Fabp5 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Fabp5
Entrez Gene ID	140868
Full Name	fatty acid binding protein 5
Synonyms	C-FABP,DA11,E-FABP
General protein information	Preferred Names fatty acid binding protein 5 Names fatty acid-binding protein, epidermal cutaneous fatty acid-binding protein epidermal-type fatty acid-binding protein fatty acid binding protein 5, epidermal
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 2 Map Location: 2q23
Summary	binds long chain fatty acids [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_145878.1	NP_665885.1	fatty acid-binding protein 5

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Fabp5	NP_034764.1
Rattus norvegicus (Norway rat)	Fabp5	NP_665885.1
Homo sapiens (human)	FABP5	NP_001435.1
	FABP5	XP_001091773.1
Pan troglodytes (chimpanzee)	FABP5	XP_003311829.1
Bos taurus (cattle)	FABP5	NP_776740.1
Gallus gallus (chicken)	FABP5	NP_001006346.1
Canis lupus familiaris (dog)	FABP5	XP_535112.4
Canis lupus familiaris (dog)	LOC102155424	XP_005642139.1

Gene Ontology
Bibliography

Related articles in PubMed

Structural basis for ligand regulation of the fatty acid-binding protein 5, peroxisome proliferator-activated receptor ?/? (FABP5-PPAR?/?) signaling pathway.
Armstrong EH, Goswami D, Griffin PR, Noy N, Ortlund EA
The Journal of biological chemistry289(21)14941-54(2014 May)

Fatty acid binding protein 4 and 5 play a crucial role in thermogenesis under the conditions of fasting and cold stress.
Syamsunarno MR, Iso T, Yamaguchi A, Hanaoka H, Putri M, Obokata M, Sunaga H, Koitabashi N, Matsui H, Maeda K, Endo K, Tsushima Y, Yokoyama T, Kurabayashi M
PloS one9(6)e90825(2014)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

FABP5 is upregulated in alveolar macrophages during severe inflammation.
Title: Increased expression of epidermal fatty acid-binding protein by alveolar macrophages during acute rejection of rat lungs.

We postulate that a differential regulation of proteasomal function, as demonstrated for TGF-beta 1, can result in an enrichment of proteins, such as EFABP, that mediate physiological functions, such as neurite regeneration.
Title: TGF-beta 1 enhances neurite outgrowth via regulation of proteasome function and EFABP.

A complex interrelationship between glucose and fatty acids in the control of FABP gene expression; FABP3 and 5 may play a role in insulin secretion.
Title: Expression of fatty acid binding proteins 3 and 5 genes in rat pancreatic islets and INS-1E cells: regulation by fatty acids and glucose.

These findings are consistent with the scenario that neurite extension of differentiating PC12 cells, including further stimulation by DHA and EPA, requires sufficient cellular levels of E-FABP.
Title: Expression of E-FABP in PC12 cells increases neurite extension during differentiation: involvement of n-3 and n-6 fatty acids.

C-FABP may play a significant role in regulating adipocyte function in response to changes in nutritional conditions.
Title: Modulation of cutaneous fatty acid-binding protein mRNA expression in rat adipose tissues by hereditary obesity and dietary fats.

The following Fabp5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Fabp5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa02767	NM_145878.1 Latest version!	Rattus norvegicus fatty acid binding protein 5 (Fabp5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Fabp5 ( NM_145878.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_665885.1 Rattus norvegicus fatty acid binding protein 5 (Fabp5), mRNA.

Price & Availability↑

CloneID	ORa02767
Clone ID Related Accession (Same CDS sequence)	NM_145878.1
Accession Version	NM_145878.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 408bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	fatty acid-binding protein 5
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U13253.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U13253.1, FQ210725.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052297, SAMN01906347 [ECO:0000348] ##Evidence-Data-END##

ATGGCCAGCC TTAAGGACCT GGAAGGGAAG TGGCGTCTGG TGGAAAGCCA CGGGTTTGAG 
GACTACATGA AGGAACTAGG AGTAGGGCTG GCTCTTAGGA AGATGGGTGC CATGGCCAAA 
CCAGACTGCA TCATTACCCT CGACAACAAC AACCTCACCG TCAAAACTGA GAGCACAGTG 
AAGACGACCG TGTTTTCTTG CACCTTGGGA GAGAAGTTTG ATGAAACCAC AGCTGATGGC 
AGGAAAACTG AGACGGTCTG CACCTTCACA GACGGTGCCC TGGTCCAGCA CCAGAAGTGG 
GAAGGGAAAG AAAGCACGAT AACGAGAAAA CTGAAGGACG GGAAGATGGT GGTGGAGTGC 
GTCATGAACA ATGCCATCTG TACTCGGGTC TATGAGAAGG TACAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_665885.1
CDS	42..449
Translation	MASLKDLEGKWRLVESHGFEDYMKELGVGLALRKMGAMAKPDCIITLDNNNLTVKTESTVKTTVFSCTLGEKFDETTADGRKTETVCTFTDGALVQHQKWEGKESTITRKLKDGKMVVECVMNNAICTRVYEKVQ

Target ORF information:

RefSeq Version	NM_145878.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus fatty acid binding protein 5 (Fabp5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_145878.1

ORF Insert Sequence:

ATGGCCAGCC TTAAGGACCT GGAAGGGAAG TGGCGTCTGG TGGAAAGCCA CGGGTTTGAG 
GACTACATGA AGGAACTAGG AGTAGGGCTG GCTCTTAGGA AGATGGGTGC CATGGCCAAA 
CCAGACTGCA TCATTACCCT CGACAACAAC AACCTCACCG TCAAAACTGA GAGCACAGTG 
AAGACGACCG TGTTTTCTTG CACCTTGGGA GAGAAGTTTG ATGAAACCAC AGCTGATGGC 
AGGAAAACTG AGACGGTCTG CACCTTCACA GACGGTGCCC TGGTCCAGCA CCAGAAGTGG 
GAAGGGAAAG AAAGCACGAT AACGAGAAAA CTGAAGGACG GGAAGATGGT GGTGGAGTGC 
GTCATGAACA ATGCCATCTG TACTCGGGTC TATGAGAAGG TACAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Structural basis for ligand regulation of the fatty acid-binding protein 5, peroxisome proliferator-activated receptor ?/? (FABP5-PPAR?/?) signaling pathway.
The Journal of biological chemistry289(21)14941-54(2014 May)
Armstrong EH,Goswami D,Griffin PR,Noy N,Ortlund EA

Fatty acid binding protein 4 and 5 play a crucial role in thermogenesis under the conditions of fasting and cold stress.
PloS one9(6)e90825(2014)
Syamsunarno MR,Iso T,Yamaguchi A,Hanaoka H,Putri M,Obokata M,Sunaga H,Koitabashi N,Matsui H,Maeda K,Endo K,Tsushima Y,Yokoyama T,Kurabayashi M

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Fabp5 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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