Brinp1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Brinp1
Entrez Gene ID	140610
Full Name	BMP/retinoic acid inducible neural specific 1
Synonyms	Dbc1,Dbccr1
General protein information	Preferred Names BMP/retinoic acid inducible neural specific 1 Names BMP/retinoic acid-inducible neural-specific protein 1 bone morphogenetic protein/retinoic acid inducible neural-specific 1 bone morphogenic protein/retinoic acid inducible neural-specific 1 deleted in bladder cancer 1 deleted in bladder cancer chromosome region candidate 1 deleted in bladder cancer protein 1 homolog
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 5 Map Location: 5q24
Summary	human homolog involved in mediating cell death in cultured bladder tumor cells [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_080482.2	NP_536730.1	BMP/retinoic acid-inducible neural-specific protein 1 precursor
XM_006238272.3	XP_006238334.1	BMP/retinoic acid-inducible neural-specific protein 1 isoform X1

Pathways from BioSystems

Homologies

Homo sapiens (human)	BRINP1	NP_055433.2
Bos taurus (cattle)	BRINP1	NP_001015669.1
	DBC1	XP_002800043.1
Danio rerio (zebrafish)	LOC100334375	XP_002662264.3
Mus musculus (house mouse)	Brinp1	NP_064351.2
Xenopus tropicalis (tropical clawed frog)	dbc1	XP_002935252.2
Pan troglodytes (chimpanzee)	DBC1	XP_520219.2
Canis lupus familiaris (dog)	BRINP1	XP_538815.2
Rattus norvegicus (Norway rat)	Brinp1	NP_536730.1
Gallus gallus (chicken)	BRINP1	NP_989780.1

Gene Ontology
Bibliography

Related articles in PubMed

Brinp1(-/-) mice exhibit autism-like behaviour, altered memory, hyperactivity and increased parvalbumin-positive cortical interneuron density.
Berkowicz SR, Featherby TJ, Qu Z, Giousoh A, Borg NA, Heng JI, Whisstock JC, Bird PI
Molecular autism722(2016)

Absence of BRINP1 in mice causes increase of hippocampal neurogenesis and behavioral alterations relevant to human psychiatric disorders.
Kobayashi M, Nakatani T, Koda T, Matsumoto K, Ozaki R, Mochida N, Takao K, Miyakawa T, Matsuoka I
Molecular brain712(2014 Feb)

Astrogliosis involves activation of retinoic acid-inducible gene-like signaling in the innate immune response after spinal cord injury.
de Rivero Vaccari JP, Minkiewicz J, Wang X, De Rivero Vaccari JC, German R, Marcillo AE, Dietrich WD, Keane RW
Glia60(3)414-21(2012 Mar)

Analysis of the expression and function of BRINP family genes during neuronal differentiation in mouse embryonic stem cell-derived neural stem cells.
Terashima M, Kobayashi M, Motomiya M, Inoue N, Yoshida T, Okano H, Iwasaki N, Minami A, Matsuoka I
Journal of neuroscience research88(7)1387-93(2010 May)

Identification and characterization of novel developmentally regulated neural-specific proteins, BRINP family.
Kawano H, Nakatani T, Mori T, Ueno S, Fukaya M, Abe A, Kobayashi M, Toda F, Watanabe M, Matsuoka I
Brain research. Molecular brain research125(1-2)60-75(2004 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The findings of this study identify a role for RLR signaling and type I IFN in regulating astrocyte innate immune responses after SCI. (c) 2011 Wiley Periodicals, Inc.
Title: Astrogliosis involves activation of retinoic acid-inducible gene-like signaling in the innate immune response after spinal cord injury.

The following Brinp1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Brinp1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa11797	NM_080482.2 Latest version!	Rattus norvegicus BMP/retinoic acid inducible neural specific 1 (Brinp1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00
ORa28238	XM_006238272.3 Latest version!	Rattus norvegicus BMP/retinoic acid inducible neural specific 1 (Brinp1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Brinp1 ( NM_080482.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_536730.1 Rattus norvegicus BMP/retinoic acid inducible neural specific 1 (Brinp1), mRNA.

