Eif2ak4 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Eif2ak4
Entrez Gene ID	114859
Full Name	eukaryotic translation initiation factor 2 alpha kinase 4
General protein information	Preferred Names eukaryotic translation initiation factor 2 alpha kinase 4 Names eIF-2-alpha kinase GCN2 GCN2-like protein
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 3 Map Location: 3q35

mRNA and Protein(s)

mRNA	Protein	Name
NM_001105744.2	NP_001099214.2	eIF-2-alpha kinase GCN2

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	EIF2AK4	XP_001140245.1
	EIF2AK4	XP_002804763.1
Gallus gallus (chicken)	EIF2AK4	XP_004941777.1
Eremothecium gossypii	AGOS_AAL083W	NP_982459.1
Rattus norvegicus (Norway rat)	Eif2ak4	NP_001099214.2
Danio rerio (zebrafish)	eif2ak4	XP_002667149.3
Drosophila melanogaster (fruit fly)	Gcn2	NP_001263141.1
Saccharomyces cerevisiae (baker's yeast)	GCN2	NP_010569.3
Kluyveromyces lactis	KLLA0C10802g	XP_452681.1
Neurospora crassa	NCU01187	XP_961553.1
Xenopus tropicalis (tropical clawed frog)	eif2ak4	NP_001243855.1
Homo sapiens (human)	EIF2AK4	NP_001013725.2
Canis lupus familiaris (dog)	EIF2AK4	XP_535431.3
Bos taurus (cattle)	EIF2AK4	XP_002690831.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP012368	XP_320188.4
Caenorhabditis elegans (roundworm)	gcn-2	NP_001254370.1
Schizosaccharomyces pombe (fission yeast)	gcn2	NP_595991.2
Mus musculus (house mouse)	Eif2ak4	NP_038747.2
Magnaporthe oryzae (rice blast fungus)	MGG_08643	XP_003711074.1

Gene Ontology
Bibliography

Related articles in PubMed

p58IPK is an inhibitor of the eIF2? kinase GCN2 and its localization and expression underpin protein synthesis and ER processing capacity.
Roobol A, Roobol J, Bastide A, Knight JR, Willis AE, Smales CM
The Biochemical journal465(2)213-25(2015 Jan)

Evolutionarily conserved IMPACT impairs various stress responses that require GCN1 for activating the eIF2 kinase GCN2.
Cambiaghi TD, Pereira CM, Shanmugam R, Bolech M, Wek RC, Sattlegger E, Castilho BA
Biochemical and biophysical research communications443(2)592-7(2014 Jan)

Vaccine activation of the nutrient sensor GCN2 in dendritic cells enhances antigen presentation.
Ravindran R, Khan N, Nakaya HI, Li S, Loebbermann J, Maddur MS, Park Y, Jones DP, Chappert P, Davoust J, Weiss DS, Virgin HW, Ron D, Pulendran B
Science (New York, N.Y.)343(6168)313-317(2014 Jan)

Gene expression analysis in response to lung toxicants: I. Sequencing and microarray development.
Shultz MA, Zhang L, Gu YZ, Baker GL, Fannuchi MV, Padua AM, Gurske WA, Morin D, Penn SG, Jovanovich SB, Plopper CG, Buckpitt AR
American journal of respiratory cell and molecular biology30(3)296-310(2004 Mar)

Activation of GCN2 in UV-irradiated cells inhibits translation.
Deng J, Harding HP, Raught B, Gingras AC, Berlanga JJ, Scheuner D, Kaufman RJ, Ron D, Sonenberg N
Current biology : CB12(15)1279-86(2002 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Eif2ak4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Eif2ak4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa11299	NM_001105744.2 Latest version!	Rattus norvegicus eukaryotic translation initiation factor 2 alpha kinase 4 (Eif2ak4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	25	$188.30 $269.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Eif2ak4 ( NM_001105744.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001099214.2 Rattus norvegicus eukaryotic translation initiation factor 2 alpha kinase 4 (Eif2ak4), mRNA.

