Ryk cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ryk
Entrez Gene ID	140585
Full Name	receptor-like tyrosine kinase
General protein information	Preferred Names receptor-like tyrosine kinase Names tyrosine-protein kinase RYK
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 8 Map Location: 8q32
Summary	an orphan receptor [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_080402.1	NP_536327.1	tyrosine-protein kinase RYK precursor
XM_008766473.2	XP_008764695.1	tyrosine-protein kinase RYK isoform X1

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Ryk	NP_038677.3
Bos taurus (cattle)	RYK	XP_002685146.3
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP006405	XP_316438.5
Pan troglodytes (chimpanzee)	RYK	XP_003310084.1
Homo sapiens (human)	RYK	NP_001005861.1
Gallus gallus (chicken)	RYK	XP_422674.4
Caenorhabditis elegans (roundworm)	lin-18	NP_508684.4
Xenopus tropicalis (tropical clawed frog)	ryk	NP_001017272.1
Canis lupus familiaris (dog)	RYK	XP_005634509.1
Rattus norvegicus (Norway rat)	Ryk	NP_536327.1
Danio rerio (zebrafish)	ryk	NP_001077295.1
Drosophila melanogaster (fruit fly)	Drl-2	NP_610835.2

Gene Ontology
Bibliography

Related articles in PubMed

Ryk receptors on unmyelinated nerve fibers mediate excitatory synaptic transmission and CCL2 release during neuropathic pain induced by peripheral nerve injury.
Yang QO, Yang WJ, Li J, Liu FT, Yuan H, Ou Yang YP
Molecular pain131744806917709372(2017 Jan-Dec)

Human epicardial cell-conditioned medium contains HGF/IgG complexes that phosphorylate RYK and protect against vascular injury.
Rao KS, Aronshtam A, McElory-Yaggy KL, Bakondi B, VanBuren P, Sobel BE, Spees JL
Cardiovascular research107(2)277-86(2015 Jul)

Ryk, a receptor regulating Wnt5a-mediated neurogenesis and axon morphogenesis of ventral midbrain dopaminergic neurons.
Blakely BD, Bye CR, Fernando CV, Prasad AA, Pasterkamp RJ, Macheda ML, Stacker SA, Parish CL
Stem cells and development22(15)2132-44(2013 Aug)

The Ryk receptor is expressed in glial and fibronectin-expressing cells after spinal cord injury.
Gonz?lez P, Fern?ndez-Martos CM, Arenas E, Rodr?guez FJ
Journal of neurotrauma30(10)806-17(2013 May)

Cleavage of the Wnt receptor Ryk regulates neuronal differentiation during cortical neurogenesis.
Lyu J, Yamamoto V, Lu W
Developmental cell15(5)773-80(2008 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Early treatment with HGF/IgG complexes after myocardial ischaemia with reperfusion may rescue tissue through vasoprotection
Title: Human epicardial cell-conditioned medium contains HGF/IgG complexes that phosphorylate RYK and protect against vascular injury.

we demonstrate that Ryk is expressed in the unlesioned spinal cord and that, after spinal cord injury, its spatiotemporal and cellular expression pattern changed dramatically, being expressed in cells involved in the spinal cord response to damage.
Title: The Ryk receptor is expressed in glial and fibronectin-expressing cells after spinal cord injury.

These results indicate that Ryk might be involved in peripheral nerve plasticity after injury. This is a novel function apart from its well-known fundamental activity as a receptor mediating axon guidance and outgrowth.
Title: Upregulation of Ryk expression in rat dorsal root ganglia after peripheral nerve injury.

In the embryonic forebrain, RYK colocalized with nestin in the ventricular zone and with MAP2 in the cortical plate, suggesting that RYK is expressed in neural progenitor cells and neurons. RYK expression in embryonic spinal cord was similar.
Title: Cell-type-specific expression of protein tyrosine kinase-related receptor RYK in the central nervous system of the rat.

The following Ryk gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ryk cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa11755	NM_080402.1 Latest version!	Rattus norvegicus receptor-like tyrosine kinase (Ryk), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$349.30 $499.00
ORa44168	XM_008766473.2 Latest version!	Rattus norvegicus receptor-like tyrosine kinase (Ryk), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$307.30 $439.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ryk ( NM_080402.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_536327.1 Rattus norvegicus receptor-like tyrosine kinase (Ryk), mRNA.