Price & Availability↑

CloneID	ORa11797
Clone ID Related Accession (Same CDS sequence)	NM_080482.2
Accession Version	NM_080482.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2283bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Rattus norvegicus(Norway rat)
Product	BMP/retinoic acid-inducible neural-specific protein 1 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB051356.1. On Aug 31, 2012 this sequence version replaced NM_080482.1. ##Evidence-Data-START## Transcript exon combination :: AB051356.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGAACTGGA GGTTTGTTGA GCTCCTCTAC TTCCTGTTTG TATGGGGCCG TATCTCAGTG 
CAGCCCTCCC ACCAGGAGCC AGCTGGGACA GACCAACATG TCTCCAAGGA ATTTGATTGG 
CTTATTTCAG ACAGGGGGCC TTTCCACCAC TCCAGGAGCT ACCTATCCTT TGTGGAAAGA 
CACCGGCAAG GATTTACAAC CAGATATAAA ATATACAGGG AGTTTGCCCG TTGGAAGGTG 
AGGAACACAG CCATAGAAAG GAGAGATCTG GTCCGTCATC CAGTGCCCCT CATGCCGGAG 
TTTCAAAGGA GCATTCGTCT GCTTGGCAGG AGACCCACCA CCCAGCAGTT CATTGATACC 
ATCATCAAAA AGTACGGCAC ACACCTGCTC ATCTCTGCTA CATTGGGAGG AGAGGAGGCT 
TTGACCATGT ACATGGACAA AAGTCGCCTC GACCGGAAGT CAGGAAATGC TACCCAAAGT 
GTTGAAGCTT TGCACCAGCT TGCATCATCC TACTTTGTCG ACCGTGATGG CACCATGAGA 
AGGCTCCATG AGATCCAGAT TTCAACTGGA GCAATCAAGG TCACAGAGAC ACGCACTGGG 
CTTCTGGGCT GTAACAGCTA TGACAATCTG GACTCTGTGA GTTCTGTCCT TCTGCAAAGC 
ACGGAGAGCA AACTGCACCT TCAAGGTCTA CAGATAATCT TCCCGCAGTA TCTGCAAGAG 
AAGTTTGTAC AGTCAGCCTT GAGTTACATC ATGTGCAATG GCGAGGGAGA GTATGTCTGT 
CAGAACAGCC AGTGTCGCTG CCAGTGTGCT GAGGAGTTCC CACAGTGCAA CTGCCCTATC 
ACCGACATCC AGATCATGGA ATTTACACTG GCTAACATGG CCAAGGCCTG GACTGAAGCT 
TATAAGGACC TGGAGAATTC AGATGAGTTC AAGTCATTTA TGAAGCGTCT CCCAAGCAAC 
CACTTCCTGA CCATTGGCAG CATCCACCAG CACTGGGGCA ATGACTGGGA CCTGCAGAGC 
CGTTACAAGC TCCTACAGAG TGCCACTGAG GCTCAGAGGC AGAAAATCCA GAGGACCGCC 
CGCAAGCTCT TTGGCCTCAG TGTGCGCTGC CGCCACAATC CCAACCACCA GCTGCCTAGA 
GAGAGGACAA TTCAACAGTG GCTTGCAAGG GTCCAGTCAC TTCTCTATTG CAATGAGAAT 
GGGTTCTGGG GAACCTTCCT GGAAAGCCAG AGGAGTTGTG TGTGCCATGG TAGCACCACA 
