Nudt1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Nudt1
Entrez Gene ID	117260
Full Name	nudix hydrolase 1
Synonyms	Mth1
General protein information	Preferred Names nudix hydrolase 1 Names 7,8-dihydro-8-oxoguanine triphosphatase 2-hydroxy-dATP diphosphatase 8-oxo-dGTPase mutT human homolog (8-oxo-dGTPase) nucleoside diphosphate-linked moiety X motif 1 nudix (nucleoside diphosphate linked moiety X)-type motif 1 nudix motif 1 nudix-type motif 1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 12 Map Location: 12q11
Summary	degrades 8-oxoguanine-containing deoxyribonucleoside triphosphate, a potentially mutagenic substrate for DNA synthesis; may control spontaneous mutagenesis [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_057120.1	NP_476461.1	7,8-dihydro-8-oxoguanine triphosphatase precursor
XM_006248911.3	XP_006248973.1	7,8-dihydro-8-oxoguanine triphosphatase isoform X1

Pathways from BioSystems

Homologies

	NUDT1	XP_002803234.1
Pan troglodytes (chimpanzee)	NUDT1	XP_003318267.1
Mus musculus (house mouse)	Nudt1	NP_032663.1
Canis lupus familiaris (dog)	NUDT1	XP_547012.4
Bos taurus (cattle)	NUDT1	XP_002698276.1
Rattus norvegicus (Norway rat)	Nudt1	NP_476461.1
Homo sapiens (human)	NUDT1	NP_945190.1
Gallus gallus (chicken)	NUDT1	NP_001006160.2
Danio rerio (zebrafish)	nudt1	NP_998583.1
Xenopus tropicalis (tropical clawed frog)	nudt1	NP_001004857.1

Gene Ontology
Bibliography

Related articles in PubMed

Chenodeoxycholic Acid Derivative HS-1200 Inhibits Hepatocarcinogenesis and Improves Liver Function in Diethylnitrosamine-Exposed Rats by Downregulating MTH1.
Xu M, Zhao Q, Shao D, Liu H, Qi J, Qin C
BioMed research international20171465912(2017)

Human MTH3 (NUDT18) protein hydrolyzes oxidized forms of guanosine and deoxyguanosine diphosphates: comparison with MTH1 and MTH2.
Takagi Y, Setoyama D, Ito R, Kamiya H, Yamagata Y, Sekiguchi M
The Journal of biological chemistry287(25)21541-9(2012 Jun)

Oxidative damage to RNA and expression patterns of MTH1 in the hippocampi of senescence-accelerated SAMP8 mice and Alzheimer's disease patients.
Song XN, Zhang LQ, Liu DG, Lin J, Zheng JD, Dai DP, Hei AL, Hayakawa H, Sekiguchi M, Cai JP
Neurochemical research36(8)1558-65(2011 Aug)

Multiple mRNA decapping enzymes in mammalian cells.
Song MG, Li Y, Kiledjian M
Molecular cell40(3)423-32(2010 Nov)

Accumulation of 8-oxo-deoxyguanosine in cardiovascular tissues with the development of hypertension.
Ohtsubo T, Ohya Y, Nakamura Y, Kansui Y, Furuichi M, Matsumura K, Fujii K, Iida M, Nakabeppu Y
DNA repair6(6)760-9(2007 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

MTH1 is downregulated by HS-1200, which inhibits hepatocarcinogenesis and improves liver function
Title: Chenodeoxycholic Acid Derivative HS-1200 Inhibits Hepatocarcinogenesis and Improves Liver Function in Diethylnitrosamine-Exposed Rats by Downregulating MTH1.

distribution of MTH1, associated apparently with the conditional changes in the dynamics of synthesis of nucleic acids, assisted by this protein
Title: Intracellular distribution of the antimutagenic enzyme MTH1 in the liver, kidney and testis of F344 rats and its modulation by cadmium.