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CloneID	ORa11299
Clone ID Related Accession (Same CDS sequence)	NM_001105744.2
Accession Version	NM_001105744.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 4950bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Rattus norvegicus(Norway rat)
Product	eIF-2-alpha kinase GCN2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH473949.1. On Oct 20, 2010 this sequence version replaced NM_001105744.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGCTGGGG GCCGCGGGGC CGCAGGACGC GGCCCGGCTG AGCCGCAGGA GAGCTATTCA 
CAGAGACAGG ACCACGAGCT GCAGGCCCTG GAGGCGATTT ACGGCTCGGA CTTCCAGGAT 
CTGCGGCCGG ATGCGCGCGG ACGGGTGAGA GAGCCTCCTG AAATCAATTT AGTTCTGTAC 
CCTCAGGGCC TGGCTGGTGA GGAAGTGTAC GTGCAGGTGG AGCTGAGGGT CAAATGCCCA 
CCGACATACC CGGATGTAGT TCCCGAAATA GAGTTAAAAA ACACTAAAGG TCTGTCGAAT 
GAGAGTGTTA ATTTGTTAAA GTCACACCTG GAAGAACTGG CCAAAAAGCA GTGTGGAGAG 
GTGATGATAT TCGAACTGGC ACACCACGTG CAGTCGTTTC TCAGCGAGCA TAACAAGCCC 
CCTCCAAAGT CTTTCCATGA AGAAATGCTG GAAAGGCAGG CTCAGGAGAA GCAGCAGAGG 
TTGCTGGAGG CCAGGCAGAA AGAGGAGCAG GAGCAACGTG AAATCCTCCA CGAGATTCAG 
AAAAGGAAAG AGGAGATCAA GGAAGAGAAG AAAAGGAAGG AAATGGCTAA GCAGGAACGT 
TTGGAAATTA CTAGTTTGAC AAACCAGGAT CATGCCTCTA AGAGAGACCC AGCAGGACAC 
AGGGCAGCTG CCATTCTCCA TGGAGGCTCT CCTGACTTTG TAGGAAATGG TAAAGCCCGG 
GCACACTCCT CAGGAAGGTC CAGGCGAGAA CGTCAGTATT CTGTCTGTAG TGGTGAAGCC 
TCTCCTGGCT CGTGTGACAT CCTCTACTTC TGTGTGGGTA GCGCTGATCA GCTCATGGTG 
CACAAAGGGA AATGTGTTGG CAGCGATGAG CAGCTGGGGA AGGTGGTATA CAATGCATTG 
GAAACAGCCA CGGGCAGCTT TGTCTTGTTG TATGAGTGGG TCCTTCAGTG GCAGAAAAAG 
ATGGGCCCTT GCCTTACCAG TCAAGAGAAA GAGAAGATCG ATAAATGTAA AAAGCAGATT 
CAAGGAGCAG AAACAGAATT CAGCTCCCTA GTGAAACTGA GCCATCCAAA CATTGTCCGC 
TACTTTGCGA TGAACTCCAG AGAGGAGAAG GATTCCATTG TGGTCGACAT TCTGGCAGAA 
CACATCAGTG GGATCTCTCT CGCTGCACAC CTGAGCCACT CAGGCCCTGT GCCCATGCAC 
CAGCTGCGCA AATACACAGC GCAGCTCCTG GCGGGCCTGG ACTACCTGCA CCGCAACTCG 