CTGTGCCAGC GCCCTATCCC ATGTATCATA GGTGGGAACA ACAGCTGTGC CATGTGCAGC 
CTGGCCAACA TCTCACTCTG TGGCTCCTGC AATAAGGGCT ACAAGCTGTA TAGAGGCCGC 
TGTGAACCAC AAAACGTGGA CTCTGAGCGG AGTGAGCAGT TCATCAGCTT TGAGACCGAC 
CTGGACTTCC AGGACTTGGA ACTGAAGTAC CTGTTGCAGA AGATGGATTC ACGCCTCTAT 
GTCCACACTA CCTTCATCAG CAATGAGATT CGCCTGGATA CGTTCTTTGA CCTTCGGTGG 
CGCAAGCGCA TGTCCCTCAC TCTCAAGAGC AACAAGAACC GCATGGACTT TATCCATATG 
GTGATCGGCA TGTCCATGCG AATCTGCCAG ATGCGAAACA GCAGCCTGGA CCCTATGTTC 
TTTGTCTATG TCAATCCCTT CAGTGGGAGC CATTCAGAAG GCTGGAACAT GCCCTTTGGG 
GAATTTGGCT ACCCACGTTG GGAGAAGATC CGTCTGCAAA ACAGCCAATG CTACAACTGG 
ACTCTCTTGT TGGGCAATCG GTGGAAAACT TTTTTCGAGA CTGTCCATAT CTACCTACGT 
AGTCGGACTC GGCTACCCAC CCTACGCAAT GAGACTGGCC AGGGCCCCGT GGACCTGTCA 
GATCCCTCCA AAAGGCAATT CTACATCAAG ATCTCCGATG TGCAGGTGTT CGGGTATAGC 
CTGAGGTTCA ATGCTGACCT CTTACGAAGT GCCGTGCAAC AGGTTAATCA ATCCTATACA 
CAGGGTGGCC AGTTCTATTC CTCCTCATCC GTGATGCTTC TCATGTTGGA CATTCGGGAC 
CGAATTAACC GCCTGGCCCC TCCTGTGGCC CCAGGAAAAC CCCAGCTGGA CTTGTTTTCC 
TGTATGCTGA AGCACCGCCT GAAGCTGACC AACAGTGAGA TTATCAGGGT GAATCATGCC 
TTGGACCTCT ACAACACTGA GATCCTCAAA CAGTCTGACC AGATGACAGC CAAACTCTGC 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_536730.1
CDS	57..2339
Translation	MNWRFVELLYFLFVWGRISVQPSHQEPAGTDQHVSKEFDWLISDRGPFHHSRSYLSFVERHRQGFTTRYKIYREFARWKVRNTAIERRDLVRHPVPLMPEFQRSIRLLGRRPTTQQFIDTIIKKYGTHLLISATLGGEEALTMYMDKSRLDRKSGNATQSVEALHQLASSYFVDRDGTMRRLHEIQISTGAIKVTETRTGLLGCNSYDNLDSVSSVLLQSTESKLHLQGLQIIFPQYLQEKFVQSALSYIMCNGEGEYVCQNSQCRCQCAEEFPQCNCPITDIQIMEFTLANMAKAWTEAYKDLENSDEFKSFMKRLPSNHFLTIGSIHQHWGNDWDLQSRYKLLQSATEAQRQKIQRTARKLFGLSVRCRHNPNHQLPRERTIQQWLARVQSLLYCNENGFWGTFLESQRSCVCHGSTTLCQRPIPCIIGGNNSCAMCSLANISLCGSCNKGYKLYRGRCEPQNVDSERSEQFISFETDLDFQDLELKYLLQKMDSRLYVHTTFISNEIRLDTFFDLRWRKRMSLTLKSNKNRMDFIHMVIGMSMRICQMRNSSLDPMFFVYVNPFSGSHSEGWNMPFGEFGYPRWEKIRLQNSQCYNWTLLLGNRWKTFFETVHIYLRSRTRLPTLRNETGQGPVDLSDPSKRQFYIKISDVQVFGYSLRFNADLLRSAVQQVNQSYTQGGQFYSSSSVMLLMLDIRDRINRLAPPVAPGKPQLDLFSCMLKHRLKLTNSEIIRVNHALDLYNTEILKQSDQMTAKLC

