Pdia4 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Pdia4
Entrez Gene ID	116598
Full Name	protein disulfide isomerase family A, member 4
Synonyms	ERp-72,Erp70,Erp72
General protein information	Preferred Names protein disulfide isomerase family A, member 4 Names protein disulfide-isomerase A4 ER protein 70 ER protein 72 caBP2 calcium-binding protein 2 endoplasmic reticulum resident protein 70 endoplasmic reticulum resident protein 72 protein disulfide isomerase associated 4 protein disulfide isomerase related protein (calcium-binding protein, intestinal-related)
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 4 Map Location: 4q24
Summary	intracisternal calcium-binding microsomal glycoprotein with significant protein disulfide isomerase activity [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_053849.1	NP_446301.1	protein disulfide-isomerase A4 precursor

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	PDIA4	XP_848238.3
Bos taurus (cattle)	PDIA4	NP_001039344.1
Danio rerio (zebrafish)	pdia4	NP_956073.1
Arabidopsis thaliana (thale cress)	PDIL1-2	NP_177875.1
Caenorhabditis elegans (roundworm)	C14B9.2	NP_498775.2
Xenopus tropicalis (tropical clawed frog)	pdia4	XP_002941424.1
Pan troglodytes (chimpanzee)	PDIA4	XP_003318916.1
Mus musculus (house mouse)	Pdia4	NP_033917.2
Rattus norvegicus (Norway rat)	Pdia4	NP_446301.1
Arabidopsis thaliana (thale cress)	PDIL1-1	NP_173594.1
Gallus gallus (chicken)	PDIA4	NP_001006370.1
Homo sapiens (human)	PDIA4	NP_004902.1
Oryza sativa (rice)	Os11g0199200	NP_001067436.1

Gene Ontology
Bibliography

Related articles in PubMed

Loss-of-function mutations in TBC1D20 cause cataracts and male infertility in blind sterile mice and Warburg micro syndrome in humans.
Liegel RP, Handley MT, Ronchetti A, Brown S, Langemeyer L, Linford A, Chang B, Morris-Rosendahl DJ, Carpanini S, Posmyk R, Harthill V, Sheridan E, Abdel-Salam GM, Terhal PA, Faravelli F, Accorsi P, Giordano L, Pinelli L, Hartmann B, Ebert AD, Barr FA, Aligianis IA, Sidjanin DJ
American journal of human genetics93(6)1001-14(2013 Dec)

An interaction map of endoplasmic reticulum chaperones and foldases.
Jansen G, M??tt?nen P, Denisov AY, Scarffe L, Schade B, Balghi H, Dejgaard K, Chen LY, Muller WJ, Gehring K, Thomas DY
Molecular & cellular proteomics : MCP11(9)710-23(2012 Sep)

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
Castello A, Fischer B, Eichelbaum K, Horos R, Beckmann BM, Strein C, Davey NE, Humphreys DT, Preiss T, Steinmetz LM, Krijgsveld J, Hentze MW
Cell149(6)1393-406(2012 Jun)

Platelets release novel thiol isomerase enzymes which are recruited to the cell surface following activation.
Holbrook LM, Watkins NA, Simmonds AD, Jones CI, Ouwehand WH, Gibbins JM
British journal of haematology148(4)627-37(2010 Feb)

Structure of the noncatalytic domains and global fold of the protein disulfide isomerase ERp72.
Kozlov G, M??tt?nen P, Schrag JD, Hura GL, Gabrielli L, Cygler M, Thomas DY, Gehring K
Structure (London, England : 1993)17(5)651-9(2009 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Here, we report the X-ray crystal structure of central non-catalytic domains of a specific isomerase, ERp72 (also called CaBP2 and protein disulfide-isomerase A4) from Rattus norvegicus
Title: Structure of the noncatalytic domains and global fold of the protein disulfide isomerase ERp72.

Tg-G2320R associated with multiple ER resident proteins, most notably ERp72, including covalent Tg-ERp72 interactions.
Title: Oxidoreductase interactions include a role for ERp72 engagement with mutant thyroglobulin from the rdw/rdw rat dwarf.

The following Pdia4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Pdia4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa10852	NM_053849.1 Latest version!	Rattus norvegicus protein disulfide isomerase family A, member 4 (Pdia4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$377.30 $539.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Pdia4 ( NM_053849.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_446301.1 Rattus norvegicus protein disulfide isomerase family A, member 4 (Pdia4), mRNA.

