Sytl4 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Sytl4
Entrez Gene ID	140594
Full Name	synaptotagmin-like 4
General protein information	Preferred Names synaptotagmin-like 4 Names synaptotagmin-like protein 4 exophilin-2 granuphilin b synaptotagmin-like 4 (granuphilin-a)
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: X Map Location: Xq32
Summary	binds small GTP-binding protein Rab3 and SNARE-binding protein Munc-18; plays a role in pancreatic beta cell exocytosis; may also be involved in secretory vesicle docking [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_008773387.2	XP_008771609.1	synaptotagmin-like protein 4 isoform X2
NM_080410.1	NP_536335.1	synaptotagmin-like protein 4
XM_006257213.3	XP_006257275.1	synaptotagmin-like protein 4 isoform X1

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Sytl4	NP_536335.1
Canis lupus familiaris (dog)	SYTL4	XP_005641613.1
Mus musculus (house mouse)	Sytl4	NP_038785.1
Danio rerio (zebrafish)	LOC100535893	XP_003199981.2
Homo sapiens (human)	SYTL4	NP_001123368.1
Danio rerio (zebrafish)	sytl4	NP_001074457.1
Xenopus tropicalis (tropical clawed frog)	sytl4	XP_002940484.1
Pan troglodytes (chimpanzee)	SYTL4	XP_003317604.1
	LOC700889	XP_002808587.1
Bos taurus (cattle)	SYTL4	NP_001179362.1
Drosophila melanogaster (fruit fly)	btsz	NP_001262582.1
Gallus gallus (chicken)	SYTL4	XP_004940758.1

Gene Ontology
Bibliography

Related articles in PubMed

A Rab3a-dependent complex essential for lysosome positioning and plasma membrane repair.
Encarna??o M, Espada L, Escrevente C, Mateus D, Ramalho J, Michelet X, Santarino I, Hsu VW, Brenner MB, Barral DC, Vieira OV
The Journal of cell biology213(6)631-40(2016 06)

Rab27a and Rab27b control different steps of the exosome secretion pathway.
Ostrowski M, Carmo NB, Krumeich S, Fanget I, Raposo G, Savina A, Moita CF, Schauer K, Hume AN, Freitas RP, Goud B, Benaroch P, Hacohen N, Fukuda M, Desnos C, Seabra MC, Darchen F, Amigorena S, Moita LF, Thery C
Nature cell biology12(1)19-30; sup pp 1-13(2010 Jan)

Transcriptional co-activator peroxisome proliferator-activated receptor (PPAR)gamma co-activator-1beta is involved in the regulation of glucose-stimulated insulin secretion in INS-1E cells.
Oberkofler H, Hafner M, Felder T, Krempler F, Patsch W
Journal of molecular medicine (Berlin, Germany)87(3)299-306(2009 Mar)

The Rab27 effector Rabphilin, unlike Granuphilin and Noc2, rapidly exchanges between secretory granules and cytosol in PC12 cells.
Handley MT, Burgoyne RD
Biochemical and biophysical research communications373(2)275-81(2008 Aug)

Granuphilin is activated by SREBP-1c and involved in impaired insulin secretion in diabetic mice.
Kato T, Shimano H, Yamamoto T, Yokoo T, Endo Y, Ishikawa M, Matsuzaka T, Nakagawa Y, Kumadaki S, Yahagi N, Takahashi A, Sone H, Suzuki H, Toyoshima H, Hasty AH, Takahashi S, Gomi H, Izumi T, Yamada N
Cell metabolism4(2)143-54(2006 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Results support a role of PGC-1 in the regulation of insulin secretion via upregulation of UCP2 and granuphilin gene expression.
Title: Transcriptional co-activator peroxisome proliferator-activated receptor (PPAR)gamma co-activator-1beta is involved in the regulation of glucose-stimulated insulin secretion in INS-1E cells.

Three Rab3/27 effectors, Granuphilin, Noc2, and Rabphilin, in PC12 cells using fluorescence recovery after photobleaching of EGFP-tagged proteins.
Title: The Rab27 effector Rabphilin, unlike Granuphilin and Noc2, rapidly exchanges between secretory granules and cytosol in PC12 cells.

Slp4-a modulates amylase release from parotid acinar cells through interaction with syntaxin-2/3 on the apical plasma membrane.
Title: Slp4-a/granuphilin-a interacts with syntaxin-2/3 in a Munc18-2-dependent manner.

Sytl4 controls regulated dense-core vesicle exocytosis via binding to Rab27A
Title: Slp4-a/granuphilin-a regulates dense-core vesicle exocytosis in PC12 cells.

binds to Rab3 and Munc-19 in pancreatic beta-cells and controls exocytosis
Title: Pancreatic beta-cell protein granuphilin binds Rab3 and Munc-18 and controls exocytosis.