Target ORF information:

RefSeq Version	NM_080482.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus BMP/retinoic acid inducible neural specific 1 (Brinp1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_080482.2

ORF Insert Sequence:

ATGAACTGGA GGTTTGTTGA GCTCCTCTAC TTCCTGTTTG TATGGGGCCG TATCTCAGTG 
CAGCCCTCCC ACCAGGAGCC AGCTGGGACA GACCAACATG TCTCCAAGGA ATTTGATTGG 
CTTATTTCAG ACAGGGGGCC TTTCCACCAC TCCAGGAGCT ACCTATCCTT TGTGGAAAGA 
CACCGGCAAG GATTTACAAC CAGATATAAA ATATACAGGG AGTTTGCCCG TTGGAAGGTG 
AGGAACACAG CCATAGAAAG GAGAGATCTG GTCCGTCATC CAGTGCCCCT CATGCCGGAG 
TTTCAAAGGA GCATTCGTCT GCTTGGCAGG AGACCCACCA CCCAGCAGTT CATTGATACC 
ATCATCAAAA AGTACGGCAC ACACCTGCTC ATCTCTGCTA CATTGGGAGG AGAGGAGGCT 
TTGACCATGT ACATGGACAA AAGTCGCCTC GACCGGAAGT CAGGAAATGC TACCCAAAGT 
GTTGAAGCTT TGCACCAGCT TGCATCATCC TACTTTGTCG ACCGTGATGG CACCATGAGA 
AGGCTCCATG AGATCCAGAT TTCAACTGGA GCAATCAAGG TCACAGAGAC ACGCACTGGG 
CTTCTGGGCT GTAACAGCTA TGACAATCTG GACTCTGTGA GTTCTGTCCT TCTGCAAAGC 
ACGGAGAGCA AACTGCACCT TCAAGGTCTA CAGATAATCT TCCCGCAGTA TCTGCAAGAG 
AAGTTTGTAC AGTCAGCCTT GAGTTACATC ATGTGCAATG GCGAGGGAGA GTATGTCTGT 
CAGAACAGCC AGTGTCGCTG CCAGTGTGCT GAGGAGTTCC CACAGTGCAA CTGCCCTATC 
ACCGACATCC AGATCATGGA ATTTACACTG GCTAACATGG CCAAGGCCTG GACTGAAGCT 
TATAAGGACC TGGAGAATTC AGATGAGTTC AAGTCATTTA TGAAGCGTCT CCCAAGCAAC 
CACTTCCTGA CCATTGGCAG CATCCACCAG CACTGGGGCA ATGACTGGGA CCTGCAGAGC 
CGTTACAAGC TCCTACAGAG TGCCACTGAG GCTCAGAGGC AGAAAATCCA GAGGACCGCC 
CGCAAGCTCT TTGGCCTCAG TGTGCGCTGC CGCCACAATC CCAACCACCA GCTGCCTAGA 
GAGAGGACAA TTCAACAGTG GCTTGCAAGG GTCCAGTCAC TTCTCTATTG CAATGAGAAT 
GGGTTCTGGG GAACCTTCCT GGAAAGCCAG AGGAGTTGTG TGTGCCATGG TAGCACCACA 
CTGTGCCAGC GCCCTATCCC ATGTATCATA GGTGGGAACA ACAGCTGTGC CATGTGCAGC 
CTGGCCAACA TCTCACTCTG TGGCTCCTGC AATAAGGGCT ACAAGCTGTA TAGAGGCCGC 
TGTGAACCAC AAAACGTGGA CTCTGAGCGG AGTGAGCAGT TCATCAGCTT TGAGACCGAC 
CTGGACTTCC AGGACTTGGA ACTGAAGTAC CTGTTGCAGA AGATGGATTC ACGCCTCTAT 
GTCCACACTA CCTTCATCAG CAATGAGATT CGCCTGGATA CGTTCTTTGA CCTTCGGTGG 
CGCAAGCGCA TGTCCCTCAC TCTCAAGAGC AACAAGAACC GCATGGACTT TATCCATATG 
GTGATCGGCA TGTCCATGCG AATCTGCCAG ATGCGAAACA GCAGCCTGGA CCCTATGTTC 
TTTGTCTATG TCAATCCCTT CAGTGGGAGC CATTCAGAAG GCTGGAACAT GCCCTTTGGG 
GAATTTGGCT ACCCACGTTG GGAGAAGATC CGTCTGCAAA ACAGCCAATG CTACAACTGG 
ACTCTCTTGT TGGGCAATCG GTGGAAAACT TTTTTCGAGA CTGTCCATAT CTACCTACGT 
