Pik3ca cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Pik3ca
Entrez Gene ID	170911
Full Name	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
General protein information	Preferred Names phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha Names phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform PI3-kinase subunit alpha PI3K-alpha PI3Kalpha p110alpha phosphatidylinositol 3-kinase, catalytic, alpha polypeptide phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha phosphoinositide-3-kinase catalytic alpha polypeptide ptdIns-3-kinase subunit alpha ptdIns-3-kinase subunit p110-alpha serine/threonine protein kinase PIK3CA
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 2 Map Location: 2q24
Summary	expression of the human homolog is associated with increased cell proliferation and decreased apoptosis and may play a role in ovarian cancer progression [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_133399.2	NP_596890.2	phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	LOC561737	XP_690235.2
Xenopus tropicalis (tropical clawed frog)	pik3ca	NP_001119972.1
Canis lupus familiaris (dog)	PIK3CA	XP_545208.2
	PIK3CA	XP_001109162.1
Bos taurus (cattle)	PIK3CA	NP_776999.1
Mus musculus (house mouse)	Pik3ca	NP_032865.2
Rattus norvegicus (Norway rat)	Pik3ca	NP_596890.2
Pan troglodytes (chimpanzee)	PIK3CA	XP_001167506.1
Danio rerio (zebrafish)	LOC100334726	XP_005174483.1
Homo sapiens (human)	PIK3CA	NP_006209.2
Gallus gallus (chicken)	PIK3CA	NP_001004410.1
Caenorhabditis elegans (roundworm)	age-1	NP_496462.2

Gene Ontology
Bibliography

Related articles in PubMed

MiR-339 inhibits proliferation of pulmonary artery smooth muscle cell by targeting FGF signaling.
Chen J, Cui X, Li L, Qu J, Raj JU, Gou D
Physiological reports5(18)(2017 Sep)

Analysis of
Takeshita T, Yamamoto Y, Yamamoto-Ibusuki M, Tomiguchi M, Sueta A, Murakami K, Omoto Y, Iwase H
Oncotarget8(32)52142-52155(2017 Aug)

Inhibition of infarction-induced sympathetic innervation with endothelin receptor antagonism via a PI3K/GSK-3?-dependent pathway.
Lee TM, Chang NC, Lin SZ
Laboratory investigation; a journal of technical methods and pathology97(3)243-255(2017 Mar)

Gypenoside Protects against Myocardial Ischemia-Reperfusion Injury by Inhibiting Cardiomyocytes Apoptosis via Inhibition of CHOP Pathway and Activation of PI3K/Akt Pathway In Vivo and In Vitro.
Yu H, Zhang H, Zhao W, Guo L, Li X, Li Y, Zhang X, Sun Y
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology39(1)123-36(2016)

Geniposide Prevents Hypoxia/Reoxygenation-Induced Apoptosis in H9c2 Cells: Improvement of Mitochondrial Dysfunction and Activation of GLP-1R and the PI3K/AKT Signaling Pathway.
Jiang YQ, Chang GL, Wang Y, Zhang DY, Cao L, Liu J
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology39(1)407-21(2016)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data suggest that ETA receptor antagonism is a mediator to attenuate sympathetic hyperinnervation probably through restoration of PI3K/Akt/GSK-3beta/ROS signaling pathway, a potential pharmacological target for arrhythmias after infarction.
Title: Inhibition of infarction-induced sympathetic innervation with endothelin receptor antagonism via a PI3K/GSK-3?-dependent pathway.

Data show that gypenoside (GP) inhibited ER-stress and apoptosis through the blockade of CHOP protein pathway and activation of PI3K/Akt pathway.
Title: Gypenoside Protects against Myocardial Ischemia-Reperfusion Injury by Inhibiting Cardiomyocytes Apoptosis via Inhibition of CHOP Pathway and Activation of PI3K/Akt Pathway In Vivo and In Vitro.