The following Nudt1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Nudt1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa11376	NM_057120.1 Latest version!	Rattus norvegicus nudix hydrolase 1 (Nudt1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
ORa34636	XM_006248911.3 Latest version!	Rattus norvegicus nudix hydrolase 1 (Nudt1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Nudt1 ( NM_057120.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_476461.1 Rattus norvegicus nudix hydrolase 1 (Nudt1), mRNA.

Price & Availability↑

CloneID	ORa11376
Clone ID Related Accession (Same CDS sequence)	NM_057120.1
Accession Version	NM_057120.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 471bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Rattus norvegicus(Norway rat)
Product	7,8-dihydro-8-oxoguanine triphosphatase precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from D49977.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: D49977.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGAGCACCT CCAGGCTTTA TACCCTCGTG CTGGTACTAC AGCCTCAGCG AGTTCTCCTG 
GGCATGAAGA AGAGGGGCTT TGGTGCTGGC CGCTGGAATG GCTTCGGGGG CAAGGTGCAG 
GAAGGAGAGA CCATTGAGGA TGGGGCTAAG AGGGAGCTTC TGGAAGAAAG TGGTCTGAGA 
GTGGATACAC TGCACAAGGT AGGCCATATC TCATTTGAGT TTGTGGGCTC CCCCGAGCTG 
ATGGACGTGC ATATCTTCTC TACCGACCAC GTGCATGGGA CACCCACAGA GAGTGAAGAA 
ATGCGCCCTC AGTGGTTCCA ACTGGACCAG ATCCCCTTTG CCGACATGTG GCCGGACGAC 
AGCTACTGGT TCCCACTCCT GCTTCAGAAG AAGAAGTTCT GTGGACACTT CAAGTTCCAT 
GGTCAGGACA CCATCCTCAG TTACTCCCTG CGGGAGGTGG ATGAGTTCTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_476461.1
CDS	15..485
Translation	MSTSRLYTLVLVLQPQRVLLGMKKRGFGAGRWNGFGGKVQEGETIEDGAKRELLEESGLRVDTLHKVGHISFEFVGSPELMDVHIFSTDHVHGTPTESEEMRPQWFQLDQIPFADMWPDDSYWFPLLLQKKKFCGHFKFHGQDTILSYSLREVDEF

Target ORF information:

RefSeq Version	NM_057120.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus nudix hydrolase 1 (Nudt1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_057120.1

ORF Insert Sequence:

ATGAGCACCT CCAGGCTTTA TACCCTCGTG CTGGTACTAC AGCCTCAGCG AGTTCTCCTG 
GGCATGAAGA AGAGGGGCTT TGGTGCTGGC CGCTGGAATG GCTTCGGGGG CAAGGTGCAG 
GAAGGAGAGA CCATTGAGGA TGGGGCTAAG AGGGAGCTTC TGGAAGAAAG TGGTCTGAGA 
GTGGATACAC TGCACAAGGT AGGCCATATC TCATTTGAGT TTGTGGGCTC CCCCGAGCTG 
ATGGACGTGC ATATCTTCTC TACCGACCAC GTGCATGGGA CACCCACAGA GAGTGAAGAA 
ATGCGCCCTC AGTGGTTCCA ACTGGACCAG ATCCCCTTTG CCGACATGTG GCCGGACGAC 
AGCTACTGGT TCCCACTCCT GCTTCAGAAG AAGAAGTTCT GTGGACACTT CAAGTTCCAT 
GGTCAGGACA CCATCCTCAG TTACTCCCTG CGGGAGGTGG ATGAGTTCTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Nudt1 ( XM_006248911.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006248973.1 Rattus norvegicus nudix hydrolase 1 (Nudt1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa34636
Clone ID Related Accession (Same CDS sequence)	XM_006248911.3
Accession Version	XM_006248911.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 471bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	7,8-dihydro-8-oxoguanine triphosphatase isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005111.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006248911.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGCACCT CCAGGCTTTA TACCCTCGTG CTGGTACTAC AGCCTCAGCG AGTTCTCCTG 
GGCATGAAGA AGAGGGGCTT TGGTGCTGGC CGCTGGAATG GCTTCGGGGG CAAGGTGCAG 
GAAGGAGAGA CCATTGAGGA TGGGGCTAAG AGGGAGCTTC TGGAAGAAAG TGGTCTGAGA 
GTGGATACAC TGCACAAGGT AGGCCATATC TCATTTGAGT TTGTGGGCTC CCCCGAGCTG 
ATGGACGTGC ATATCTTCTC TACCGACCAC GTGCATGGGA CGCCCACAGA GAGTGAAGAA 
ATGCGCCCTC AGTGGTTCCA ACTGGACCAG ATCCCCTTTG CCGACATGTG GCCGGACGAC 
AGCTACTGGT TCCCACTCCT GCTTCAGAAG AAGAAGTTCT GTGGACACTT CAAGTTCCAT 
GGTCAGGACA CCATCCTCAG TTACTCCCTG CGGGAGGTGG ATGAGTTCTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006248973.1
CDS	91..561
Translation	MSTSRLYTLVLVLQPQRVLLGMKKRGFGAGRWNGFGGKVQEGETIEDGAKRELLEESGLRVDTLHKVGHISFEFVGSPELMDVHIFSTDHVHGTPTESEEMRPQWFQLDQIPFADMWPDDSYWFPLLLQKKKFCGHFKFHGQDTILSYSLREVDEF