The following Sytl4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Sytl4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa44176	XM_008773387.2 Latest version!	Rattus norvegicus synaptotagmin-like 4 (Sytl4), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
ORa11769	NM_080410.1 Latest version!	Rattus norvegicus synaptotagmin-like 4 (Sytl4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00
ORa40080	XM_006257213.3 Latest version!	Rattus norvegicus synaptotagmin-like 4 (Sytl4), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Sytl4 ( XM_008773387.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008771609.1 Rattus norvegicus synaptotagmin-like 4 (Sytl4), transcript variant X2, mRNA.

Price & Availability↑

CloneID	ORa44176
Clone ID Related Accession (Same CDS sequence)	XM_008773387.2
Accession Version	XM_008773387.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1506bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	synaptotagmin-like protein 4 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005120.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008773387.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCGGAGA TACTAGACCT CTCTTTTCTG TCTGAGATGG AAAGAGATTT GATTCTCAGT 
GTTCTGCAGA GAGATGAAGA GCTCAGAAAA GCAGATGAGA AAAGGATTCG GCGACTGAAG 
AACGAGCTCC TGGAGATCAA ACGAAAAGGT GCCAAAAGGG GCAGCCAACA CTACAGTGAT 
CGAACCTGTG CCAGGTGCCA GGAAGGCCTG GGCCGTTTAA TTTCCAAAAG CAACACTTGT 
GTGGGTTGTA ATCATTTAGT GTGCCGAGAA TGCCGAGTTC TGGAGAGCAA TGGCTCCTGG 
AGGTGCAAGG TGTGCTCGAA GGAAATAGAG CTGAAGAAAG CAACTGGAGA TTGGTTTTAT 
GACCAGAAAG TAAATCGCTT TGCTTACAGA ACAGGCAGCG ACATCATCAG GATGTCCCTG 
CGCCGTAAGC CTGCAGTGAA TAAAAGAGAG ACAGTGGGGC AGTCCCTCCT TCAGCAGACC 
CAGATGGGTG ATATCTGGCC GGGAAGAAGG ATCATTCAGG AACAGCAGAA GGAACAAAGT 
GTGCTGTTTG AAGTGCCAAA GCTGAAGAGT GGAAAGAGCG CACTGGAGGC TGAGAGCGAG 
AGTCTGGATA GCTACACCGC TGACTCGGAC AGCACCTCCA GGAGAGATTC TCTGGATAAA 
TCTGGACTCT TCCCAGAATG GAAGAAGATG TCTGCTCCCA AATCTCAAGT TGAAAAGGAA 
ATTGCACCAG GGAACCAGAA TGCAGTGTGT GGTGATGAGG GTGACATGAT ATTTAAGAAG 
AACACTAGGA AAGTCCTGAG GCCTTCAGAA TACACTAAGT CTGTGATAGA CCTTCGTCCA 
GAAGATGTGG CCCAAGAAAG TGGCATCTTG GGAGATAGAA GCAAATCTGT ACCAGGCCTC 
AGTGTGGATA TGGAAGAGGA GGAGGAGGAG GAAGAGGACA TTGACCACCT GGTGAAGTTG 
CATCGCCAGA AACTGGCCAG AGGCAGCATG CAGAGCGGCT CCTCCATGAG TACCATTGGC 
AGCATGATGA GCCTCTATAG CGAAGCTGGT GATTTTGGGA ACGTCTCTGT GACTGGCAAA 
ATTGCCTTTT CACTGAAGTT TGAGCAGAAA ACACAGACTC TGGTCATCCA TGTCAAGGAG 
TGCCACCAGT TGGCTTATGC TGATGAAGCC AAGAAGCGTT CTAACCCATA CGTGAAGACT 
TATCTTCTGC CTGACAAGTC CCGCCAAGGA AAAAGAAAAA CCAGCATCAA GCGGGACACC 
ATCAATCCAC TATATGATGA GACCTTTCGG TATGAGATTT CGGAGTCTCT TCTGGCTCAG 
AGGACCTTGC AGTTTTCCGT TTGGCATCAT GGTCGTTTCG GTAGAAACAC CTTCCTTGGA 
GAGGCGGAGG TCCACATGGA CTCTTGGAAG CTGGATAAGA AGCTGGATCA TTGCCTCCCT 
TTACATGGAA AGGGATCAGT AGTGGCGAAG TGGTGGACTG GATGGATTCG ACTGGTGAAG 
AAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008771609.1
CDS	209..1714
Translation	MSEILDLSFLSEMERDLILSVLQRDEELRKADEKRIRRLKNELLEIKRKGAKRGSQHYSDRTCARCQEGLGRLISKSNTCVGCNHLVCRECRVLESNGSWRCKVCSKEIELKKATGDWFYDQKVNRFAYRTGSDIIRMSLRRKPAVNKRETVGQSLLQQTQMGDIWPGRRIIQEQQKEQSVLFEVPKLKSGKSALEAESESLDSYTADSDSTSRRDSLDKSGLFPEWKKMSAPKSQVEKEIAPGNQNAVCGDEGDMIFKKNTRKVLRPSEYTKSVIDLRPEDVAQESGILGDRSKSVPGLSVDMEEEEEEEEDIDHLVKLHRQKLARGSMQSGSSMSTIGSMMSLYSEAGDFGNVSVTGKIAFSLKFEQKTQTLVIHVKECHQLAYADEAKKRSNPYVKTYLLPDKSRQGKRKTSIKRDTINPLYDETFRYEISESLLAQRTLQFSVWHHGRFGRNTFLGEAEVHMDSWKLDKKLDHCLPLHGKGSVVAKWWTGWIRLVKK

