Atxn10 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Atxn10
Entrez Gene ID	170821
Full Name	ataxin 10
Synonyms	Sca10
General protein information	Preferred Names ataxin 10 Names ataxin-10 ataxin 10 homolog neuronal beta-catenin-like protein spinocerebellar ataxia 10 homolog spinocerebellar ataxia type 10 protein homolog
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 7 Map Location: 7q34
Summary	human homolog is a region of a chromosome highly linked to autosomal dominant cerebellar ataxias [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_133313.2	NP_579847.1	ataxin-10

Pathways from BioSystems

Homologies

	ATXN10	XP_001110207.1
Bos taurus (cattle)	ATXN10	NP_001070519.1
Mus musculus (house mouse)	Atxn10	NP_058539.2
Gallus gallus (chicken)	ATXN10	XP_416469.2
Danio rerio (zebrafish)	atxn10	NP_001124084.1
Rattus norvegicus (Norway rat)	Atxn10	NP_579847.1
Homo sapiens (human)	ATXN10	NP_037368.1
Pan troglodytes (chimpanzee)	ATXN10	XP_525623.3
Canis lupus familiaris (dog)	ATXN10	XP_531697.2
Xenopus tropicalis (tropical clawed frog)	atxn10	NP_001015825.1

Gene Ontology
Bibliography

Related articles in PubMed

Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma na?ve to therapy.
Pieragostino D, Agnifili L, Fasanella V, D'Aguanno S, Mastropasqua R, Di Ilio C, Sacchetta P, Urbani A, Del Boccio P
Molecular bioSystems9(6)1108-16(2013 Jun)

Changes in Ataxin-10 expression after sciatic nerve crush in adult rats.
Cheng X, Gan L, Zhao J, Chen M, Liu Y, Wang Y
Neurochemical research38(5)1013-21(2013 May)

Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways.
Sang L, Miller JJ, Corbit KC, Giles RH, Brauer MJ, Otto EA, Baye LM, Wen X, Scales SJ, Kwong M, Huntzicker EG, Sfakianos MK, Sandoval W, Bazan JF, Kulkarni P, Garcia-Gonzalo FR, Seol AD, O'Toole JF, Held S, Reutter HM, Lane WS, Rafiq MA, Noor A, Ansar M, Devi AR, Sheffield VC, Slusarski DC, Vincent JB, Doherty DA, Hildebrandt F, Reiter JF, Jackson PK
Cell145(4)513-28(2011 May)

Defining the membrane proteome of NK cells.
Ghosh D, Lippert D, Krokhin O, Cortens JP, Wilkins JA
Journal of mass spectrometry : JMS45(1)1-25(2010 Jan)

Ataxin-10 interacts with O-linked beta-N-acetylglucosamine transferase in the brain.
M?rz P, Stetefeld J, Bendfeldt K, Nitsch C, Reinstein J, Shoeman RL, Dimitriades-Schmutz B, Schwager M, Leiser D, Ozcan S, Otten U, Ozbek S
The Journal of biological chemistry281(29)20263-70(2006 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

findings suggested that Ataxin-10 may be involved in the pathophysiology of sciatic nerve after SNC.
Title: Changes in Ataxin-10 expression after sciatic nerve crush in adult rats.

Neurodegenerative disease protein ataxin-10 (Atx-10) is associated with cytoplasmic O-linked beta-N-acetylglucosamine transferase in in the brain
Title: Ataxin-10 interacts with O-linked beta-N-acetylglucosamine transferase in the brain.

Our data suggest that the ataxin 10-Gbeta2 interaction represents a novel mechanism for inducing neuritogenesis in PC12 cells by activating the Ras-MAP kinase-Elk-1 cascade
Title: Ataxin 10 induces neuritogenesis via interaction with G-protein beta2 subunit.

knock down of SCA10 in primary neuronal cells resulted in an increased apoptosis of cerebellar neurons
Title: Ataxin-10, the spinocerebellar ataxia type 10 neurodegenerative disorder protein, is essential for survival of cerebellar neurons.

The following Atxn10 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Atxn10 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa00600	NM_133313.2 Latest version!	Rattus norvegicus ataxin 10 (Atxn10), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Atxn10 ( NM_133313.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_579847.1 Rattus norvegicus ataxin 10 (Atxn10), mRNA.

