Ptpn12 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ptpn12
Entrez Gene ID	117255
Full Name	protein tyrosine phosphatase, non-receptor type 12
Synonyms	Ptpg1,RKPTP
General protein information	Preferred Names protein tyrosine phosphatase, non-receptor type 12 Names tyrosine-protein phosphatase non-receptor type 12
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 4 Map Location: 4q11
Summary	has protein tyrosine phosphatase activity [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_006235868.3	XP_006235930.1	tyrosine-protein phosphatase non-receptor type 12 isoform X1
NM_057115.2	NP_476456.2	tyrosine-protein phosphatase non-receptor type 12
XM_006235870.2	XP_006235932.1	tyrosine-protein phosphatase non-receptor type 12 isoform X2
XM_017592401.1	XP_017447890.1	tyrosine-protein phosphatase non-receptor type 12 isoform X2

Pathways from BioSystems

Homologies

Homo sapiens (human)	PTPN12	NP_002826.3
Pan troglodytes (chimpanzee)	PTPN12	XP_003318598.1
	LOC694133	XP_001082837.2
Canis lupus familiaris (dog)	PTPN12	XP_540396.4
Danio rerio (zebrafish)	ptpn12	NP_956963.1
Rattus norvegicus (Norway rat)	Ptpn12	NP_476456.2
Bos taurus (cattle)	PTPN12	NP_001192920.1
Mus musculus (house mouse)	Ptpn12	NP_035333.2
Gallus gallus (chicken)	PTPN12	XP_415970.4
Xenopus tropicalis (tropical clawed frog)	ptpn12	NP_001025666.1

Gene Ontology
Bibliography

Related articles in PubMed

ACTH Modulates PTP-PEST Activity and Promotes Its Interaction With Paxillin.
Gorostizaga AB, Mori Sequeiros Garcia MM, Acquier AB, Lopez-Costa JJ, Mendez CF, Maloberti PM, Paz C
Journal of cellular biochemistry117(9)2170-81(2016 09)

Crystal Structure and Substrate Specificity of PTPN12.
Li H, Yang F, Liu C, Xiao P, Xu Y, Liang Z, Liu C, Wang H, Wang W, Zheng W, Zhang W, Ma X, He D, Song X, Cui F, Xu Z, Yi F, Sun JP, Yu X
Cell reports15(6)1345-58(2016 05)

Protein tyrosine phosphatase-PEST (PTP-PEST) regulates mast cell-activating signals in PTP activity-dependent and -independent manners.
Motohashi S, Koizumi K, Honda R, Maruyama A, Palmer HE, Mashima K
Cellular immunology289(1-2)128-34(2014 May-Jun)

Activation of multiple proto-oncogenic tyrosine kinases in breast cancer via loss of the PTPN12 phosphatase.
Sun T, Aceto N, Meerbrey KL, Kessler JD, Zhou C, Migliaccio I, Nguyen DX, Pavlova NN, Botero M, Huang J, Bernardi RJ, Schmitt E, Hu G, Li MZ, Dephoure N, Gygi SP, Rao M, Creighton CJ, Hilsenbeck SG, Shaw CA, Muzny D, Gibbs RA, Wheeler DA, Osborne CK, Schiff R, Bentires-Alj M, Elledge SJ, Westbrook TF
Cell144(5)703-18(2011 Mar)

Nitric oxide attenuates IGF-I-induced aortic smooth muscle cell motility by decreasing Rac1 activity: essential role of PTP-PEST and p130cas.
Ceacareanu AC, Ceacareanu B, Zhuang D, Chang Y, Ray RM, Desai L, Chapman KE, Waters CM, Hassid A
American journal of physiology. Cell physiology290(4)C1263-70(2006 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

data demonstrate PTP-PEST expression in adrenal ZF and its regulation by ACTH/PKA and also suggest an ACTH-induced PTP-PEST-paxillin interaction
Title: ACTH Modulates PTP-PEST Activity and Promotes Its Interaction With Paxillin.

PTP-PEST is involved in the regulation of FcepsilonRI-mediated mast cell activation through at least two different processes represented by PTP activity-dependent and -independent pathways.
Title: Protein tyrosine phosphatase-PEST (PTP-PEST) regulates mast cell-activating signals in PTP activity-dependent and -independent manners.

Data suggest that IGF-I induces smooth muscle cell motility by increasing phosphotyrosine levels of p130(cas) and activating Rac1, and that nitric oxide decreases motility by activating PTP-PEST
Title: Nitric oxide attenuates IGF-I-induced aortic smooth muscle cell motility by decreasing Rac1 activity: essential role of PTP-PEST and p130cas.

The following Ptpn12 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ptpn12 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa26871	XM_017592401.1 Latest version!	Rattus norvegicus protein tyrosine phosphatase, non-receptor type 12 (Ptpn12), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
ORa26871	XM_006235870.2 Latest version!	Rattus norvegicus protein tyrosine phosphatase, non-receptor type 12 (Ptpn12), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
ORa11363	NM_057115.2 Latest version!	Rattus norvegicus protein tyrosine phosphatase, non-receptor type 12 (Ptpn12), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$447.30 $639.00
ORa26869	XM_006235868.3 Latest version!	Rattus norvegicus protein tyrosine phosphatase, non-receptor type 12 (Ptpn12), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ptpn12 ( XM_006235870.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006235932.1 Rattus norvegicus protein tyrosine phosphatase, non-receptor type 12 (Ptpn12), transcript variant X2, mRNA.