Price & Availability↑

CloneID	ORa11755
Clone ID Related Accession (Same CDS sequence)	NM_080402.1
Accession Version	NM_080402.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1785bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-05-26
Organism	Rattus norvegicus(Norway rat)
Product	tyrosine-protein kinase RYK precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY669340.1. On Apr 19, 2005 this sequence version replaced XM_343458.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY669340.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGCGCGCGG GCCGGGGCGG CGTCCCGGGG ACCGGCGGCC TGAGGGCCCC GCCGCCGCCG 
CTGCTCCTGC TGCTGCTGGC GATGCTGCCC GCCGCCGCCC CGCGGTCCCC GGCCCTGGCC 
GCCGCTCCTG CGGGACCCAG CGTGAGCCTC TACCTGAGCG AGGACGAGGT GCGCCGGCTA 
CTCGGTCTTG ATGCAGAACT TTACTATGTG AGAAATGACC TCATCAGTCA CTACGCTCTG 
TCCTTTAACC TGCTAGTGCC CAGTGAGACA AACTTCCTGC ACTTCACTTG GCATGCAAAG 
TCCAAGGTTG AATATAAGCT GGGATTCCAA GTAGACAACT TTGTGGCCAT GGGCATGCCC 
CAGGTCAATA TTTCTGCTCA AGGGGAGGTC CCACGCACTT TATCAGTGTT TCGGGTCGAG 
CTTTCGTGTA CCGGCAAAGT AGACTCGGAA GTCATGATAC TAATGCAGCT CAATCTGACA 
GTGAATTCTT CAAAAAATTT TACAGTTTTA AATTTTAAAC GAAGGAAAAT GTGCTACAAA 
AAACTTGAAG AAGTAAAAAC TTCAGCCTTG GACAAAAACA CTAGCAGAAC TATTTATGAT 
CCTGTACACG CAGCTCCAAC TACTTCCACA CGTGTGTTTT ACATCAGTGT GGGGGTTTGT 
TGTGCAGTAA TATTTCTTGT AGCAATAATA TTAGCAGTTT TGCACCTTCA TAGTATGAAA 
AGGATTGAAC TGGATGACAG CATCAGCGCC AGCAGCAGTT CACAGGGGCT GTCTCAGCCG 
TCCACCCAGA CGACCCAGTA TCTGAGAGCT GACACACCCA ACAATGCAAC TCCTGTCACC 
AGCTCCTCAG GTTACCCTAC CTTGCGGATA GAGAAGAACG ACTTGCGAAG TGTCACTCTT 
TTGGAAGCCA AAGCCAAGGT GAAGGATATT GCAATATCCA GGGAAAGGGT CACACTGAAA 