Results suggest that geniposide pretreatment inhibits hypoxia/reoxygenation (H/R)-induced myocardial apoptosis by reversing mitochondrial dysfunction, an effect in part due to activation of GLP-1R and PI3K/AKT signaling pathway.
Title: Geniposide Prevents Hypoxia/Reoxygenation-Induced Apoptosis in H9c2 Cells: Improvement of Mitochondrial Dysfunction and Activation of GLP-1R and the PI3K/AKT Signaling Pathway.

Data show that up-regulation of cyclin D1 by hepatitis B virus X protein (HBx) in oval Cells ss dependent of the activation of MEK/ERK and PI-3K/Akt signaling pathways.
Title: HBx protein promotes oval cell proliferation by up-regulation of cyclin D1 via activation of the MEK/ERK and PI3K/Akt pathways.

Data indicate that NHE5 depletion reduces cell surface abundance of TrkA and nerve growth factor (NGF)-induced PI3K signaling.
Title: Endosomal acidification by Na+/H+ exchanger NHE5 regulates TrkA cell-surface targeting and NGF-induced PI3K signaling.

The following Pik3ca gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Pik3ca cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa39862	NM_133399.2 Latest version!	Rattus norvegicus phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (Pik3ca), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	20	$559.30 $799.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Pik3ca ( NM_133399.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_596890.2 Rattus norvegicus phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (Pik3ca), mRNA.