Price & Availability↑

CloneID	ORa26871
Clone ID Related Accession (Same CDS sequence)	XM_006235870.2 , XM_017592401.1
Accession Version	XM_006235870.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1944bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	tyrosine-protein phosphatase non-receptor type 12 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005103.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006235870.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGATATGGG AGTACAATGT GGTGATCATT GTAATGGCCT GTCGTGAATT TGAGATGGGA 
AGGAAAAAGT GTGAGCGCTA TTGGCCTTTG TATGGAGAAG ATCCTATAAC ATTTGCACCA 
TTTAAAATTT CTTGTGAAAA TGAACAAGCA AGAACAGACT ACTTCATTCG AACACTTTTA 
CTTGAATTTC AAAATGAATC CCGTCGACTC TATCAGTTTC ATTACGTGAA CTGGCCAGAC 
CATGATGTCC CTTCGTCATT CGATTCTATC CTGGACATGA TAAGTCTAAT GAGGAAGTAC 
CAAGAGCACG AAGATGTGCC TATTTGTATC CATTGCAGTG CAGGCTGTGG ACGGACAGGT 
GCTATTTGTG CCATCGACTA CACGTGGAAC TTACTGAAAG CAGGGAAAAT TCCAGAGGAA 
TTTAATGTAT TTAATTTAAT ACAAGAAATG AGAACACAAA GGCACTCTGC AGTACAAACG 
AAGGAGCAGT ATGAACTCGT CCATAGAGCT ATTGCCCAAC TGTTTGAAAA ACAGCTACAA 
CTGTATGAAA TCCACGGAGC CCAGAAAATC ACTGATGGTA ATGAAATTAG CACTGGAAAC 
ATGGTCAGTT CCATTGATAG TGAAAAACAA GATTCTCCTC CTCCAAAGCC ACCACGGACT 
CGAAGTTGTC TTGTAGAGGG GGATGCCAAG GAAGAAATCC TCCAGCCACC AGAGCCTCAC 
CCGGTGCCGC CCATCCTGAC ACCGTCGCCT CCTTCAGCAT TCCCAACCGT TACCACTGTG 
TGGCAAGACA GTGACAGGTA CCACCCAAAG CCAGTGCTGC ACATGGCTTC CCCAGAGCAG 
CCCCCAACGG ACCTCAACAG AAACTATGAT AAGTCAGCGG ACCTAATGGG GAGAAGCGAA 
TCTGCTGTTG AGCACACAGA TAAAAAGTTA GAACAAAATT TAAGTTTTGA GATTAAGAAA 
GTCCCTCTCC AAGAAGGGCC CAAAAGTTTT GATGGGAACA CACTCTTGAA TAGGGGACAT 
GCGATTAAAA TTAAGTCTGC TTCATCTTCT GTAGTTGACA AAAGCTCTAA GCCACAGGAG 
TTAAGTTCAG GTGATCTAAA GGTTCACGAT GTGTCTCAGA ATTCCTGTGC GGACTGCAGT 
GCCTCACACT TAGACAACGC TCCTGAGTCT TCAGAAGAGT CCCAGAACTC ACACACACCT 
CCACGGCCAG ACTGCTTGCC CCTTGATAAG AAAGGACATG TGACATGGTC ACTTCATGGA 
CCTGAAAATG CCACACCTGT ATCTGACTCA CCAGATAATC ATTCTCAAAC TCTAAAAACT 
GTGAGTTCCA CACCAAACTC GACAGCAGAA GAGGAATCCC ACGATCTCAC AGAGCACCAT 
AACAGCTCCC CTCTGCCGAG AGCTCCTCTC AGCTTTACCA ACCCTCTTCA CTCTGACGAC 
TCCGACTCAG ACGAAGGGAA CTCCGATGGT GCTGTGACCA AGAACAAAAC TAGCATTTCA 
ACAGCAAGTG CCACCGTGTC TCCTGCCAGT AGTACCGAGA GTGCTTGCAC TAGGAGAGTA 
CTGCCCATGT CCATTGCCAG GCAGGAAATG GCAGGAAGGC GGCATTCAGG TGCTGAGAAA 
GATGCTGACG TTAGTGAAGA GTCGCCTCCT CCCTTACCTG AAAGAACTCC CGAGTCTTTT 
GTATTAGCAG ATATGCCCAT AAGATCTGAT TGGCATGAAC TTCCAAGTCA GGAGTGCTCG 
GAGCACAGGG AATCTGAAGG CTTGATAACC TCTGGAAATG ACAAACACGA TGCAGGGGTT 
TCCCACACAG CGGCTTGTTC ACCCACTTTC AGTGACAAGA AAGAGGAAAT AACAGAAAGT 
CTAACAGAAG TCACAGACAT TGGTTTTGGT AATCGCTGTG GAAAACCTAA AGGACCAAGA 
GATCCACCTT CAGAATGGAC ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006235932.1
CDS	194..2137
Translation	MIWEYNVVIIVMACREFEMGRKKCERYWPLYGEDPITFAPFKISCENEQARTDYFIRTLLLEFQNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEHEDVPICIHCSAGCGRTGAICAIDYTWNLLKAGKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFEKQLQLYEIHGAQKITDGNEISTGNMVSSIDSEKQDSPPPKPPRTRSCLVEGDAKEEILQPPEPHPVPPILTPSPPSAFPTVTTVWQDSDRYHPKPVLHMASPEQPPTDLNRNYDKSADLMGRSESAVEHTDKKLEQNLSFEIKKVPLQEGPKSFDGNTLLNRGHAIKIKSASSSVVDKSSKPQELSSGDLKVHDVSQNSCADCSASHLDNAPESSEESQNSHTPPRPDCLPLDKKGHVTWSLHGPENATPVSDSPDNHSQTLKTVSSTPNSTAEEESHDLTEHHNSSPLPRAPLSFTNPLHSDDSDSDEGNSDGAVTKNKTSISTASATVSPASSTESACTRRVLPMSIARQEMAGRRHSGAEKDADVSEESPPPLPERTPESFVLADMPIRSDWHELPSQECSEHRESEGLITSGNDKHDAGVSHTAACSPTFSDKKEEITESLTEVTDIGFGNRCGKPKGPRDPPSEWT

Target ORF information:

RefSeq Version	XM_006235870.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus protein tyrosine phosphatase, non-receptor type 12 (Ptpn12), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006235870.2

ORF Insert Sequence:

ATGATATGGG AGTACAATGT GGTGATCATT GTAATGGCCT GTCGTGAATT TGAGATGGGA 
AGGAAAAAGT GTGAGCGCTA TTGGCCTTTG TATGGAGAAG ATCCTATAAC ATTTGCACCA 
TTTAAAATTT CTTGTGAAAA TGAACAAGCA AGAACAGACT ACTTCATTCG AACACTTTTA 
CTTGAATTTC AAAATGAATC CCGTCGACTC TATCAGTTTC ATTACGTGAA CTGGCCAGAC 
CATGATGTCC CTTCGTCATT CGATTCTATC CTGGACATGA TAAGTCTAAT GAGGAAGTAC 
CAAGAGCACG AAGATGTGCC TATTTGTATC CATTGCAGTG CAGGCTGTGG ACGGACAGGT 
GCTATTTGTG CCATCGACTA CACGTGGAAC TTACTGAAAG CAGGGAAAAT TCCAGAGGAA 
TTTAATGTAT TTAATTTAAT ACAAGAAATG AGAACACAAA GGCACTCTGC AGTACAAACG 
AAGGAGCAGT ATGAACTCGT CCATAGAGCT ATTGCCCAAC TGTTTGAAAA ACAGCTACAA 
CTGTATGAAA TCCACGGAGC CCAGAAAATC ACTGATGGTA ATGAAATTAG CACTGGAAAC 
ATGGTCAGTT CCATTGATAG TGAAAAACAA GATTCTCCTC CTCCAAAGCC ACCACGGACT 
CGAAGTTGTC TTGTAGAGGG GGATGCCAAG GAAGAAATCC TCCAGCCACC AGAGCCTCAC 
CCGGTGCCGC CCATCCTGAC ACCGTCGCCT CCTTCAGCAT TCCCAACCGT TACCACTGTG 
TGGCAAGACA GTGACAGGTA CCACCCAAAG CCAGTGCTGC ACATGGCTTC CCCAGAGCAG 
CCCCCAACGG ACCTCAACAG AAACTATGAT AAGTCAGCGG ACCTAATGGG GAGAAGCGAA 
TCTGCTGTTG AGCACACAGA TAAAAAGTTA GAACAAAATT TAAGTTTTGA GATTAAGAAA 
GTCCCTCTCC AAGAAGGGCC CAAAAGTTTT GATGGGAACA CACTCTTGAA TAGGGGACAT 
GCGATTAAAA TTAAGTCTGC TTCATCTTCT GTAGTTGACA AAAGCTCTAA GCCACAGGAG 
TTAAGTTCAG GTGATCTAAA GGTTCACGAT GTGTCTCAGA ATTCCTGTGC GGACTGCAGT 
GCCTCACACT TAGACAACGC TCCTGAGTCT TCAGAAGAGT CCCAGAACTC ACACACACCT 
CCACGGCCAG ACTGCTTGCC CCTTGATAAG AAAGGACATG TGACATGGTC ACTTCATGGA 
CCTGAAAATG CCACACCTGT ATCTGACTCA CCAGATAATC ATTCTCAAAC TCTAAAAACT 
GTGAGTTCCA CACCAAACTC GACAGCAGAA GAGGAATCCC ACGATCTCAC AGAGCACCAT 
AACAGCTCCC CTCTGCCGAG AGCTCCTCTC AGCTTTACCA ACCCTCTTCA CTCTGACGAC 
TCCGACTCAG ACGAAGGGAA CTCCGATGGT GCTGTGACCA AGAACAAAAC TAGCATTTCA 
ACAGCAAGTG CCACCGTGTC TCCTGCCAGT AGTACCGAGA GTGCTTGCAC TAGGAGAGTA 
CTGCCCATGT CCATTGCCAG GCAGGAAATG GCAGGAAGGC GGCATTCAGG TGCTGAGAAA 
GATGCTGACG TTAGTGAAGA GTCGCCTCCT CCCTTACCTG AAAGAACTCC CGAGTCTTTT 
GTATTAGCAG ATATGCCCAT AAGATCTGAT TGGCATGAAC TTCCAAGTCA GGAGTGCTCG 
GAGCACAGGG AATCTGAAGG CTTGATAACC TCTGGAAATG ACAAACACGA TGCAGGGGTT 
TCCCACACAG CGGCTTGTTC ACCCACTTTC AGTGACAAGA AAGAGGAAAT AACAGAAAGT 
CTAACAGAAG TCACAGACAT TGGTTTTGGT AATCGCTGTG GAAAACCTAA AGGACCAAGA 
GATCCACCTT CAGAATGGAC ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Ptpn12 ( XM_017592401.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017447890.1 Rattus norvegicus protein tyrosine phosphatase, non-receptor type 12 (Ptpn12), transcript variant X3, mRNA.

Price & Availability↑

CloneID	ORa26871
Clone ID Related Accession (Same CDS sequence)	XM_006235870.2 , XM_017592401.1
Accession Version	XM_017592401.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1944bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	tyrosine-protein phosphatase non-receptor type 12 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005103.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGATATGGG AGTACAATGT GGTGATCATT GTAATGGCCT GTCGTGAATT TGAGATGGGA 
AGGAAAAAGT GTGAGCGCTA TTGGCCTTTG TATGGAGAAG ATCCTATAAC ATTTGCACCA 
TTTAAAATTT CTTGTGAAAA TGAACAAGCA AGAACAGACT ACTTCATTCG AACACTTTTA 
CTTGAATTTC AAAATGAATC CCGTCGACTC TATCAGTTTC ATTACGTGAA CTGGCCAGAC 
CATGATGTCC CTTCGTCATT CGATTCTATC CTGGACATGA TAAGTCTAAT GAGGAAGTAC 
CAAGAGCACG AAGATGTGCC TATTTGTATC CATTGCAGTG CAGGCTGTGG ACGGACAGGT 
GCTATTTGTG CCATCGACTA CACGTGGAAC TTACTGAAAG CAGGGAAAAT TCCAGAGGAA 
TTTAATGTAT TTAATTTAAT ACAAGAAATG AGAACACAAA GGCACTCTGC AGTACAAACG 
AAGGAGCAGT ATGAACTCGT CCATAGAGCT ATTGCCCAAC TGTTTGAAAA ACAGCTACAA 
CTGTATGAAA TCCACGGAGC CCAGAAAATC ACTGATGGTA ATGAAATTAG CACTGGAAAC 
ATGGTCAGTT CCATTGATAG TGAAAAACAA GATTCTCCTC CTCCAAAGCC ACCACGGACT 
CGAAGTTGTC TTGTAGAGGG GGATGCCAAG GAAGAAATCC TCCAGCCACC AGAGCCTCAC 
CCGGTGCCGC CCATCCTGAC ACCGTCGCCT CCTTCAGCAT TCCCAACCGT TACCACTGTG 
TGGCAAGACA GTGACAGGTA CCACCCAAAG CCAGTGCTGC ACATGGCTTC CCCAGAGCAG 
CCCCCAACGG ACCTCAACAG AAACTATGAT AAGTCAGCGG ACCTAATGGG GAGAAGCGAA 
TCTGCTGTTG AGCACACAGA TAAAAAGTTA GAACAAAATT TAAGTTTTGA GATTAAGAAA 
GTCCCTCTCC AAGAAGGGCC CAAAAGTTTT GATGGGAACA CACTCTTGAA TAGGGGACAT 
GCGATTAAAA TTAAGTCTGC TTCATCTTCT GTAGTTGACA AAAGCTCTAA GCCACAGGAG 
TTAAGTTCAG GTGATCTAAA GGTTCACGAT GTGTCTCAGA ATTCCTGTGC GGACTGCAGT 
GCCTCACACT TAGACAACGC TCCTGAGTCT TCAGAAGAGT CCCAGAACTC ACACACACCT 
CCACGGCCAG ACTGCTTGCC CCTTGATAAG AAAGGACATG TGACATGGTC ACTTCATGGA 
CCTGAAAATG CCACACCTGT ATCTGACTCA CCAGATAATC ATTCTCAAAC TCTAAAAACT 
GTGAGTTCCA CACCAAACTC GACAGCAGAA GAGGAATCCC ACGATCTCAC AGAGCACCAT 
AACAGCTCCC CTCTGCCGAG AGCTCCTCTC AGCTTTACCA ACCCTCTTCA CTCTGACGAC 
TCCGACTCAG ACGAAGGGAA CTCCGATGGT GCTGTGACCA AGAACAAAAC TAGCATTTCA 
ACAGCAAGTG CCACCGTGTC TCCTGCCAGT AGTACCGAGA GTGCTTGCAC TAGGAGAGTA 
CTGCCCATGT CCATTGCCAG GCAGGAAATG GCAGGAAGGC GGCATTCAGG TGCTGAGAAA 
GATGCTGACG TTAGTGAAGA GTCGCCTCCT CCCTTACCTG AAAGAACTCC CGAGTCTTTT 
GTATTAGCAG ATATGCCCAT AAGATCTGAT TGGCATGAAC TTCCAAGTCA GGAGTGCTCG 
GAGCACAGGG AATCTGAAGG CTTGATAACC TCTGGAAATG ACAAACACGA TGCAGGGGTT 
TCCCACACAG CGGCTTGTTC ACCCACTTTC AGTGACAAGA AAGAGGAAAT AACAGAAAGT 
CTAACAGAAG TCACAGACAT TGGTTTTGGT AATCGCTGTG GAAAACCTAA AGGACCAAGA 
GATCCACCTT CAGAATGGAC ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017447890.1
CDS	354..2297
Translation	MIWEYNVVIIVMACREFEMGRKKCERYWPLYGEDPITFAPFKISCENEQARTDYFIRTLLLEFQNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEHEDVPICIHCSAGCGRTGAICAIDYTWNLLKAGKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFEKQLQLYEIHGAQKITDGNEISTGNMVSSIDSEKQDSPPPKPPRTRSCLVEGDAKEEILQPPEPHPVPPILTPSPPSAFPTVTTVWQDSDRYHPKPVLHMASPEQPPTDLNRNYDKSADLMGRSESAVEHTDKKLEQNLSFEIKKVPLQEGPKSFDGNTLLNRGHAIKIKSASSSVVDKSSKPQELSSGDLKVHDVSQNSCADCSASHLDNAPESSEESQNSHTPPRPDCLPLDKKGHVTWSLHGPENATPVSDSPDNHSQTLKTVSSTPNSTAEEESHDLTEHHNSSPLPRAPLSFTNPLHSDDSDSDEGNSDGAVTKNKTSISTASATVSPASSTESACTRRVLPMSIARQEMAGRRHSGAEKDADVSEESPPPLPERTPESFVLADMPIRSDWHELPSQECSEHRESEGLITSGNDKHDAGVSHTAACSPTFSDKKEEITESLTEVTDIGFGNRCGKPKGPRDPPSEWT