GATGTACTTC AAGAAGGTAC TTTTGGGCGT ATTTTCCATG GGATTTTAGT AGATGAAAAA 
GATCCAAATA AAGAAAAACA AACATTCGTA AAAACAGTTA AAGACCAAGC TTCTGAAGTT 
CAGGTGACCA TGATGCTTAC TGAGAGCTGC AAGCTGCGAG GTCTGCACCA CAGAAACCTC 
CTTCCTATTA CTCATGTGTG CATAGAAGAA GGAGAAAAGC CTATGGTGAT ATCGCCATAT 
ATGAACTGGG GGAATCTTAA ATTATTTCTA CGGCAGTGCA AATTAGTAGA AGCCAATAAT 
CCACAGGCAA TTTCCCAACA AGATCTGGTA CATATGGCTA TTCAGATTGC CTGCGGAATG 
AGCTACCTGG CCAGAAGGGA AGTGATTCAT AAAGACCTGG CTGCTCGGAA CTGCGTCATC 
GACGACACTC TTCAAGTAAA AATCACAGAC AATGCCCTTT CCAGAGACCT GTTTCCGATG 
GACTACCACT GTCTGGGGGA CAACGAGAAC AGGCCAGTGA GATGGATGGC TCTGGAAAGC 
CTGGTCAACA ATGAGTTCTC TAGTGCTAGT GACGTGTGGG CCTTTGGAGT GACACTGTGG 
GAGCTCATGA CTCTGGGCCA GACGCCCTAC GTGGACATCG ACCCCTTTGA GATGGCCGCT 
TACCTGAAAG ATGGTTACCG AATAGCCCAG CCAATCAACT GCCCTGACGA ACTGTTTGCT 
GTGATGGCCT GTTGCTGGGC CTTGGACCCA GAGGAGCGGC CTAAGTTTCA GCAGCTGGTC 
CAGTGCCTCA CAGAGTTCCA TGCTGCCCTG GGCGCCTACG TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_536327.1
CDS	1..1785
Translation	MRAGRGGVPGTGGLRAPPPPLLLLLLAMLPAAAPRSPALAAAPAGPSVSLYLSEDEVRRLLGLDAELYYVRNDLISHYALSFNLLVPSETNFLHFTWHAKSKVEYKLGFQVDNFVAMGMPQVNISAQGEVPRTLSVFRVELSCTGKVDSEVMILMQLNLTVNSSKNFTVLNFKRRKMCYKKLEEVKTSALDKNTSRTIYDPVHAAPTTSTRVFYISVGVCCAVIFLVAIILAVLHLHSMKRIELDDSISASSSSQGLSQPSTQTTQYLRADTPNNATPVTSSSGYPTLRIEKNDLRSVTLLEAKAKVKDIAISRERVTLKDVLQEGTFGRIFHGILVDEKDPNKEKQTFVKTVKDQASEVQVTMMLTESCKLRGLHHRNLLPITHVCIEEGEKPMVISPYMNWGNLKLFLRQCKLVEANNPQAISQQDLVHMAIQIACGMSYLARREVIHKDLAARNCVIDDTLQVKITDNALSRDLFPMDYHCLGDNENRPVRWMALESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDIDPFEMAAYLKDGYRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQCLTEFHAALGAYV

Target ORF information:

RefSeq Version	NM_080402.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus receptor-like tyrosine kinase (Ryk), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_080402.1

ORF Insert Sequence:

ATGCGCGCGG GCCGGGGCGG CGTCCCGGGG ACCGGCGGCC TGAGGGCCCC GCCGCCGCCG 
CTGCTCCTGC TGCTGCTGGC GATGCTGCCC GCCGCCGCCC CGCGGTCCCC GGCCCTGGCC 
GCCGCTCCTG CGGGACCCAG CGTGAGCCTC TACCTGAGCG AGGACGAGGT GCGCCGGCTA 
CTCGGTCTTG ATGCAGAACT TTACTATGTG AGAAATGACC TCATCAGTCA CTACGCTCTG 
TCCTTTAACC TGCTAGTGCC CAGTGAGACA AACTTCCTGC ACTTCACTTG GCATGCAAAG 
TCCAAGGTTG AATATAAGCT GGGATTCCAA GTAGACAACT TTGTGGCCAT GGGCATGCCC 
CAGGTCAATA TTTCTGCTCA AGGGGAGGTC CCACGCACTT TATCAGTGTT TCGGGTCGAG 
CTTTCGTGTA CCGGCAAAGT AGACTCGGAA GTCATGATAC TAATGCAGCT CAATCTGACA 
GTGAATTCTT CAAAAAATTT TACAGTTTTA AATTTTAAAC GAAGGAAAAT GTGCTACAAA 
AAACTTGAAG AAGTAAAAAC TTCAGCCTTG GACAAAAACA CTAGCAGAAC TATTTATGAT 
CCTGTACACG CAGCTCCAAC TACTTCCACA CGTGTGTTTT ACATCAGTGT GGGGGTTTGT 
TGTGCAGTAA TATTTCTTGT AGCAATAATA TTAGCAGTTT TGCACCTTCA TAGTATGAAA 
AGGATTGAAC TGGATGACAG CATCAGCGCC AGCAGCAGTT CACAGGGGCT GTCTCAGCCG 
TCCACCCAGA CGACCCAGTA TCTGAGAGCT GACACACCCA ACAATGCAAC TCCTGTCACC 
AGCTCCTCAG GTTACCCTAC CTTGCGGATA GAGAAGAACG ACTTGCGAAG TGTCACTCTT 
TTGGAAGCCA AAGCCAAGGT GAAGGATATT GCAATATCCA GGGAAAGGGT CACACTGAAA 
GATGTACTTC AAGAAGGTAC TTTTGGGCGT ATTTTCCATG GGATTTTAGT AGATGAAAAA 
GATCCAAATA AAGAAAAACA AACATTCGTA AAAACAGTTA AAGACCAAGC TTCTGAAGTT 
CAGGTGACCA TGATGCTTAC TGAGAGCTGC AAGCTGCGAG GTCTGCACCA CAGAAACCTC 
CTTCCTATTA CTCATGTGTG CATAGAAGAA GGAGAAAAGC CTATGGTGAT ATCGCCATAT 
ATGAACTGGG GGAATCTTAA ATTATTTCTA CGGCAGTGCA AATTAGTAGA AGCCAATAAT 
CCACAGGCAA TTTCCCAACA AGATCTGGTA CATATGGCTA TTCAGATTGC CTGCGGAATG 
AGCTACCTGG CCAGAAGGGA AGTGATTCAT AAAGACCTGG CTGCTCGGAA CTGCGTCATC 
GACGACACTC TTCAAGTAAA AATCACAGAC AATGCCCTTT CCAGAGACCT GTTTCCGATG 
GACTACCACT GTCTGGGGGA CAACGAGAAC AGGCCAGTGA GATGGATGGC TCTGGAAAGC 
CTGGTCAACA ATGAGTTCTC TAGTGCTAGT GACGTGTGGG CCTTTGGAGT GACACTGTGG 
GAGCTCATGA CTCTGGGCCA GACGCCCTAC GTGGACATCG ACCCCTTTGA GATGGCCGCT 
TACCTGAAAG ATGGTTACCG AATAGCCCAG CCAATCAACT GCCCTGACGA ACTGTTTGCT 
GTGATGGCCT GTTGCTGGGC CTTGGACCCA GAGGAGCGGC CTAAGTTTCA GCAGCTGGTC 
CAGTGCCTCA CAGAGTTCCA TGCTGCCCTG GGCGCCTACG TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Ryk ( XM_008766473.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008764695.1 Rattus norvegicus receptor-like tyrosine kinase (Ryk), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa44168
Clone ID Related Accession (Same CDS sequence)	XM_008766473.2
Accession Version	XM_008766473.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1776bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	tyrosine-protein kinase RYK isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005107.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008766473.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCGCGCGG GCCGGGGCGG CGTCCCGGGA CCGGGCGGCC TGAGGGCCCC GCCGCCGCCG 