AGTCGGACTC GGCTACCCAC CCTACGCAAT GAGACTGGCC AGGGCCCCGT GGACCTGTCA 
GATCCCTCCA AAAGGCAATT CTACATCAAG ATCTCCGATG TGCAGGTGTT CGGGTATAGC 
CTGAGGTTCA ATGCTGACCT CTTACGAAGT GCCGTGCAAC AGGTTAATCA ATCCTATACA 
CAGGGTGGCC AGTTCTATTC CTCCTCATCC GTGATGCTTC TCATGTTGGA CATTCGGGAC 
CGAATTAACC GCCTGGCCCC TCCTGTGGCC CCAGGAAAAC CCCAGCTGGA CTTGTTTTCC 
TGTATGCTGA AGCACCGCCT GAAGCTGACC AACAGTGAGA TTATCAGGGT GAATCATGCC 
TTGGACCTCT ACAACACTGA GATCCTCAAA CAGTCTGACC AGATGACAGC CAAACTCTGC 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Brinp1 ( XM_006238272.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006238334.1 Rattus norvegicus BMP/retinoic acid inducible neural specific 1 (Brinp1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa28238
Clone ID Related Accession (Same CDS sequence)	XM_006238272.3
Accession Version	XM_006238272.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2283bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	BMP/retinoic acid-inducible neural-specific protein 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005104.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006238272.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAACTGGA GGTTTGTTGA GCTCCTCTAC TTCCTGTTTG TATGGGGCCG TATCTCAGTG 
CAGCCCTCCC ACCAGGAGCC AGCTGGGACA GACCAACATG TCTCCAAGGA ATTTGATTGG 
CTTATTTCAG ACAGGGGGCC TTTCCACCAC TCCAGGAGCT ACCTATCCTT TGTGGAAAGA 
CACCGGCAAG GATTTACAAC CAGATATAAA ATATACAGGG AGTTTGCCCG TTGGAAGGTG 
AGGAACACAG CCATAGAAAG GAGAGATCTG GTCCGTCATC CAGTGCCCCT CATGCCGGAG 
TTTCAAAGGA GCATTCGTCT GCTTGGCAGG AGACCCACCA CCCAGCAGTT CATTGATACC 
ATCATCAAAA AGTACGGCAC ACACCTGCTC ATCTCTGCTA CATTGGGAGG AGAGGAGGCT 
TTGACCATGT ACATGGACAA AAGTCGCCTC GACCGGAAGT CAGGAAATGC TACCCAAAGT 
GTTGAAGCTT TGCACCAGCT TGCATCATCC TACTTTGTCG ACCGTGATGG CACCATGAGA 
AGGCTCCATG AGATCCAGAT TTCAACTGGA GCAATCAAGG TCACAGAGAC ACGCACTGGG 
CCTCTGGGCT GTAACAGCTA TGACAATCTG GACTCTGTGA GTTCTGTCCT TCTGCAAAGC 
ACGGAGAGCA AACTGCACCT TCAAGGTCTA CAGATAATCT TCCCGCAGTA TCTGCAAGAG 
AAGTTTGTAC AGTCAGCCTT GAGTTACATC ATGTGCAATG GCGAGGGAGA GTATGTCTGT 
CAGAACAGCC AGTGTCGCTG CCAGTGTGCT GAGGAGTTCC CACAGTGCAA CTGCCCTATC 
ACCGACATCC AGATCATGGA ATTTACACTG GCTAACATGG CCAAGGCCTG GACTGAAGCT 
TATAAGGACC TGGAGAATTC AGATGAGTTC AAGTCATTTA TGAAGCGTCT CCCAAGCAAC 
