifs of pancreatic exocrine genes [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001035237.1	NP_001030314.1	transcription factor E2-alpha isoform b
NM_133524.2	NP_598208.2	transcription factor E2-alpha isoform a

Pathways from BioSystems

Homologies

Homo sapiens (human)	TCF3	NP_001129611.1
Pan troglodytes (chimpanzee)	TCF3	XP_003954574.1
Xenopus tropicalis (tropical clawed frog)	tcf3	NP_001093743.1
Bos taurus (cattle)	TCF3	NP_001179627.1
Gallus gallus (chicken)	TCF3	NP_989817.2
Canis lupus familiaris (dog)	TCF3	XP_542197.3
Rattus norvegicus (Norway rat)	Tcf3	NP_598208.2
Mus musculus (house mouse)	Tcf3	NP_001157619.1
Danio rerio (zebrafish)	tcf3b	NP_001166154.1

Gene Ontology
Bibliography

Related articles in PubMed

TCF7 is suppressed by the androgen receptor via microRNA-1-mediated downregulation and is involved in the development of resistance to androgen deprivation in prostate cancer.
Siu MK, Chen WY, Tsai HY, Chen HY, Yin JJ, Chen CL, Tsai YC, Liu YN
Prostate cancer and prostatic diseases20(2)172-178(2017 Jun)

Loss of ATF3 promotes hormone-induced prostate carcinogenesis and the emergence of CK5(+)CK8(+) epithelial cells.
Wang Z, Kim J, Teng Y, Ding HF, Zhang J, Hai T, Cowell JK, Yan C
Oncogene35(27)3555-64(2016 Jul)

Edelfosine Promotes Apoptosis in Androgen-Deprived Prostate Tumors by Increasing ATF3 and Inhibiting Androgen Receptor Activity.
Udayakumar TS, Stoyanova R, Shareef MM, Mu Z, Philip S, Burnstein KL, Pollack A
Molecular cancer therapeutics15(6)1353-63(2016 06)

PAK5-mediated E47 phosphorylation promotes epithelial-mesenchymal transition and metastasis of colon cancer.
Zhu G, Li X, Guo B, Ke Q, Dong M, Li F
Oncogene35(15)1943-54(2016 Apr)

Hypomethylation-associated up-regulation of TCF3 expression and recurrence in stage II and III colorectal cancer.
Li C, Cai S, Wang X, Jiang Z
PloS one9(11)e112005(2014)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Tcf3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Tcf3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa09174	NM_001035237.1 Latest version!	Rattus norvegicus transcription factor 3 (Tcf3), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$307.30 $439.00
ORa00821	NM_133524.2 Latest version!	Rattus norvegicus transcription factor 3 (Tcf3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Tcf3 ( NM_001035237.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001030314.1 Rattus norvegicus transcription factor 3 (Tcf3), transcript variant 2, mRNA.