Price & Availability↑

CloneID	ORa10852
Clone ID Related Accession (Same CDS sequence)	NM_053849.1
Accession Version	NM_053849.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1932bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-14
Organism	Rattus norvegicus(Norway rat)
Product	protein disulfide-isomerase A4 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from M86870.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M86870.1, BC061535.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01906355 [ECO:0000348] ##Evidence-Data-END##

ATGAAGCTCC GGAAAGCTTG GCTGTTGGTC CTGCTCTTGG CGCTGACACA GCTGCTGGCT 
GCTGCGAGCG CCGAAGATGC GCACGAAGAT GCTTCAGATT CAGAAAATCC CATTGAGGAT 
GACGACGAGG AGGAGGAAGA TGAAGAAGAT GAAGATGACT TGGAAGTTAA GGAAGAAAAT 
GGTGTTTGGG TCCTAAACGA TGAAAACTTC GATAACTTTG TGGCTGACAA AGATACAGTG 
CTCCTGGAGT TCTATGCACC GTGGTGTGGA CACTGCAAGC AATTTGCTCC AGAATATGAG 
AAAATTGCCA GTACTTTGAA GGATAATGAT CCTCCCATTG CTGTTGCAAA GATTGACGCG 
ACCTCAGCAT CCATGTTGGC CAGCAAATTC GATGTGAGTG GCTACCCCAC CATCAAGATC 
CTGAAGAAGG GACAGGCTGT TGACTATGAC GGCTCCAGGA CCCAGGAAGA AATTGTTGCC 
AAAGTCAGAG AAGTTTCCCA GCCTGATTGG ACACCTCCAC CTGAAGTCAC TCTTACATTG 
ACTAAAGAGA ACTTTGACGA TGTTGTAAAT AATGCAGACA TCATTTTGGT GGAGTTCTAT 
GCCCCATGGT GCGGACACTG CAAGAAACTT GCCCCTGAGT ATGAGAAGGC TGCCAAGGAG 
CTCAGCAAGC GCTCTCCCCC AATTCCCTTA GCCAAAGTTG ATGCCACCGA ACAGACAGAC 
CTGGCTAAGA GGTTTGATGT CTCTGGCTAC CCCACTTTGA AAATATTCCG CAAAGGAAGG 
CCTTTTGACT ACAATGGTCC ACGAGAGAAA TATGGAATTG TTGACTACAT GGTTGAGCAG 
TCTGGACCTC CTTCCAAGGA GATTCTGACC CTGAAGCAGG TCCAGGAGTT TCTGAAGGAT 
GGAGATGATG TAGTCATCCT TGGAGTCTTT CAGGGAGTCG GTGACCCAGG CTACTTGCAG 
TATCAGGATG CTGCTAACAC CCTGAGAGAA GATTACAAAT TTCACCACAC TTTCAGCACT 
