Khdrbs1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Khdrbs1
Entrez Gene ID	117268
Full Name	KH RNA binding domain containing, signal transduction associated 1
Synonyms	P62,Sam68
General protein information	Preferred Names KH RNA binding domain containing, signal transduction associated 1 Names KH domain-containing, RNA-binding, signal transduction-associated protein 1 GAP-associated tyrosine phosphoprotein p62 KH domain containing, RNA binding, signal transduction associated 1 KH domain-containing, RNA-binding, signal transduction-associated protein 1-like p21 Ras GTPase-activating protein-associated p62 p68 src associated in mitosis, 68 kDa src-associated in mitosis 68 kDa protein
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 5 Map Location: 5q36
Summary	RNA binding protein and acts as a substrate of the Insulin receprot and may have a role as a docking protein in Insulin receptor signaling [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_130405.1	NP_569089.1	KH domain-containing, RNA-binding, signal transduction-associated protein 1

Pathways from BioSystems

Homologies

	LOC706598	XP_002802339.1
Mus musculus (house mouse)	Khdrbs1	NP_035447.3
Rattus norvegicus (Norway rat)	Khdrbs1	NP_569089.1
Gallus gallus (chicken)	KHDRBS1	NP_989561.1
Homo sapiens (human)	KHDRBS1	NP_006550.1
Pan troglodytes (chimpanzee)	KHDRBS1	XP_513273.3
Bos taurus (cattle)	KHDRBS1	NP_001039907.1
Danio rerio (zebrafish)	khdrbs1b	NP_998400.1
Xenopus tropicalis (tropical clawed frog)	khdrbs1	NP_001017045.1
Canis lupus familiaris (dog)	KHDRBS1	XP_005617713.1

Gene Ontology
Bibliography

Related articles in PubMed

Expression of Sam68 Associates with Neuronal Apoptosis and Reactive Astrocytes After Spinal Cord Injury.
Chen X, Liu L, Qian R, Liu J, Yao Y, Jiang Z, Song X, Ren J, Zhang F
Cellular and molecular neurobiology37(3)487-498(2017 Apr)

Up-regulation of miRNA-221 inhibits hypoxia/reoxygenation-induced autophagy through the DDIT4/mTORC1 and Tp53inp1/p62 pathways.
Chen Q, Zhou Y, Richards AM, Wang P
Biochemical and biophysical research communications474(1)168-174(2016 05)

Sam68 promotes Schwann cell proliferation by enhancing the PI3K/Akt pathway and acts on regeneration after sciatic nerve crush.
Wu W, Liu Y, Wang Y
Biochemical and biophysical research communications473(4)1045-1051(2016 05)

Sam68 Promotes NF-?B Activation and Apoptosis Signaling in Articular Chondrocytes during Osteoarthritis.
Xu L, Sun C, Zhang S, Xu X, Zhai L, Wang Y, Wang S, Liu Z, Cheng H, Xiao M, Tao R, Zhang D
Inflammation research : official journal of the European Histamine Research Society ... [et al.]64(11)895-902(2015 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Sam68 might be illustrated in the apoptosis of neurons and proliferation of astrocytes after spinal cord injury.
Title: Expression of Sam68 Associates with Neuronal Apoptosis and Reactive Astrocytes After Spinal Cord Injury.

In conclusion, miRNA-221 exerts cytoprotective effects in hypoxia-reoxygenation injury in association with alterations in autophagic cell injury. Mir-221 may constitute is a novel therapeutic target in the treatment of cardiac I/R injury.
Title: Up-regulation of miRNA-221 inhibits hypoxia/reoxygenation-induced autophagy through the DDIT4/mTORC1 and Tp53inp1/p62 pathways.

Finally, we detected the variance during regeneration progress through the rat walk footprint test. In summary, all these evidences demonstrated that Sam68 might participate in Schwann cell proliferation partially via PI3K/Akt pathway and also regulate regeneration after sciatic nerve crush.
Title: Sam68 promotes Schwann cell proliferation by enhancing the PI3K/Akt pathway and acts on regeneration after sciatic nerve crush.

Sam68 Promotes NF-kappaB Activation and Apoptosis Signaling in Articular Chondrocytes during Osteoarthritis
Title: Sam68 Promotes NF-?B Activation and Apoptosis Signaling in Articular Chondrocytes during Osteoarthritis.

Enhanced p62 expression triggers concomitant autophagy and apoptosis in a rat chronic spinal cord compression model.
Title: Enhanced p62 expression triggers concomitant autophagy and apoptosis in a rat chronic spinal cord compression model.