GTGGTGCACA AGGTGCTGAG CACCGCCAGC GTCTTGGTGG ATGCTGAGGG CACCGTCAAG 
ATAACAGACT ACAGCATCTC TAAGCGCCTG GCAGACATTT GCAAGGAGGA TGTTTTTGAG 
CAAACTCGAG TTCGCTTTAG TGACAGTGCT CTGCCTTATA AAACCGGGAA GAAAGGGGAT 
GTGTGGCGTC TTGGCCTCCT GCTGTTGTCT CTTAGCCAAG GTCAGGAGTG TGAGGAGTAT 
CCTGTGACCA TCCCCAGTGA TCTGCCAGCT GACTTCCAGG ACTTCCTGAA GAAGTGTGTT 
TGCCTGGACG ACAAGGAAAG GTGGAGCCCT CAACAGTTGC TGAAACACAG CTTTATAAAC 
CCTCAGCCAA AAATGCCTTT GGTGGAGCAG AGTCCTGAAG ATTCTGGGGG ACAAGATTAC 
ATCGAGACCA TCATCCCCAG CAACCAGCTG CCCAGCGCTG CGTTCTTCAC TGAGACACAG 
AGACAGTTCT CTCGATACTT CATTGAGTTT GAAGAACTAC AGCTTCTGGG GAAAGGAGCT 
TTTGGAGCTG TCATCAAGGT GCAAAACAAG CTTGATGGCT GTTGCTATGC TGTGAAGCGC 
ATCCCTATCA ACCCTGCAAG CAGGCAGTTC CGCAGGATCA AGGGCGAGGT GACGCTGCTA 
TCGCGCCTGC ACCATGAGAA CATTGTACGC TACTACAACG CCTGGATCGA ACGGCATGAG 
CGCCCAGCGG TGCCAGGGAC ACCACCCCCA GACTACATAC CCCAGGCCCA GAACAGCTCA 
GCCACCGGCG GGAAAGCATC AGGCGACACT GAGGAACTGG GCAGCGTGGA GGCTGCAGCA 
CCACCGCCCA TCCTCAGCAG CTCAGTGGAG TGGAGCACAT CTGCAGAGCG CTCTAACAGC 
GCCCGTTTCC CAGTCACAGG CCAGGACTCC AGCAGCGATG AGGAAGATGA GGACGAGCGC 
GATGGTGTCT TCTCACAGTC CTTTCTACCT GCTTCAGATT CTGACAGTGA CATCATCTTT 
GACAATGAAG ATGAAAACAG TAAAAGTCAG AATCAGGATG AAGACTGCAA TGAAAAGGAC 
AGTCGCCATG AGATTGAGCC ATCAGTGACG ACCGAGGCTG TGCACTACCT GTACATCCAG 
ATGGAGTACT GCGAGAAGAG CACACTGCGA GACACCATTG ACCAGGGGCT GTTCCGAGAC 
ACCAGCCGGC TCTGGAGGCT TTTCCGAGAG ATTCTGGATG GATTAGCTTA TATCCATGAG 
AAAGGAATGA TTCACCGGGA TTTGAAGCCT GTCAACATTT TTTTGGATTC TGATGACCAT 
GTGAAAATAG GTGATTTTGG TTTGGCAACA GACCATCTGG CCTTCAATGC TGAAGGTAAA 
CAGGACGACC AAGCAGGTGA TCATGTGATT AAGTCAGACC CTTCAGGCCA TTTGACTGGC 
ATGGTTGGCA CCGCTCTGTA TGTAAGCCCT GAGGTCCAAG GAAGTACCAA GTCTGCGTAC 
AACCAGAAAG TGGATCTCTT CAGCCTGGGA ATTATCCTCT TTGAGATGTC GTATCACCCG 
ATGGTGACTG CCTCAGAAAG AATTTTCGTT CTCAACCAAC TTCGAGATCC CACGTCACCC 
AAGTTCCCAG ACGACTTTGA GGACGGAGAG CATACAAAGC AGAAATCTGT CATCTCCTGG 
CTGTTAAACC ATGATCCAGC CAAACGGCCC ACAGCCATGG AGCTGCTCAA GAGTGAGCTG 
