Serpinb5 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Serpinb5
Entrez Gene ID	116589
Full Name	serpin family B member 5
Synonyms	Maspin,PI-5,Pi5
General protein information	Preferred Names serpin family B member 5 Names serpin B5 peptidase inhibitor 5 protease inhibitor 5 serine (or cysteine) peptidase inhibitor, clade B, member 5 serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 13 Map Location: 13p11
Summary	may act as a tumor suppressor [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_057108.2	NP_476449.1	serpin B5

Pathways from BioSystems

Homologies

	SERPINB5	XP_001090203.1
Mus musculus (house mouse)	Serpinb5	NP_033283.1
Gallus gallus (chicken)	SERPINB5	XP_418986.3
Homo sapiens (human)	SERPINB5	NP_002630.2
Rattus norvegicus (Norway rat)	Serpinb5	NP_476449.1
Pan troglodytes (chimpanzee)	SERPINB5	XP_001146935.1
Canis lupus familiaris (dog)	SERPINB5	XP_533382.3
Xenopus tropicalis (tropical clawed frog)	serpinb5	NP_001011282.1

Gene Ontology
Bibliography

Related articles in PubMed

miRNA-7/21/107 contribute to HBx-induced hepatocellular carcinoma progression through suppression of maspin.
Chen WS, Yen CJ, Chen YJ, Chen JY, Wang LY, Chiu SJ, Shih WL, Ho CY, Wei TT, Pan HL, Chien PH, Hung MC, Chen CC, Huang WC
Oncotarget6(28)25962-74(2015 Sep)

Possible involvement of maspin in tooth development.
Davaadorj P, Tokuyama R, Ide S, Tadokoro S, Kudoh K, Satomura K
Histochemistry and cell biology134(6)603-14(2010 Dec)

Haploinsufficiency of the maspin tumor suppressor gene leads to hyperplastic lesions in prostate.
Shao LJ, Shi HY, Ayala G, Rowley D, Zhang M
Cancer research68(13)5143-51(2008 Jul)

Expression of VACM-1/cul5 mutant in endothelial cells induces MAPK phosphorylation and maspin degradation and converts cells to the angiogenic phenotype.
Buchwalter A, Van Dort C, Schultz S, Smith R, Le IP, Abbott JL, Oosterhouse E, Johnson AE, Hansen-Smith F, Burnatowska-Hledin M
Microvascular research75(2)155-68(2008 Mar)

Maspin is involved in bone matrix maturation by enhancing the accumulation of latent TGF-beta.
Tokuyama R, Satomura K, Maeda E, Kudoh K, Yamasaki Y, Nagayama M
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research22(10)1581-91(2007 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

During rat tooth development, maspin expression was observed for the first time in inner and outer enamel epithelial cells and dental papilla cells at early bell stage.
Title: Possible involvement of maspin in tooth development.

Results show that VACM-1 protein regulates endothelial cell growth and may modulate angiogenesis by a mechanism that involves MAPK phosphorylation and maspin expression.
Title: Expression of VACM-1/cul5 mutant in endothelial cells induces MAPK phosphorylation and maspin degradation and converts cells to the angiogenic phenotype.

maspin expressed in active osteoblasts plays an important physiological role during maturation of the bone matrix, and in particular, during the process of accumulation of latent TGF-beta in the extracellular matrix
Title: Maspin is involved in bone matrix maturation by enhancing the accumulation of latent TGF-beta.

The following Serpinb5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Serpinb5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa11350	NM_057108.2 Latest version!	Rattus norvegicus serpin family B member 5 (Serpinb5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Serpinb5 ( NM_057108.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_476449.1 Rattus norvegicus serpin family B member 5 (Serpinb5), mRNA.

