Stk17b cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Stk17b
Entrez Gene ID	170904
Full Name	serine/threonine kinase 17b
Synonyms	Drak2
General protein information	Preferred Names serine/threonine kinase 17b Names serine/threonine-protein kinase 17B DAP kinase-related apoptosis-inducing protein kinase 2 death-associated protein kinase-related 2 serine/threonine kinase 17b (apoptosis-inducing)
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 9 Map Location: 9q31
Summary	over-expression causes apoptosis-like cell death which is dependent on the kinase activity [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_006244908.2	XP_006244970.1	serine/threonine-protein kinase 17B isoform X1
NM_133392.1	NP_596883.1	serine/threonine-protein kinase 17B

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Stk17b	NP_598571.2
	STK17B	XP_001085519.2
Drosophila melanogaster (fruit fly)	Drak	NP_727533.1
Pan troglodytes (chimpanzee)	STK17B	XP_001168212.1
Bos taurus (cattle)	STK17B	NP_001033169.1
Homo sapiens (human)	STK17B	NP_004217.1
Danio rerio (zebrafish)	stk17b	NP_956829.1
Canis lupus familiaris (dog)	STK17B	XP_545575.1
Rattus norvegicus (Norway rat)	Stk17b	NP_596883.1
Gallus gallus (chicken)	STK17B	NP_001026420.1

Gene Ontology
Bibliography

Related articles in PubMed

Nuclear localization signal and phosphorylation of Serine350 specify intracellular localization of DRAK2.
Kuwahara H, Nishizaki M, Kanazawa H
Journal of biochemistry143(3)349-58(2008 Mar)

The apoptosis-inducing protein kinase DRAK2 is inhibited in a calcium-dependent manner by the calcium-binding protein CHP.
Kuwahara H, Kamei J, Nakamura N, Matsumoto M, Inoue H, Kanazawa H
Journal of biochemistry134(2)245-50(2003 Aug)

A serine/threonine kinase which causes apoptosis-like cell death interacts with a calcineurin B-like protein capable of binding Na(+)/H(+) exchanger.
Matsumoto M, Miyake Y, Nagita M, Inoue H, Shitakubo D, Takemoto K, Ohtsuka C, Murakami H, Nakamura N, Kanazawa H
Journal of biochemistry130(2)217-25(2001 Aug)

DRAKs, novel serine/threonine kinases related to death-associated protein kinase that trigger apoptosis.
Sanjo H, Kawai T, Akira S
The Journal of biological chemistry273(44)29066-71(1998 Oct)

CFU-C in Agar.
Praloran V, Bartocci A
Methods in molecular biology (Clifton, N.J.)5323-30(1990)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These results suggest that phosphorylation of Ser350 plays an essential role in regulating translocation of DRAK2 to the nucleus from the cytoplasm, possibly by affecting the activity of the nuclear localization signal.
Title: Nuclear localization signal and phosphorylation of Serine350 specify intracellular localization of DRAK2.

The following Stk17b gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Stk17b cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa00665	NM_133392.1 Latest version!	Rattus norvegicus serine/threonine kinase 17b (Stk17b), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
ORa00665	XM_006244908.2 Latest version!	Rattus norvegicus serine/threonine kinase 17b (Stk17b), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Stk17b ( NM_133392.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_596883.1 Rattus norvegicus serine/threonine kinase 17b (Stk17b), mRNA.