Target ORF information:

RefSeq Version	XM_017592401.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus protein tyrosine phosphatase, non-receptor type 12 (Ptpn12), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017592401.1

ORF Insert Sequence:

ATGATATGGG AGTACAATGT GGTGATCATT GTAATGGCCT GTCGTGAATT TGAGATGGGA 
AGGAAAAAGT GTGAGCGCTA TTGGCCTTTG TATGGAGAAG ATCCTATAAC ATTTGCACCA 
TTTAAAATTT CTTGTGAAAA TGAACAAGCA AGAACAGACT ACTTCATTCG AACACTTTTA 
CTTGAATTTC AAAATGAATC CCGTCGACTC TATCAGTTTC ATTACGTGAA CTGGCCAGAC 
CATGATGTCC CTTCGTCATT CGATTCTATC CTGGACATGA TAAGTCTAAT GAGGAAGTAC 
CAAGAGCACG AAGATGTGCC TATTTGTATC CATTGCAGTG CAGGCTGTGG ACGGACAGGT 
GCTATTTGTG CCATCGACTA CACGTGGAAC TTACTGAAAG CAGGGAAAAT TCCAGAGGAA 
TTTAATGTAT TTAATTTAAT ACAAGAAATG AGAACACAAA GGCACTCTGC AGTACAAACG 
AAGGAGCAGT ATGAACTCGT CCATAGAGCT ATTGCCCAAC TGTTTGAAAA ACAGCTACAA 
CTGTATGAAA TCCACGGAGC CCAGAAAATC ACTGATGGTA ATGAAATTAG CACTGGAAAC 
ATGGTCAGTT CCATTGATAG TGAAAAACAA GATTCTCCTC CTCCAAAGCC ACCACGGACT 
CGAAGTTGTC TTGTAGAGGG GGATGCCAAG GAAGAAATCC TCCAGCCACC AGAGCCTCAC 
CCGGTGCCGC CCATCCTGAC ACCGTCGCCT CCTTCAGCAT TCCCAACCGT TACCACTGTG 
TGGCAAGACA GTGACAGGTA CCACCCAAAG CCAGTGCTGC ACATGGCTTC CCCAGAGCAG 
CCCCCAACGG ACCTCAACAG AAACTATGAT AAGTCAGCGG ACCTAATGGG GAGAAGCGAA 
TCTGCTGTTG AGCACACAGA TAAAAAGTTA GAACAAAATT TAAGTTTTGA GATTAAGAAA 
GTCCCTCTCC AAGAAGGGCC CAAAAGTTTT GATGGGAACA CACTCTTGAA TAGGGGACAT 
GCGATTAAAA TTAAGTCTGC TTCATCTTCT GTAGTTGACA AAAGCTCTAA GCCACAGGAG 
TTAAGTTCAG GTGATCTAAA GGTTCACGAT GTGTCTCAGA ATTCCTGTGC GGACTGCAGT 
GCCTCACACT TAGACAACGC TCCTGAGTCT TCAGAAGAGT CCCAGAACTC ACACACACCT 
CCACGGCCAG ACTGCTTGCC CCTTGATAAG AAAGGACATG TGACATGGTC ACTTCATGGA 
CCTGAAAATG CCACACCTGT ATCTGACTCA CCAGATAATC ATTCTCAAAC TCTAAAAACT 
GTGAGTTCCA CACCAAACTC GACAGCAGAA GAGGAATCCC ACGATCTCAC AGAGCACCAT 
AACAGCTCCC CTCTGCCGAG AGCTCCTCTC AGCTTTACCA ACCCTCTTCA CTCTGACGAC 
TCCGACTCAG ACGAAGGGAA CTCCGATGGT GCTGTGACCA AGAACAAAAC TAGCATTTCA 
ACAGCAAGTG CCACCGTGTC TCCTGCCAGT AGTACCGAGA GTGCTTGCAC TAGGAGAGTA 
CTGCCCATGT CCATTGCCAG GCAGGAAATG GCAGGAAGGC GGCATTCAGG TGCTGAGAAA 
GATGCTGACG TTAGTGAAGA GTCGCCTCCT CCCTTACCTG AAAGAACTCC CGAGTCTTTT 
GTATTAGCAG ATATGCCCAT AAGATCTGAT TGGCATGAAC TTCCAAGTCA GGAGTGCTCG 
GAGCACAGGG AATCTGAAGG CTTGATAACC TCTGGAAATG ACAAACACGA TGCAGGGGTT 
TCCCACACAG CGGCTTGTTC ACCCACTTTC AGTGACAAGA AAGAGGAAAT AACAGAAAGT 
CTAACAGAAG TCACAGACAT TGGTTTTGGT AATCGCTGTG GAAAACCTAA AGGACCAAGA 
GATCCACCTT CAGAATGGAC ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Ptpn12 ( NM_057115.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_476456.2 Rattus norvegicus protein tyrosine phosphatase, non-receptor type 12 (Ptpn12), mRNA.