Price & Availability↑

CloneID	ORa09174
Clone ID Related Accession (Same CDS sequence)	NM_001035237.1
Accession Version	NM_001035237.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1941bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-22
Organism	Rattus norvegicus(Norway rat)
Product	transcription factor E2-alpha isoform b
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from X54549.1, BC078750.1 and BQ192196.1. On Jun 25, 2006 this sequence version replaced XM_001076440.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC078750.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGATGAACC AGTCTCAGAG AATGGCACCT GTTGGCTCGG ACAAAGAACT GAGTGACCTC 
CTGGACTTCA GTATGATGTT CCCGCTACCT GTGGCCAATG GCAAGGGCCG GCCCGCCTCC 
CTAGCTGGAA CCCAGTTCGC AGGCTCAGGA CTGGAGGACC GACCCAGCTC AGGGTCCTGG 
GGCAACAGTG AACAGAACAG TTCTTCCTTT GACCCTAGCC GGGCATACAG CGAAGGTGCC 
CACTTCAGTG ACTCCCACAG CAGCCTGCCG CCTTCCACGT TCCTAGGAGC TGGGCTTGGA 
GGCAAGGGCA GTGAACGGAA TGCCTATGCC ACCTTCGGGA GAGACACCAG TGTTGGCACC 
CTGAGTCAGG CTGGCTTCCT ACCAGGTGAG CTGGGCCTCA GCAGTCCCGG GCCACTGTCC 
CCATCAGGCG TCAAGAGCAG CTCCCAGTAT TACACCTCAT TCCCCAGCAA CCCTCGGCGG 
AGAGCTGCAG ATGGTGGCCT GGATACTCAG CCCAAGAAGG TCCGGAAGGT TCCGCCTGGT 
CTTCCTTCCT CGGTATATCC ATCCAGCTCA GGTGATAACT ACAGCAGGGA CGCCACAGCC 
TACCCCTCCG CCAAGACCCC CAGCAGCGCT TACCCCTCCC CCTTCTACGT GGCAGACGGC 
AGCCTGCACC CCTCAGCGGA GCTCTGGAGT CCCCCTGGCC AGGTGGGCTT TGGGCCCATG 
CTAGGTGATG GCTCGGCCCC CCTGCCGCTT GCACCGGGCA GCAGTTCCGT GAGCAGTGGT 
GCCTTTGGGG GCCTCCAGCA GCAGGATCGC ATGGGCTACC AGCTGCATGG GTCTGAGGTC 
AATGGCACGC TCCCAGCTGT ATCCAGCTTC TCAGCTGCCC CTGGCACTTA CAGTGGGACT 
TCTGGCCACA CGCCACCCGT GAGCGGGGCC GACAGCCTCT TAGGCACCCG AGGGACTACA 
GCCAGCAGCT CAGGGGATGC CCTTGGGAAG GCACTGGCCT CCATCTACTC CCCGGATCAC 