Target ORF information:

RefSeq Version	XM_008773387.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus synaptotagmin-like 4 (Sytl4), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008773387.2

ORF Insert Sequence:

ATGTCGGAGA TACTAGACCT CTCTTTTCTG TCTGAGATGG AAAGAGATTT GATTCTCAGT 
GTTCTGCAGA GAGATGAAGA GCTCAGAAAA GCAGATGAGA AAAGGATTCG GCGACTGAAG 
AACGAGCTCC TGGAGATCAA ACGAAAAGGT GCCAAAAGGG GCAGCCAACA CTACAGTGAT 
CGAACCTGTG CCAGGTGCCA GGAAGGCCTG GGCCGTTTAA TTTCCAAAAG CAACACTTGT 
GTGGGTTGTA ATCATTTAGT GTGCCGAGAA TGCCGAGTTC TGGAGAGCAA TGGCTCCTGG 
AGGTGCAAGG TGTGCTCGAA GGAAATAGAG CTGAAGAAAG CAACTGGAGA TTGGTTTTAT 
GACCAGAAAG TAAATCGCTT TGCTTACAGA ACAGGCAGCG ACATCATCAG GATGTCCCTG 
CGCCGTAAGC CTGCAGTGAA TAAAAGAGAG ACAGTGGGGC AGTCCCTCCT TCAGCAGACC 
CAGATGGGTG ATATCTGGCC GGGAAGAAGG ATCATTCAGG AACAGCAGAA GGAACAAAGT 
GTGCTGTTTG AAGTGCCAAA GCTGAAGAGT GGAAAGAGCG CACTGGAGGC TGAGAGCGAG 
AGTCTGGATA GCTACACCGC TGACTCGGAC AGCACCTCCA GGAGAGATTC TCTGGATAAA 
TCTGGACTCT TCCCAGAATG GAAGAAGATG TCTGCTCCCA AATCTCAAGT TGAAAAGGAA 
ATTGCACCAG GGAACCAGAA TGCAGTGTGT GGTGATGAGG GTGACATGAT ATTTAAGAAG 
AACACTAGGA AAGTCCTGAG GCCTTCAGAA TACACTAAGT CTGTGATAGA CCTTCGTCCA 
GAAGATGTGG CCCAAGAAAG TGGCATCTTG GGAGATAGAA GCAAATCTGT ACCAGGCCTC 
AGTGTGGATA TGGAAGAGGA GGAGGAGGAG GAAGAGGACA TTGACCACCT GGTGAAGTTG 
CATCGCCAGA AACTGGCCAG AGGCAGCATG CAGAGCGGCT CCTCCATGAG TACCATTGGC 
AGCATGATGA GCCTCTATAG CGAAGCTGGT GATTTTGGGA ACGTCTCTGT GACTGGCAAA 
ATTGCCTTTT CACTGAAGTT TGAGCAGAAA ACACAGACTC TGGTCATCCA TGTCAAGGAG 
TGCCACCAGT TGGCTTATGC TGATGAAGCC AAGAAGCGTT CTAACCCATA CGTGAAGACT 
TATCTTCTGC CTGACAAGTC CCGCCAAGGA AAAAGAAAAA CCAGCATCAA GCGGGACACC 
ATCAATCCAC TATATGATGA GACCTTTCGG TATGAGATTT CGGAGTCTCT TCTGGCTCAG 
AGGACCTTGC AGTTTTCCGT TTGGCATCAT GGTCGTTTCG GTAGAAACAC CTTCCTTGGA 
GAGGCGGAGG TCCACATGGA CTCTTGGAAG CTGGATAAGA AGCTGGATCA TTGCCTCCCT 
TTACATGGAA AGGGATCAGT AGTGGCGAAG TGGTGGACTG GATGGATTCG ACTGGTGAAG 
AAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Sytl4 ( NM_080410.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_536335.1 Rattus norvegicus synaptotagmin-like 4 (Sytl4), mRNA.