Price & Availability↑

CloneID	ORa11363
Clone ID Related Accession (Same CDS sequence)	NM_057115.2
Accession Version	NM_057115.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2301bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Rattus norvegicus(Norway rat)
Product	tyrosine-protein phosphatase non-receptor type 12
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from D38072.1, CK367675.1, DY560717.1, CV102923.1, BP489229.1 and CX570435.1. On Jan 3, 2008 this sequence version replaced NM_057115.1. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGAGCAAG TGGAGATTCT GAGGAGGTTC ATCCAGAGGG TCCAGGCCAT GAAAAGTCCG 
GACCACAATG GGGAGGACAA CTTCGCCCGG GACTTCATGC GATTGAGAAG ATTGTCTACC 
AAATATAGAA CAGAAAAGAT TTATCCCACA GCCACTGGAG AAAAAGAAGA AAATGTTAAA 
AAGAACAGAT ATAAGGACAT ACTGCCATTT GATCACAGCC GAGTTAAGTT GACTTTGAAG 
ACACCATCCC AAGATTCAGA TTATATCAAT GCAAATTTTA TTAAGGGTGT ATATGGGCCG 
AGAGCATACG TGGCAACCCA AGGGCCTTTG GCGAATACAG TCATAGACTT CTGGAGGATG 
ATATGGGAGT ACAATGTGGT GATCATTGTA ATGGCCTGTC GTGAATTTGA GATGGGAAGG 
AAAAAGTGTG AGCGCTATTG GCCTTTGTAT GGAGAAGATC CTATAACATT TGCACCATTT 
AAAATTTCTT GTGAAAATGA ACAAGCAAGA ACAGACTACT TCATTCGAAC ACTTTTACTT 
GAATTTCAAA ATGAATCCCG TCGACTCTAT CAGTTTCATT ACGTGAACTG GCCAGACCAT 
GATGTCCCTT CGTCATTCGA TTCTATCCTG GACATGATAA GTCTAATGAG GAAGTACCAA 
GAGCACGAAG ATGTGCCTAT TTGTATCCAT TGCAGTGCAG GCTGTGGACG GACAGGTGCT 
ATTTGTGCCA TCGACTACAC GTGGAACTTA CTGAAAGCAG GGAAAATTCC AGAGGAATTT 
AATGTATTTA ATTTAATACA AGAAATGAGA ACACAAAGGC ACTCTGCAGT ACAAACGAAG 
GAGCAGTATG AACTCGTCCA TAGAGCTATT GCCCAACTGT TTGAAAAACA GCTACAACTG 
TATGAAATCC ACGGAGCCCA GAAAATCACT GATGGTAATG AAATTAGCAC TGGAAACATG 
GTCAGTTCCA TTGATAGTGA AAAACAAGAT TCTCCTCCTC CAAAGCCACC ACGGACTCGA 
AGTTGTCTTG TAGAGGGGGA TGCCAAGGAA GAAATCCTCC AGCCACCAGA GCCTCACCCG 
GTGCCGCCCA TCCTGACACC GTCGCCTCCT TCAGCATTCC CAACCGTTAC CACTGTGTGG 
CAAGACAGTG ACAGGTACCA CCCAAAGCCA GTGCTGCACA TGGCTTCCCC AGAGCAGCCC 
CCAACGGACC TCAACAGAAA CTATGATAAG TCAGCGGACC TAATGGGGAG AAGCGAATCT 
GCTGTTGAGC ACACAGATAA AAAGTTAGAA CAAAATTTAA GTTTTGAGAT TAAGAAAGTC 
CCTCTCCAAG AAGGGCCCAA AAGTTTTGAT GGGAACACAC TCTTGAATAG GGGACATGCG 
ATTAAAATTA AGTCTGCTTC ATCTTCTGTA GTTGACAAAA GCTCTAAGCC ACAGGAGTTA 
AGTTCAGGTG ATCTAAAGGT TCACGATGTG TCTCAGAATT CCTGTGCGGA CTGCAGTGCC 
TCACACTTAG ACAACGCTCC TGAGTCTTCA GAAGAGTCCC AGAACTCACA CACACCTCCA 
CGGCCAGACT GCTTGCCCCT TGATAAGAAA GGACATGTGA CATGGTCACT TCATGGACCT 
GAAAATGCCA CACCTGTATC TGACTCACCA GATAATCATT CTCAAACTCT AAAAACTGTG 
AGTTCCACAC CAAACTCGAC AGCAGAAGAG GAATCCCACG ATCTCACAGA GCACCATAAC 
AGCTCCCCTC TGCCGAGAGC TCCTCTCAGC TTTACCAACC CTCTTCACTC TGACGACTCC 
GACTCAGACG AAGGGAACTC CGATGGTGCT GTGACCAAGA ACAAAACTAG CATTTCAACA 
GCAAGTGCCA CCGTGTCTCC TGCCAGTAGT ACCGAGAGTG CTTGCACTAG GAGAGTACTG 
CCCATGTCCA TTGCCAGGCA GGAAATGGCA GGAAGGCGGC ATTCAGGTGC TGAGAAAGAT 
GCTGACGTTA GTGAAGAGTC GCCTCCTCCC TTACCTGAAA GAACTCCCGA GTCTTTTGTA 
TTAGCAGATA TGCCCATAAG ATCTGATTGG CATGAACTTC CAAGTCAGGA GTGCTCGGAG 
CACAGGGAAT CTGAAGGCTT GATAACCTCT GGAAATGACA AACACGATGC AGGGGTTTCC 
CACACAGCGG CTTGTTCACC CACTTTCAGT GACAAGAAAG AGGAAATAAC AGAAAGTCTA 
ACAGAAGTCA CAGACATTGG TTTTGGTAAT CGCTGTGGAA AACCTAAAGG ACCAAGAGAT 
CCACCTTCAG AATGGACATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_476456.2
CDS	70..2370
Translation	MEQVEILRRFIQRVQAMKSPDHNGEDNFARDFMRLRRLSTKYRTEKIYPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPRAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLYGEDPITFAPFKISCENEQARTDYFIRTLLLEFQNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEHEDVPICIHCSAGCGRTGAICAIDYTWNLLKAGKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFEKQLQLYEIHGAQKITDGNEISTGNMVSSIDSEKQDSPPPKPPRTRSCLVEGDAKEEILQPPEPHPVPPILTPSPPSAFPTVTTVWQDSDRYHPKPVLHMASPEQPPTDLNRNYDKSADLMGRSESAVEHTDKKLEQNLSFEIKKVPLQEGPKSFDGNTLLNRGHAIKIKSASSSVVDKSSKPQELSSGDLKVHDVSQNSCADCSASHLDNAPESSEESQNSHTPPRPDCLPLDKKGHVTWSLHGPENATPVSDSPDNHSQTLKTVSSTPNSTAEEESHDLTEHHNSSPLPRAPLSFTNPLHSDDSDSDEGNSDGAVTKNKTSISTASATVSPASSTESACTRRVLPMSIARQEMAGRRHSGAEKDADVSEESPPPLPERTPESFVLADMPIRSDWHELPSQECSEHRESEGLITSGNDKHDAGVSHTAACSPTFSDKKEEITESLTEVTDIGFGNRCGKPKGPRDPPSEWT