Price & Availability↑

CloneID	ORa00665
Clone ID Related Accession (Same CDS sequence)	XM_006244908.2 , NM_133392.1
Accession Version	NM_133392.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1116bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-19
Organism	Rattus norvegicus(Norway rat)
Product	serine/threonine-protein kinase 17B
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB070349.1. ##Evidence-Data-START## Transcript exon combination :: AB070349.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGTCTCGGA GGAGATTTGA TTGCCGAAGT ATCTCGGGCT TGCTAACTAC AACCCCTCAA 
ACGCCGATGA AAACAGAGAA TTTTAATAAT TTCTATACGC TTACCCCGAA AGAACTTGGG 
AGAGGAAAAT TTGCAGTAGT TAGACAGTGT ATATCAAAGT CAACTGGACA GGAGTATGCT 
GCCAAATTCC TGAAGAAGAG GAGAAGAGGG CAGGACTGCC GGGCAGAGAT TCTGCACGAG 
ATAGCGGTGC TGGAGCTGGC CAGGTCTTGT CCCCACGTGA TTAATCTGCA CGAGGTCTAT 
GAAACGGCAA CGGAAATCAT TTTGGTGTTA GAATATGCTG CAGGTGGAGA AATTTTCAAC 
CTGTGTTTAC CTGAGTTGGC TGAAATGGTG TCTGAAAATG ATGTTATCCG ACTCATTAAA 
CAAATACTTG AAGGAGTTCA TTATCTACAT CAGAATAACA TTGTTCATCT TGATTTAAAG 
CCACAGAATA TACTTTTGAG CAGTATATAC CCACTTGGGG ACATAAAAAT TGTAGATTTT 
GGAATGTCTC GAAAAATTGG GAATGCAAGT GAGCTTCGGG AAATCATGGG AACGCCTGAA 
TACTTAGCTC CAGAAATCCT CAACTATGAT CCCATTACCA CAGCAACAGA TATGTGGAAT 
ATTGGCATAA TAGCATATAT GTTGTTGACT CATACATCAC CATTTGTAGG AGAAGATAAC 
CAAGAAACAT ATCTGAATAT TTCTCAAGTG AATGTAGATT ATTCAGAAGA AATGTTTTCA 
TCAGTTTCAC AACTGGCCAC AGACTTCATC CAGAGCCTTC TAGTAAAGAA TCCAGAGAAA 
AGACCAACAG CAGAATCCTG CCTTTCCCAC TCATGGCTGC AGCAGTGGGA CTTTGGAAGC 
TTGTTTCATC CTGAGGAAAC TTCAGAGTCC TCTCAAACTC AGGATCTGAG CCTCAGGTCC 
TCTGAAGATA AGACCCCCAA GTCCTGTAAT GGAAGCTGTG GAGACCGAGA GGACAAGGAG 
AACATCCCTG AGGATGACAG CTTACTTTCT AAAAGATTTC GATTCGATGA CTCCTTGCCC 
AGCCCCCACG AACTCGTTCC AGATTTGTTC TGTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_596883.1
CDS	168..1283
Translation	MSRRRFDCRSISGLLTTTPQTPMKTENFNNFYTLTPKELGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQDCRAEILHEIAVLELARSCPHVINLHEVYETATEIILVLEYAAGGEIFNLCLPELAEMVSENDVIRLIKQILEGVHYLHQNNIVHLDLKPQNILLSSIYPLGDIKIVDFGMSRKIGNASELREIMGTPEYLAPEILNYDPITTATDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQVNVDYSEEMFSSVSQLATDFIQSLLVKNPEKRPTAESCLSHSWLQQWDFGSLFHPEETSESSQTQDLSLRSSEDKTPKSCNGSCGDREDKENIPEDDSLLSKRFRFDDSLPSPHELVPDLFC

Target ORF information:

RefSeq Version	NM_133392.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus serine/threonine kinase 17b (Stk17b), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_133392.1

ORF Insert Sequence:

ATGTCTCGGA GGAGATTTGA TTGCCGAAGT ATCTCGGGCT TGCTAACTAC AACCCCTCAA 
ACGCCGATGA AAACAGAGAA TTTTAATAAT TTCTATACGC TTACCCCGAA AGAACTTGGG 
AGAGGAAAAT TTGCAGTAGT TAGACAGTGT ATATCAAAGT CAACTGGACA GGAGTATGCT 
GCCAAATTCC TGAAGAAGAG GAGAAGAGGG CAGGACTGCC GGGCAGAGAT TCTGCACGAG 
ATAGCGGTGC TGGAGCTGGC CAGGTCTTGT CCCCACGTGA TTAATCTGCA CGAGGTCTAT 
GAAACGGCAA CGGAAATCAT TTTGGTGTTA GAATATGCTG CAGGTGGAGA AATTTTCAAC 
CTGTGTTTAC CTGAGTTGGC TGAAATGGTG TCTGAAAATG ATGTTATCCG ACTCATTAAA 
CAAATACTTG AAGGAGTTCA TTATCTACAT CAGAATAACA TTGTTCATCT TGATTTAAAG 
CCACAGAATA TACTTTTGAG CAGTATATAC CCACTTGGGG ACATAAAAAT TGTAGATTTT 
GGAATGTCTC GAAAAATTGG GAATGCAAGT GAGCTTCGGG AAATCATGGG AACGCCTGAA 
TACTTAGCTC CAGAAATCCT CAACTATGAT CCCATTACCA CAGCAACAGA TATGTGGAAT 
ATTGGCATAA TAGCATATAT GTTGTTGACT CATACATCAC CATTTGTAGG AGAAGATAAC 
CAAGAAACAT ATCTGAATAT TTCTCAAGTG AATGTAGATT ATTCAGAAGA AATGTTTTCA 
TCAGTTTCAC AACTGGCCAC AGACTTCATC CAGAGCCTTC TAGTAAAGAA TCCAGAGAAA 
AGACCAACAG CAGAATCCTG CCTTTCCCAC TCATGGCTGC AGCAGTGGGA CTTTGGAAGC 
TTGTTTCATC CTGAGGAAAC TTCAGAGTCC TCTCAAACTC AGGATCTGAG CCTCAGGTCC 
TCTGAAGATA AGACCCCCAA GTCCTGTAAT GGAAGCTGTG GAGACCGAGA GGACAAGGAG 
AACATCCCTG AGGATGACAG CTTACTTTCT AAAAGATTTC GATTCGATGA CTCCTTGCCC 
AGCCCCCACG AACTCGTTCC AGATTTGTTC TGTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Stk17b ( XM_006244908.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006244970.1 Rattus norvegicus serine/threonine kinase 17b (Stk17b), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa00665
Clone ID Related Accession (Same CDS sequence)	XM_006244908.2 , NM_133392.1
Accession Version	XM_006244908.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1116bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	serine/threonine-protein kinase 17B isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005108.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 7, 2014 this sequence version replaced XM_006244908.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCTCGGA GGAGATTTGA TTGCCGAAGT ATCTCGGGCT TGCTAACTAC AACCCCTCAA 
ACGCCGATGA AAACAGAGAA TTTTAATAAT TTCTATACGC TTACCCCGAA AGAACTTGGG 
AGAGGAAAAT TTGCAGTAGT TAGACAGTGT ATATCAAAGT CAACTGGACA GGAGTATGCT 
GCCAAATTCC TGAAGAAGAG GAGAAGAGGG CAGGACTGCC GGGCAGAGAT TCTGCACGAG 
ATAGCGGTGC TGGAGCTGGC CAGGTCTTGT CCCCACGTGA TTAATCTGCA CGAGGTCTAT 
GAAACGGCAA CGGAAATCAT TTTGGTGTTA GAATATGCTG CAGGTGGAGA AATTTTCAAC 
CTGTGTTTAC CTGAGTTGGC TGAAATGGTG TCTGAAAATG ATGTTATCCG ACTCATTAAA 
CAAATACTTG AAGGAGTTCA TTATCTACAT CAGAATAACA TTGTTCATCT TGATTTAAAG 
CCACAGAATA TACTTTTGAG CAGTATATAC CCACTTGGGG ACATAAAAAT TGTAGATTTT 
GGAATGTCTC GAAAAATTGG GAATGCAAGT GAGCTTCGGG AAATCATGGG AACGCCTGAA 
TACTTAGCTC CAGAAATCCT CAACTATGAT CCCATTACCA CAGCAACAGA TATGTGGAAT 
ATTGGCATAA TAGCATATAT GTTGTTGACT CATACATCAC CATTTGTAGG AGAAGATAAC 
CAAGAAACAT ATCTGAATAT TTCTCAAGTG AATGTAGATT ATTCAGAAGA AATGTTTTCA 
TCAGTTTCAC AACTGGCCAC AGACTTCATC CAGAGCCTTC TAGTAAAGAA TCCAGAGAAA 
AGACCAACAG CAGAATCCTG CCTTTCCCAC TCATGGCTGC AGCAGTGGGA CTTTGGAAGC 
TTGTTTCATC CTGAGGAAAC TTCAGAGTCC TCTCAAACTC AGGATCTGAG CCTCAGGTCC 
TCTGAAGATA AGACCCCCAA GTCCTGTAAT GGAAGCTGTG GAGACCGAGA GGACAAGGAG 
AACATCCCTG AGGATGACAG CTTACTTTCT AAAAGATTTC GATTCGATGA CTCCTTGCCC 
AGCCCCCACG AACTCGTTCC AGATTTGTTC TGTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006244970.1
CDS	937..2052
Translation	MSRRRFDCRSISGLLTTTPQTPMKTENFNNFYTLTPKELGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQDCRAEILHEIAVLELARSCPHVINLHEVYETATEIILVLEYAAGGEIFNLCLPELAEMVSENDVIRLIKQILEGVHYLHQNNIVHLDLKPQNILLSSIYPLGDIKIVDFGMSRKIGNASELREIMGTPEYLAPEILNYDPITTATDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQVNVDYSEEMFSSVSQLATDFIQSLLVKNPEKRPTAESCLSHSWLQQWDFGSLFHPEETSESSQTQDLSLRSSEDKTPKSCNGSCGDREDKENIPEDDSLLSKRFRFDDSLPSPHELVPDLFC