Price & Availability↑

CloneID	ORa39862
Clone ID Related Accession (Same CDS sequence)	NM_133399.2
Accession Version	NM_133399.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3207bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Rattus norvegicus(Norway rat)
Product	phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AABR07009968.1, CB793501.1, FM035395.1, CK366305.1, FM096453.1, CK366194.1, CR754046.1, BC099154.1, DV722574.1, DV728106.1, DY314099.1, BP500486.1 and BQ203660.1. On or before May 22, 2010 this sequence version replaced XM_001059350.2, XM_001063573.3, NM_133399.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data from several strains because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCTCCAC GACCATCTTC GGGTGAACTG TGGGGCATCC ACTTGATGCC CCCACGAATC 
CTAGTGGAAT GTTTACTCCC AAATGGAATG ATAGTGACTT TAGAATGCCT CCGTGAGGCC 
ACACTAGTCA CCATCAAGCA TGAACTGTTC AAAGAGGCCA GGAAATACCC TCTCCATCAG 
CTTCTGCAAG ATGAATCATC TTACATTTTC GTAAGTGTTA CCCAAGAAGC AGAAAGGGAA 
GAATTTTTCG ATGAAACAAG ACGGCTTTGT GACCTTCGGC TTTTTCAACC CTTTTTAAAA 
GTAATTGAGC CAGTAGGCAA CCGTGAAGAA AAGATCCTCA ACCGAGAAAT TGGTTTTGTT 
ATTGGCATGC CAGTGTGTGA ATTTGATATG GTTAAAGATC CAGAAGTCCA AGACTTCCGA 
AGGAACATTC TGAATGTTTG CAAAGAAGCC GTGGACCTGC GGGATCTCAA CTCGCCTCAT 
AGCAGAGCAA TGTATGTCTA CCCTCCAAAT GTCGAGTCTT CCCCAGAACT GCCAAAGCAC 
ATCTACAACA AGTTAGATAA AGGACAAATC ATAGTGGTGA TTTGGGTGAT AGTCTCTCCA 
AACAACGACA AGCAGAAGTA CACTCTGAAG ATCAACCATG ACTGCGTGCC AGAGCAAGTC 
ATTGCTGAGG CCATCAGGAA GAAGACCCGG AGCATGTTGC TGTCCTCGGA GCAGCTGAAA 
CTCTGTGTCT TAGAATACCA GGGCAAGTAC ATTCTCAAAG TGTGTGGCTG TGATGAGTAC 
TTCCTAGAGA AGTACCCTCT GAGTCAGTAC AAGTACATAA GAAGCTGTAT AATGCTGGGG 
AGGATGCCCA ACTTGATGCT GATGGCCAAG GAGAGCCTGT ACTCTCAGCT GCCGATCGAT 
AGCTTCACAA TGCCATCCTA CTCCAGGCGC ATTTCCACAG CGACACCCTA TATGAACGGG 
GAGACTGCTA CGAAATCCCT CTGGGTTATA AATAGCGCGC TCAGAATAAA AATTCTGTGT 
GCAACCTATG TAAATGTAAA TATTCGAGAC ATTGATAAGA TCTATGTTCG AACAGGTATC 
TACCATGGAG GAGAACCCTT ATGTGACAAT GTGAATACTC AAAGAGTCCC TTGTTCCAAT 
CCTAGGTGGA ATGAATGGCT GAATTATGAT ATATACATTC CTGATCTTCC TCGTGCTGCC 
CGCCTTTGCC TTTCAATCTG CTCTGTTAAA GGCCGAAAGG GTGCTAAGGA GGAGCACTGT 
CCGTTGGCCT GGGGAAACAT AAACTTGTTT GATTATACAG ACACCCTAGT GTCCGGGAAA 
ATGGCTTTGA ATCTCTGGCC TGTACCACAT GGGTTGGAAG ATCTGCTGAA CCCTATTGGT 
GTTACTGGGT CAAATCCAAA TAAAGAAACT CCATGCTTAG AGTTGGAGTT TGATTGGTTC 
AGCAGTGTGG TGAAGTTTCC AGATATGTCT GTGATCGAAG AGCATGCCAA TTGGTCTGTG 
TCCCGAGAAG CCGGATTCAG TTACTCTCAT ACAGGACTGA GTAACAGACT AGCCAGAGAC 
AATGAGTTAA GAGAAAATGA CAAGGAACAG CTCCGAGCAC TTTGTACCCG GGACCCACTG 
TCTGAAATCA CTGAACAAGA GAAAGACTTC CTATGGAGCC ACAGACACTA CTGTGTAACT 
ATTCCTGAAA TCCTACCCAA ATTGCTTCTG TCTGTCAAGT GGAATTCCAG AGATGAAGTG 
GCCCAGATGT ACTGCTTAGT AAAAGATTGG CCTCCAATCA AACCAGAGCA AGCCATGGAG 