TCCAGCAATA ATTTCTCGCC CAGCCCCTCA ACGCCTGTGG GTTCACCCCA GGGCCTGCCA 
GGGACATCAC AGTGGCCCCG GGCAGGAGCG CCCAGTGCCT TATCCCCCAA CTACGATGCA 
GGTCTCCATG GCCTGAGTAA AATGGAAGAT CGCTTGGACG AGGCCATCCA CGTCCTCCGC 
AGTCACGCTG TCGGCACTGC AAGCGAGCTC CATGGACTGC TGCCTGGCCA CAGCACGTTG 
ACCACAAGCT TTGCGGGCCC CATGTCACTG GGCGGGCGGC ATGCAGGCCT GGTCAGCGGA 
AGCCACCCTG AGGATGGCCT CACAAGTGGT GCCAGTCTTT TGCATAACCA TGCCAGCCTT 
CCCAGCCAGC CCAGCTCCCT CCCTGACCTC TCACAGAGGC CACCCGACTC CTTTAGTGGA 
CTCGGGAGGG CAGGCGTGAC TGCAGGCGCC AGTGAGATCA AGCGGGAGGA GAAAGAGGAC 
GAGGAGGTCA CATCAGTGGC AGACGCTGAG GAAGACAAGA AGGACCTGAA GGTCCCACGC 
ACACGTACCA GCAGTACAGA TGAGGTGCTG TCCCTGGAGG AGAAGGACCT GAGGGACCGG 
GAGAGGCGCA TGGCCAATAA CGCTCGGGAG CGGGTGCGCG TGCGGGACAT TAACGAGGCC 
TTCCGGGAGC TGGGCCGCAT GTGCCAGCTG CACCTCAAGT CGGATAAGGC GCAGACCAAG 
CTGCTGATCC TGCAGCAGGC GGTGCAGGTT ATCCTGGGCC TGGAGCAGCA GGTGCGAGAA 
CGCAACCTGA ACCCCAAAGC AGCCTGCTTG AAGCGGCGGG AGGAGGAGAA GGTATCTGGC 
GTGGTCGGGG ATCCGCAGCT GGCGCTGTCA GCCGCCCACC CGGGCCTGGG TGAGGCCCAC 
AATCCAGCTG GGCACCTGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001030314.1
CDS	74..2014
Translation	MMNQSQRMAPVGSDKELSDLLDFSMMFPLPVANGKGRPASLAGTQFAGSGLEDRPSSGSWGNSEQNSSSFDPSRAYSEGAHFSDSHSSLPPSTFLGAGLGGKGSERNAYATFGRDTSVGTLSQAGFLPGELGLSSPGPLSPSGVKSSSQYYTSFPSNPRRRAADGGLDTQPKKVRKVPPGLPSSVYPSSSGDNYSRDATAYPSAKTPSSAYPSPFYVADGSLHPSAELWSPPGQVGFGPMLGDGSAPLPLAPGSSSVSSGAFGGLQQQDRMGYQLHGSEVNGTLPAVSSFSAAPGTYSGTSGHTPPVSGADSLLGTRGTTASSSGDALGKALASIYSPDHSSNNFSPSPSTPVGSPQGLPGTSQWPRAGAPSALSPNYDAGLHGLSKMEDRLDEAIHVLRSHAVGTASELHGLLPGHSTLTTSFAGPMSLGGRHAGLVSGSHPEDGLTSGASLLHNHASLPSQPSSLPDLSQRPPDSFSGLGRAGVTAGASEIKREEKEDEEVTSVADAEEDKKDLKVPRTRTSSTDEVLSLEEKDLRDRERRMANNARERVRVRDINEAFRELGRMCQLHLKSDKAQTKLLILQQAVQVILGLEQQVRERNLNPKAACLKRREEEKVSGVVGDPQLALSAAHPGLGEAHNPAGHL