Target ORF information:

RefSeq Version	NM_057115.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus protein tyrosine phosphatase, non-receptor type 12 (Ptpn12), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_057115.2

ORF Insert Sequence:

ATGGAGCAAG TGGAGATTCT GAGGAGGTTC ATCCAGAGGG TCCAGGCCAT GAAAAGTCCG 
GACCACAATG GGGAGGACAA CTTCGCCCGG GACTTCATGC GATTGAGAAG ATTGTCTACC 
AAATATAGAA CAGAAAAGAT TTATCCCACA GCCACTGGAG AAAAAGAAGA AAATGTTAAA 
AAGAACAGAT ATAAGGACAT ACTGCCATTT GATCACAGCC GAGTTAAGTT GACTTTGAAG 
ACACCATCCC AAGATTCAGA TTATATCAAT GCAAATTTTA TTAAGGGTGT ATATGGGCCG 
AGAGCATACG TGGCAACCCA AGGGCCTTTG GCGAATACAG TCATAGACTT CTGGAGGATG 
ATATGGGAGT ACAATGTGGT GATCATTGTA ATGGCCTGTC GTGAATTTGA GATGGGAAGG 
AAAAAGTGTG AGCGCTATTG GCCTTTGTAT GGAGAAGATC CTATAACATT TGCACCATTT 
AAAATTTCTT GTGAAAATGA ACAAGCAAGA ACAGACTACT TCATTCGAAC ACTTTTACTT 
GAATTTCAAA ATGAATCCCG TCGACTCTAT CAGTTTCATT ACGTGAACTG GCCAGACCAT 
GATGTCCCTT CGTCATTCGA TTCTATCCTG GACATGATAA GTCTAATGAG GAAGTACCAA 
GAGCACGAAG ATGTGCCTAT TTGTATCCAT TGCAGTGCAG GCTGTGGACG GACAGGTGCT 
ATTTGTGCCA TCGACTACAC GTGGAACTTA CTGAAAGCAG GGAAAATTCC AGAGGAATTT 
AATGTATTTA ATTTAATACA AGAAATGAGA ACACAAAGGC ACTCTGCAGT ACAAACGAAG 
GAGCAGTATG AACTCGTCCA TAGAGCTATT GCCCAACTGT TTGAAAAACA GCTACAACTG 
TATGAAATCC ACGGAGCCCA GAAAATCACT GATGGTAATG AAATTAGCAC TGGAAACATG 
GTCAGTTCCA TTGATAGTGA AAAACAAGAT TCTCCTCCTC CAAAGCCACC ACGGACTCGA 
AGTTGTCTTG TAGAGGGGGA TGCCAAGGAA GAAATCCTCC AGCCACCAGA GCCTCACCCG 
GTGCCGCCCA TCCTGACACC GTCGCCTCCT TCAGCATTCC CAACCGTTAC CACTGTGTGG 
CAAGACAGTG ACAGGTACCA CCCAAAGCCA GTGCTGCACA TGGCTTCCCC AGAGCAGCCC 
CCAACGGACC TCAACAGAAA CTATGATAAG TCAGCGGACC TAATGGGGAG AAGCGAATCT 
GCTGTTGAGC ACACAGATAA AAAGTTAGAA CAAAATTTAA GTTTTGAGAT TAAGAAAGTC 
CCTCTCCAAG AAGGGCCCAA AAGTTTTGAT GGGAACACAC TCTTGAATAG GGGACATGCG 
ATTAAAATTA AGTCTGCTTC ATCTTCTGTA GTTGACAAAA GCTCTAAGCC ACAGGAGTTA 
AGTTCAGGTG ATCTAAAGGT TCACGATGTG TCTCAGAATT CCTGTGCGGA CTGCAGTGCC 
TCACACTTAG ACAACGCTCC TGAGTCTTCA GAAGAGTCCC AGAACTCACA CACACCTCCA 
CGGCCAGACT GCTTGCCCCT TGATAAGAAA GGACATGTGA CATGGTCACT TCATGGACCT 
GAAAATGCCA CACCTGTATC TGACTCACCA GATAATCATT CTCAAACTCT AAAAACTGTG 
AGTTCCACAC CAAACTCGAC AGCAGAAGAG GAATCCCACG ATCTCACAGA GCACCATAAC 
AGCTCCCCTC TGCCGAGAGC TCCTCTCAGC TTTACCAACC CTCTTCACTC TGACGACTCC 
GACTCAGACG AAGGGAACTC CGATGGTGCT GTGACCAAGA ACAAAACTAG CATTTCAACA 
GCAAGTGCCA CCGTGTCTCC TGCCAGTAGT ACCGAGAGTG CTTGCACTAG GAGAGTACTG 
CCCATGTCCA TTGCCAGGCA GGAAATGGCA GGAAGGCGGC ATTCAGGTGC TGAGAAAGAT 
GCTGACGTTA GTGAAGAGTC GCCTCCTCCC TTACCTGAAA GAACTCCCGA GTCTTTTGTA 
TTAGCAGATA TGCCCATAAG ATCTGATTGG CATGAACTTC CAAGTCAGGA GTGCTCGGAG 
CACAGGGAAT CTGAAGGCTT GATAACCTCT GGAAATGACA AACACGATGC AGGGGTTTCC 
CACACAGCGG CTTGTTCACC CACTTTCAGT GACAAGAAAG AGGAAATAAC AGAAAGTCTA 
ACAGAAGTCA CAGACATTGG TTTTGGTAAT CGCTGTGGAA AACCTAAAGG ACCAAGAGAT 
CCACCTTCAG AATGGACATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Ptpn12 ( XM_006235868.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006235930.1 Rattus norvegicus protein tyrosine phosphatase, non-receptor type 12 (Ptpn12), transcript variant X1, mRNA.