Price & Availability↑

CloneID	ORa00600
Clone ID Related Accession (Same CDS sequence)	NM_133313.2
Accession Version	NM_133313.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1428bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Rattus norvegicus(Norway rat)
Product	ataxin-10
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC062087.1. On Jun 10, 2007 this sequence version replaced NM_133313.1. ##Evidence-Data-START## Transcript exon combination :: BC062087.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGCGGCGC CCAGGATGCC ACCCTCCCGG CTGTCGGGCA TCATGGTGCC AGCACCTATC 
CAGGACCTGG AGGCCCTGCG CGCGCTCACG GCGCTCTTCA AGGAGCAGCG TAACCGGGAA 
ACAGCACCCA GAACGATCTT CCAGAGAGTC CTGGATATCT TAAAGAAATC CACTCAGGCT 
GTTGAGCTGG CCTGCAGAGA TCCCTCCCAA GTGGAGCACC TGGCTTCCAG TCTTCAGCTG 
ATCACCGAGT GCTTCAGATG CCTTCGTAAT GCTTGTATAG AGTGTTCTGT GAACCAGAAT 
TCAATCAGGA ACCTGGATAC CATTGGAGTT GCCGTTGATT TGGTTCTTCT CTTTCGTGAA 
CTTCGGGTGG AACAAGACTC TTTGTTGACA GCTTTCCGCT GTGGCCTGCA GTTTTTAGGC 
AACGTTGCCT CACGGAATGA AGATTCCCAG TCCATTGTTT GGGTCCACGC CTTCCCAGAA 
CTCTTCATGT CTTGCTTAAA TCATCCAGAC AAAAAGATTG TTGCCTACTG TTCCATGATT 
CTGTTCACAT CTCTTAATTC TGAAAGGATG AAGGACCTGG AAGAGAACCT CAATATTGCA 
ATTAACGTCA TAGAAGCTCA CCAAAAGCAC CCAGAGTCAG AGTGGCCGTT CTTGATCATT 
ACAGACCACT TTCTGAAAAG CCCGGAATTG GTGGAAGCTA TGTATGGCAA ACTCAGCAAT 
CAGGAAAGGG TCACACTGTT AGACATCATG ATAGCCAAGA TCGTGGGTGA CGAGCAGTTG 
ACAAAGGATG ACATCTCTAT ATTTTTGCGC CATGCTGAGT TGATTGCAAA CTCATTCGTG 
GATCAGTGTC GGAATGTGCT GAAGTTGACC TCAGAACCTC AGACGGAGGA CAAGGAAGCA 
CTGGTTACGA TTCGGCTCCT GGATGTCTTG TGTGAAATGA CGTCCAACAC TGAGCTGCTC 
GGCTACCTGC AGGTTTTTCC TGGCCTGATG GAACGCGTGA TTGATGTTTT ACGAGTGATT 
CATTCAGTTG GAAAAGATAG CACGAACATC TTCAGTCCCT CCGACTCTCT AAAAGCAGAG 
GGTGATATCG AACACATGAC TGAAGGGTTT AAGTCTCACC TCATCCGTCT GATTGGAAAT 
CTGTGCTACA AGAATAAAGA AAACCAAGAC AAAGTGAATG AGCTGGATGG CATTCCTCTG 
ATCCTGGACA GCAGCAACAT CGATGACAAC AACCCCTTTA TGATGCAGTG GGTGGTGTAT 
GCCGTGCGAA ATCTCACTGA AGACAACAGC CAAAACCAAG ATTTCATTGC CAAGATGGAG 
GAGCAGGGGT TGGCAGATGC GTCCCTACTG AAGAAGATGG GCTTTGAGGT TGAGAAGAGT 
GGGGACAAAC TGATTCTGAA GTCCAATAAT GACATCCCCC CACCTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_579847.1
CDS	92..1519
Translation	MAAPRMPPSRLSGIMVPAPIQDLEALRALTALFKEQRNRETAPRTIFQRVLDILKKSTQAVELACRDPSQVEHLASSLQLITECFRCLRNACIECSVNQNSIRNLDTIGVAVDLVLLFRELRVEQDSLLTAFRCGLQFLGNVASRNEDSQSIVWVHAFPELFMSCLNHPDKKIVAYCSMILFTSLNSERMKDLEENLNIAINVIEAHQKHPESEWPFLIITDHFLKSPELVEAMYGKLSNQERVTLLDIMIAKIVGDEQLTKDDISIFLRHAELIANSFVDQCRNVLKLTSEPQTEDKEALVTIRLLDVLCEMTSNTELLGYLQVFPGLMERVIDVLRVIHSVGKDSTNIFSPSDSLKAEGDIEHMTEGFKSHLIRLIGNLCYKNKENQDKVNELDGIPLILDSSNIDDNNPFMMQWVVYAVRNLTEDNSQNQDFIAKMEEQGLADASLLKKMGFEVEKSGDKLILKSNNDIPPP

Target ORF information:

RefSeq Version	NM_133313.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus ataxin 10 (Atxn10), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_133313.2

ORF Insert Sequence:

ATGGCGGCGC CCAGGATGCC ACCCTCCCGG CTGTCGGGCA TCATGGTGCC AGCACCTATC 
CAGGACCTGG AGGCCCTGCG CGCGCTCACG GCGCTCTTCA AGGAGCAGCG TAACCGGGAA 
ACAGCACCCA GAACGATCTT CCAGAGAGTC CTGGATATCT TAAAGAAATC CACTCAGGCT 
GTTGAGCTGG CCTGCAGAGA TCCCTCCCAA GTGGAGCACC TGGCTTCCAG TCTTCAGCTG 
ATCACCGAGT GCTTCAGATG CCTTCGTAAT GCTTGTATAG AGTGTTCTGT GAACCAGAAT 
TCAATCAGGA ACCTGGATAC CATTGGAGTT GCCGTTGATT TGGTTCTTCT CTTTCGTGAA 
CTTCGGGTGG AACAAGACTC TTTGTTGACA GCTTTCCGCT GTGGCCTGCA GTTTTTAGGC 
AACGTTGCCT CACGGAATGA AGATTCCCAG TCCATTGTTT GGGTCCACGC CTTCCCAGAA 
CTCTTCATGT CTTGCTTAAA TCATCCAGAC AAAAAGATTG TTGCCTACTG TTCCATGATT 
CTGTTCACAT CTCTTAATTC TGAAAGGATG AAGGACCTGG AAGAGAACCT CAATATTGCA 
ATTAACGTCA TAGAAGCTCA CCAAAAGCAC CCAGAGTCAG AGTGGCCGTT CTTGATCATT 
ACAGACCACT TTCTGAAAAG CCCGGAATTG GTGGAAGCTA TGTATGGCAA ACTCAGCAAT 
CAGGAAAGGG TCACACTGTT AGACATCATG ATAGCCAAGA TCGTGGGTGA CGAGCAGTTG 
ACAAAGGATG ACATCTCTAT ATTTTTGCGC CATGCTGAGT TGATTGCAAA CTCATTCGTG 
GATCAGTGTC GGAATGTGCT GAAGTTGACC TCAGAACCTC AGACGGAGGA CAAGGAAGCA 
CTGGTTACGA TTCGGCTCCT GGATGTCTTG TGTGAAATGA CGTCCAACAC TGAGCTGCTC 
GGCTACCTGC AGGTTTTTCC TGGCCTGATG GAACGCGTGA TTGATGTTTT ACGAGTGATT 
CATTCAGTTG GAAAAGATAG CACGAACATC TTCAGTCCCT CCGACTCTCT AAAAGCAGAG 
GGTGATATCG AACACATGAC TGAAGGGTTT AAGTCTCACC TCATCCGTCT GATTGGAAAT 
CTGTGCTACA AGAATAAAGA AAACCAAGAC AAAGTGAATG AGCTGGATGG CATTCCTCTG 
ATCCTGGACA GCAGCAACAT CGATGACAAC AACCCCTTTA TGATGCAGTG GGTGGTGTAT 
GCCGTGCGAA ATCTCACTGA AGACAACAGC CAAAACCAAG ATTTCATTGC CAAGATGGAG 
GAGCAGGGGT TGGCAGATGC GTCCCTACTG AAGAAGATGG GCTTTGAGGT TGAGAAGAGT 
GGGGACAAAC TGATTCTGAA GTCCAATAAT GACATCCCCC CACCTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma na?ve to therapy.
Molecular bioSystems9(6)1108-16(2013 Jun)
Pieragostino D,Agnifili L,Fasanella V,D'Aguanno S,Mastropasqua R,Di Ilio C,Sacchetta P,Urbani A,Del Boccio P

Changes in Ataxin-10 expression after sciatic nerve crush in adult rats.
Neurochemical research38(5)1013-21(2013 May)
Cheng X,Gan L,Zhao J,Chen M,Liu Y,Wang Y

Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways.
Cell145(4)513-28(2011 May)
Sang L,Miller JJ,Corbit KC,Giles RH,Brauer MJ,Otto EA,Baye LM,Wen X,Scales SJ,Kwong M,Huntzicker EG,Sfakianos MK,Sandoval W,Bazan JF,Kulkarni P,Garcia-Gonzalo FR,Seol AD,O'Toole JF,Held S,Reutter HM,Lane WS,Rafiq MA,Noor A,Ansar M,Devi AR,Sheffield VC,Slusarski DC,Vincent JB,Doherty DA,Hildebrandt F,Reiter JF,Jackson PK

Defining the membrane proteome of NK cells.
Journal of mass spectrometry : JMS45(1)1-25(2010 Jan)
Ghosh D,Lippert D,Krokhin O,Cortens JP,Wilkins JA

Ataxin-10 interacts with O-linked beta-N-acetylglucosamine transferase in the brain.
The Journal of biological chemistry281(29)20263-70(2006 Jul)
M?rz P,Stetefeld J,Bendfeldt K,Nitsch C,Reinstein J,Shoeman RL,Dimitriades-Schmutz B,Schwager M,Leiser D,Ozcan S,Otten U,Ozbek S

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Atxn10 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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