Target ORF information:

RefSeq Version	NM_001035237.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus transcription factor 3 (Tcf3), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001035237.1

ORF Insert Sequence:

ATGATGAACC AGTCTCAGAG AATGGCACCT GTTGGCTCGG ACAAAGAACT GAGTGACCTC 
CTGGACTTCA GTATGATGTT CCCGCTACCT GTGGCCAATG GCAAGGGCCG GCCCGCCTCC 
CTAGCTGGAA CCCAGTTCGC AGGCTCAGGA CTGGAGGACC GACCCAGCTC AGGGTCCTGG 
GGCAACAGTG AACAGAACAG TTCTTCCTTT GACCCTAGCC GGGCATACAG CGAAGGTGCC 
CACTTCAGTG ACTCCCACAG CAGCCTGCCG CCTTCCACGT TCCTAGGAGC TGGGCTTGGA 
GGCAAGGGCA GTGAACGGAA TGCCTATGCC ACCTTCGGGA GAGACACCAG TGTTGGCACC 
CTGAGTCAGG CTGGCTTCCT ACCAGGTGAG CTGGGCCTCA GCAGTCCCGG GCCACTGTCC 
CCATCAGGCG TCAAGAGCAG CTCCCAGTAT TACACCTCAT TCCCCAGCAA CCCTCGGCGG 
AGAGCTGCAG ATGGTGGCCT GGATACTCAG CCCAAGAAGG TCCGGAAGGT TCCGCCTGGT 
CTTCCTTCCT CGGTATATCC ATCCAGCTCA GGTGATAACT ACAGCAGGGA CGCCACAGCC 
TACCCCTCCG CCAAGACCCC CAGCAGCGCT TACCCCTCCC CCTTCTACGT GGCAGACGGC 
AGCCTGCACC CCTCAGCGGA GCTCTGGAGT CCCCCTGGCC AGGTGGGCTT TGGGCCCATG 
CTAGGTGATG GCTCGGCCCC CCTGCCGCTT GCACCGGGCA GCAGTTCCGT GAGCAGTGGT 
GCCTTTGGGG GCCTCCAGCA GCAGGATCGC ATGGGCTACC AGCTGCATGG GTCTGAGGTC 
AATGGCACGC TCCCAGCTGT ATCCAGCTTC TCAGCTGCCC CTGGCACTTA CAGTGGGACT 
TCTGGCCACA CGCCACCCGT GAGCGGGGCC GACAGCCTCT TAGGCACCCG AGGGACTACA 
GCCAGCAGCT CAGGGGATGC CCTTGGGAAG GCACTGGCCT CCATCTACTC CCCGGATCAC 
TCCAGCAATA ATTTCTCGCC CAGCCCCTCA ACGCCTGTGG GTTCACCCCA GGGCCTGCCA 
GGGACATCAC AGTGGCCCCG GGCAGGAGCG CCCAGTGCCT TATCCCCCAA CTACGATGCA 
GGTCTCCATG GCCTGAGTAA AATGGAAGAT CGCTTGGACG AGGCCATCCA CGTCCTCCGC 
AGTCACGCTG TCGGCACTGC AAGCGAGCTC CATGGACTGC TGCCTGGCCA CAGCACGTTG 
ACCACAAGCT TTGCGGGCCC CATGTCACTG GGCGGGCGGC ATGCAGGCCT GGTCAGCGGA 
AGCCACCCTG AGGATGGCCT CACAAGTGGT GCCAGTCTTT TGCATAACCA TGCCAGCCTT 
CCCAGCCAGC CCAGCTCCCT CCCTGACCTC TCACAGAGGC CACCCGACTC CTTTAGTGGA 
CTCGGGAGGG CAGGCGTGAC TGCAGGCGCC AGTGAGATCA AGCGGGAGGA GAAAGAGGAC 
GAGGAGGTCA CATCAGTGGC AGACGCTGAG GAAGACAAGA AGGACCTGAA GGTCCCACGC 
ACACGTACCA GCAGTACAGA TGAGGTGCTG TCCCTGGAGG AGAAGGACCT GAGGGACCGG 
GAGAGGCGCA TGGCCAATAA CGCTCGGGAG CGGGTGCGCG TGCGGGACAT TAACGAGGCC 
TTCCGGGAGC TGGGCCGCAT GTGCCAGCTG CACCTCAAGT CGGATAAGGC GCAGACCAAG 
CTGCTGATCC TGCAGCAGGC GGTGCAGGTT ATCCTGGGCC TGGAGCAGCA GGTGCGAGAA 
CGCAACCTGA ACCCCAAAGC AGCCTGCTTG AAGCGGCGGG AGGAGGAGAA GGTATCTGGC 
GTGGTCGGGG ATCCGCAGCT GGCGCTGTCA GCCGCCCACC CGGGCCTGGG TGAGGCCCAC 
AATCCAGCTG GGCACCTGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Tcf3 ( NM_133524.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_598208.2 Rattus norvegicus transcription factor 3 (Tcf3), transcript variant 1, mRNA.

