Steap3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Steap3
Entrez Gene ID	170824
Full Name	STEAP3 metalloreductase
General protein information	Preferred Names STEAP3 metalloreductase Names metalloreductase STEAP3 STEAP family member 3, metalloreductase pHyde six-transmembrane epithelial antigen of prostate 3 tumor suppressor pHyde
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 13 Map Location: 13q11
Summary	induces apoptosis; inhibits prostate tumor growth in some cell lines [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_133314.1	NP_579848.1	metalloreductase STEAP3

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Steap3	NP_001078878.1
Danio rerio (zebrafish)	steap3	XP_002663339.1
Canis lupus familiaris (dog)	STEAP3	XP_005631969.1
Bos taurus (cattle)	STEAP3	XP_002685484.2
Rattus norvegicus (Norway rat)	Steap3	NP_579848.1
Pan troglodytes (chimpanzee)	STEAP3	XP_003309256.1
	STEAP3	XP_002799457.1
Homo sapiens (human)	STEAP3	NP_878919.2
Gallus gallus (chicken)	STEAP3	XP_004943027.1

Gene Ontology
Bibliography

Related articles in PubMed

Cellular iron uptake, trafficking and metabolism: Key molecules and mechanisms and their roles in disease.
Lane DJ, Merlot AM, Huang ML, Bae DH, Jansson PJ, Sahni S, Kalinowski DS, Richardson DR
Biochimica et biophysica acta1853(5)1130-44(2015 May)

E-cadherin interactome complexity and robustness resolved by quantitative proteomics.
Guo Z, Neilson LJ, Zhong H, Murray PS, Zanivan S, Zaidel-Bar R
Science signaling7(354)rs7(2014 Dec)

Exosome-related multi-pass transmembrane protein TSAP6 is a target of rhomboid protease RHBDD1-induced proteolysis.
Wan C, Fu J, Wang Y, Miao S, Song W, Wang L
PloS one7(5)e37452(2012)

Identification of a Steap3 endosomal targeting motif essential for normal iron metabolism.
Lambe T, Simpson RJ, Dawson S, Bouriez-Jones T, Crockford TL, Lepherd M, Latunde-Dada GO, Robinson H, Raja KB, Campagna DR, Villarreal G Jr, Ellory JC, Goodnow CC, Fleming MD, McKie AT, Cornall RJ
Blood113(8)1805-8(2009 Feb)

Exosome secretion, including the DNA damage-induced p53-dependent secretory pathway, is severely compromised in TSAP6/Steap3-null mice.
Lespagnol A, Duflaut D, Beekman C, Blanc L, Fiucci G, Marine JC, Vidal M, Amson R, Telerman A
Cell death and differentiation15(11)1723-33(2008 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Steap3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Steap3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa00601	NM_133314.1 Latest version!	Rattus norvegicus STEAP3 metalloreductase (Steap3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$286.30 $409.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Steap3 ( NM_133314.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_579848.1 Rattus norvegicus STEAP3 metalloreductase (Steap3), mRNA.

Price & Availability↑

CloneID	ORa00601
Clone ID Related Accession (Same CDS sequence)	NM_133314.1
Accession Version	NM_133314.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1467bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-15
Organism	Rattus norvegicus(Norway rat)
Product	metalloreductase STEAP3
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF335281.1. ##Evidence-Data-START## Transcript exon combination :: BC085696.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMN01906347 [ECO:0000348] ##Evidence-Data-END##