CTCCCCCCAC CACAGATGGA GGAGTCGGAG CTGCATGAAG TGCTGCACCA CACGCTGGCC 
AACACGGATG GGAAGGCCTA CCGCACCATG ATGAGCCAGC TCTTCTGCCA GCACAGCTCC 
CCCGCCATAG ACTACACCTA CGACAGCGAC ATCCTGAAGG GCAACTTCTT GATTCGCACA 
GCCAAGATCC AGCAGCTTGT GTGTGAAACC ATCGTCCGCG TCTTCAAAAG GCATGGAGCT 
GTCCAGCTGT GCACCCCGCT GCTGCTTCCC CGAAACAGGC AAATATATGA GCACAACGAA 
GCCGCTCTGT TCATGGATCA CAGTGGCATG CTGGTGATGC TTCCTTTCGA CCTGCGGGTC 
CCTTTTGCAA GATATGTGGC AAGAAATAAC ATACTGAATT TAAAGCGATA CTGCATAGAG 
CGGGTGTTCA GACCTAGGAA GTTAGACCGA TTTCATCCCA AAGAACTCCT GGAATGTGCA 
TTTGACATCG TCACTTCTAC CGCCAACAGC TCCCTGCCCA CTGCTGAAAC CATCTACACC 
ATCTATGAAG TCATCCAGGA GTTTCCTGCA CTTCAGGAAA GAAATTACAG CATTTACTTG 
AACCATACAA TGCTCCTAAA GGCAATACTC CTACACTGTG GGATCCCAGA GGATAAACTC 
AGTCAAGTCT ACGTTATTCT GTATGATGCT GTGACAGAGA AGCTGACTAG GAGGGAAGTA 
GAAGCTAAGT TCTGTAACCT GTCCTTGTCA TCTAATAGTC TGTGTCGACT CTATAAGTTC 
ATCGAGCAGA AGGGGGATTT GCAAGACCTA ACGCCGACCA TAAACTCACT AATAAAACAG 
AAAACAGGCA TTGCTCAGCT GGTGAAGTAT AGCTTAAAAG ACCTAGAGGA AGTTGTCGGG 
CTGCTGAAGA AACTTGGCGT GAAGTTGCAG GTCTCCATCA ACCTGGGCTT GGTTTACAAG 
GTGCAGCAGC ACAATGGCAT CATCTTCCAG TTCCTGGCAT TCAGCAAACG CAGGCAGAGG 
GTTGTGCCTG AGATCCTTGC AGCTGGTGGC AGATATGACC TGCTGATTCC CAAGTTCAGA 
GGCCCACAGG CTCTGGGGCC AGTGCCCACT GCTGTCGGTG TCAGCATAGC CATAGACAAG 
ATATTCGCCG CTGTCCTCAA CATGGGAGAG CCTGTTACAG TGAGCTCCTG TGACCTCCTG 
GTTGTCAGTG CTGGCCAGAT GTCCATGTCC AGGGCCATCA ACCTAACCCA GAAACTCTGG 
ACGGCCGGCA TCACTGCAGA GATCATGTAT GACTGGTCAC AGTCCCAGGA AGAGTTACAA 
GAATACTGCA GACATCACGA AATCACCTAT GTGGCCCTGG TCTCTGATAA AGAAGGAAGC 
CATGTCAAGG TCAAGTCCTT TGAGAAGGAG AGGCAAACAG AAAAACGTGT GTTGGAATCA 
GATCTTGTGG ACCATGTTAT GCAGAAACTA AGGACCAAAG TTGGTGACGA AAGGAATTTC 
AGAGACGCTT CTGATAATCT TGCCGTACAA ACTCTGAAGG GGTCGTTTTC TAATGCTTCA 
GGTTTGTTTG AAATCCATGG AACAACAGTA GTCCCCACTG TGAGTGTTAT ATCACCAGAA 
AAACTGTCGG CCAGCACCAG GAGGCGACAT GAGATTCAGG TGCAAACCCG ACTTCAGACT 
ACCCTTGCCA ATTTACATCA GAAAAGCAGT GAAATTGAAA TTTTGGCTGT GGATCTACCC 
