Aldh1a2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Aldh1a2
Entrez Gene ID	116676
Full Name	aldehyde dehydrogenase 1 family, member A2
Synonyms	Raldh-2
General protein information	Preferred Names aldehyde dehydrogenase 1 family, member A2 Names retinal dehydrogenase 2 RALDH 2 RalDH(II) aldehyde dehydrogenase 1A2 aldehyde dehydrogenase family 1 member A2 aldehyde dehydrogenase family 1, subfamily A2 ralDH2 retinal dehydrogenase, type II retinaldehyde-specific dehydrogenase type 2
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 8 Map Location: 8q24
Summary	enzyme necessary for the production of retinoic acid; may be associated with congenital diaphragmatic hernia [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_053896.2	NP_446348.2	retinal dehydrogenase 2

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	ALDH1A2	XP_001172159.1
Bos taurus (cattle)	ALDH1A2	XP_002690901.1
Danio rerio (zebrafish)	aldh1a2	NP_571925.1
Rattus norvegicus (Norway rat)	Aldh1a2	NP_446348.2
Gallus gallus (chicken)	ALDH1A2	NP_990326.1
Homo sapiens (human)	ALDH1A2	NP_003879.2
	ALDH1A2	XP_001090504.2
Canis lupus familiaris (dog)	ALDH1A2	XP_535494.2
Mus musculus (house mouse)	Aldh1a2	NP_033048.2
Xenopus tropicalis (tropical clawed frog)	aldh1a2	NP_001039196.1
Saccharomyces cerevisiae (baker's yeast)	ALD6	NP_015264.1
Kluyveromyces lactis	KLLA0E23057g	XP_454992.1

Gene Ontology
Bibliography

Related articles in PubMed

Structural Basis of ALDH1A2 Inhibition by Irreversible and Reversible Small Molecule Inhibitors.
Chen Y, Zhu JY, Hong KH, Mikles DC, Georg GI, Goldstein AS, Amory JK, Sch?nbrunn E
ACS chemical biology(2018 Jan)

Mitochondrial Aldehyde Dehydrogenase 2 Regulates Revascularization in Chronic Ischemia: Potential Impact on the Development of Coronary Collateral Circulation.
Liu X, Sun X, Liao H, Dong Z, Zhao J, Zhu H, Wang P, Shen L, Xu L, Ma X, Shen C, Fan F, Wang C, Hu K, Zou Y, Ge J, Ren J, Sun A
Arteriosclerosis, thrombosis, and vascular biology35(10)2196-206(2015 Oct)

Haploinsufficiency of retinaldehyde dehydrogenase 2 decreases the severity and incidence of duodenal atresia in the fibroblast growth factor receptor 2IIIb-/- mouse model.
Reeder AL, Botham RA, Zaremba KM, Nichol PF
Surgery152(4)768-75; discussion 775-6(2012 Oct)

Upregulation of retinal dehydrogenase 2 in alternatively activated macrophages during retinoid-dependent type-2 immunity to helminth infection in mice.
Broadhurst MJ, Leung JM, Lim KC, Girgis NM, Gundra UM, Fallon PG, Premenko-Lanier M, McKerrow JH, McCune JM, Loke P
PLoS pathogens8(8)e1002883(2012)

Physiological insights into all-trans-retinoic acid biosynthesis.
Napoli JL
Biochimica et biophysica acta1821(1)152-67(2012 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

This study is the first to show that RALDH2 and RALDH3, but not RALDH1, are expressed in the embryonic anterior pituitary gland of the rat.
Title: Expression of retinaldehyde dehydrogenase (RALDH)2 and RALDH3 but not RALDH1 in the developing anterior pituitary glands of rats.

eRolDH and RalDH II and their mRNAs were increased in uteri of rats during estrus. RalDH II was observed in the stromal compartment, particularly in cells close to the uterine lumenal epithelium.
Title: Estrogen directly induces expression of retinoic acid biosynthetic enzymes, compartmentalized between the epithelium and underlying stromal cells in rat uterus.

Results suggest that postnatal expressions of hepatocyte-specific genes might be up-regulated by retinoid receptors, which may be related with the alterations of RALDH expression during postnatal development in the liver.
Title: Postnatal changes in gene expression of retinal dehydrogenase and retinoid receptors in liver of rats.

inhibited by compounds that induce congenital diaphragmatic hernias (CDH); data provide an important component of mounting evidence suggesting that the retinoid system warrants consideration in future studies of the etiology of CDH.
Title: Retinal dehydrogenase-2 is inhibited by compounds that induce congenital diaphragmatic hernias in rodents.

The following Aldh1a2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Aldh1a2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa10990	NM_053896.2 Latest version!	Rattus norvegicus aldehyde dehydrogenase 1 family, member A2 (Aldh1a2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Aldh1a2 ( NM_053896.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_446348.2 Rattus norvegicus aldehyde dehydrogenase 1 family, member A2 (Aldh1a2), mRNA.