CACTTCCTGA CCATTGGCAG CATCCACCAG CACTGGGGCA ATGACTGGGA CCTGCAGAGC 
CGTTACAAGC TTCTGCAGAG TGCCACTGAG GCTCAAAGGC AGAAAATCCA GCGTACTGCC 
CGCAAGCTCT TTGGCCTCAG TGTGCGCTGT CGTCACAATC CCAACCACCA GCTGCCTAGA 
GAGAGGACAA TTCAGCAGTG GCTTGCAAGG GTCCAGTCAC TTCTCTACTG CAATGAGAAT 
GGGTTCTGGG GAACCTTCCT GGAAAGCCAG AGGAGTTGTG TGTGCCATGG TAGCACCACA 
CTGTGTCAGC GCCCTATCCC ATGCATCATA GGTGGGAACA ACAGCTGTGC CATGTGCAGC 
CTGGCCAACA TCTCACTCTG TGGCTCCTGC AATAAGGGCT ACAAGCTGTA TAGAGGCCGC 
TGTGAACCAC AAAACGTGGA CTCTGAGCGG AGTGAGCAGT TCATCAGCTT TGAGACCGAC 
CTGGACTTCC AGGACTTGGA ACTGAAGTAC CTGTTGCAGA AGATGGATTC ACGCCTCTAT 
GTCCACACTA CCTTCATCAG CAATGAGATT CGCCTGGATA CGTTCTTTGA CCCTCGGTGG 
CGCAAGCGCA TGTCCCTCAC TCTCAAGAGC AACAAGAACC GCATGGACTT TATCCATATG 
GTGATCGGCA TGTCCATGCG AATCTGCCAG ATGCGAAACA GCAGCCTGGA CCCTATGTTC 
TTTGTCTATG TCAATCCCTT CAGTGGGAGC CATTCAGAAG GCTGGAACAT GCCCTTTGGG 
GAATTTGGCT ACCCACGTTG GGAGAAGATC CGTCTGCAAA ACAGCCAATG CTACAACTGG 
ACTCTCTTGT TGGGCAATCG GTGGAAAACT TTTTTCGAGA CTGTCCATAT CTACCTACGT 
AGTCGGACTC GGCTACCCAC CCTACGCAAT GAGACTGGCC AGGGCCCCGT GGACCTGTCA 
GATCCCTCCA AAAGGCAATT CTACATCAAG ATCTCCGATG TGCAGGTGTT CGGGTATAGC 
CTGAGGTTCA ATGCTGACCT CTTACGAAGT GCCGTGCAAC AGGTTAATCA ATCCTATACA 
CAGGGTGGCC AGTTCTATTC CTCCTCATCC GTGATGCTTC TCATGTTGGA CATTCGGGAC 
CGAATTAACC GCCTGGCCCC TCCTGTGGCC CCAGGAAAAC CCCAGCTGGA CTTGTTTTCC 
TGTATGCTGA AGCACCGCCT GAAGCTGACC AACAGTGAGA TTATCAGGGT GAATCATGCC 
TTGGACCTCT ACAACACTGA GATCCTCAAA CAGTCTGACC AGATGACAGC CAAACTCTGC 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006238334.1
CDS	424..2706
Translation	MNWRFVELLYFLFVWGRISVQPSHQEPAGTDQHVSKEFDWLISDRGPFHHSRSYLSFVERHRQGFTTRYKIYREFARWKVRNTAIERRDLVRHPVPLMPEFQRSIRLLGRRPTTQQFIDTIIKKYGTHLLISATLGGEEALTMYMDKSRLDRKSGNATQSVEALHQLASSYFVDRDGTMRRLHEIQISTGAIKVTETRTGPLGCNSYDNLDSVSSVLLQSTESKLHLQGLQIIFPQYLQEKFVQSALSYIMCNGEGEYVCQNSQCRCQCAEEFPQCNCPITDIQIMEFTLANMAKAWTEAYKDLENSDEFKSFMKRLPSNHFLTIGSIHQHWGNDWDLQSRYKLLQSATEAQRQKIQRTARKLFGLSVRCRHNPNHQLPRERTIQQWLARVQSLLYCNENGFWGTFLESQRSCVCHGSTTLCQRPIPCIIGGNNSCAMCSLANISLCGSCNKGYKLYRGRCEPQNVDSERSEQFISFETDLDFQDLELKYLLQKMDSRLYVHTTFISNEIRLDTFFDPRWRKRMSLTLKSNKNRMDFIHMVIGMSMRICQMRNSSLDPMFFVYVNPFSGSHSEGWNMPFGEFGYPRWEKIRLQNSQCYNWTLLLGNRWKTFFETVHIYLRSRTRLPTLRNETGQGPVDLSDPSKRQFYIKISDVQVFGYSLRFNADLLRSAVQQVNQSYTQGGQFYSSSSVMLLMLDIRDRINRLAPPVAPGKPQLDLFSCMLKHRLKLTNSEIIRVNHALDLYNTEILKQSDQMTAKLC