AAGGAGACCA TCTTACAGTT TCTATCGCTA GAGTGGGACG CTGATGAACA GGCATTTAAC 
ACAACCGTGA AACAGCTGCT GTCACGCCTG CCAAAGCAAA GATACCTCAA ACTCGTCTGC 
GACGAAATCT ATAACATCAA AGTTGAGAAG AAGGTGTCGG TGTTGTTCCT GTACAGCTAC 
AGAGATGACT ACTACAGAAT CCTATTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001099214.2
CDS	93..5042
Translation	MAGGRGAAGRGPAEPQESYSQRQDHELQALEAIYGSDFQDLRPDARGRVREPPEINLVLYPQGLAGEEVYVQVELRVKCPPTYPDVVPEIELKNTKGLSNESVNLLKSHLEELAKKQCGEVMIFELAHHVQSFLSEHNKPPPKSFHEEMLERQAQEKQQRLLEARQKEEQEQREILHEIQKRKEEIKEEKKRKEMAKQERLEITSLTNQDHASKRDPAGHRAAAILHGGSPDFVGNGKARAHSSGRSRRERQYSVCSGEASPGSCDILYFCVGSADQLMVHKGKCVGSDEQLGKVVYNALETATGSFVLLYEWVLQWQKKMGPCLTSQEKEKIDKCKKQIQGAETEFSSLVKLSHPNIVRYFAMNSREEKDSIVVDILAEHISGISLAAHLSHSGPVPMHQLRKYTAQLLAGLDYLHRNSVVHKVLSTASVLVDAEGTVKITDYSISKRLADICKEDVFEQTRVRFSDSALPYKTGKKGDVWRLGLLLLSLSQGQECEEYPVTIPSDLPADFQDFLKKCVCLDDKERWSPQQLLKHSFINPQPKMPLVEQSPEDSGGQDYIETIIPSNQLPSAAFFTETQRQFSRYFIEFEELQLLGKGAFGAVIKVQNKLDGCCYAVKRIPINPASRQFRRIKGEVTLLSRLHHENIVRYYNAWIERHERPAVPGTPPPDYIPQAQNSSATGGKASGDTEELGSVEAAAPPPILSSSVEWSTSAERSNSARFPVTGQDSSSDEEDEDERDGVFSQSFLPASDSDSDIIFDNEDENSKSQNQDEDCNEKDSRHEIEPSVTTEAVHYLYIQMEYCEKSTLRDTIDQGLFRDTSRLWRLFREILDGLAYIHEKGMIHRDLKPVNIFLDSDDHVKIGDFGLATDHLAFNAEGKQDDQAGDHVIKSDPSGHLTGMVGTALYVSPEVQGSTKSAYNQKVDLFSLGIILFEMSYHPMVTASERIFVLNQLRDPTSPKFPDDFEDGEHTKQKSVISWLLNHDPAKRPTAMELLKSELLPPPQMEESELHEVLHHTLANTDGKAYRTMMSQLFCQHSSPAIDYTYDSDILKGNFLIRTAKIQQLVCETIVRVFKRHGAVQLCTPLLLPRNRQIYEHNEAALFMDHSGMLVMLPFDLRVPFARYVARNNILNLKRYCIERVFRPRKLDRFHPKELLECAFDIVTSTANSSLPTAETIYTIYEVIQEFPALQERNYSIYLNHTMLLKAILLHCGIPEDKLSQVYVILYDAVTEKLTRREVEAKFCNLSLSSNSLCRLYKFIEQKGDLQDLTPTINSLIKQKTGIAQLVKYSLKDLEEVVGLLKKLGVKLQVSINLGLVYKVQQHNGIIFQFLAFSKRRQRVVPEILAAGGRYDLLIPKFRGPQALGPVPTAVGVSIAIDKIFAAVLNMGEPVTVSSCDLLVVSAGQMSMSRAINLTQKLWTAGITAEIMYDWSQSQEELQEYCRHHEITYVALVSDKEGSHVKVKSFEKERQTEKRVLESDLVDHVMQKLRTKVGDERNFRDASDNLAVQTLKGSFSNASGLFEIHGTTVVPTVSVISPEKLSASTRRRHEIQVQTRLQTTLANLHQKSSEIEILAVDLPKETILQFLSLEWDADEQAFNTTVKQLLSRLPKQRYLKLVCDEIYNIKVEKKVSVLFLYSYRDDYYRILF