The following Khdrbs1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Khdrbs1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa12281	NM_130405.1 Latest version!	Rattus norvegicus KH RNA binding domain containing, signal transduction associated 1 (Khdrbs1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$258.30 $369.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Khdrbs1 ( NM_130405.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_569089.1 Rattus norvegicus KH RNA binding domain containing, signal transduction associated 1 (Khdrbs1), mRNA.

Price & Availability↑

CloneID	ORa12281
Clone ID Related Accession (Same CDS sequence)	NM_130405.1
Accession Version	NM_130405.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1332bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Rattus norvegicus(Norway rat)
Product	KH domain-containing, RNA-binding, signal transduction-associated protein 1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF305619.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF305619.1, BC061987.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGCAGCGCC GGGACGACCC TGCCGCGCGC CTCACCCGGT CCTCGGGCCG CAGCTGCTCC 
AAGGACCCGT CAGGTGCCCA CCCCTCGGTG CGTCTGACCC CGTCTCGGCC GTCGCCGCTT 
CCTCACCGGT CCCGGGGAGG CGGAGGTGGG CCCAGAGGAG GCGCTCGGGC CTCGCCCGCT 
ACGCAGCCGC CGCCGCTGCT GCCTCCCTCT AATCCGGGTC CCGACGCGAC TGTGGTGGGT 
TCCGCGCCGA CCCCGCTACT GCCCCCGTCA GCCACAGCCG CGGCCAAGAT GGAGCCGGAG 
AATAAGTACC TGCCTGAACT CATGGCTGAG AAGGACTCGC TCGACCCGTC CTTCACTCAC 
GCCATGCAGC TGCTGTCCGT AGAAATTGAG AAGATTCAGA AGGGAGAGTC AAAAAAAGAT 
GACGAGGAGA ATTATTTGGA CTTATTTTCT CATAAGAACA TGAAGCTGAA AGAGCGGGTA 
CTGATCCCTG TCAAGCAGTA TCCAAAGTTC AATTTTGTGG GGAAGATTCT TGGACCACAA 
GGAAATACAA TCAAAAGACT CCAGGAAGAG ACTGGTGCAA AGATCTCTGT CTTGGGGAAG 
GGTTCGATGA GAGACAAAGC CAAGGAGGAA GAGTTGCGCA AGGGTGGAGA CCCCAAATAT 
GCCCATTTAA ATATGGATCT GCATGTCTTC ATTGAAGTCT TTGGACCCCC ATGTGAAGCT 
TATGCTCTTA TGGCCCATGC TATGGAAGAA GTCAAGAAAT TTCTAGTACC AGACATGATG 
GATGATATCT GCCAGGAGCA GTTTCTAGAA TTGTCCTACT TGAATGGAGT TCCTGAACCC 
TCTCGTGGTC GTGGGGTGTC TGTGAGAGGA CGAGGAGCTG CCCCTCCTCC TCCACCTGTT 
CCCAGAGGAC GTGGTGTTGG GCCACCTAGA GGGGCTTTGG TTCGTGGAAC CCCAGTAAGA 
GGCTCCATCA CCAGAGGTGC CACTGTGACT CGAGGGGTGC CACCCCCACC TACTGTGAGG 
GGTGCTCCAA CACCGAGAGC TCGGACAGCT GGTATTCAGA GAATACCTTT GCCTCCAACA 
CCTGCACCAG AAACATACGA AGATTATGGA TATGATGATT CATATGCAGA ACAGAGCTAC 
GAAGGCTATG AAGGCTATTA CAGCCAGAGT CAAGGGGAGT CAGAGTATTA TGACTATGGA 
CATGGGGAGC TTCAAGATTC TTATGAAGCC TATGGACAAG ATGACTGGAA TGGGACCAGG 
CCATCACTGA AGGCTCCTCC AGCTAGGCCA GTGAAGGGAG CATACAGAGA GCACCCATAT 
GGACGTTATT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_569089.1
CDS	84..1415
Translation	MQRRDDPAARLTRSSGRSCSKDPSGAHPSVRLTPSRPSPLPHRSRGGGGGPRGGARASPATQPPPLLPPSNPGPDATVVGSAPTPLLPPSATAAAKMEPENKYLPELMAEKDSLDPSFTHAMQLLSVEIEKIQKGESKKDDEENYLDLFSHKNMKLKERVLIPVKQYPKFNFVGKILGPQGNTIKRLQEETGAKISVLGKGSMRDKAKEEELRKGGDPKYAHLNMDLHVFIEVFGPPCEAYALMAHAMEEVKKFLVPDMMDDICQEQFLELSYLNGVPEPSRGRGVSVRGRGAAPPPPPVPRGRGVGPPRGALVRGTPVRGSITRGATVTRGVPPPPTVRGAPTPRARTAGIQRIPLPPTPAPETYEDYGYDDSYAEQSYEGYEGYYSQSQGESEYYDYGHGELQDSYEAYGQDDWNGTRPSLKAPPARPVKGAYREHPYGRY