Target ORF information:

RefSeq Version	XM_006248911.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus nudix hydrolase 1 (Nudt1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006248911.3

ORF Insert Sequence:

ATGAGCACCT CCAGGCTTTA TACCCTCGTG CTGGTACTAC AGCCTCAGCG AGTTCTCCTG 
GGCATGAAGA AGAGGGGCTT TGGTGCTGGC CGCTGGAATG GCTTCGGGGG CAAGGTGCAG 
GAAGGAGAGA CCATTGAGGA TGGGGCTAAG AGGGAGCTTC TGGAAGAAAG TGGTCTGAGA 
GTGGATACAC TGCACAAGGT AGGCCATATC TCATTTGAGT TTGTGGGCTC CCCCGAGCTG 
ATGGACGTGC ATATCTTCTC TACCGACCAC GTGCATGGGA CGCCCACAGA GAGTGAAGAA 
ATGCGCCCTC AGTGGTTCCA ACTGGACCAG ATCCCCTTTG CCGACATGTG GCCGGACGAC 
AGCTACTGGT TCCCACTCCT GCTTCAGAAG AAGAAGTTCT GTGGACACTT CAAGTTCCAT 
GGTCAGGACA CCATCCTCAG TTACTCCCTG CGGGAGGTGG ATGAGTTCTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Chenodeoxycholic Acid Derivative HS-1200 Inhibits Hepatocarcinogenesis and Improves Liver Function in Diethylnitrosamine-Exposed Rats by Downregulating MTH1.
BioMed research international20171465912(2017)
Xu M,Zhao Q,Shao D,Liu H,Qi J,Qin C

Human MTH3 (NUDT18) protein hydrolyzes oxidized forms of guanosine and deoxyguanosine diphosphates: comparison with MTH1 and MTH2.
The Journal of biological chemistry287(25)21541-9(2012 Jun)
Takagi Y,Setoyama D,Ito R,Kamiya H,Yamagata Y,Sekiguchi M

Oxidative damage to RNA and expression patterns of MTH1 in the hippocampi of senescence-accelerated SAMP8 mice and Alzheimer's disease patients.
Neurochemical research36(8)1558-65(2011 Aug)
Song XN,Zhang LQ,Liu DG,Lin J,Zheng JD,Dai DP,Hei AL,Hayakawa H,Sekiguchi M,Cai JP

Multiple mRNA decapping enzymes in mammalian cells.
Molecular cell40(3)423-32(2010 Nov)
Song MG,Li Y,Kiledjian M

Accumulation of 8-oxo-deoxyguanosine in cardiovascular tissues with the development of hypertension.
DNA repair6(6)760-9(2007 Jun)
Ohtsubo T,Ohya Y,Nakamura Y,Kansui Y,Furuichi M,Matsumura K,Fujii K,Iida M,Nakabeppu Y

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Nudt1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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