Target ORF information:

RefSeq Version	NM_001105744.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus eukaryotic translation initiation factor 2 alpha kinase 4 (Eif2ak4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001105744.2

ORF Insert Sequence:

ATGGCTGGGG GCCGCGGGGC CGCAGGACGC GGCCCGGCTG AGCCGCAGGA GAGCTATTCA 
CAGAGACAGG ACCACGAGCT GCAGGCCCTG GAGGCGATTT ACGGCTCGGA CTTCCAGGAT 
CTGCGGCCGG ATGCGCGCGG ACGGGTGAGA GAGCCTCCTG AAATCAATTT AGTTCTGTAC 
CCTCAGGGCC TGGCTGGTGA GGAAGTGTAC GTGCAGGTGG AGCTGAGGGT CAAATGCCCA 
CCGACATACC CGGATGTAGT TCCCGAAATA GAGTTAAAAA ACACTAAAGG TCTGTCGAAT 
GAGAGTGTTA ATTTGTTAAA GTCACACCTG GAAGAACTGG CCAAAAAGCA GTGTGGAGAG 
GTGATGATAT TCGAACTGGC ACACCACGTG CAGTCGTTTC TCAGCGAGCA TAACAAGCCC 
CCTCCAAAGT CTTTCCATGA AGAAATGCTG GAAAGGCAGG CTCAGGAGAA GCAGCAGAGG 
TTGCTGGAGG CCAGGCAGAA AGAGGAGCAG GAGCAACGTG AAATCCTCCA CGAGATTCAG 
AAAAGGAAAG AGGAGATCAA GGAAGAGAAG AAAAGGAAGG AAATGGCTAA GCAGGAACGT 
TTGGAAATTA CTAGTTTGAC AAACCAGGAT CATGCCTCTA AGAGAGACCC AGCAGGACAC 
AGGGCAGCTG CCATTCTCCA TGGAGGCTCT CCTGACTTTG TAGGAAATGG TAAAGCCCGG 
GCACACTCCT CAGGAAGGTC CAGGCGAGAA CGTCAGTATT CTGTCTGTAG TGGTGAAGCC 
TCTCCTGGCT CGTGTGACAT CCTCTACTTC TGTGTGGGTA GCGCTGATCA GCTCATGGTG 
CACAAAGGGA AATGTGTTGG CAGCGATGAG CAGCTGGGGA AGGTGGTATA CAATGCATTG 
GAAACAGCCA CGGGCAGCTT TGTCTTGTTG TATGAGTGGG TCCTTCAGTG GCAGAAAAAG 
ATGGGCCCTT GCCTTACCAG TCAAGAGAAA GAGAAGATCG ATAAATGTAA AAAGCAGATT 
CAAGGAGCAG AAACAGAATT CAGCTCCCTA GTGAAACTGA GCCATCCAAA CATTGTCCGC 
TACTTTGCGA TGAACTCCAG AGAGGAGAAG GATTCCATTG TGGTCGACAT TCTGGCAGAA 
CACATCAGTG GGATCTCTCT CGCTGCACAC CTGAGCCACT CAGGCCCTGT GCCCATGCAC 
CAGCTGCGCA AATACACAGC GCAGCTCCTG GCGGGCCTGG ACTACCTGCA CCGCAACTCG 
GTGGTGCACA AGGTGCTGAG CACCGCCAGC GTCTTGGTGG ATGCTGAGGG CACCGTCAAG 
ATAACAGACT ACAGCATCTC TAAGCGCCTG GCAGACATTT GCAAGGAGGA TGTTTTTGAG 
CAAACTCGAG TTCGCTTTAG TGACAGTGCT CTGCCTTATA AAACCGGGAA GAAAGGGGAT 
GTGTGGCGTC TTGGCCTCCT GCTGTTGTCT CTTAGCCAAG GTCAGGAGTG TGAGGAGTAT 
CCTGTGACCA TCCCCAGTGA TCTGCCAGCT GACTTCCAGG ACTTCCTGAA GAAGTGTGTT 
TGCCTGGACG ACAAGGAAAG GTGGAGCCCT CAACAGTTGC TGAAACACAG CTTTATAAAC 
CCTCAGCCAA AAATGCCTTT GGTGGAGCAG AGTCCTGAAG ATTCTGGGGG ACAAGATTAC 