CTGCTCCTGC TGCTGCTGGC GATGCTGCCC GCCGCCGCCC CGCGGTCCCC GTCCCTGGCC 
GCCGCTCGTG CGGGACCCAG CGTGAGCCTC TACCTGAGCG AGGACGAGGT GCGCCGGCTG 
CTCGGTCTTG ATGCAGAACT TTACTATGTG AGAAATGACC TCATCAGTCA CTACGCTCTG 
TCCTTTAACC TGCTAGTGCC CAGTGAGACA AACTTCCTGC ACTTCACTTG GCATGCAAAG 
TCCAAGGTTG AATATAAGCT GGGATTCCAA GTAGACAACT TTGTGGCCAT GGGCATGCCC 
CAGGTCAATA TTTCTGCTCA AGGGGAGGTC CCACGCACTT TATCAGTGTT TCGGGTCGAG 
CTTTCGTGTA CCGGCAAAGT AGACTCGGAA GTCATGATAC TAATGCAGCT CAATCTGACA 
GTGAATTCTT CAAAAAATTT TACAGTTTTA AATTTTAAAC GAAGGAAAAT GTGCTACAAA 
AAACTTGAAG AAGTAAAAAC TTCAGCCTTG GACAAAAACA CTAGCAGAAC TATTTATGAT 
CCTGTACACG CAGCTCCAAC TACTTCCACA CGTGTGTTTT ACATCAGTGT GGGGGTTTGT 
TGTGCAGTAA TATTTCTTGT AGCAATAATA TTAGCAGTTT TGCACCTTCA TAGTATGAAA 
AGGATTGAAC TGGATGACAG CATCAGCGCC AGCAGCAGTT CACAGGGGCT GTCTCAGCCG 
TCCACCCAGA CGACCCAGTA TCTGAGAGCT GACACACCCA ACAATGCAAC TCCTGTCACC 
AGTTACCCTA CCTTGCGGAT AGAGAAGAAC GACTTGCGAA GTGTCACTCT TTTGGAAGCC 
AAAGCCAAGG TGAAGGATAT TGCAATATCC AGGGAAAGGG TCACACTGAA AGATGTACTT 
CAAGAAGGTA CTTTTGGGCG TATTTTCCAT GGGATTTTAG TAGATGAAAA AGATCCAAAT 
AAAGAAAAAC AAACATTCGT AAAAACAGTT AAAGACCAAG CTTCTGAAGT TCAGGTGACC 
ATGATGCTTA CTGAGAGCTG CAAGCTGCGA GGTCTGCACC ACAGAAACCT CCTTCCTATT 
ACTCATGTGT GCATAGAAGA AGGAGAAAAG CCTATGGTGA TATCGCCATA TATGAACTGG 
GGGAATCTTA AATTATTTCT ACGGCAGTGC AAATTAGTAG AAGCCAATAA TCCACAGGCA 
ATTTCCCAAC AAGATCTGGT ACATATGGCT ATTCAGATTG CCTGCGGAAT GAGCTACCTG 
GCCAGAAGGG AAGTGATTCA TAAAGACCTG GCTGCTAGGA ACTGCGTCAT CGACGACACT 
CTTCAAGTAA AAATCACAGA CAATGCCCTT TCCAGAGACC TGTTTCCGAT GGACTACCAC 
TGTCTGGGGG ACAACGAGAA CAGGCCAGTG AGATGGATGG CTCTGGAAAG CCTGGTCAAC 
AATGAGTTCT CTAGTGCTAG TGACGTGTGG GCCTTTGGAG TGACACTGTG GGAGCTCATG 
ACTCTGGGCC AGACGCCCTA CGTGGACATC GACCCCTTTG AGATGGCCGC TTACCTGAAA 
GATGGTTACC GAATAGCCCA GCCAATCAAC TGCCCTGACG AACTGTTTGC TGTGATGGCC 
TGTTGCTGGG CCTTGGACCC AGAGGAGCGG CCTAAGTTTC AGCAGCTGGT CCAGTGCCTC 
ACAGAGTTCC ATGCTGCCCT GGGCGCCTAC GTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008764695.1
CDS	16..1791
Translation	MRAGRGGVPGPGGLRAPPPPLLLLLLAMLPAAAPRSPSLAAARAGPSVSLYLSEDEVRRLLGLDAELYYVRNDLISHYALSFNLLVPSETNFLHFTWHAKSKVEYKLGFQVDNFVAMGMPQVNISAQGEVPRTLSVFRVELSCTGKVDSEVMILMQLNLTVNSSKNFTVLNFKRRKMCYKKLEEVKTSALDKNTSRTIYDPVHAAPTTSTRVFYISVGVCCAVIFLVAIILAVLHLHSMKRIELDDSISASSSSQGLSQPSTQTTQYLRADTPNNATPVTSYPTLRIEKNDLRSVTLLEAKAKVKDIAISRERVTLKDVLQEGTFGRIFHGILVDEKDPNKEKQTFVKTVKDQASEVQVTMMLTESCKLRGLHHRNLLPITHVCIEEGEKPMVISPYMNWGNLKLFLRQCKLVEANNPQAISQQDLVHMAIQIACGMSYLARREVIHKDLAARNCVIDDTLQVKITDNALSRDLFPMDYHCLGDNENRPVRWMALESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDIDPFEMAAYLKDGYRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQCLTEFHAALGAYV

Target ORF information:

RefSeq Version	XM_008766473.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus receptor-like tyrosine kinase (Ryk), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008766473.2

ORF Insert Sequence:

ATGCGCGCGG GCCGGGGCGG CGTCCCGGGA CCGGGCGGCC TGAGGGCCCC GCCGCCGCCG 
CTGCTCCTGC TGCTGCTGGC GATGCTGCCC GCCGCCGCCC CGCGGTCCCC GTCCCTGGCC 
GCCGCTCGTG CGGGACCCAG CGTGAGCCTC TACCTGAGCG AGGACGAGGT GCGCCGGCTG 
CTCGGTCTTG ATGCAGAACT TTACTATGTG AGAAATGACC TCATCAGTCA CTACGCTCTG 
TCCTTTAACC TGCTAGTGCC CAGTGAGACA AACTTCCTGC ACTTCACTTG GCATGCAAAG 
TCCAAGGTTG AATATAAGCT GGGATTCCAA GTAGACAACT TTGTGGCCAT GGGCATGCCC 
CAGGTCAATA TTTCTGCTCA AGGGGAGGTC CCACGCACTT TATCAGTGTT TCGGGTCGAG 
CTTTCGTGTA CCGGCAAAGT AGACTCGGAA GTCATGATAC TAATGCAGCT CAATCTGACA 
GTGAATTCTT CAAAAAATTT TACAGTTTTA AATTTTAAAC GAAGGAAAAT GTGCTACAAA 
AAACTTGAAG AAGTAAAAAC TTCAGCCTTG GACAAAAACA CTAGCAGAAC TATTTATGAT 
CCTGTACACG CAGCTCCAAC TACTTCCACA CGTGTGTTTT ACATCAGTGT GGGGGTTTGT 
TGTGCAGTAA TATTTCTTGT AGCAATAATA TTAGCAGTTT TGCACCTTCA TAGTATGAAA 
AGGATTGAAC TGGATGACAG CATCAGCGCC AGCAGCAGTT CACAGGGGCT GTCTCAGCCG 
TCCACCCAGA CGACCCAGTA TCTGAGAGCT GACACACCCA ACAATGCAAC TCCTGTCACC 
AGTTACCCTA CCTTGCGGAT AGAGAAGAAC GACTTGCGAA GTGTCACTCT TTTGGAAGCC 
AAAGCCAAGG TGAAGGATAT TGCAATATCC AGGGAAAGGG TCACACTGAA AGATGTACTT 
CAAGAAGGTA CTTTTGGGCG TATTTTCCAT GGGATTTTAG TAGATGAAAA AGATCCAAAT 
AAAGAAAAAC AAACATTCGT AAAAACAGTT AAAGACCAAG CTTCTGAAGT TCAGGTGACC 
ATGATGCTTA CTGAGAGCTG CAAGCTGCGA GGTCTGCACC ACAGAAACCT CCTTCCTATT 
ACTCATGTGT GCATAGAAGA AGGAGAAAAG CCTATGGTGA TATCGCCATA TATGAACTGG 
GGGAATCTTA AATTATTTCT ACGGCAGTGC AAATTAGTAG AAGCCAATAA TCCACAGGCA 
ATTTCCCAAC AAGATCTGGT ACATATGGCT ATTCAGATTG CCTGCGGAAT GAGCTACCTG 
GCCAGAAGGG AAGTGATTCA TAAAGACCTG GCTGCTAGGA ACTGCGTCAT CGACGACACT 
CTTCAAGTAA AAATCACAGA CAATGCCCTT TCCAGAGACC TGTTTCCGAT GGACTACCAC 
TGTCTGGGGG ACAACGAGAA CAGGCCAGTG AGATGGATGG CTCTGGAAAG CCTGGTCAAC 
AATGAGTTCT CTAGTGCTAG TGACGTGTGG GCCTTTGGAG TGACACTGTG GGAGCTCATG 
ACTCTGGGCC AGACGCCCTA CGTGGACATC GACCCCTTTG AGATGGCCGC TTACCTGAAA 
GATGGTTACC GAATAGCCCA GCCAATCAAC TGCCCTGACG AACTGTTTGC TGTGATGGCC 
TGTTGCTGGG CCTTGGACCC AGAGGAGCGG CCTAAGTTTC AGCAGCTGGT CCAGTGCCTC 
ACAGAGTTCC ATGCTGCCCT GGGCGCCTAC GTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Ryk receptors on unmyelinated nerve fibers mediate excitatory synaptic transmission and CCL2 release during neuropathic pain induced by peripheral nerve injury.
Molecular pain131744806917709372(2017 Jan-Dec)
Yang QO,Yang WJ,Li J,Liu FT,Yuan H,Ou Yang YP

Human epicardial cell-conditioned medium contains HGF/IgG complexes that phosphorylate RYK and protect against vascular injury.
Cardiovascular research107(2)277-86(2015 Jul)
Rao KS,Aronshtam A,McElory-Yaggy KL,Bakondi B,VanBuren P,Sobel BE,Spees JL

Ryk, a receptor regulating Wnt5a-mediated neurogenesis and axon morphogenesis of ventral midbrain dopaminergic neurons.
Stem cells and development22(15)2132-44(2013 Aug)
Blakely BD,Bye CR,Fernando CV,Prasad AA,Pasterkamp RJ,Macheda ML,Stacker SA,Parish CL

The Ryk receptor is expressed in glial and fibronectin-expressing cells after spinal cord injury.
Journal of neurotrauma30(10)806-17(2013 May)
Gonz?lez P,Fern?ndez-Martos CM,Arenas E,Rodr?guez FJ

Cleavage of the Wnt receptor Ryk regulates neuronal differentiation during cortical neurogenesis.
Developmental cell15(5)773-80(2008 Nov)
Lyu J,Yamamoto V,Lu W

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Ryk cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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