Price & Availability↑

CloneID	ORa11769
Clone ID Related Accession (Same CDS sequence)	NM_080410.1
Accession Version	NM_080410.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2019bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-10
Organism	Rattus norvegicus(Norway rat)
Product	synaptotagmin-like protein 4
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF419341.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF419341.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGTCGGAGA TACTAGACCT CTCTTTTCTG TCTGAGATGG AAAGAGATTT GATTCTCAGT 
GTTCTGCAGA GAGATGAAGA GCTCAGAAAA GCAGATGAGA AAAGGATTCG GCGACTGAAG 
AACGAGCTCC TGGAGATCAA ACGAAAAGGT GCCAAAAGGG GCAGCCAACA CTACAGTGAT 
CGAACCTGTG CCAGGTGCCA GGAAGGCCTG GGCCGTTTAA TTTCCAAAAG CAACACTTGT 
GTGGGTTGTA ATCATTTAGT GTGCCGAGAA TGCCGAGTTC TGGAGAGCAA TGGCTCCTGG 
AGGTGCAAGG TGTGCTCGAA GGAAATAGAG CTGAAGAAAG CAACTGGAGA TTGGTTTTAT 
GACCAGAAAG TAAATCGCTT TGCTTACAGA ACAGGCAGCG ACATCATCAG GATGTCCCTG 
CGCCGTAAGC CTGCAGTGAA TAAAAGAGAG ACAGTGGGGC AGTCCCTCCT TCAGCAGACC 
CAGATGGGTG ATATCTGGCC GGGAAGAAGG ATCATTCAGG AACAGCAGAA GGAACAAAGT 
GTGCTGTTTG AAGTGCCAAA GCTGAAGAGT GGAAAGAGCG CACTGGAGGC TGAGAGCGAG 
AGTCTGGATA GCTACACCGC TGACTCGGAC AGCACCTCCA GGAGAGATTC TCTGGATAAA 
TCTGGACTCT TCCCAGAATG GAAGAAGATG TCTGCTCCCA AATCTCAAGT TGAAAAGGAA 
ATTGCACCAG GGAACCAGAA TGCAGTGTGT GGTGATGAGG GTGACATGAT ATTTAAGAAG 
AACACTAGGA AAGTCCTGAG GCCTTCAGAA TACACTAAGT CTGTGATAGA CCTTCGTCCA 
GAAGATGTGG CCCAAGAAAG TGGCATCTTG GGAGATAGAA GCAAATCTGT ACCAGGCCTC 
AGTGTGGATA TGGAAGACGA GGAGGAGGAG GAAGAGGACA TTGACCACCT GGTGAAGTTG 
CATCGCCAGA AACTGGCCAG AGGCAGCATG CAGAGCGGCT CCTCCATGAG TACCATTGGC 
AGCATGATGA GCCTCTATAG CGAAGCTGGT GATTTTGGGA ACGTCTCTGT GACTGGCAAA 
ATTGCCTTTT CACTGAAGTT TGAGCAGAAA ACACAGACTC TGGTCATCCA TGTCAAGGAG 
TGCCACCAGT TGGCTTATGC TGATGAAGCC AAGAAGCGTT CTAACCCATA CGTGAAGACT 
TATCTTCTGC CTGACAAGTC CCGCCAAGGA AAAAGAAAAA CCAGCATCAA GCGGGACACC 
ATCAATCCAC TATATGATGA GACCTTTCGG TATGAGATTT CGGAGTCTCT TCTGGCTCAG 
AGGACCTTGC AGTTTTCCGT TTGGCATCAT GGTCGTTTCG GTAGAAACAC CTTCCTTGGA 
GAGGCGGAGG TCCACATGGA CTCTTGGAAG CTGGATAAGA AGCTGGATCA TTGCCTCCCT 
TTACATGGAA AGATCAGTAC TGAGTCCTCG CCTGGTTTGC CAGCACACAA AGGCGAGTTG 
GTGGTTTCAT TGAAATACAT CCCAGCCTCC AAACTCCCTG TTGGAGGTGA CCGGAAAAAG 
AGTAAAGGTG GGGAAGGGGG AGAACTCCAG GTGTGGATCA AAGAAGCCAA GAACCTGACG 
GCTGCCAAAT CAGGAGGGAC ATCAGACAGC TTTGTCAAGG GATACCTCCT TCCCATGAGG 
AACAAGGCCA GTAAGCGTAA AACTCCTGTG ATGAAGAAGA CCTTGAATCC CCACTACAAC 
CACACATTTG TCTACAATGG TGTGAGGCTG GAAGATCTAC AACACATGTG CCTGGAACTG 
ACTGTATGGG ACCGGGAGCC CCTGGCCAGC AATGACTTCC TGGGAGGGGT CAGACTGGGT 
GTTGGCACTG GGATCAGTAG TGGCGAAGTG GTGGACTGGA TGGATTCGAC TGGTGAAGAA 
GTAAGCCTGT GGCAGAAGAT GCGACAGTAC CCAGGGTCTT GGGCAGAAGG AACTCTGCAG 
CTACGTTCTT CAATGGTCAA GCAGAAGCTG GGTGTATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_536335.1
CDS	1..2019
Translation	MSEILDLSFLSEMERDLILSVLQRDEELRKADEKRIRRLKNELLEIKRKGAKRGSQHYSDRTCARCQEGLGRLISKSNTCVGCNHLVCRECRVLESNGSWRCKVCSKEIELKKATGDWFYDQKVNRFAYRTGSDIIRMSLRRKPAVNKRETVGQSLLQQTQMGDIWPGRRIIQEQQKEQSVLFEVPKLKSGKSALEAESESLDSYTADSDSTSRRDSLDKSGLFPEWKKMSAPKSQVEKEIAPGNQNAVCGDEGDMIFKKNTRKVLRPSEYTKSVIDLRPEDVAQESGILGDRSKSVPGLSVDMEDEEEEEEDIDHLVKLHRQKLARGSMQSGSSMSTIGSMMSLYSEAGDFGNVSVTGKIAFSLKFEQKTQTLVIHVKECHQLAYADEAKKRSNPYVKTYLLPDKSRQGKRKTSIKRDTINPLYDETFRYEISESLLAQRTLQFSVWHHGRFGRNTFLGEAEVHMDSWKLDKKLDHCLPLHGKISTESSPGLPAHKGELVVSLKYIPASKLPVGGDRKKSKGGEGGELQVWIKEAKNLTAAKSGGTSDSFVKGYLLPMRNKASKRKTPVMKKTLNPHYNHTFVYNGVRLEDLQHMCLELTVWDREPLASNDFLGGVRLGVGTGISSGEVVDWMDSTGEEVSLWQKMRQYPGSWAEGTLQLRSSMVKQKLGV