Price & Availability↑

CloneID	ORa10990
Clone ID Related Accession (Same CDS sequence)	NM_053896.2
Accession Version	NM_053896.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1557bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-09
Organism	Rattus norvegicus(Norway rat)
Product	retinal dehydrogenase 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BE111477.1, BC098910.1 and EV764818.1. On Mar 28, 2009 this sequence version replaced NM_053896.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC098910.1, U60063.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689595, SAMEA2689597 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGACTTCCA GCGAGATCGC CATGCCCGGC GAGGTGAAGG CCGACCCCGC CGCGCTCATG 
GCCTCGCTGC AGCTCCTGCC GTCACCCACG CCCAACCTCG AGATCAAGTA CACCAAGATC 
TTTATTAACA ATGAATGGCA GAACTCAGAG AGTGGGAGAG TGTTCCCTGT CTGTAATCCA 
GCCACAGGAG AGCAAGTGTG TGAAGTTCAA GAAGCAGACA AGGTGGATAT AGACAAGGCA 
GTGCAGGCGG CCCGCCTGGC CTTCTCTCTT GGTTCTGTGT GGAGAAGGAT GGACGCTTCT 
GAAAGAGGAC GTCTGCTGGA CAAGCTTGCA GACTTGGTGG AACGGGACAG GGCAACTCTT 
GCAACTATGG AATCACTAAA TGGCGGTAAG CCATTCCTGC AAGCTTTTTA CATCGATTTG 
CAGGGAGTCA TCAAAACCCT GAGGTATTAT GCAGGCTGGG CTGATAAAAT TCACGGAATG 
ACCATTCCTG TAGATGGAGA CTATTTTACC TTCACGAGAC ATGAGCCCAT CGGAGTGTGT 
GGACAGATTA TCCCGTGGAA TTTCCCCCTG CTGATGTTCA CCTGGAAAAT TGCTCCCGCA 
CTGTGCTGTG GTAACACTGT GGTCATCAAG CCTGCAGAGC AGACACCACT CAGTGCACTG 
TATATGGGAG CCCTCATCAA GGAGGCTGGC TTTCCACCCG GGGTCGTCAA CATTCTGCCA 
GGGTATGGGC CAACAGCAGG GGCAGCAATA GCGTCTCACA TTGGCATAGA CAAGATTGCA 
TTCACAGGCT CTACTGAGGT TGGAAAGCTT ATTCAAGAAG CAGCTGGAAG AAGTAATTTG 
AAGAGAGTAA CTCTGGAACT TGGAGGGAAA AGCCCTAATA TTATTTTTGC AGATGCTGAC 
TTGGACTACG CTGTGGAGCA GGCTCACCAG GGTGTGTTCT TCAACCAAGG CCAGTGCTGC 
ACTGCGGGGT CTCGAATCTT TGTGGAGGAG TCCATCTATG AGGAATTTGT GAAAAGAAGT 
GTGGAAAGAG CCAAGAGGCG CATTGTGGGG AGCCCCTTTG ATCCCACTAC TGAGCAGGGT 
CCTCAGATTG ATAAGAAGCA ATACAACAAA ATCCTGGAGC TCATCCAGAG CGGTGTGGCC 
GAGGGCGCCA AGCTCGAGTG TGGAGGCAAA GGACTGGGAA GGAAGGGCTT CTTCATTGAG 
CCTACCGTGT TCTCCAACGT TACAGATGAC ATGCGGATCG CCAAGGAGGA GATCTTTGGT 
CCTGTCCAGG AAATTTTGAG GTTTAAGACT ATGGATGAAG TTATAGAAAG AGCCAATAAC 
TCAGACTTCG GGCTTGTAGC GGCTGTCTTC ACTAATGACA TCAACAAGGC TCTCATGGTG 
TCCTCTGCAA TGCAAGCTGG GACAGTTTGG ATCAATTGTT ACAACGCCTT AAATGCTCAG 
AGCCCCTTCG GGGGGTTCAA GATGTCTGGA AATGGGAGAG AAATGGGTGA GTTTGGCTTA 
CGGGAGTACT CAGAAGTAAA GACCGTGACG GTGAAGATCC CCCAGAAGAA CTCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_446348.2
CDS	10..1566
Translation	MTSSEIAMPGEVKADPAALMASLQLLPSPTPNLEIKYTKIFINNEWQNSESGRVFPVCNPATGEQVCEVQEADKVDIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRATLATMESLNGGKPFLQAFYIDLQGVIKTLRYYAGWADKIHGMTIPVDGDYFTFTRHEPIGVCGQIIPWNFPLLMFTWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEAGFPPGVVNILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAGRSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVKRSVERAKRRIVGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKALMVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVKIPQKNS

Target ORF information:

RefSeq Version	NM_053896.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus aldehyde dehydrogenase 1 family, member A2 (Aldh1a2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053896.2

ORF Insert Sequence:

ATGACTTCCA GCGAGATCGC CATGCCCGGC GAGGTGAAGG CCGACCCCGC CGCGCTCATG 
GCCTCGCTGC AGCTCCTGCC GTCACCCACG CCCAACCTCG AGATCAAGTA CACCAAGATC 
TTTATTAACA ATGAATGGCA GAACTCAGAG AGTGGGAGAG TGTTCCCTGT CTGTAATCCA 
GCCACAGGAG AGCAAGTGTG TGAAGTTCAA GAAGCAGACA AGGTGGATAT AGACAAGGCA 
GTGCAGGCGG CCCGCCTGGC CTTCTCTCTT GGTTCTGTGT GGAGAAGGAT GGACGCTTCT 
GAAAGAGGAC GTCTGCTGGA CAAGCTTGCA GACTTGGTGG AACGGGACAG GGCAACTCTT 
GCAACTATGG AATCACTAAA TGGCGGTAAG CCATTCCTGC AAGCTTTTTA CATCGATTTG 
CAGGGAGTCA TCAAAACCCT GAGGTATTAT GCAGGCTGGG CTGATAAAAT TCACGGAATG 
ACCATTCCTG TAGATGGAGA CTATTTTACC TTCACGAGAC ATGAGCCCAT CGGAGTGTGT 
GGACAGATTA TCCCGTGGAA TTTCCCCCTG CTGATGTTCA CCTGGAAAAT TGCTCCCGCA 
CTGTGCTGTG GTAACACTGT GGTCATCAAG CCTGCAGAGC AGACACCACT CAGTGCACTG 
TATATGGGAG CCCTCATCAA GGAGGCTGGC TTTCCACCCG GGGTCGTCAA CATTCTGCCA 
GGGTATGGGC CAACAGCAGG GGCAGCAATA GCGTCTCACA TTGGCATAGA CAAGATTGCA 
TTCACAGGCT CTACTGAGGT TGGAAAGCTT ATTCAAGAAG CAGCTGGAAG AAGTAATTTG 
AAGAGAGTAA CTCTGGAACT TGGAGGGAAA AGCCCTAATA TTATTTTTGC AGATGCTGAC 
TTGGACTACG CTGTGGAGCA GGCTCACCAG GGTGTGTTCT TCAACCAAGG CCAGTGCTGC 
ACTGCGGGGT CTCGAATCTT TGTGGAGGAG TCCATCTATG AGGAATTTGT GAAAAGAAGT 
GTGGAAAGAG CCAAGAGGCG CATTGTGGGG AGCCCCTTTG ATCCCACTAC TGAGCAGGGT 
CCTCAGATTG ATAAGAAGCA ATACAACAAA ATCCTGGAGC TCATCCAGAG CGGTGTGGCC 
GAGGGCGCCA AGCTCGAGTG TGGAGGCAAA GGACTGGGAA GGAAGGGCTT CTTCATTGAG 
CCTACCGTGT TCTCCAACGT TACAGATGAC ATGCGGATCG CCAAGGAGGA GATCTTTGGT 
CCTGTCCAGG AAATTTTGAG GTTTAAGACT ATGGATGAAG TTATAGAAAG AGCCAATAAC 
TCAGACTTCG GGCTTGTAGC GGCTGTCTTC ACTAATGACA TCAACAAGGC TCTCATGGTG 
TCCTCTGCAA TGCAAGCTGG GACAGTTTGG ATCAATTGTT ACAACGCCTT AAATGCTCAG 
AGCCCCTTCG GGGGGTTCAA GATGTCTGGA AATGGGAGAG AAATGGGTGA GTTTGGCTTA 
CGGGAGTACT CAGAAGTAAA GACCGTGACG GTGAAGATCC CCCAGAAGAA CTCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Structural Basis of ALDH1A2 Inhibition by Irreversible and Reversible Small Molecule Inhibitors.
ACS chemical biology(2018 Jan)
Chen Y,Zhu JY,Hong KH,Mikles DC,Georg GI,Goldstein AS,Amory JK,Sch?nbrunn E

Mitochondrial Aldehyde Dehydrogenase 2 Regulates Revascularization in Chronic Ischemia: Potential Impact on the Development of Coronary Collateral Circulation.
Arteriosclerosis, thrombosis, and vascular biology35(10)2196-206(2015 Oct)
Liu X,Sun X,Liao H,Dong Z,Zhao J,Zhu H,Wang P,Shen L,Xu L,Ma X,Shen C,Fan F,Wang C,Hu K,Zou Y,Ge J,Ren J,Sun A

Haploinsufficiency of retinaldehyde dehydrogenase 2 decreases the severity and incidence of duodenal atresia in the fibroblast growth factor receptor 2IIIb-/- mouse model.
Surgery152(4)768-75; discussion 775-6(2012 Oct)
Reeder AL,Botham RA,Zaremba KM,Nichol PF

Upregulation of retinal dehydrogenase 2 in alternatively activated macrophages during retinoid-dependent type-2 immunity to helminth infection in mice.
PLoS pathogens8(8)e1002883(2012)
Broadhurst MJ,Leung JM,Lim KC,Girgis NM,Gundra UM,Fallon PG,Premenko-Lanier M,McKerrow JH,McCune JM,Loke P

Physiological insights into all-trans-retinoic acid biosynthesis.
Biochimica et biophysica acta1821(1)152-67(2012 Jan)
Napoli JL

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Aldh1a2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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