CTCCTGGACT GTAACTACCC AGACCCCATG GTTCGGAGCT TTGCTGTCCG GTGCTTGGAA 
AAATACTTAA CAGATGACAA ACTTTCTCAG TACCTCATCC AGCTTGTACA GGTCTTAAAA 
TATGAACAGT ATTTGGATAA CCTGCTTGTG AGATTTTTAC TCAAGAAAGC ACTGACAAAT 
CAAAGGATTG GCCATTTTTT CTTTTGGCAT TTAAAATCTG AGATGCACAA TAAGACTGTC 
AGTCAGAGGT TCGGCCTGCT GTTGGAGTCC TACTGCCGTG CCTGTGGGAT GTATCTGAAG 
CACCTGAACA GACAGGTAGA GGCCATGGAG AAGCTCATCA ATCTAACTGA CATCCTCAAG 
CAGGAGAAGA AGGATGAGAC ACAGAAGGTA CAGATGAAGT TCTTGGTTGA ACAGATGAGA 
CAGCCAGATT TCATGGATGC TTTGCAGGGT TTTCTGTCCC CTCTAAATCC TGCTCATCAA 
CTAGGAAACC TCAGGCTTGA AGAGTGTCGA ATTATGTCCT CTGCAAAAAG GCCACTGTGG 
TTGAATTGGG AGAACCCAGA CATCATGTCA GAGCTACTGT TTCAGAACAA TGAGATCATC 
TTTAAAAATG GCGATGACTT ACGGCAAGAC ATGTTAACCC TTCAGATCAT CCGAATCATG 
GAGAACATCT GGCAAAACCA AGGCCTTGAC CTTCGCATGC TACCTTATGG CTGTCTATCC 
ATTGGGGACT GTGTGGGTCT CATCGAGGTG GTGAGAAACT CTCACACCAT CATGCAGATT 
CAGTGCAAAG GAGGCCTGAA AGGGGCACTG CAGTTCAACA GCCACACGCT GCATCAGTGG 
CTCAAGGACA AGAACAAGGG CGAGATATAT GACGCAGCCA TTGACCTGTT CACTCGGTCC 
TGCGCTGGGT ACTGCGTGGC AACCTTTATC TTGGGAATTG GAGACCGGCA CAACAGCAAC 
ATCATGGTGA AAGATGACGG ACAGCTGTTT CATATAGATT TTGGGCACTT TTTGGATCAC 
AAGAAGAAAA AATTTGGCTA TAAACGGGAA CGTGTGCCGT TTGTTTTGAC GCAGGATTTC 
TTAATAGTGA TTAGTAAAGG AGCACAAGAG TACACAAAGA CCAGAGAGTT TGAGAGGTTT 
CAGGAGATGT GTTACAAGGC GTACCTAGCA ATTCGGCAGC ATGCCAATCT CTTCATCAAC 
CTTTTCTCCA TGATGCTTGG CTCCGGAATG CCAGAACTGC AGTCTTTCGA TGATATTGCA 
TATATTCGAA AGACTCTAGC CTTAGACAAA ACTGAGCAAG AGGCTCTGGA GTATTTCACA 
AAGCAAATGA ATGACGCACA TCATGGTGGC TGGACAACAA AAATGGACTG GATCTTCCAC 
ACCATCAAGC AGCATGCATT GAACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_596890.2
CDS	1..3207
Translation	MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLVTIKHELFKEARKYPLHQLLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFVIGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKHIYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLKLCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPIDSFTMPSYSRRISTATPYMNGETATKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGIYHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEEHCPLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWFSSVVKFPDMSVIEEHANWSVSREAGFSYSHTGLSNRLARDNELRENDKEQLRALCTRDPLSEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAMELLDCNYPDPMVRSFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTNQRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILKQEKKDETQKVQMKFLVEQMRQPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLWLNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLSIGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRSCAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDFLIVISKGAQEYTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIAYIRKTLALDKTEQEALEYFTKQMNDAHHGGWTTKMDWIFHTIKQHALN