Target ORF information:

RefSeq Version	NM_130405.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus KH RNA binding domain containing, signal transduction associated 1 (Khdrbs1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_130405.1

ORF Insert Sequence:

ATGCAGCGCC GGGACGACCC TGCCGCGCGC CTCACCCGGT CCTCGGGCCG CAGCTGCTCC 
AAGGACCCGT CAGGTGCCCA CCCCTCGGTG CGTCTGACCC CGTCTCGGCC GTCGCCGCTT 
CCTCACCGGT CCCGGGGAGG CGGAGGTGGG CCCAGAGGAG GCGCTCGGGC CTCGCCCGCT 
ACGCAGCCGC CGCCGCTGCT GCCTCCCTCT AATCCGGGTC CCGACGCGAC TGTGGTGGGT 
TCCGCGCCGA CCCCGCTACT GCCCCCGTCA GCCACAGCCG CGGCCAAGAT GGAGCCGGAG 
AATAAGTACC TGCCTGAACT CATGGCTGAG AAGGACTCGC TCGACCCGTC CTTCACTCAC 
GCCATGCAGC TGCTGTCCGT AGAAATTGAG AAGATTCAGA AGGGAGAGTC AAAAAAAGAT 
GACGAGGAGA ATTATTTGGA CTTATTTTCT CATAAGAACA TGAAGCTGAA AGAGCGGGTA 
CTGATCCCTG TCAAGCAGTA TCCAAAGTTC AATTTTGTGG GGAAGATTCT TGGACCACAA 
GGAAATACAA TCAAAAGACT CCAGGAAGAG ACTGGTGCAA AGATCTCTGT CTTGGGGAAG 
GGTTCGATGA GAGACAAAGC CAAGGAGGAA GAGTTGCGCA AGGGTGGAGA CCCCAAATAT 
GCCCATTTAA ATATGGATCT GCATGTCTTC ATTGAAGTCT TTGGACCCCC ATGTGAAGCT 
TATGCTCTTA TGGCCCATGC TATGGAAGAA GTCAAGAAAT TTCTAGTACC AGACATGATG 
GATGATATCT GCCAGGAGCA GTTTCTAGAA TTGTCCTACT TGAATGGAGT TCCTGAACCC 
TCTCGTGGTC GTGGGGTGTC TGTGAGAGGA CGAGGAGCTG CCCCTCCTCC TCCACCTGTT 
CCCAGAGGAC GTGGTGTTGG GCCACCTAGA GGGGCTTTGG TTCGTGGAAC CCCAGTAAGA 
GGCTCCATCA CCAGAGGTGC CACTGTGACT CGAGGGGTGC CACCCCCACC TACTGTGAGG 
GGTGCTCCAA CACCGAGAGC TCGGACAGCT GGTATTCAGA GAATACCTTT GCCTCCAACA 
CCTGCACCAG AAACATACGA AGATTATGGA TATGATGATT CATATGCAGA ACAGAGCTAC 
GAAGGCTATG AAGGCTATTA CAGCCAGAGT CAAGGGGAGT CAGAGTATTA TGACTATGGA 
CATGGGGAGC TTCAAGATTC TTATGAAGCC TATGGACAAG ATGACTGGAA TGGGACCAGG 
CCATCACTGA AGGCTCCTCC AGCTAGGCCA GTGAAGGGAG CATACAGAGA GCACCCATAT 
GGACGTTATT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Expression of Sam68 Associates with Neuronal Apoptosis and Reactive Astrocytes After Spinal Cord Injury.
Cellular and molecular neurobiology37(3)487-498(2017 Apr)
Chen X,Liu L,Qian R,Liu J,Yao Y,Jiang Z,Song X,Ren J,Zhang F

Up-regulation of miRNA-221 inhibits hypoxia/reoxygenation-induced autophagy through the DDIT4/mTORC1 and Tp53inp1/p62 pathways.
Biochemical and biophysical research communications474(1)168-174(2016 05)
Chen Q,Zhou Y,Richards AM,Wang P

Sam68 promotes Schwann cell proliferation by enhancing the PI3K/Akt pathway and acts on regeneration after sciatic nerve crush.
Biochemical and biophysical research communications473(4)1045-1051(2016 05)
Wu W,Liu Y,Wang Y

Sam68 Promotes NF-?B Activation and Apoptosis Signaling in Articular Chondrocytes during Osteoarthritis.
Inflammation research : official journal of the European Histamine Research Society ... [et al.]64(11)895-902(2015 Nov)
Xu L,Sun C,Zhang S,Xu X,Zhai L,Wang Y,Wang S,Liu Z,Cheng H,Xiao M,Tao R,Zhang D

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Khdrbs1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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