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CloneID	ORa26869
Clone ID Related Accession (Same CDS sequence)	XM_006235868.3
Accession Version	XM_006235868.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2208bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	tyrosine-protein phosphatase non-receptor type 12 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005103.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006235868.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGCAAG TGGAGATTCT GAGGAGGTTC ATCCAGAGGG TCCAGGCCAT GAAAAGTCCG 
GACCACAATG GGGAGGACAA CTTCGCCCGG GACTTCATGC GATTGAGAAG ATTGTCTACC 
AAATATAGAA CAGAAAAGAT TTATCCCACA GCCACTGGAG AAAAAGAAGA AAATGTTAAA 
AAGAACAGAT ATAAGGACAT ACTGCCATTT GATCACAGCC GAGTTAAGTT GACTTTGAAG 
ACACCATCCC AAGATTCAGA TTATATCAAT GCAAATTTTA TTAAGGGTGT ATATGGGCCG 
AGAGCATACG TGGCAACCCA AGGGCCTTTG GCGAATACAG TCATAGACTT CTGGAGGATG 
ATATGGGAGT ACAATGTGGT GATCATTGTA ATGGCCTGTC GTGAATTTGA GATGGGAAGG 
AAAAAGTGTG AGCGCTATTG GCCTTTGTAT GGAGAAGATC CTATAACATT TGCACCATTT 
AAAATTTCTT GTGAAAATGA ACAAGCAAGA ACAGACTACT TCATTCGAAC ACTTTTACTT 
GAATTTCAAA ATGAATCCCG TCGACTCTAT CAGTTTCATT ACGTGAACTG GCCAGACCAT 
GATGTCCCTT CGTCATTCGA TTCTATCCTG GACATGATAA GTCTAATGAG GAAGTACCAA 
GAGCACGAAG ATGTGCCTAT TTGTATCCAT TGCAGTGCAG GCTGTGGACG GACAGGTGCT 
ATTTGTGCCA TCGACTACAC GTGGAACTTA CTGAAAGCAG GGAAAATTCC AGAGGAATTT 
AATGTATTTA ATTTAATACA AGAAATGAGA ACACAAAGGC ACTCTGCAGT ACAAACGAAG 
GAGCAGTATG AACTCGTCCA TAGAGCTATT GCCCAACTGT TTGAAAAACA GCTACAACTG 
TATGAAATCC ACGGAGCCCA GAAAATCACT GATGGTAATG AAATTAGCAC TGGAAACATG 
GTCAGTTCCA TTGATAGTGA AAAACAAGAT TCTCCTCCTC CAAAGCCACC ACGGACTCGA 
AGTTGTCTTG TAGAGGGGGA TGCCAAGGAA GAAATCCTCC AGCCACCAGA GCCTCACCCG 
GTGCCGCCCA TCCTGACACC GTCGCCTCCT TCAGCATTCC CAACCGTTAC CACTGTGTGG 
CAAGACAGTG ACAGGTACCA CCCAAAGCCA GTGCTGCACA TGGCTTCCCC AGAGCAGCCC 
CCAACGGACC TCAACAGAAA CTATGATAAG TCAGCGGACC TAATGGGGAG AAGCGAATCT 
GCTGTTGAGC ACACAGATAA AAAGTTAGAA CAAAATTTAA GTTTTGAGAT TAAGAAAGTC 
CCTCTCCAAG AAGGGCCCAA AAGTTTTGAT GGGAACACAC TCTTGAATAG GGGACATGCG 
ATTAAAATTA AGTCTGCTTC ATCTTCTGTA GTTGACAAAA GCTCTAAGCC ACAGGAGTTA 
AGTTCAGGTG ATCTAAAGGT TCACGATGTG TCTCAGAATT CCTGTGCGGA CTGCAGTGCC 
TCACACTTAG ACAACGCTCC TGAGTCTTCA GAAGAGTCCC AGAACTCACA CACACCTCCA 
CGGCCAGACT GCTTGCCCCT TGATAAGAAA GGACATGTGA CATGGTCACT TCATGGACCT 
GAAAATGCCA CACCTGTATC TGACTCACCA GATAATCATT CTCAAACTCT AAAAACTGTG 
AGTTCCACAC CAAACTCGAC AGCAGAAGAG GAATCCCACG ATCTCACAGA GCACCATAAC 
AGCTCCCCTC TGCCGAGAGC TCCTCTCAGC TTTACCAACC CTCTTCACTC TGACGACTCC 
GACTCAGACG AAGGGAACTC CGATGGTGCT GTGACCAAGA ACAAAACTAG CATTTCAACA 
GCAAGTGCCA CCGTGTCTCC TGCCAGTAGT ACCGAGAGTG CTTGCACTAG GAGAGTACTG 
CCCATGTCCA TTGCCAGGCA GGAAATGGCA GGAAGGCGGC ATTCAGGTGC TGAGAAAGAT 
GCTGACGTTA GTGAAGAGTC GCCTCCTCCC TTACCTGAAA GAACTCCCGA GTCTTTTGTA 
TTAGCAGATA TGCCCATAAG ATCTGATTGG CATGAACTTC CAAGTCAGGA GTGCTCGGAG 
CACAGGGAAT CTGAAGGCTT GATAACCTCT GGAAATGACA AACACGGTTT TGGTAATCGC 
TGTGGAAAAC CTAAAGGACC AAGAGATCCA CCTTCAGAAT GGACATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006235930.1
CDS	60..2267
Translation	MEQVEILRRFIQRVQAMKSPDHNGEDNFARDFMRLRRLSTKYRTEKIYPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPRAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLYGEDPITFAPFKISCENEQARTDYFIRTLLLEFQNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEHEDVPICIHCSAGCGRTGAICAIDYTWNLLKAGKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFEKQLQLYEIHGAQKITDGNEISTGNMVSSIDSEKQDSPPPKPPRTRSCLVEGDAKEEILQPPEPHPVPPILTPSPPSAFPTVTTVWQDSDRYHPKPVLHMASPEQPPTDLNRNYDKSADLMGRSESAVEHTDKKLEQNLSFEIKKVPLQEGPKSFDGNTLLNRGHAIKIKSASSSVVDKSSKPQELSSGDLKVHDVSQNSCADCSASHLDNAPESSEESQNSHTPPRPDCLPLDKKGHVTWSLHGPENATPVSDSPDNHSQTLKTVSSTPNSTAEEESHDLTEHHNSSPLPRAPLSFTNPLHSDDSDSDEGNSDGAVTKNKTSISTASATVSPASSTESACTRRVLPMSIARQEMAGRRHSGAEKDADVSEESPPPLPERTPESFVLADMPIRSDWHELPSQECSEHRESEGLITSGNDKHGFGNRCGKPKGPRDPPSEWT

Target ORF information:

RefSeq Version	XM_006235868.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus protein tyrosine phosphatase, non-receptor type 12 (Ptpn12), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006235868.3

ORF Insert Sequence:

ATGGAGCAAG TGGAGATTCT GAGGAGGTTC ATCCAGAGGG TCCAGGCCAT GAAAAGTCCG 
GACCACAATG GGGAGGACAA CTTCGCCCGG GACTTCATGC GATTGAGAAG ATTGTCTACC 
AAATATAGAA CAGAAAAGAT TTATCCCACA GCCACTGGAG AAAAAGAAGA AAATGTTAAA 
AAGAACAGAT ATAAGGACAT ACTGCCATTT GATCACAGCC GAGTTAAGTT GACTTTGAAG 
ACACCATCCC AAGATTCAGA TTATATCAAT GCAAATTTTA TTAAGGGTGT ATATGGGCCG 
AGAGCATACG TGGCAACCCA AGGGCCTTTG GCGAATACAG TCATAGACTT CTGGAGGATG 
ATATGGGAGT ACAATGTGGT GATCATTGTA ATGGCCTGTC GTGAATTTGA GATGGGAAGG 
AAAAAGTGTG AGCGCTATTG GCCTTTGTAT GGAGAAGATC CTATAACATT TGCACCATTT 
AAAATTTCTT GTGAAAATGA ACAAGCAAGA ACAGACTACT TCATTCGAAC ACTTTTACTT 
GAATTTCAAA ATGAATCCCG TCGACTCTAT CAGTTTCATT ACGTGAACTG GCCAGACCAT 
GATGTCCCTT CGTCATTCGA TTCTATCCTG GACATGATAA GTCTAATGAG GAAGTACCAA 
GAGCACGAAG ATGTGCCTAT TTGTATCCAT TGCAGTGCAG GCTGTGGACG GACAGGTGCT 
ATTTGTGCCA TCGACTACAC GTGGAACTTA CTGAAAGCAG GGAAAATTCC AGAGGAATTT 
AATGTATTTA ATTTAATACA AGAAATGAGA ACACAAAGGC ACTCTGCAGT ACAAACGAAG 
GAGCAGTATG AACTCGTCCA TAGAGCTATT GCCCAACTGT TTGAAAAACA GCTACAACTG 
TATGAAATCC ACGGAGCCCA GAAAATCACT GATGGTAATG AAATTAGCAC TGGAAACATG 
GTCAGTTCCA TTGATAGTGA AAAACAAGAT TCTCCTCCTC CAAAGCCACC ACGGACTCGA 
AGTTGTCTTG TAGAGGGGGA TGCCAAGGAA GAAATCCTCC AGCCACCAGA GCCTCACCCG 
GTGCCGCCCA TCCTGACACC GTCGCCTCCT TCAGCATTCC CAACCGTTAC CACTGTGTGG 
CAAGACAGTG ACAGGTACCA CCCAAAGCCA GTGCTGCACA TGGCTTCCCC AGAGCAGCCC 
CCAACGGACC TCAACAGAAA CTATGATAAG TCAGCGGACC TAATGGGGAG AAGCGAATCT 
GCTGTTGAGC ACACAGATAA AAAGTTAGAA CAAAATTTAA GTTTTGAGAT TAAGAAAGTC 
CCTCTCCAAG AAGGGCCCAA AAGTTTTGAT GGGAACACAC TCTTGAATAG GGGACATGCG 
ATTAAAATTA AGTCTGCTTC ATCTTCTGTA GTTGACAAAA GCTCTAAGCC ACAGGAGTTA 
AGTTCAGGTG ATCTAAAGGT TCACGATGTG TCTCAGAATT CCTGTGCGGA CTGCAGTGCC 
TCACACTTAG ACAACGCTCC TGAGTCTTCA GAAGAGTCCC AGAACTCACA CACACCTCCA 
CGGCCAGACT GCTTGCCCCT TGATAAGAAA GGACATGTGA CATGGTCACT TCATGGACCT 
GAAAATGCCA CACCTGTATC TGACTCACCA GATAATCATT CTCAAACTCT AAAAACTGTG 
AGTTCCACAC CAAACTCGAC AGCAGAAGAG GAATCCCACG ATCTCACAGA GCACCATAAC 
AGCTCCCCTC TGCCGAGAGC TCCTCTCAGC TTTACCAACC CTCTTCACTC TGACGACTCC 
GACTCAGACG AAGGGAACTC CGATGGTGCT GTGACCAAGA ACAAAACTAG CATTTCAACA 
GCAAGTGCCA CCGTGTCTCC TGCCAGTAGT ACCGAGAGTG CTTGCACTAG GAGAGTACTG 
CCCATGTCCA TTGCCAGGCA GGAAATGGCA GGAAGGCGGC ATTCAGGTGC TGAGAAAGAT 
GCTGACGTTA GTGAAGAGTC GCCTCCTCCC TTACCTGAAA GAACTCCCGA GTCTTTTGTA 
TTAGCAGATA TGCCCATAAG ATCTGATTGG CATGAACTTC CAAGTCAGGA GTGCTCGGAG 
CACAGGGAAT CTGAAGGCTT GATAACCTCT GGAAATGACA AACACGGTTT TGGTAATCGC 
TGTGGAAAAC CTAAAGGACC AAGAGATCCA CCTTCAGAAT GGACATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

ACTH Modulates PTP-PEST Activity and Promotes Its Interaction With Paxillin.
Journal of cellular biochemistry117(9)2170-81(2016 09)
Gorostizaga AB,Mori Sequeiros Garcia MM,Acquier AB,Lopez-Costa JJ,Mendez CF,Maloberti PM,Paz C

Crystal Structure and Substrate Specificity of PTPN12.
Cell reports15(6)1345-58(2016 05)
Li H,Yang F,Liu C,Xiao P,Xu Y,Liang Z,Liu C,Wang H,Wang W,Zheng W,Zhang W,Ma X,He D,Song X,Cui F,Xu Z,Yi F,Sun JP,Yu X

Protein tyrosine phosphatase-PEST (PTP-PEST) regulates mast cell-activating signals in PTP activity-dependent and -independent manners.
Cellular immunology289(1-2)128-34(2014 May-Jun)
Motohashi S,Koizumi K,Honda R,Maruyama A,Palmer HE,Mashima K

Activation of multiple proto-oncogenic tyrosine kinases in breast cancer via loss of the PTPN12 phosphatase.
Cell144(5)703-18(2011 Mar)
Sun T,Aceto N,Meerbrey KL,Kessler JD,Zhou C,Migliaccio I,Nguyen DX,Pavlova NN,Botero M,Huang J,Bernardi RJ,Schmitt E,Hu G,Li MZ,Dephoure N,Gygi SP,Rao M,Creighton CJ,Hilsenbeck SG,Shaw CA,Muzny D,Gibbs RA,Wheeler DA,Osborne CK,Schiff R,Bentires-Alj M,Elledge SJ,Westbrook TF

Nitric oxide attenuates IGF-I-induced aortic smooth muscle cell motility by decreasing Rac1 activity: essential role of PTP-PEST and p130cas.
American journal of physiology. Cell physiology290(4)C1263-70(2006 Apr)
Ceacareanu AC,Ceacareanu B,Zhuang D,Chang Y,Ray RM,Desai L,Chapman KE,Waters CM,Hassid A

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Ptpn12 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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