Target ORF information:

RefSeq Version	NM_080410.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus synaptotagmin-like 4 (Sytl4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_080410.1

ORF Insert Sequence:

ATGTCGGAGA TACTAGACCT CTCTTTTCTG TCTGAGATGG AAAGAGATTT GATTCTCAGT 
GTTCTGCAGA GAGATGAAGA GCTCAGAAAA GCAGATGAGA AAAGGATTCG GCGACTGAAG 
AACGAGCTCC TGGAGATCAA ACGAAAAGGT GCCAAAAGGG GCAGCCAACA CTACAGTGAT 
CGAACCTGTG CCAGGTGCCA GGAAGGCCTG GGCCGTTTAA TTTCCAAAAG CAACACTTGT 
GTGGGTTGTA ATCATTTAGT GTGCCGAGAA TGCCGAGTTC TGGAGAGCAA TGGCTCCTGG 
AGGTGCAAGG TGTGCTCGAA GGAAATAGAG CTGAAGAAAG CAACTGGAGA TTGGTTTTAT 
GACCAGAAAG TAAATCGCTT TGCTTACAGA ACAGGCAGCG ACATCATCAG GATGTCCCTG 
CGCCGTAAGC CTGCAGTGAA TAAAAGAGAG ACAGTGGGGC AGTCCCTCCT TCAGCAGACC 
CAGATGGGTG ATATCTGGCC GGGAAGAAGG ATCATTCAGG AACAGCAGAA GGAACAAAGT 
GTGCTGTTTG AAGTGCCAAA GCTGAAGAGT GGAAAGAGCG CACTGGAGGC TGAGAGCGAG 
AGTCTGGATA GCTACACCGC TGACTCGGAC AGCACCTCCA GGAGAGATTC TCTGGATAAA 
TCTGGACTCT TCCCAGAATG GAAGAAGATG TCTGCTCCCA AATCTCAAGT TGAAAAGGAA 
ATTGCACCAG GGAACCAGAA TGCAGTGTGT GGTGATGAGG GTGACATGAT ATTTAAGAAG 
AACACTAGGA AAGTCCTGAG GCCTTCAGAA TACACTAAGT CTGTGATAGA CCTTCGTCCA 
GAAGATGTGG CCCAAGAAAG TGGCATCTTG GGAGATAGAA GCAAATCTGT ACCAGGCCTC 
AGTGTGGATA TGGAAGACGA GGAGGAGGAG GAAGAGGACA TTGACCACCT GGTGAAGTTG 
CATCGCCAGA AACTGGCCAG AGGCAGCATG CAGAGCGGCT CCTCCATGAG TACCATTGGC 
AGCATGATGA GCCTCTATAG CGAAGCTGGT GATTTTGGGA ACGTCTCTGT GACTGGCAAA 
ATTGCCTTTT CACTGAAGTT TGAGCAGAAA ACACAGACTC TGGTCATCCA TGTCAAGGAG 
TGCCACCAGT TGGCTTATGC TGATGAAGCC AAGAAGCGTT CTAACCCATA CGTGAAGACT 
TATCTTCTGC CTGACAAGTC CCGCCAAGGA AAAAGAAAAA CCAGCATCAA GCGGGACACC 
ATCAATCCAC TATATGATGA GACCTTTCGG TATGAGATTT CGGAGTCTCT TCTGGCTCAG 
AGGACCTTGC AGTTTTCCGT TTGGCATCAT GGTCGTTTCG GTAGAAACAC CTTCCTTGGA 
GAGGCGGAGG TCCACATGGA CTCTTGGAAG CTGGATAAGA AGCTGGATCA TTGCCTCCCT 
TTACATGGAA AGATCAGTAC TGAGTCCTCG CCTGGTTTGC CAGCACACAA AGGCGAGTTG 
GTGGTTTCAT TGAAATACAT CCCAGCCTCC AAACTCCCTG TTGGAGGTGA CCGGAAAAAG 
AGTAAAGGTG GGGAAGGGGG AGAACTCCAG GTGTGGATCA AAGAAGCCAA GAACCTGACG 
GCTGCCAAAT CAGGAGGGAC ATCAGACAGC TTTGTCAAGG GATACCTCCT TCCCATGAGG 
AACAAGGCCA GTAAGCGTAA AACTCCTGTG ATGAAGAAGA CCTTGAATCC CCACTACAAC 
CACACATTTG TCTACAATGG TGTGAGGCTG GAAGATCTAC AACACATGTG CCTGGAACTG 
ACTGTATGGG ACCGGGAGCC CCTGGCCAGC AATGACTTCC TGGGAGGGGT CAGACTGGGT 
GTTGGCACTG GGATCAGTAG TGGCGAAGTG GTGGACTGGA TGGATTCGAC TGGTGAAGAA 
GTAAGCCTGT GGCAGAAGAT GCGACAGTAC CCAGGGTCTT GGGCAGAAGG AACTCTGCAG 
CTACGTTCTT CAATGGTCAA GCAGAAGCTG GGTGTATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Sytl4 ( XM_006257213.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006257275.1 Rattus norvegicus synaptotagmin-like 4 (Sytl4), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa40080
Clone ID Related Accession (Same CDS sequence)	XM_006257213.3
Accession Version	XM_006257213.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2019bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	synaptotagmin-like protein 4 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005120.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006257213.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCGGAGA TACTAGACCT CTCTTTTCTG TCTGAGATGG AAAGAGATTT GATTCTCAGT 