Target ORF information:

RefSeq Version	XM_006238272.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus BMP/retinoic acid inducible neural specific 1 (Brinp1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006238272.3

ORF Insert Sequence:

ATGAACTGGA GGTTTGTTGA GCTCCTCTAC TTCCTGTTTG TATGGGGCCG TATCTCAGTG 
CAGCCCTCCC ACCAGGAGCC AGCTGGGACA GACCAACATG TCTCCAAGGA ATTTGATTGG 
CTTATTTCAG ACAGGGGGCC TTTCCACCAC TCCAGGAGCT ACCTATCCTT TGTGGAAAGA 
CACCGGCAAG GATTTACAAC CAGATATAAA ATATACAGGG AGTTTGCCCG TTGGAAGGTG 
AGGAACACAG CCATAGAAAG GAGAGATCTG GTCCGTCATC CAGTGCCCCT CATGCCGGAG 
TTTCAAAGGA GCATTCGTCT GCTTGGCAGG AGACCCACCA CCCAGCAGTT CATTGATACC 
ATCATCAAAA AGTACGGCAC ACACCTGCTC ATCTCTGCTA CATTGGGAGG AGAGGAGGCT 
TTGACCATGT ACATGGACAA AAGTCGCCTC GACCGGAAGT CAGGAAATGC TACCCAAAGT 
GTTGAAGCTT TGCACCAGCT TGCATCATCC TACTTTGTCG ACCGTGATGG CACCATGAGA 
AGGCTCCATG AGATCCAGAT TTCAACTGGA GCAATCAAGG TCACAGAGAC ACGCACTGGG 
CCTCTGGGCT GTAACAGCTA TGACAATCTG GACTCTGTGA GTTCTGTCCT TCTGCAAAGC 
ACGGAGAGCA AACTGCACCT TCAAGGTCTA CAGATAATCT TCCCGCAGTA TCTGCAAGAG 
AAGTTTGTAC AGTCAGCCTT GAGTTACATC ATGTGCAATG GCGAGGGAGA GTATGTCTGT 
CAGAACAGCC AGTGTCGCTG CCAGTGTGCT GAGGAGTTCC CACAGTGCAA CTGCCCTATC 
ACCGACATCC AGATCATGGA ATTTACACTG GCTAACATGG CCAAGGCCTG GACTGAAGCT 
TATAAGGACC TGGAGAATTC AGATGAGTTC AAGTCATTTA TGAAGCGTCT CCCAAGCAAC 
CACTTCCTGA CCATTGGCAG CATCCACCAG CACTGGGGCA ATGACTGGGA CCTGCAGAGC 
CGTTACAAGC TTCTGCAGAG TGCCACTGAG GCTCAAAGGC AGAAAATCCA GCGTACTGCC 
CGCAAGCTCT TTGGCCTCAG TGTGCGCTGT CGTCACAATC CCAACCACCA GCTGCCTAGA 
GAGAGGACAA TTCAGCAGTG GCTTGCAAGG GTCCAGTCAC TTCTCTACTG CAATGAGAAT 
GGGTTCTGGG GAACCTTCCT GGAAAGCCAG AGGAGTTGTG TGTGCCATGG TAGCACCACA 
CTGTGTCAGC GCCCTATCCC ATGCATCATA GGTGGGAACA ACAGCTGTGC CATGTGCAGC 
CTGGCCAACA TCTCACTCTG TGGCTCCTGC AATAAGGGCT ACAAGCTGTA TAGAGGCCGC 
TGTGAACCAC AAAACGTGGA CTCTGAGCGG AGTGAGCAGT TCATCAGCTT TGAGACCGAC 
CTGGACTTCC AGGACTTGGA ACTGAAGTAC CTGTTGCAGA AGATGGATTC ACGCCTCTAT 
GTCCACACTA CCTTCATCAG CAATGAGATT CGCCTGGATA CGTTCTTTGA CCCTCGGTGG 
CGCAAGCGCA TGTCCCTCAC TCTCAAGAGC AACAAGAACC GCATGGACTT TATCCATATG 
GTGATCGGCA TGTCCATGCG AATCTGCCAG ATGCGAAACA GCAGCCTGGA CCCTATGTTC 
TTTGTCTATG TCAATCCCTT CAGTGGGAGC CATTCAGAAG GCTGGAACAT GCCCTTTGGG 
GAATTTGGCT ACCCACGTTG GGAGAAGATC CGTCTGCAAA ACAGCCAATG CTACAACTGG 
ACTCTCTTGT TGGGCAATCG GTGGAAAACT TTTTTCGAGA CTGTCCATAT CTACCTACGT 
AGTCGGACTC GGCTACCCAC CCTACGCAAT GAGACTGGCC AGGGCCCCGT GGACCTGTCA 
GATCCCTCCA AAAGGCAATT CTACATCAAG ATCTCCGATG TGCAGGTGTT CGGGTATAGC 
CTGAGGTTCA ATGCTGACCT CTTACGAAGT GCCGTGCAAC AGGTTAATCA ATCCTATACA 
CAGGGTGGCC AGTTCTATTC CTCCTCATCC GTGATGCTTC TCATGTTGGA CATTCGGGAC 
CGAATTAACC GCCTGGCCCC TCCTGTGGCC CCAGGAAAAC CCCAGCTGGA CTTGTTTTCC 
TGTATGCTGA AGCACCGCCT GAAGCTGACC AACAGTGAGA TTATCAGGGT GAATCATGCC 
TTGGACCTCT ACAACACTGA GATCCTCAAA CAGTCTGACC AGATGACAGC CAAACTCTGC 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Brinp1(-/-) mice exhibit autism-like behaviour, altered memory, hyperactivity and increased parvalbumin-positive cortical interneuron density.
Molecular autism722(2016)
Berkowicz SR,Featherby TJ,Qu Z,Giousoh A,Borg NA,Heng JI,Whisstock JC,Bird PI