ATGTCCGGGG AGATGGACAA ACCGCTCATC AGTCGCCGCT TGGTGGACAG TGATGGCAGT 
CTGGCTGAGG TCCCCAAGGA GGCTCCCAAA GTGGGCATCC TGGGCAGCGG GGATTTTGCC 
CGGTCCCTGG CCACACGCCT GGTGGGCTCT GGCTTCTTTG TGGTGGTGGG AAGCCGTAAC 
CCCAAACGCA CTGCCGGCCT CTTCCCCTCC TTAGCCCAAG TGACTTTCCA GGAGGAGGCC 
GTGAGCTCTC CAGAGGTCAT CTTTGTGGCC GTGTTCCGGG AGCACTACTC CTCACTGTGC 
AGTCTTGCTG ACCAGTTGGC TGGCAAGATC CTAGTGGATG TAAGCAACCC CACGGAGAAG 
GAGCGTCTTC AGCACCGCCA GTCGAACGCC GAGTACCTGG CCTCCCTCTT CCCTGCCTGC 
ACTGTGGTCA AGGCCTTCAA CGTCATCTCT GCATGGGCCC TACAGGCTGG CCCAAGGGAT 
GGGAACAGGC AGGTGCTCAT CTGCGGTGAC CAGCTGGAAG CCAAGCACAC CGTCTCAGAG 
ATGGCGCGCG CCATGGGTTT CACCCCACTG GACATGGGAT CCCTGGCCTC AGCGAGGGAG 
GTAGAGGCCA TACCCCTGCG CCTCCTTCCA TCCTGGAAGG TGCCCACCCT CCTGGCCCTG 
GGGCTAAGCA CACAAAGCTA TGCCTACAAC TTCATCCGGG ACGTTCTACA GCCGTACATC 
CGGAAAGATG AGAACAAGTT CTACAAGATG CCCCTGTCTG TGGTCAACAC CACGATACCC 
TGTGTGGCTT ACGTGCTGCT GTCCCTGGTT TACCTGCCTG GTGTGCTGGC AGCTGCCCTT 
CAGCTGAGGA GGGGGACCAA GTACCAGCGC TTCCCAGACT GGCTGGACCA TTGGCTGCAG 
CACCGCAAGC AGATCGGGCT ACTCAGCTTT TTTTTCGCCA TGCTGCACGC TCTCTACAGC 
TTCTGCCTGC CGCTGCGCCG CTCCCACCGC TATGATCTGG TCAACCTGGC TGTGAAGCAG 
GTCCTGGCCA ACAAGAGCCG CCTCTGGGTT GAGGAAGAAG TCTGGCGGAT GGAGATATAC 
CTGTCCCTGG GTGTGCTGGC TCTGGGCATG CTGTCACTGC TGGCGGTTAC CTCGATCCCT 
TCCATTGCAA ACTCACTCAA CTGGAAGGAG TTCAGCTTTG TGCAGTCCAC GCTGGGCTTC 
GTGGCCCTGA TGCTGAGCAC AATGCACACC CTCACCTACG GCTGGACCCG TGCTTTTGAG 
GAAAACCACT ACAAGTTCTA CCTGCCACCC ACATTCACGC TCACGCTGCT CCTGCCCTGT 
GTCATCATCC TGGCCAAGGG CCTCTTCCTC CTGCCCTGCC TCAGCCACAG ACTCACCAAG 
ATCCGCAGGG GCTGGGAGAG GGATGGTGCC GTCAAGTTCA TGCTGCCCGC TGGCCACACA 
CAGGGGGAGA AAACAAGCCA CGTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_579848.1
CDS	26..1492
Translation	MSGEMDKPLISRRLVDSDGSLAEVPKEAPKVGILGSGDFARSLATRLVGSGFFVVVGSRNPKRTAGLFPSLAQVTFQEEAVSSPEVIFVAVFREHYSSLCSLADQLAGKILVDVSNPTEKERLQHRQSNAEYLASLFPACTVVKAFNVISAWALQAGPRDGNRQVLICGDQLEAKHTVSEMARAMGFTPLDMGSLASAREVEAIPLRLLPSWKVPTLLALGLSTQSYAYNFIRDVLQPYIRKDENKFYKMPLSVVNTTIPCVAYVLLSLVYLPGVLAAALQLRRGTKYQRFPDWLDHWLQHRKQIGLLSFFFAMLHALYSFCLPLRRSHRYDLVNLAVKQVLANKSRLWVEEEVWRMEIYLSLGVLALGMLSLLAVTSIPSIANSLNWKEFSFVQSTLGFVALMLSTMHTLTYGWTRAFEENHYKFYLPPTFTLTLLLPCVIILAKGLFLLPCLSHRLTKIRRGWERDGAVKFMLPAGHTQGEKTSHV

Target ORF information:

RefSeq Version	NM_133314.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus STEAP3 metalloreductase (Steap3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_133314.1

ORF Insert Sequence:

ATGTCCGGGG AGATGGACAA ACCGCTCATC AGTCGCCGCT TGGTGGACAG TGATGGCAGT 
CTGGCTGAGG TCCCCAAGGA GGCTCCCAAA GTGGGCATCC TGGGCAGCGG GGATTTTGCC 
CGGTCCCTGG CCACACGCCT GGTGGGCTCT GGCTTCTTTG TGGTGGTGGG AAGCCGTAAC 
CCCAAACGCA CTGCCGGCCT CTTCCCCTCC TTAGCCCAAG TGACTTTCCA GGAGGAGGCC 
GTGAGCTCTC CAGAGGTCAT CTTTGTGGCC GTGTTCCGGG AGCACTACTC CTCACTGTGC 
AGTCTTGCTG ACCAGTTGGC TGGCAAGATC CTAGTGGATG TAAGCAACCC CACGGAGAAG 
GAGCGTCTTC AGCACCGCCA GTCGAACGCC GAGTACCTGG CCTCCCTCTT CCCTGCCTGC 
ACTGTGGTCA AGGCCTTCAA CGTCATCTCT GCATGGGCCC TACAGGCTGG CCCAAGGGAT 
GGGAACAGGC AGGTGCTCAT CTGCGGTGAC CAGCTGGAAG CCAAGCACAC CGTCTCAGAG 
ATGGCGCGCG CCATGGGTTT CACCCCACTG GACATGGGAT CCCTGGCCTC AGCGAGGGAG 
GTAGAGGCCA TACCCCTGCG CCTCCTTCCA TCCTGGAAGG TGCCCACCCT CCTGGCCCTG 
GGGCTAAGCA CACAAAGCTA TGCCTACAAC TTCATCCGGG ACGTTCTACA GCCGTACATC 
CGGAAAGATG AGAACAAGTT CTACAAGATG CCCCTGTCTG TGGTCAACAC CACGATACCC 
TGTGTGGCTT ACGTGCTGCT GTCCCTGGTT TACCTGCCTG GTGTGCTGGC AGCTGCCCTT 
CAGCTGAGGA GGGGGACCAA GTACCAGCGC TTCCCAGACT GGCTGGACCA TTGGCTGCAG 
CACCGCAAGC AGATCGGGCT ACTCAGCTTT TTTTTCGCCA TGCTGCACGC TCTCTACAGC 
TTCTGCCTGC CGCTGCGCCG CTCCCACCGC TATGATCTGG TCAACCTGGC TGTGAAGCAG 
GTCCTGGCCA ACAAGAGCCG CCTCTGGGTT GAGGAAGAAG TCTGGCGGAT GGAGATATAC 
CTGTCCCTGG GTGTGCTGGC TCTGGGCATG CTGTCACTGC TGGCGGTTAC CTCGATCCCT 
TCCATTGCAA ACTCACTCAA CTGGAAGGAG TTCAGCTTTG TGCAGTCCAC GCTGGGCTTC 
GTGGCCCTGA TGCTGAGCAC AATGCACACC CTCACCTACG GCTGGACCCG TGCTTTTGAG 
GAAAACCACT ACAAGTTCTA CCTGCCACCC ACATTCACGC TCACGCTGCT CCTGCCCTGT 
GTCATCATCC TGGCCAAGGG CCTCTTCCTC CTGCCCTGCC TCAGCCACAG ACTCACCAAG 
ATCCGCAGGG GCTGGGAGAG GGATGGTGCC GTCAAGTTCA TGCTGCCCGC TGGCCACACA 
CAGGGGGAGA AAACAAGCCA CGTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Cellular iron uptake, trafficking and metabolism: Key molecules and mechanisms and their roles in disease.
Biochimica et biophysica acta1853(5)1130-44(2015 May)
Lane DJ,Merlot AM,Huang ML,Bae DH,Jansson PJ,Sahni S,Kalinowski DS,Richardson DR

E-cadherin interactome complexity and robustness resolved by quantitative proteomics.
Science signaling7(354)rs7(2014 Dec)
Guo Z,Neilson LJ,Zhong H,Murray PS,Zanivan S,Zaidel-Bar R

Exosome-related multi-pass transmembrane protein TSAP6 is a target of rhomboid protease RHBDD1-induced proteolysis.
PloS one7(5)e37452(2012)
Wan C,Fu J,Wang Y,Miao S,Song W,Wang L

Identification of a Steap3 endosomal targeting motif essential for normal iron metabolism.
Blood113(8)1805-8(2009 Feb)
Lambe T,Simpson RJ,Dawson S,Bouriez-Jones T,Crockford TL,Lepherd M,Latunde-Dada GO,Robinson H,Raja KB,Campagna DR,Villarreal G Jr,Ellory JC,Goodnow CC,Fleming MD,McKie AT,Cornall RJ

Exosome secretion, including the DNA damage-induced p53-dependent secretory pathway, is severely compromised in TSAP6/Steap3-null mice.
Cell death and differentiation15(11)1723-33(2008 Nov)
Lespagnol A,Duflaut D,Beekman C,Blanc L,Fiucci G,Marine JC,Vidal M,Amson R,Telerman A

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Steap3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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