Csrp3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Csrp3
Entrez Gene ID	117505
Full Name	cysteine and glycine rich protein 3
Synonyms	MLP
General protein information	Preferred Names cysteine and glycine rich protein 3 Names cysteine and glycine-rich protein 3 CRP3 LIM domain protein, cardiac cysteine and glycine-rich protein 3 (cardiac LIM protein) cysteine-rich protein 3 muscle LIM protein
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q22
Summary	may play a role in positive regulation of myogenesis [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_006229237.2	XP_006229299.1	cysteine and glycine-rich protein 3 isoform X1
NM_057144.1	NP_476485.1	cysteine and glycine-rich protein 3

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Csrp3	NP_001185770.1
Drosophila melanogaster (fruit fly)	Mlp60A	NP_001137750.1
Rattus norvegicus (Norway rat)	Csrp3	NP_476485.1
Gallus gallus (chicken)	CSRP3	NP_001186415.1
Xenopus tropicalis (tropical clawed frog)	csrp3	NP_001006836.1
Homo sapiens (human)	CSRP3	NP_003467.1
Pan troglodytes (chimpanzee)	CSRP3	XP_528813.2
Canis lupus familiaris (dog)	CSRP3	XP_852328.1
Bos taurus (cattle)	CSRP3	NP_001019860.1
	CSRP3	XP_001095430.1
Danio rerio (zebrafish)	csrp3	NP_001006026.1

Gene Ontology
Bibliography

Related articles in PubMed

Mitsugumin 29 regulates t-tubule architecture in the failing heart.
Correll RN, Lynch JM, Schips TG, Prasad V, York AJ, Sargent MA, Brochet DXP, Ma J, Molkentin JD
Scientific reports7(1)5328(2017 Jul)

MLP and CARP are linked to chronic PKC? signalling in dilated cardiomyopathy.
Lange S, Gehmlich K, Lun AS, Blondelle J, Hooper C, Dalton ND, Alvarez EA, Zhang X, Bang ML, Abassi YA, Dos Remedios CG, Peterson KL, Chen J, Ehler E
Nature communications712120(2016 Jun)

Muscle lim protein isoform negatively regulates striated muscle actin dynamics and differentiation.
Vafiadaki E, Arvanitis DA, Papalouka V, Terzis G, Roumeliotis TI, Spengos K, Garbis SD, Manta P, Kranias EG, Sanoudou D
The FEBS journal281(14)3261-79(2014 Jul)

Neuronal expression of muscle LIM protein in postnatal retinae of rodents.
Levin E, Leibinger M, Andreadaki A, Fischer D
PloS one9(6)e100756(2014)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Retinal MLP expression correlates with the morphologic and functional development of cholinergic amacrine cells, suggesting a potential role of this protein in postnatal maturation.
Title: Neuronal expression of muscle LIM protein in postnatal retinae of rodents.

Cardiac overexpression of muscle LIM protein does not modulate the heart's response to various forms of pathological stress.
Title: Cardiac remodeling is not modulated by overexpression of muscle LIM protein (MLP).

These findings suggest that nucleocytoplasmic shuttling MLP plays an important role in the regulation of the myocyte remodeling and hypertrophy and is required for adaptation to hypertrophic stimuli.
Title: Myocyte remodeling in response to hypertrophic stimuli requires nucleocytoplasmic shuttling of muscle LIM protein.

CRP3/MLP is primarily expressed in arterial smooth muscle cells and that stretch is the main stimulus for CRP3/MLP induction in veins exposed to arterial haemodynamic conditions.
Title: Induction of CRP3/MLP expression during vein arterialization is dependent on stretch rather than shear stress.

MLP plays a critical role in vascular remodeling.
Title: A role for muscle LIM protein (MLP) in vascular remodeling.

The following Csrp3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Csrp3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa11476	NM_057144.1 Latest version!	Rattus norvegicus cysteine and glycine rich protein 3 (Csrp3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
ORa22812	XM_006229237.2 Latest version!	Rattus norvegicus cysteine and glycine rich protein 3 (Csrp3), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Csrp3 ( NM_057144.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_476485.1 Rattus norvegicus cysteine and glycine rich protein 3 (Csrp3), mRNA.