GAAATAGCTA AGTTCCTGAA AGTCTCCCTG GGGAAACTGG TGCTGATGCA GCCTGAGAAG 
TTCCAGTCCA AGTATGAGCC CAGGATGCAT GTGATGGATG TTCAGGGCTC CACAGAGGCA 
TCAGCCATTA AGGACTATGT GGTGAAACAT GACTTGCCCC TAGTGGGCCA CAGGAAGACT 
TCTAACGATG CTAAGCGGTA CAGCAAGCGC CCCCTGGTGG TTGTATACTA CAGCGTGGAC 
TTCAGCTTTG ATTACAGAAC TGCTACTCAG TTTTGGCGTA ACAAAGTCCT AGAGGTGGCC 
AAGGACTTCC CTGAGTACAC ATTCGCCATT GCTGATGAAG AAGACTATGC CACAGAGGTG 
AAGGACCTGG GACTGAGTGA GAGTGGAGAG GACGTCAATG CAGCCATCCT AGATGAGAGT 
GGGAAGAAGT TTGCCATGGA GCCAGAGGAG TTTGATTCAG ATGCTCTCCG AGAATTTGTC 
ATGGCTTTCA AAAAAGGAAA ACTAAAGCCA GTTATCAAAT CACAGCCAGT TCCCAAGAAC 
AACAAGGGAC CAGTCAGGGT GGTAGTGGGG AAGACCTTTG ATGCCATTGT GATGGACCCC 
AAAAAGGACG TCCTCATTGA ATTCTATGCA CCGTGGTGTG GGCACTGCAA GCAGCTGGAG 
CCTGTCTACA CCAGCCTAGG CAAGAAGTAC AAGGGCCAGA AGGACTTGGT CATCGCCAAG 
ATGGATGCTA CTGCCAATGA CATCACCAAC GACCGATACA AGGTGGAGGG CTTCCCCACC 
ATCTATTTTG CCCCCAGTGG GGACAAAAAG AACCCAATTA AGTTTGAGGG TGGCAACAGA 
GATCTGGAGC ATTTGAGCAA GTTTATCGAT GAACATGCCA CAAAGAGGAG CAGGACCAAG 
GAAGAGCTTT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_446301.1
CDS	289..2220
Translation	MKLRKAWLLVLLLALTQLLAAASAEDAHEDASDSENPIEDDDEEEEDEEDEDDLEVKEENGVWVLNDENFDNFVADKDTVLLEFYAPWCGHCKQFAPEYEKIASTLKDNDPPIAVAKIDATSASMLASKFDVSGYPTIKILKKGQAVDYDGSRTQEEIVAKVREVSQPDWTPPPEVTLTLTKENFDDVVNNADIILVEFYAPWCGHCKKLAPEYEKAAKELSKRSPPIPLAKVDATEQTDLAKRFDVSGYPTLKIFRKGRPFDYNGPREKYGIVDYMVEQSGPPSKEILTLKQVQEFLKDGDDVVILGVFQGVGDPGYLQYQDAANTLREDYKFHHTFSTEIAKFLKVSLGKLVLMQPEKFQSKYEPRMHVMDVQGSTEASAIKDYVVKHDLPLVGHRKTSNDAKRYSKRPLVVVYYSVDFSFDYRTATQFWRNKVLEVAKDFPEYTFAIADEEDYATEVKDLGLSESGEDVNAAILDESGKKFAMEPEEFDSDALREFVMAFKKGKLKPVIKSQPVPKNNKGPVRVVVGKTFDAIVMDPKKDVLIEFYAPWCGHCKQLEPVYTSLGKKYKGQKDLVIAKMDATANDITNDRYKVEGFPTIYFAPSGDKKNPIKFEGGNRDLEHLSKFIDEHATKRSRTKEEL