GTTCTGCAGA GAGATGAAGA GCTCAGAAAA GCAGATGAGA AAAGGATTCG GCGACTGAAG 
AACGAGCTCC TGGAGATCAA ACGAAAAGGT GCCAAAAGGG GCAGCCAACA CTACAGTGAT 
CGAACCTGTG CCAGGTGCCA GGAAGGCCTG GGCCGTTTAA TTTCCAAAAG CAACACTTGT 
GTGGGTTGTA ATCATTTAGT GTGCCGAGAA TGCCGAGTTC TGGAGAGCAA TGGCTCCTGG 
AGGTGCAAGG TGTGCTCGAA GGAAATAGAG CTGAAGAAAG CAACTGGAGA TTGGTTTTAT 
GACCAGAAAG TAAATCGCTT TGCTTACAGA ACAGGCAGCG ACATCATCAG GATGTCCCTG 
CGCCGTAAGC CTGCAGTGAA TAAAAGAGAG ACAGTGGGGC AGTCCCTCCT TCAGCAGACC 
CAGATGGGTG ATATCTGGCC GGGAAGAAGG ATCATTCAGG AACAGCAGAA GGAACAAAGT 
GTGCTGTTTG AAGTGCCAAA GCTGAAGAGT GGAAAGAGCG CACTGGAGGC TGAGAGCGAG 
AGTCTGGATA GCTACACCGC TGACTCGGAC AGCACCTCCA GGAGAGATTC TCTGGATAAA 
TCTGGACTCT TCCCAGAATG GAAGAAGATG TCTGCTCCCA AATCTCAAGT TGAAAAGGAA 
ATTGCACCAG GGAACCAGAA TGCAGTGTGT GGTGATGAGG GTGACATGAT ATTTAAGAAG 
AACACTAGGA AAGTCCTGAG GCCTTCAGAA TACACTAAGT CTGTGATAGA CCTTCGTCCA 
GAAGATGTGG CCCAAGAAAG TGGCATCTTG GGAGATAGAA GCAAATCTGT ACCAGGCCTC 
AGTGTGGATA TGGAAGAGGA GGAGGAGGAG GAAGAGGACA TTGACCACCT GGTGAAGTTG 
CATCGCCAGA AACTGGCCAG AGGCAGCATG CAGAGCGGCT CCTCCATGAG TACCATTGGC 
AGCATGATGA GCCTCTATAG CGAAGCTGGT GATTTTGGGA ACGTCTCTGT GACTGGCAAA 
ATTGCCTTTT CACTGAAGTT TGAGCAGAAA ACACAGACTC TGGTCATCCA TGTCAAGGAG 
TGCCACCAGT TGGCTTATGC TGATGAAGCC AAGAAGCGTT CTAACCCATA CGTGAAGACT 
TATCTTCTGC CTGACAAGTC CCGCCAAGGA AAAAGAAAAA CCAGCATCAA GCGGGACACC 
ATCAATCCAC TATATGATGA GACCTTTCGG TATGAGATTT CGGAGTCTCT TCTGGCTCAG 
AGGACCTTGC AGTTTTCCGT TTGGCATCAT GGTCGTTTCG GTAGAAACAC CTTCCTTGGA 
GAGGCGGAGG TCCACATGGA CTCTTGGAAG CTGGATAAGA AGCTGGATCA TTGCCTCCCT 
TTACATGGAA AGATCAGTAC TGAGTCCTCG CCTGGTTTGC CAGCACACAA AGGCGAGTTG 
GTGGTTTCAT TGAAATACAT CCCAGCCTCC AAACTCCCTG TTGGAGGTGA CCGGAAAAAG 
AGTAAAGGTG GGGAAGGGGG AGAACTCCAG GTGTGGATCA AAGAAGCCAA GAACCTGACG 
GCTGCCAAAT CAGGAGGGAC ATCAGACAGC TTTGTCAAGG GATACCTCCT TCCCATGAGG 
AACAAGGCCA GTAAGCGTAA AACTCCTGTG ATGAAGAAGA CCTTGAATCC CCACTACAAC 
CACACATTTG TCTACAATGG TGTGAGGCTG GAAGATCTAC AACACATGTG CCTGGAACTG 
ACTGTATGGG ACCGGGAGCC CCTGGCCAGC AATGACTTCC TGGGAGGGGT CAGACTGGGT 
GTTGGCACTG GGATCAGTAG TGGCGAAGTG GTGGACTGGA TGGATTCGAC TGGTGAAGAA 
GTAAGCCTGT GGCAGAAGAT GCGACAGTAC CCAGGGTCTT GGGCAGAAGG AACTCTGCAG 
CTACGTTCTT CAATGGTCAA GCAGAAGCTG GGTGTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006257275.1
CDS	210..2228
Translation	MSEILDLSFLSEMERDLILSVLQRDEELRKADEKRIRRLKNELLEIKRKGAKRGSQHYSDRTCARCQEGLGRLISKSNTCVGCNHLVCRECRVLESNGSWRCKVCSKEIELKKATGDWFYDQKVNRFAYRTGSDIIRMSLRRKPAVNKRETVGQSLLQQTQMGDIWPGRRIIQEQQKEQSVLFEVPKLKSGKSALEAESESLDSYTADSDSTSRRDSLDKSGLFPEWKKMSAPKSQVEKEIAPGNQNAVCGDEGDMIFKKNTRKVLRPSEYTKSVIDLRPEDVAQESGILGDRSKSVPGLSVDMEEEEEEEEDIDHLVKLHRQKLARGSMQSGSSMSTIGSMMSLYSEAGDFGNVSVTGKIAFSLKFEQKTQTLVIHVKECHQLAYADEAKKRSNPYVKTYLLPDKSRQGKRKTSIKRDTINPLYDETFRYEISESLLAQRTLQFSVWHHGRFGRNTFLGEAEVHMDSWKLDKKLDHCLPLHGKISTESSPGLPAHKGELVVSLKYIPASKLPVGGDRKKSKGGEGGELQVWIKEAKNLTAAKSGGTSDSFVKGYLLPMRNKASKRKTPVMKKTLNPHYNHTFVYNGVRLEDLQHMCLELTVWDREPLASNDFLGGVRLGVGTGISSGEVVDWMDSTGEEVSLWQKMRQYPGSWAEGTLQLRSSMVKQKLGV