Price & Availability↑

CloneID	ORa00821
Clone ID Related Accession (Same CDS sequence)	NM_133524.2
Accession Version	NM_133524.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1950bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-16
Organism	Rattus norvegicus(Norway rat)
Product	transcription factor E2-alpha isoform a
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from X54549.1, BC078750.1 and BQ192196.1. On Oct 28, 2005 this sequence version replaced NM_133524.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ973227.1, X54549.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGATGAACC AGTCTCAGAG AATGGCACCT GTTGGCTCGG ACAAAGAACT GAGTGACCTC 
CTGGACTTCA GTATGATGTT CCCGCTACCT GTGGCCAATG GCAAGGGCCG GCCCGCCTCC 
CTAGCTGGAA CCCAGTTCGC AGGCTCAGGA CTGGAGGACC GACCCAGCTC AGGGTCCTGG 
GGCAACAGTG AACAGAACAG TTCTTCCTTT GACCCTAGCC GGGCATACAG CGAAGGTGCC 
CACTTCAGTG ACTCCCACAG CAGCCTGCCG CCTTCCACGT TCCTAGGAGC TGGGCTTGGA 
GGCAAGGGCA GTGAACGGAA TGCCTATGCC ACCTTCGGGA GAGACACCAG TGTTGGCACC 
CTGAGTCAGG CTGGCTTCCT ACCAGGTGAG CTGGGCCTCA GCAGTCCCGG GCCACTGTCC 
CCATCAGGCG TCAAGAGCAG CTCCCAGTAT TACACCTCAT TCCCCAGCAA CCCTCGGCGG 
AGAGCTGCAG ATGGTGGCCT GGATACTCAG CCCAAGAAGG TCCGGAAGGT TCCGCCTGGT 
CTTCCTTCCT CGGTATATCC ATCCAGCTCA GGTGATAACT ACAGCAGGGA CGCCACAGCC 
TACCCCTCCG CCAAGACCCC CAGCAGCGCT TACCCCTCCC CCTTCTACGT GGCAGACGGC 
AGCCTGCACC CCTCAGCGGA GCTCTGGAGT CCCCCTGGCC AGGTGGGCTT TGGGCCCATG 
CTAGGTGATG GCTCGGCCCC CCTGCCGCTT GCACCGGGCA GCAGTTCCGT GAGCAGTGGT 
GCCTTTGGGG GCCTCCAGCA GCAGGATCGC ATGGGCTACC AGCTGCATGG GTCTGAGGTC 
AATGGCACGC TCCCAGCTGT ATCCAGCTTC TCAGCTGCCC CTGGCACTTA CAGTGGGACT 
TCTGGCCACA CGCCACCCGT GAGCGGGGCC GACAGCCTCT TAGGCACCCG AGGGACTACA 
GCCAGCAGCT CAGGGGATGC CCTTGGGAAG GCACTGGCCT CCATCTACTC CCCGGATCAC 