Target ORF information:

RefSeq Version	NM_133399.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (Pik3ca), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_133399.2

ORF Insert Sequence:

ATGCCTCCAC GACCATCTTC GGGTGAACTG TGGGGCATCC ACTTGATGCC CCCACGAATC 
CTAGTGGAAT GTTTACTCCC AAATGGAATG ATAGTGACTT TAGAATGCCT CCGTGAGGCC 
ACACTAGTCA CCATCAAGCA TGAACTGTTC AAAGAGGCCA GGAAATACCC TCTCCATCAG 
CTTCTGCAAG ATGAATCATC TTACATTTTC GTAAGTGTTA CCCAAGAAGC AGAAAGGGAA 
GAATTTTTCG ATGAAACAAG ACGGCTTTGT GACCTTCGGC TTTTTCAACC CTTTTTAAAA 
GTAATTGAGC CAGTAGGCAA CCGTGAAGAA AAGATCCTCA ACCGAGAAAT TGGTTTTGTT 
ATTGGCATGC CAGTGTGTGA ATTTGATATG GTTAAAGATC CAGAAGTCCA AGACTTCCGA 
AGGAACATTC TGAATGTTTG CAAAGAAGCC GTGGACCTGC GGGATCTCAA CTCGCCTCAT 
AGCAGAGCAA TGTATGTCTA CCCTCCAAAT GTCGAGTCTT CCCCAGAACT GCCAAAGCAC 
ATCTACAACA AGTTAGATAA AGGACAAATC ATAGTGGTGA TTTGGGTGAT AGTCTCTCCA 
AACAACGACA AGCAGAAGTA CACTCTGAAG ATCAACCATG ACTGCGTGCC AGAGCAAGTC 
ATTGCTGAGG CCATCAGGAA GAAGACCCGG AGCATGTTGC TGTCCTCGGA GCAGCTGAAA 
CTCTGTGTCT TAGAATACCA GGGCAAGTAC ATTCTCAAAG TGTGTGGCTG TGATGAGTAC 
TTCCTAGAGA AGTACCCTCT GAGTCAGTAC AAGTACATAA GAAGCTGTAT AATGCTGGGG 
AGGATGCCCA ACTTGATGCT GATGGCCAAG GAGAGCCTGT ACTCTCAGCT GCCGATCGAT 
AGCTTCACAA TGCCATCCTA CTCCAGGCGC ATTTCCACAG CGACACCCTA TATGAACGGG 
GAGACTGCTA CGAAATCCCT CTGGGTTATA AATAGCGCGC TCAGAATAAA AATTCTGTGT 
GCAACCTATG TAAATGTAAA TATTCGAGAC ATTGATAAGA TCTATGTTCG AACAGGTATC 
TACCATGGAG GAGAACCCTT ATGTGACAAT GTGAATACTC AAAGAGTCCC TTGTTCCAAT 
CCTAGGTGGA ATGAATGGCT GAATTATGAT ATATACATTC CTGATCTTCC TCGTGCTGCC 
CGCCTTTGCC TTTCAATCTG CTCTGTTAAA GGCCGAAAGG GTGCTAAGGA GGAGCACTGT 
CCGTTGGCCT GGGGAAACAT AAACTTGTTT GATTATACAG ACACCCTAGT GTCCGGGAAA 
ATGGCTTTGA ATCTCTGGCC TGTACCACAT GGGTTGGAAG ATCTGCTGAA CCCTATTGGT 
GTTACTGGGT CAAATCCAAA TAAAGAAACT CCATGCTTAG AGTTGGAGTT TGATTGGTTC 
AGCAGTGTGG TGAAGTTTCC AGATATGTCT GTGATCGAAG AGCATGCCAA TTGGTCTGTG 
TCCCGAGAAG CCGGATTCAG TTACTCTCAT ACAGGACTGA GTAACAGACT AGCCAGAGAC 
AATGAGTTAA GAGAAAATGA CAAGGAACAG CTCCGAGCAC TTTGTACCCG GGACCCACTG 
TCTGAAATCA CTGAACAAGA GAAAGACTTC CTATGGAGCC ACAGACACTA CTGTGTAACT 
ATTCCTGAAA TCCTACCCAA ATTGCTTCTG TCTGTCAAGT GGAATTCCAG AGATGAAGTG 
GCCCAGATGT ACTGCTTAGT AAAAGATTGG CCTCCAATCA AACCAGAGCA AGCCATGGAG 
CTCCTGGACT GTAACTACCC AGACCCCATG GTTCGGAGCT TTGCTGTCCG GTGCTTGGAA 
AAATACTTAA CAGATGACAA ACTTTCTCAG TACCTCATCC AGCTTGTACA GGTCTTAAAA 
TATGAACAGT ATTTGGATAA CCTGCTTGTG AGATTTTTAC TCAAGAAAGC ACTGACAAAT 
CAAAGGATTG GCCATTTTTT CTTTTGGCAT TTAAAATCTG AGATGCACAA TAAGACTGTC 
AGTCAGAGGT TCGGCCTGCT GTTGGAGTCC TACTGCCGTG CCTGTGGGAT GTATCTGAAG 
CACCTGAACA GACAGGTAGA GGCCATGGAG AAGCTCATCA ATCTAACTGA CATCCTCAAG 
CAGGAGAAGA AGGATGAGAC ACAGAAGGTA CAGATGAAGT TCTTGGTTGA ACAGATGAGA 
CAGCCAGATT TCATGGATGC TTTGCAGGGT TTTCTGTCCC CTCTAAATCC TGCTCATCAA 
CTAGGAAACC TCAGGCTTGA AGAGTGTCGA ATTATGTCCT CTGCAAAAAG GCCACTGTGG 
TTGAATTGGG AGAACCCAGA CATCATGTCA GAGCTACTGT TTCAGAACAA TGAGATCATC 
TTTAAAAATG GCGATGACTT ACGGCAAGAC ATGTTAACCC TTCAGATCAT CCGAATCATG 
GAGAACATCT GGCAAAACCA AGGCCTTGAC CTTCGCATGC TACCTTATGG CTGTCTATCC 
ATTGGGGACT GTGTGGGTCT CATCGAGGTG GTGAGAAACT CTCACACCAT CATGCAGATT 
CAGTGCAAAG GAGGCCTGAA AGGGGCACTG CAGTTCAACA GCCACACGCT GCATCAGTGG 
CTCAAGGACA AGAACAAGGG CGAGATATAT GACGCAGCCA TTGACCTGTT CACTCGGTCC 
TGCGCTGGGT ACTGCGTGGC AACCTTTATC TTGGGAATTG GAGACCGGCA CAACAGCAAC 
ATCATGGTGA AAGATGACGG ACAGCTGTTT CATATAGATT TTGGGCACTT TTTGGATCAC 
AAGAAGAAAA AATTTGGCTA TAAACGGGAA CGTGTGCCGT TTGTTTTGAC GCAGGATTTC 
TTAATAGTGA TTAGTAAAGG AGCACAAGAG TACACAAAGA CCAGAGAGTT TGAGAGGTTT 
CAGGAGATGT GTTACAAGGC GTACCTAGCA ATTCGGCAGC ATGCCAATCT CTTCATCAAC 
CTTTTCTCCA TGATGCTTGG CTCCGGAATG CCAGAACTGC AGTCTTTCGA TGATATTGCA 
TATATTCGAA AGACTCTAGC CTTAGACAAA ACTGAGCAAG AGGCTCTGGA GTATTTCACA 
AAGCAAATGA ATGACGCACA TCATGGTGGC TGGACAACAA AAATGGACTG GATCTTCCAC 
ACCATCAAGC AGCATGCATT GAACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