Price & Availability↑

CloneID	ORa11476
Clone ID Related Accession (Same CDS sequence)	NM_057144.1
Accession Version	NM_057144.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 585bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-20
Organism	Rattus norvegicus(Norway rat)
Product	cysteine and glycine-rich protein 3
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from X81193.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X81193.1, FM052263.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN01906347, SAMN01906348 [ECO:0000350] ##Evidence-Data-END##

ATGCCGAACT GGGGTGGAGG TGCAAAATGT GGAGCCTGCG ACAAGACGGT TTACCATGCA 
GAAGAAATCC AGTGCAATGG GAGGAGCTTC CATAAGACCT GTTTCCACTG CATGGCCTGC 
AGGAAGGCTC TGGACAGCAC CACAGTGGCA GCTCATGAGT CAGAGATCTA CTGTAAGGTC 
TGCTATGGGC GCAAGTATGG CCCCAAGGGG ATCGGGTTTG GACAAGGCGC TGGCTGCCTC 
AGCACAGACA CCGGCGAGCA CCTTGGCCTG CAGTTCCAAC AATCCCCAAA GCCAGCACGT 
GCAGCCACCA CGAGCAACCC TTCCAAGTTC TCTGCGAAGT TTGGAGAATC AGAGAAGTGC 
CCACGATGCG GAAAGTCGGT ATATGCTGCT GAGAAGGTCA TGGGAGGTGG CAAGCCCTGG 
CATAAGACCT GCTTTCCGTG CGCCATCTGT GGGAAGAGCC TGGAGTCCAC AAATGTCACT 
GACAAGGATG GGGAGCTTTA TTGCAAAGTT TGCTATGCCA AAAATTTTGG CCCCACAGGC 
ATTGGGTTTG GAGGGCTTAC ACACCAAGTG GAAAAGAAGG AGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_476485.1
CDS	40..624
Translation	MPNWGGGAKCGACDKTVYHAEEIQCNGRSFHKTCFHCMACRKALDSTTVAAHESEIYCKVCYGRKYGPKGIGFGQGAGCLSTDTGEHLGLQFQQSPKPARAATTSNPSKFSAKFGESEKCPRCGKSVYAAEKVMGGGKPWHKTCFPCAICGKSLESTNVTDKDGELYCKVCYAKNFGPTGIGFGGLTHQVEKKE

Target ORF information:

RefSeq Version	NM_057144.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus cysteine and glycine rich protein 3 (Csrp3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_057144.1

ORF Insert Sequence:

ATGCCGAACT GGGGTGGAGG TGCAAAATGT GGAGCCTGCG ACAAGACGGT TTACCATGCA 
GAAGAAATCC AGTGCAATGG GAGGAGCTTC CATAAGACCT GTTTCCACTG CATGGCCTGC 
AGGAAGGCTC TGGACAGCAC CACAGTGGCA GCTCATGAGT CAGAGATCTA CTGTAAGGTC 
TGCTATGGGC GCAAGTATGG CCCCAAGGGG ATCGGGTTTG GACAAGGCGC TGGCTGCCTC 
AGCACAGACA CCGGCGAGCA CCTTGGCCTG CAGTTCCAAC AATCCCCAAA GCCAGCACGT 
GCAGCCACCA CGAGCAACCC TTCCAAGTTC TCTGCGAAGT TTGGAGAATC AGAGAAGTGC 
CCACGATGCG GAAAGTCGGT ATATGCTGCT GAGAAGGTCA TGGGAGGTGG CAAGCCCTGG 
CATAAGACCT GCTTTCCGTG CGCCATCTGT GGGAAGAGCC TGGAGTCCAC AAATGTCACT 
GACAAGGATG GGGAGCTTTA TTGCAAAGTT TGCTATGCCA AAAATTTTGG CCCCACAGGC 
ATTGGGTTTG GAGGGCTTAC ACACCAAGTG GAAAAGAAGG AGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Csrp3 ( XM_006229237.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006229299.1 Rattus norvegicus cysteine and glycine rich protein 3 (Csrp3), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa22812
Clone ID Related Accession (Same CDS sequence)	XM_006229237.2
Accession Version	XM_006229237.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 585bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	cysteine and glycine-rich protein 3 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 7, 2014 this sequence version replaced XM_006229237.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCGAACT GGGGTGGAGG TGCAAAATGT GGAGCCTGCG ACAAGACGGT TTACCATGCA 
GAAGAAATCC AGTGCAATGG GAGGAGCTTC CATAAGACCT GTTTCCACTG CATGGCCTGC 
AGGAAGGCTC TGGACAGCAC CACAGTGGCA GCTCATGAGT CAGAGATCTA CTGTAAGGTC 
TGCTATGGGC GCAAGTATGG CCCCAAGGGG ATCGGGTTTG GACAAGGCGC TGGCTGCCTC 
AGCACAGACA CCGGCGAGCA CCTTGGCCTG CAGTTCCAAC AATCCCCAAA GCCAGCACGT 
GCAGCCACCA CGAGCAACCC TTCCAAGTTC TCTGCGAAGT TTGGAGAATC AGAGAAGTGC 
CCACGATGCG GAAAGTCGGT ATATGCTGCT GAGAAGGTCA TGGGAGGTGG CAAGCCCTGG 
CATAAGACCT GCTTTCGCTG CGCCATCTGT GGGAAGAGCC TGGAGTCCAC AAATGTCACT 
GACAAGGATG GGGAGCTTTA TTGCAAAGTT TGCTATGCCA AAAATTTTGG CCCCACAGGC 
ATTGGGTTTG GAGGGCTTAC ACACCAAGTG GAAAAGAAGG AGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006229299.1
CDS	144..728
Translation	MPNWGGGAKCGACDKTVYHAEEIQCNGRSFHKTCFHCMACRKALDSTTVAAHESEIYCKVCYGRKYGPKGIGFGQGAGCLSTDTGEHLGLQFQQSPKPARAATTSNPSKFSAKFGESEKCPRCGKSVYAAEKVMGGGKPWHKTCFRCAICGKSLESTNVTDKDGELYCKVCYAKNFGPTGIGFGGLTHQVEKKE