Price & Availability↑

CloneID	ORa11350
Clone ID Related Accession (Same CDS sequence)	NM_057108.2
Accession Version	NM_057108.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1128bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-14
Organism	Rattus norvegicus(Norway rat)
Product	serpin B5
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U58857.1. On Apr 5, 2007 this sequence version replaced NM_057108.1. Sequence Note: The sequence U58857.1 is from a chimeric clone. Only the serine (or cysteine) peptidase inhibitor, clade B, member 5 sequence region was propagated into this RefSeq record. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA2689602, SAMEA2689605 [ECO:0000348] ##Evidence-Data-END##

ATGGATGCCT TGAGACTGGC AAATTCAGCT TTTGCTGTTG AATTGTTCAA ACAACTATGT 
GAAAAGGAGC CAGCAGGAAA CATTCTCTTC TCTCCGATAT GCCTCTCCAC TTCTCTGTCC 
CTTGCTCAAG TAGGCGCCAA AGGTGACACG GCAAATGAAA TTGGACAGGT CCTTCATTTT 
GAGAATGTTA AAGATGTACC CTTTGGTTTC AAACCAATCA CTTCTGATGT TAATAAGCTC 
AGTTCCTTTT ATTCGCTGAA ACTAATCAAG CGACTATACA TTGACAAATC TCTGAACCTT 
TCTACAGAAT TTATCAGTTC TACAAAAAGA CCATATGCCA ACGAATTGGA AACTGTTGAC 
TTCAAAGATA AACTGGAAGA GACGAAAGGT CAAATTAACA GCTCCATTAA GGAACTCACA 
GACGGCCACT TTGAAGATAT TTTGCCAGAG AACAGTATAA GTGACCAGAC CAAAATCCTT 
GTGGTTAATG CTGCCTACTT TGTTGGAAAG TGGATGAAGA AATTTCCAGA ATCAGAAACA 
AAAGAATGTC CATTCAGAAT CAACAAGACA GACACCAAAC CAGTACAAAT GATGAATCTT 
GAGGCTACCT TCTGCTTGGG TAACATTGAT GACATCAACT GTAAGATCAT AGAACTTCCT 
TTCCAGAATA AGCATCTCAG TATGCTCATT GTGCTCCCTA AGGACGTGGA AGATGAATCC 
ACAGGCCTGG AGAAGATTGA AAAACAACTC AACCCAGAAA CACTGTTACA GTGGACCAAC 
CCCAGCACCA TGGCCAATGC CAAAGTCAAG CTTTCCCTTC CAAAGTTTAA GGTAGAAAAG 
ATGATTGACC CCAAGGCTAG TCTGGAAAGC CTAGGGCTGA AAAGTCTCTT CAATGAAAGT 
ACATCGGATT TCTCTGGAAT GTCAGAGACC AAGGGAGTGT CCGTATCAAA TGTGATTCAC 
AGAGTATGCC TAGAAATAAC TGAAGATGGT GGTGATTCCA TCGAGGTGCC AGGGTCCCGG 
ATCTTACAGC ACAAGGATGA ATTCAAAGCT GACCATCCAT TTCTTTTTAT CGTTCGACAC 
AACAAAACTC GAAACATCGT TTTCTTGGGC AAATTCTCTT CTCCTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_476449.1
CDS	108..1235
Translation	MDALRLANSAFAVELFKQLCEKEPAGNILFSPICLSTSLSLAQVGAKGDTANEIGQVLHFENVKDVPFGFKPITSDVNKLSSFYSLKLIKRLYIDKSLNLSTEFISSTKRPYANELETVDFKDKLEETKGQINSSIKELTDGHFEDILPENSISDQTKILVVNAAYFVGKWMKKFPESETKECPFRINKTDTKPVQMMNLEATFCLGNIDDINCKIIELPFQNKHLSMLIVLPKDVEDESTGLEKIEKQLNPETLLQWTNPSTMANAKVKLSLPKFKVEKMIDPKASLESLGLKSLFNESTSDFSGMSETKGVSVSNVIHRVCLEITEDGGDSIEVPGSRILQHKDEFKADHPFLFIVRHNKTRNIVFLGKFSSP

Target ORF information:

RefSeq Version	NM_057108.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus serpin family B member 5 (Serpinb5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_057108.2

ORF Insert Sequence:

ATGGATGCCT TGAGACTGGC AAATTCAGCT TTTGCTGTTG AATTGTTCAA ACAACTATGT 
GAAAAGGAGC CAGCAGGAAA CATTCTCTTC TCTCCGATAT GCCTCTCCAC TTCTCTGTCC 
CTTGCTCAAG TAGGCGCCAA AGGTGACACG GCAAATGAAA TTGGACAGGT CCTTCATTTT 
GAGAATGTTA AAGATGTACC CTTTGGTTTC AAACCAATCA CTTCTGATGT TAATAAGCTC 
AGTTCCTTTT ATTCGCTGAA ACTAATCAAG CGACTATACA TTGACAAATC TCTGAACCTT 
TCTACAGAAT TTATCAGTTC TACAAAAAGA CCATATGCCA ACGAATTGGA AACTGTTGAC 
TTCAAAGATA AACTGGAAGA GACGAAAGGT CAAATTAACA GCTCCATTAA GGAACTCACA 
GACGGCCACT TTGAAGATAT TTTGCCAGAG AACAGTATAA GTGACCAGAC CAAAATCCTT 
GTGGTTAATG CTGCCTACTT TGTTGGAAAG TGGATGAAGA AATTTCCAGA ATCAGAAACA 
AAAGAATGTC CATTCAGAAT CAACAAGACA GACACCAAAC CAGTACAAAT GATGAATCTT 
GAGGCTACCT TCTGCTTGGG TAACATTGAT GACATCAACT GTAAGATCAT AGAACTTCCT 
TTCCAGAATA AGCATCTCAG TATGCTCATT GTGCTCCCTA AGGACGTGGA AGATGAATCC 
ACAGGCCTGG AGAAGATTGA AAAACAACTC AACCCAGAAA CACTGTTACA GTGGACCAAC 
CCCAGCACCA TGGCCAATGC CAAAGTCAAG CTTTCCCTTC CAAAGTTTAA GGTAGAAAAG 
ATGATTGACC CCAAGGCTAG TCTGGAAAGC CTAGGGCTGA AAAGTCTCTT CAATGAAAGT 
ACATCGGATT TCTCTGGAAT GTCAGAGACC AAGGGAGTGT CCGTATCAAA TGTGATTCAC 
AGAGTATGCC TAGAAATAAC TGAAGATGGT GGTGATTCCA TCGAGGTGCC AGGGTCCCGG 
ATCTTACAGC ACAAGGATGA ATTCAAAGCT GACCATCCAT TTCTTTTTAT CGTTCGACAC 
AACAAAACTC GAAACATCGT TTTCTTGGGC AAATTCTCTT CTCCTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

miRNA-7/21/107 contribute to HBx-induced hepatocellular carcinoma progression through suppression of maspin.
Oncotarget6(28)25962-74(2015 Sep)
Chen WS,Yen CJ,Chen YJ,Chen JY,Wang LY,Chiu SJ,Shih WL,Ho CY,Wei TT,Pan HL,Chien PH,Hung MC,Chen CC,Huang WC

Possible involvement of maspin in tooth development.
Histochemistry and cell biology134(6)603-14(2010 Dec)
Davaadorj P,Tokuyama R,Ide S,Tadokoro S,Kudoh K,Satomura K

Haploinsufficiency of the maspin tumor suppressor gene leads to hyperplastic lesions in prostate.
Cancer research68(13)5143-51(2008 Jul)
Shao LJ,Shi HY,Ayala G,Rowley D,Zhang M

Expression of VACM-1/cul5 mutant in endothelial cells induces MAPK phosphorylation and maspin degradation and converts cells to the angiogenic phenotype.
Microvascular research75(2)155-68(2008 Mar)
Buchwalter A,Van Dort C,Schultz S,Smith R,Le IP,Abbott JL,Oosterhouse E,Johnson AE,Hansen-Smith F,Burnatowska-Hledin M

Maspin is involved in bone matrix maturation by enhancing the accumulation of latent TGF-beta.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research22(10)1581-91(2007 Oct)
Tokuyama R,Satomura K,Maeda E,Kudoh K,Yamasaki Y,Nagayama M

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Serpinb5 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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