Target ORF information:

RefSeq Version	XM_006244908.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus serine/threonine kinase 17b (Stk17b), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006244908.2

ORF Insert Sequence:

ATGTCTCGGA GGAGATTTGA TTGCCGAAGT ATCTCGGGCT TGCTAACTAC AACCCCTCAA 
ACGCCGATGA AAACAGAGAA TTTTAATAAT TTCTATACGC TTACCCCGAA AGAACTTGGG 
AGAGGAAAAT TTGCAGTAGT TAGACAGTGT ATATCAAAGT CAACTGGACA GGAGTATGCT 
GCCAAATTCC TGAAGAAGAG GAGAAGAGGG CAGGACTGCC GGGCAGAGAT TCTGCACGAG 
ATAGCGGTGC TGGAGCTGGC CAGGTCTTGT CCCCACGTGA TTAATCTGCA CGAGGTCTAT 
GAAACGGCAA CGGAAATCAT TTTGGTGTTA GAATATGCTG CAGGTGGAGA AATTTTCAAC 
CTGTGTTTAC CTGAGTTGGC TGAAATGGTG TCTGAAAATG ATGTTATCCG ACTCATTAAA 
CAAATACTTG AAGGAGTTCA TTATCTACAT CAGAATAACA TTGTTCATCT TGATTTAAAG 
CCACAGAATA TACTTTTGAG CAGTATATAC CCACTTGGGG ACATAAAAAT TGTAGATTTT 
GGAATGTCTC GAAAAATTGG GAATGCAAGT GAGCTTCGGG AAATCATGGG AACGCCTGAA 
TACTTAGCTC CAGAAATCCT CAACTATGAT CCCATTACCA CAGCAACAGA TATGTGGAAT 
ATTGGCATAA TAGCATATAT GTTGTTGACT CATACATCAC CATTTGTAGG AGAAGATAAC 
CAAGAAACAT ATCTGAATAT TTCTCAAGTG AATGTAGATT ATTCAGAAGA AATGTTTTCA 
TCAGTTTCAC AACTGGCCAC AGACTTCATC CAGAGCCTTC TAGTAAAGAA TCCAGAGAAA 
AGACCAACAG CAGAATCCTG CCTTTCCCAC TCATGGCTGC AGCAGTGGGA CTTTGGAAGC 
TTGTTTCATC CTGAGGAAAC TTCAGAGTCC TCTCAAACTC AGGATCTGAG CCTCAGGTCC 
TCTGAAGATA AGACCCCCAA GTCCTGTAAT GGAAGCTGTG GAGACCGAGA GGACAAGGAG 
AACATCCCTG AGGATGACAG CTTACTTTCT AAAAGATTTC GATTCGATGA CTCCTTGCCC 
AGCCCCCACG AACTCGTTCC AGATTTGTTC TGTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Nuclear localization signal and phosphorylation of Serine350 specify intracellular localization of DRAK2.
Journal of biochemistry143(3)349-58(2008 Mar)
Kuwahara H,Nishizaki M,Kanazawa H

The apoptosis-inducing protein kinase DRAK2 is inhibited in a calcium-dependent manner by the calcium-binding protein CHP.
Journal of biochemistry134(2)245-50(2003 Aug)
Kuwahara H,Kamei J,Nakamura N,Matsumoto M,Inoue H,Kanazawa H

A serine/threonine kinase which causes apoptosis-like cell death interacts with a calcineurin B-like protein capable of binding Na(+)/H(+) exchanger.
Journal of biochemistry130(2)217-25(2001 Aug)
Matsumoto M,Miyake Y,Nagita M,Inoue H,Shitakubo D,Takemoto K,Ohtsuka C,Murakami H,Nakamura N,Kanazawa H

DRAKs, novel serine/threonine kinases related to death-associated protein kinase that trigger apoptosis.
The Journal of biological chemistry273(44)29066-71(1998 Oct)
Sanjo H,Kawai T,Akira S

CFU-C in Agar.
Methods in molecular biology (Clifton, N.J.)5323-30(1990)
Praloran V,Bartocci A

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Stk17b cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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