Target ORF information:

RefSeq Version	XM_006229237.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus cysteine and glycine rich protein 3 (Csrp3), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006229237.2

ORF Insert Sequence:

ATGCCGAACT GGGGTGGAGG TGCAAAATGT GGAGCCTGCG ACAAGACGGT TTACCATGCA 
GAAGAAATCC AGTGCAATGG GAGGAGCTTC CATAAGACCT GTTTCCACTG CATGGCCTGC 
AGGAAGGCTC TGGACAGCAC CACAGTGGCA GCTCATGAGT CAGAGATCTA CTGTAAGGTC 
TGCTATGGGC GCAAGTATGG CCCCAAGGGG ATCGGGTTTG GACAAGGCGC TGGCTGCCTC 
AGCACAGACA CCGGCGAGCA CCTTGGCCTG CAGTTCCAAC AATCCCCAAA GCCAGCACGT 
GCAGCCACCA CGAGCAACCC TTCCAAGTTC TCTGCGAAGT TTGGAGAATC AGAGAAGTGC 
CCACGATGCG GAAAGTCGGT ATATGCTGCT GAGAAGGTCA TGGGAGGTGG CAAGCCCTGG 
CATAAGACCT GCTTTCGCTG CGCCATCTGT GGGAAGAGCC TGGAGTCCAC AAATGTCACT 
GACAAGGATG GGGAGCTTTA TTGCAAAGTT TGCTATGCCA AAAATTTTGG CCCCACAGGC 
ATTGGGTTTG GAGGGCTTAC ACACCAAGTG GAAAAGAAGG AGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Mitsugumin 29 regulates t-tubule architecture in the failing heart.
Scientific reports7(1)5328(2017 Jul)
Correll RN,Lynch JM,Schips TG,Prasad V,York AJ,Sargent MA,Brochet DXP,Ma J,Molkentin JD

MLP and CARP are linked to chronic PKC? signalling in dilated cardiomyopathy.
Nature communications712120(2016 Jun)
Lange S,Gehmlich K,Lun AS,Blondelle J,Hooper C,Dalton ND,Alvarez EA,Zhang X,Bang ML,Abassi YA,Dos Remedios CG,Peterson KL,Chen J,Ehler E

Muscle lim protein isoform negatively regulates striated muscle actin dynamics and differentiation.
The FEBS journal281(14)3261-79(2014 Jul)
Vafiadaki E,Arvanitis DA,Papalouka V,Terzis G,Roumeliotis TI,Spengos K,Garbis SD,Manta P,Kranias EG,Sanoudou D

Neuronal expression of muscle LIM protein in postnatal retinae of rodents.
PloS one9(6)e100756(2014)
Levin E,Leibinger M,Andreadaki A,Fischer D

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Csrp3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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