Target ORF information:

RefSeq Version	XM_006257213.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus synaptotagmin-like 4 (Sytl4), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006257213.3

ORF Insert Sequence:

ATGTCGGAGA TACTAGACCT CTCTTTTCTG TCTGAGATGG AAAGAGATTT GATTCTCAGT 
GTTCTGCAGA GAGATGAAGA GCTCAGAAAA GCAGATGAGA AAAGGATTCG GCGACTGAAG 
AACGAGCTCC TGGAGATCAA ACGAAAAGGT GCCAAAAGGG GCAGCCAACA CTACAGTGAT 
CGAACCTGTG CCAGGTGCCA GGAAGGCCTG GGCCGTTTAA TTTCCAAAAG CAACACTTGT 
GTGGGTTGTA ATCATTTAGT GTGCCGAGAA TGCCGAGTTC TGGAGAGCAA TGGCTCCTGG 
AGGTGCAAGG TGTGCTCGAA GGAAATAGAG CTGAAGAAAG CAACTGGAGA TTGGTTTTAT 
GACCAGAAAG TAAATCGCTT TGCTTACAGA ACAGGCAGCG ACATCATCAG GATGTCCCTG 
CGCCGTAAGC CTGCAGTGAA TAAAAGAGAG ACAGTGGGGC AGTCCCTCCT TCAGCAGACC 
CAGATGGGTG ATATCTGGCC GGGAAGAAGG ATCATTCAGG AACAGCAGAA GGAACAAAGT 
GTGCTGTTTG AAGTGCCAAA GCTGAAGAGT GGAAAGAGCG CACTGGAGGC TGAGAGCGAG 
AGTCTGGATA GCTACACCGC TGACTCGGAC AGCACCTCCA GGAGAGATTC TCTGGATAAA 
TCTGGACTCT TCCCAGAATG GAAGAAGATG TCTGCTCCCA AATCTCAAGT TGAAAAGGAA 
ATTGCACCAG GGAACCAGAA TGCAGTGTGT GGTGATGAGG GTGACATGAT ATTTAAGAAG 
AACACTAGGA AAGTCCTGAG GCCTTCAGAA TACACTAAGT CTGTGATAGA CCTTCGTCCA 
GAAGATGTGG CCCAAGAAAG TGGCATCTTG GGAGATAGAA GCAAATCTGT ACCAGGCCTC 
AGTGTGGATA TGGAAGAGGA GGAGGAGGAG GAAGAGGACA TTGACCACCT GGTGAAGTTG 
CATCGCCAGA AACTGGCCAG AGGCAGCATG CAGAGCGGCT CCTCCATGAG TACCATTGGC 
AGCATGATGA GCCTCTATAG CGAAGCTGGT GATTTTGGGA ACGTCTCTGT GACTGGCAAA 
ATTGCCTTTT CACTGAAGTT TGAGCAGAAA ACACAGACTC TGGTCATCCA TGTCAAGGAG 
TGCCACCAGT TGGCTTATGC TGATGAAGCC AAGAAGCGTT CTAACCCATA CGTGAAGACT 
TATCTTCTGC CTGACAAGTC CCGCCAAGGA AAAAGAAAAA CCAGCATCAA GCGGGACACC 
ATCAATCCAC TATATGATGA GACCTTTCGG TATGAGATTT CGGAGTCTCT TCTGGCTCAG 
AGGACCTTGC AGTTTTCCGT TTGGCATCAT GGTCGTTTCG GTAGAAACAC CTTCCTTGGA 
GAGGCGGAGG TCCACATGGA CTCTTGGAAG CTGGATAAGA AGCTGGATCA TTGCCTCCCT 
TTACATGGAA AGATCAGTAC TGAGTCCTCG CCTGGTTTGC CAGCACACAA AGGCGAGTTG 
GTGGTTTCAT TGAAATACAT CCCAGCCTCC AAACTCCCTG TTGGAGGTGA CCGGAAAAAG 
AGTAAAGGTG GGGAAGGGGG AGAACTCCAG GTGTGGATCA AAGAAGCCAA GAACCTGACG 