Target ORF information:

RefSeq Version	NM_053849.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus protein disulfide isomerase family A, member 4 (Pdia4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053849.1

ORF Insert Sequence:

ATGAAGCTCC GGAAAGCTTG GCTGTTGGTC CTGCTCTTGG CGCTGACACA GCTGCTGGCT 
GCTGCGAGCG CCGAAGATGC GCACGAAGAT GCTTCAGATT CAGAAAATCC CATTGAGGAT 
GACGACGAGG AGGAGGAAGA TGAAGAAGAT GAAGATGACT TGGAAGTTAA GGAAGAAAAT 
GGTGTTTGGG TCCTAAACGA TGAAAACTTC GATAACTTTG TGGCTGACAA AGATACAGTG 
CTCCTGGAGT TCTATGCACC GTGGTGTGGA CACTGCAAGC AATTTGCTCC AGAATATGAG 
AAAATTGCCA GTACTTTGAA GGATAATGAT CCTCCCATTG CTGTTGCAAA GATTGACGCG 
ACCTCAGCAT CCATGTTGGC CAGCAAATTC GATGTGAGTG GCTACCCCAC CATCAAGATC 
CTGAAGAAGG GACAGGCTGT TGACTATGAC GGCTCCAGGA CCCAGGAAGA AATTGTTGCC 
AAAGTCAGAG AAGTTTCCCA GCCTGATTGG ACACCTCCAC CTGAAGTCAC TCTTACATTG 
ACTAAAGAGA ACTTTGACGA TGTTGTAAAT AATGCAGACA TCATTTTGGT GGAGTTCTAT 
GCCCCATGGT GCGGACACTG CAAGAAACTT GCCCCTGAGT ATGAGAAGGC TGCCAAGGAG 
CTCAGCAAGC GCTCTCCCCC AATTCCCTTA GCCAAAGTTG ATGCCACCGA ACAGACAGAC 
CTGGCTAAGA GGTTTGATGT CTCTGGCTAC CCCACTTTGA AAATATTCCG CAAAGGAAGG 
CCTTTTGACT ACAATGGTCC ACGAGAGAAA TATGGAATTG TTGACTACAT GGTTGAGCAG 
TCTGGACCTC CTTCCAAGGA GATTCTGACC CTGAAGCAGG TCCAGGAGTT TCTGAAGGAT 
GGAGATGATG TAGTCATCCT TGGAGTCTTT CAGGGAGTCG GTGACCCAGG CTACTTGCAG 
TATCAGGATG CTGCTAACAC CCTGAGAGAA GATTACAAAT TTCACCACAC TTTCAGCACT 
GAAATAGCTA AGTTCCTGAA AGTCTCCCTG GGGAAACTGG TGCTGATGCA GCCTGAGAAG 
TTCCAGTCCA AGTATGAGCC CAGGATGCAT GTGATGGATG TTCAGGGCTC CACAGAGGCA 
TCAGCCATTA AGGACTATGT GGTGAAACAT GACTTGCCCC TAGTGGGCCA CAGGAAGACT 
TCTAACGATG CTAAGCGGTA CAGCAAGCGC CCCCTGGTGG TTGTATACTA CAGCGTGGAC 
TTCAGCTTTG ATTACAGAAC TGCTACTCAG TTTTGGCGTA ACAAAGTCCT AGAGGTGGCC 
AAGGACTTCC CTGAGTACAC ATTCGCCATT GCTGATGAAG AAGACTATGC CACAGAGGTG 
AAGGACCTGG GACTGAGTGA GAGTGGAGAG GACGTCAATG CAGCCATCCT AGATGAGAGT 
GGGAAGAAGT TTGCCATGGA GCCAGAGGAG TTTGATTCAG ATGCTCTCCG AGAATTTGTC 
ATGGCTTTCA AAAAAGGAAA ACTAAAGCCA GTTATCAAAT CACAGCCAGT TCCCAAGAAC 
AACAAGGGAC CAGTCAGGGT GGTAGTGGGG AAGACCTTTG ATGCCATTGT GATGGACCCC 
AAAAAGGACG TCCTCATTGA ATTCTATGCA CCGTGGTGTG GGCACTGCAA GCAGCTGGAG 
CCTGTCTACA CCAGCCTAGG CAAGAAGTAC AAGGGCCAGA AGGACTTGGT CATCGCCAAG 
ATGGATGCTA CTGCCAATGA CATCACCAAC GACCGATACA AGGTGGAGGG CTTCCCCACC 
ATCTATTTTG CCCCCAGTGG GGACAAAAAG AACCCAATTA AGTTTGAGGG TGGCAACAGA 
GATCTGGAGC ATTTGAGCAA GTTTATCGAT GAACATGCCA CAAAGAGGAG CAGGACCAAG 
GAAGAGCTTT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Loss-of-function mutations in TBC1D20 cause cataracts and male infertility in blind sterile mice and Warburg micro syndrome in humans.
American journal of human genetics93(6)1001-14(2013 Dec)
Liegel RP,Handley MT,Ronchetti A,Brown S,Langemeyer L,Linford A,Chang B,Morris-Rosendahl DJ,Carpanini S,Posmyk R,Harthill V,Sheridan E,Abdel-Salam GM,Terhal PA,Faravelli F,Accorsi P,Giordano L,Pinelli L,Hartmann B,Ebert AD,Barr FA,Aligianis IA,Sidjanin DJ

An interaction map of endoplasmic reticulum chaperones and foldases.
Molecular & cellular proteomics : MCP11(9)710-23(2012 Sep)
Jansen G,M??tt?nen P,Denisov AY,Scarffe L,Schade B,Balghi H,Dejgaard K,Chen LY,Muller WJ,Gehring K,Thomas DY

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
Cell149(6)1393-406(2012 Jun)
Castello A,Fischer B,Eichelbaum K,Horos R,Beckmann BM,Strein C,Davey NE,Humphreys DT,Preiss T,Steinmetz LM,Krijgsveld J,Hentze MW

Platelets release novel thiol isomerase enzymes which are recruited to the cell surface following activation.
British journal of haematology148(4)627-37(2010 Feb)
Holbrook LM,Watkins NA,Simmonds AD,Jones CI,Ouwehand WH,Gibbins JM

Structure of the noncatalytic domains and global fold of the protein disulfide isomerase ERp72.
Structure (London, England : 1993)17(5)651-9(2009 May)
Kozlov G,M??tt?nen P,Schrag JD,Hura GL,Gabrielli L,Cygler M,Thomas DY,Gehring K

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Pdia4 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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