TCCAGCAATA ATTTCTCGCC CAGCCCCTCA ACGCCTGTGG GTTCACCCCA GGGCCTGCCA 
GGGACATCAC AGTGGCCCCG GGCAGGAGCG CCCAGTGCCT TATCCCCCAA CTACGATGCA 
GGTCTCCATG GCCTGAGTAA AATGGAAGAT CGCTTGGACG AGGCCATCCA CGTCCTCCGC 
AGTCACGCTG TCGGCACTGC AAGCGAGCTC CATGGACTGC TGCCTGGCCA CAGCACGTTG 
ACCACAAGCT TTGCGGGCCC CATGTCACTG GGCGGGCGGC ATGCAGGCCT GGTCAGCGGA 
AGCCACCCTG AGGATGGCCT CACAAGTGGT GCCAGTCTTT TGCATAACCA TGCCAGCCTT 
CCCAGCCAGC CCAGCTCCCT CCCTGACCTC TCACAGAGGC CACCCGACTC CTTTAGTGGA 
CTCGGGAGGG CAGGCGTGAC TGCAGGCGCC AGTGAGATCA AGCGGGAGGA GAAAGAGGAC 
GAGGAGGTCA CATCAGTGGC AGACGCTGAG GAAGACAAGA AGGACCTGAA GGTCCCACGC 
ACACGTACCA GCCCAGACGA GGACGAGGAC GACCTTCTCC CCCCAGAGCA GAAGGCCGAG 
CGGGAGAAGG AGCGCCGGGT GGCCAATAAC GCCCGAGAGC GCCTGCGTGT CCGCGACATC 
AATGAGGCCT TTAAGGAGCT CGGCCGCATG TGCCAGCTGC ACCTCAGCAC TGAGAAGCCG 
CAGACCAAAC TGCTCATCCT GCACCAGGCC GTGGCCGTCA TCCTCAGCCT GGAGCAGCAG 
GTGCGAGAAC GCAACCTGAA CCCCAAAGCA GCCTGCTTGA AGCGGCGGGA GGAGGAGAAG 
GTATCTGGCG TGGTCGGGGA TCCGCAGCTG GCGCTGTCAG CCGCCCACCC GGGCCTGGGT 
GAGGCCCACA ATCCAGCTGG GCACCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_598208.2
CDS	74..2023
Translation	MMNQSQRMAPVGSDKELSDLLDFSMMFPLPVANGKGRPASLAGTQFAGSGLEDRPSSGSWGNSEQNSSSFDPSRAYSEGAHFSDSHSSLPPSTFLGAGLGGKGSERNAYATFGRDTSVGTLSQAGFLPGELGLSSPGPLSPSGVKSSSQYYTSFPSNPRRRAADGGLDTQPKKVRKVPPGLPSSVYPSSSGDNYSRDATAYPSAKTPSSAYPSPFYVADGSLHPSAELWSPPGQVGFGPMLGDGSAPLPLAPGSSSVSSGAFGGLQQQDRMGYQLHGSEVNGTLPAVSSFSAAPGTYSGTSGHTPPVSGADSLLGTRGTTASSSGDALGKALASIYSPDHSSNNFSPSPSTPVGSPQGLPGTSQWPRAGAPSALSPNYDAGLHGLSKMEDRLDEAIHVLRSHAVGTASELHGLLPGHSTLTTSFAGPMSLGGRHAGLVSGSHPEDGLTSGASLLHNHASLPSQPSSLPDLSQRPPDSFSGLGRAGVTAGASEIKREEKEDEEVTSVADAEEDKKDLKVPRTRTSPDEDEDDLLPPEQKAEREKERRVANNARERLRVRDINEAFKELGRMCQLHLSTEKPQTKLLILHQAVAVILSLEQQVRERNLNPKAACLKRREEEKVSGVVGDPQLALSAAHPGLGEAHNPAGHL