MiR-339 inhibits proliferation of pulmonary artery smooth muscle cell by targeting FGF signaling.
Physiological reports5(18)(2017 Sep)
Chen J,Cui X,Li L,Qu J,Raj JU,Gou D

Analysis of
Oncotarget8(32)52142-52155(2017 Aug)
Takeshita T,Yamamoto Y,Yamamoto-Ibusuki M,Tomiguchi M,Sueta A,Murakami K,Omoto Y,Iwase H

Inhibition of infarction-induced sympathetic innervation with endothelin receptor antagonism via a PI3K/GSK-3?-dependent pathway.
Laboratory investigation; a journal of technical methods and pathology97(3)243-255(2017 Mar)
Lee TM,Chang NC,Lin SZ

Gypenoside Protects against Myocardial Ischemia-Reperfusion Injury by Inhibiting Cardiomyocytes Apoptosis via Inhibition of CHOP Pathway and Activation of PI3K/Akt Pathway In Vivo and In Vitro.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology39(1)123-36(2016)
Yu H,Zhang H,Zhao W,Guo L,Li X,Li Y,Zhang X,Sun Y

Geniposide Prevents Hypoxia/Reoxygenation-Induced Apoptosis in H9c2 Cells: Improvement of Mitochondrial Dysfunction and Activation of GLP-1R and the PI3K/AKT Signaling Pathway.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology39(1)407-21(2016)
Jiang YQ,Chang GL,Wang Y,Zhang DY,Cao L,Liu J

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Pik3ca cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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