GCTGCCAAAT CAGGAGGGAC ATCAGACAGC TTTGTCAAGG GATACCTCCT TCCCATGAGG 
AACAAGGCCA GTAAGCGTAA AACTCCTGTG ATGAAGAAGA CCTTGAATCC CCACTACAAC 
CACACATTTG TCTACAATGG TGTGAGGCTG GAAGATCTAC AACACATGTG CCTGGAACTG 
ACTGTATGGG ACCGGGAGCC CCTGGCCAGC AATGACTTCC TGGGAGGGGT CAGACTGGGT 
GTTGGCACTG GGATCAGTAG TGGCGAAGTG GTGGACTGGA TGGATTCGAC TGGTGAAGAA 
GTAAGCCTGT GGCAGAAGAT GCGACAGTAC CCAGGGTCTT GGGCAGAAGG AACTCTGCAG 
CTACGTTCTT CAATGGTCAA GCAGAAGCTG GGTGTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A Rab3a-dependent complex essential for lysosome positioning and plasma membrane repair.
The Journal of cell biology213(6)631-40(2016 06)
Encarna??o M,Espada L,Escrevente C,Mateus D,Ramalho J,Michelet X,Santarino I,Hsu VW,Brenner MB,Barral DC,Vieira OV

Rab27a and Rab27b control different steps of the exosome secretion pathway.
Nature cell biology12(1)19-30; sup pp 1-13(2010 Jan)
Ostrowski M,Carmo NB,Krumeich S,Fanget I,Raposo G,Savina A,Moita CF,Schauer K,Hume AN,Freitas RP,Goud B,Benaroch P,Hacohen N,Fukuda M,Desnos C,Seabra MC,Darchen F,Amigorena S,Moita LF,Thery C

Transcriptional co-activator peroxisome proliferator-activated receptor (PPAR)gamma co-activator-1beta is involved in the regulation of glucose-stimulated insulin secretion in INS-1E cells.
Journal of molecular medicine (Berlin, Germany)87(3)299-306(2009 Mar)
Oberkofler H,Hafner M,Felder T,Krempler F,Patsch W

The Rab27 effector Rabphilin, unlike Granuphilin and Noc2, rapidly exchanges between secretory granules and cytosol in PC12 cells.
Biochemical and biophysical research communications373(2)275-81(2008 Aug)
Handley MT,Burgoyne RD

Granuphilin is activated by SREBP-1c and involved in impaired insulin secretion in diabetic mice.
Cell metabolism4(2)143-54(2006 Aug)
Kato T,Shimano H,Yamamoto T,Yokoo T,Endo Y,Ishikawa M,Matsuzaka T,Nakagawa Y,Kumadaki S,Yahagi N,Takahashi A,Sone H,Suzuki H,Toyoshima H,Hasty AH,Takahashi S,Gomi H,Izumi T,Yamada N

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Sytl4 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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