Absence of BRINP1 in mice causes increase of hippocampal neurogenesis and behavioral alterations relevant to human psychiatric disorders.
Molecular brain712(2014 Feb)
Kobayashi M,Nakatani T,Koda T,Matsumoto K,Ozaki R,Mochida N,Takao K,Miyakawa T,Matsuoka I

Astrogliosis involves activation of retinoic acid-inducible gene-like signaling in the innate immune response after spinal cord injury.
Glia60(3)414-21(2012 Mar)
de Rivero Vaccari JP,Minkiewicz J,Wang X,De Rivero Vaccari JC,German R,Marcillo AE,Dietrich WD,Keane RW

Analysis of the expression and function of BRINP family genes during neuronal differentiation in mouse embryonic stem cell-derived neural stem cells.
Journal of neuroscience research88(7)1387-93(2010 May)
Terashima M,Kobayashi M,Motomiya M,Inoue N,Yoshida T,Okano H,Iwasaki N,Minami A,Matsuoka I

Identification and characterization of novel developmentally regulated neural-specific proteins, BRINP family.
Brain research. Molecular brain research125(1-2)60-75(2004 Jun)
Kawano H,Nakatani T,Mori T,Ueno S,Fukaya M,Abe A,Kobayashi M,Toda F,Watanabe M,Matsuoka I

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Brinp1 cDNA ORF clone, Rattus norvegicus(Norway rat)

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Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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