Target ORF information:

RefSeq Version	NM_133524.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus transcription factor 3 (Tcf3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_133524.2

ORF Insert Sequence:

ATGATGAACC AGTCTCAGAG AATGGCACCT GTTGGCTCGG ACAAAGAACT GAGTGACCTC 
CTGGACTTCA GTATGATGTT CCCGCTACCT GTGGCCAATG GCAAGGGCCG GCCCGCCTCC 
CTAGCTGGAA CCCAGTTCGC AGGCTCAGGA CTGGAGGACC GACCCAGCTC AGGGTCCTGG 
GGCAACAGTG AACAGAACAG TTCTTCCTTT GACCCTAGCC GGGCATACAG CGAAGGTGCC 
CACTTCAGTG ACTCCCACAG CAGCCTGCCG CCTTCCACGT TCCTAGGAGC TGGGCTTGGA 
GGCAAGGGCA GTGAACGGAA TGCCTATGCC ACCTTCGGGA GAGACACCAG TGTTGGCACC 
CTGAGTCAGG CTGGCTTCCT ACCAGGTGAG CTGGGCCTCA GCAGTCCCGG GCCACTGTCC 
CCATCAGGCG TCAAGAGCAG CTCCCAGTAT TACACCTCAT TCCCCAGCAA CCCTCGGCGG 
AGAGCTGCAG ATGGTGGCCT GGATACTCAG CCCAAGAAGG TCCGGAAGGT TCCGCCTGGT 
CTTCCTTCCT CGGTATATCC ATCCAGCTCA GGTGATAACT ACAGCAGGGA CGCCACAGCC 
TACCCCTCCG CCAAGACCCC CAGCAGCGCT TACCCCTCCC CCTTCTACGT GGCAGACGGC 
AGCCTGCACC CCTCAGCGGA GCTCTGGAGT CCCCCTGGCC AGGTGGGCTT TGGGCCCATG 
CTAGGTGATG GCTCGGCCCC CCTGCCGCTT GCACCGGGCA GCAGTTCCGT GAGCAGTGGT 
GCCTTTGGGG GCCTCCAGCA GCAGGATCGC ATGGGCTACC AGCTGCATGG GTCTGAGGTC 
AATGGCACGC TCCCAGCTGT ATCCAGCTTC TCAGCTGCCC CTGGCACTTA CAGTGGGACT 
TCTGGCCACA CGCCACCCGT GAGCGGGGCC GACAGCCTCT TAGGCACCCG AGGGACTACA 
GCCAGCAGCT CAGGGGATGC CCTTGGGAAG GCACTGGCCT CCATCTACTC CCCGGATCAC 
TCCAGCAATA ATTTCTCGCC CAGCCCCTCA ACGCCTGTGG GTTCACCCCA GGGCCTGCCA 
GGGACATCAC AGTGGCCCCG GGCAGGAGCG CCCAGTGCCT TATCCCCCAA CTACGATGCA 
GGTCTCCATG GCCTGAGTAA AATGGAAGAT CGCTTGGACG AGGCCATCCA CGTCCTCCGC 
AGTCACGCTG TCGGCACTGC AAGCGAGCTC CATGGACTGC TGCCTGGCCA CAGCACGTTG 
ACCACAAGCT TTGCGGGCCC CATGTCACTG GGCGGGCGGC ATGCAGGCCT GGTCAGCGGA 
AGCCACCCTG AGGATGGCCT CACAAGTGGT GCCAGTCTTT TGCATAACCA TGCCAGCCTT 
CCCAGCCAGC CCAGCTCCCT CCCTGACCTC TCACAGAGGC CACCCGACTC CTTTAGTGGA 
CTCGGGAGGG CAGGCGTGAC TGCAGGCGCC AGTGAGATCA AGCGGGAGGA GAAAGAGGAC 
GAGGAGGTCA CATCAGTGGC AGACGCTGAG GAAGACAAGA AGGACCTGAA GGTCCCACGC 
ACACGTACCA GCCCAGACGA GGACGAGGAC GACCTTCTCC CCCCAGAGCA GAAGGCCGAG 
CGGGAGAAGG AGCGCCGGGT GGCCAATAAC GCCCGAGAGC GCCTGCGTGT CCGCGACATC 
AATGAGGCCT TTAAGGAGCT CGGCCGCATG TGCCAGCTGC ACCTCAGCAC TGAGAAGCCG 
CAGACCAAAC TGCTCATCCT GCACCAGGCC GTGGCCGTCA TCCTCAGCCT GGAGCAGCAG 
GTGCGAGAAC GCAACCTGAA CCCCAAAGCA GCCTGCTTGA AGCGGCGGGA GGAGGAGAAG 
GTATCTGGCG TGGTCGGGGA TCCGCAGCTG GCGCTGTCAG CCGCCCACCC GGGCCTGGGT 
GAGGCCCACA ATCCAGCTGG GCACCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

TCF7 is suppressed by the androgen receptor via microRNA-1-mediated downregulation and is involved in the development of resistance to androgen deprivation in prostate cancer.
Prostate cancer and prostatic diseases20(2)172-178(2017 Jun)
Siu MK,Chen WY,Tsai HY,Chen HY,Yin JJ,Chen CL,Tsai YC,Liu YN

Loss of ATF3 promotes hormone-induced prostate carcinogenesis and the emergence of CK5(+)CK8(+) epithelial cells.
Oncogene35(27)3555-64(2016 Jul)
Wang Z,Kim J,Teng Y,Ding HF,Zhang J,Hai T,Cowell JK,Yan C

Edelfosine Promotes Apoptosis in Androgen-Deprived Prostate Tumors by Increasing ATF3 and Inhibiting Androgen Receptor Activity.
Molecular cancer therapeutics15(6)1353-63(2016 06)
Udayakumar TS,Stoyanova R,Shareef MM,Mu Z,Philip S,Burnstein KL,Pollack A

PAK5-mediated E47 phosphorylation promotes epithelial-mesenchymal transition and metastasis of colon cancer.
Oncogene35(15)1943-54(2016 Apr)
Zhu G,Li X,Guo B,Ke Q,Dong M,Li F

Hypomethylation-associated up-regulation of TCF3 expression and recurrence in stage II and III colorectal cancer.
PloS one9(11)e112005(2014)
Li C,Cai S,Wang X,Jiang Z

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Tcf3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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