ATCGAGACCA TCATCCCCAG CAACCAGCTG CCCAGCGCTG CGTTCTTCAC TGAGACACAG 
AGACAGTTCT CTCGATACTT CATTGAGTTT GAAGAACTAC AGCTTCTGGG GAAAGGAGCT 
TTTGGAGCTG TCATCAAGGT GCAAAACAAG CTTGATGGCT GTTGCTATGC TGTGAAGCGC 
ATCCCTATCA ACCCTGCAAG CAGGCAGTTC CGCAGGATCA AGGGCGAGGT GACGCTGCTA 
TCGCGCCTGC ACCATGAGAA CATTGTACGC TACTACAACG CCTGGATCGA ACGGCATGAG 
CGCCCAGCGG TGCCAGGGAC ACCACCCCCA GACTACATAC CCCAGGCCCA GAACAGCTCA 
GCCACCGGCG GGAAAGCATC AGGCGACACT GAGGAACTGG GCAGCGTGGA GGCTGCAGCA 
CCACCGCCCA TCCTCAGCAG CTCAGTGGAG TGGAGCACAT CTGCAGAGCG CTCTAACAGC 
GCCCGTTTCC CAGTCACAGG CCAGGACTCC AGCAGCGATG AGGAAGATGA GGACGAGCGC 
GATGGTGTCT TCTCACAGTC CTTTCTACCT GCTTCAGATT CTGACAGTGA CATCATCTTT 
GACAATGAAG ATGAAAACAG TAAAAGTCAG AATCAGGATG AAGACTGCAA TGAAAAGGAC 
AGTCGCCATG AGATTGAGCC ATCAGTGACG ACCGAGGCTG TGCACTACCT GTACATCCAG 
ATGGAGTACT GCGAGAAGAG CACACTGCGA GACACCATTG ACCAGGGGCT GTTCCGAGAC 
ACCAGCCGGC TCTGGAGGCT TTTCCGAGAG ATTCTGGATG GATTAGCTTA TATCCATGAG 
AAAGGAATGA TTCACCGGGA TTTGAAGCCT GTCAACATTT TTTTGGATTC TGATGACCAT 
GTGAAAATAG GTGATTTTGG TTTGGCAACA GACCATCTGG CCTTCAATGC TGAAGGTAAA 
CAGGACGACC AAGCAGGTGA TCATGTGATT AAGTCAGACC CTTCAGGCCA TTTGACTGGC 
ATGGTTGGCA CCGCTCTGTA TGTAAGCCCT GAGGTCCAAG GAAGTACCAA GTCTGCGTAC 
AACCAGAAAG TGGATCTCTT CAGCCTGGGA ATTATCCTCT TTGAGATGTC GTATCACCCG 
ATGGTGACTG CCTCAGAAAG AATTTTCGTT CTCAACCAAC TTCGAGATCC CACGTCACCC 
AAGTTCCCAG ACGACTTTGA GGACGGAGAG CATACAAAGC AGAAATCTGT CATCTCCTGG 
CTGTTAAACC ATGATCCAGC CAAACGGCCC ACAGCCATGG AGCTGCTCAA GAGTGAGCTG 
CTCCCCCCAC CACAGATGGA GGAGTCGGAG CTGCATGAAG TGCTGCACCA CACGCTGGCC 
AACACGGATG GGAAGGCCTA CCGCACCATG ATGAGCCAGC TCTTCTGCCA GCACAGCTCC 
CCCGCCATAG ACTACACCTA CGACAGCGAC ATCCTGAAGG GCAACTTCTT GATTCGCACA 
GCCAAGATCC AGCAGCTTGT GTGTGAAACC ATCGTCCGCG TCTTCAAAAG GCATGGAGCT 
GTCCAGCTGT GCACCCCGCT GCTGCTTCCC CGAAACAGGC AAATATATGA GCACAACGAA 
GCCGCTCTGT TCATGGATCA CAGTGGCATG CTGGTGATGC TTCCTTTCGA CCTGCGGGTC 
CCTTTTGCAA GATATGTGGC AAGAAATAAC ATACTGAATT TAAAGCGATA CTGCATAGAG 
CGGGTGTTCA GACCTAGGAA GTTAGACCGA TTTCATCCCA AAGAACTCCT GGAATGTGCA 
TTTGACATCG TCACTTCTAC CGCCAACAGC TCCCTGCCCA CTGCTGAAAC CATCTACACC 
ATCTATGAAG TCATCCAGGA GTTTCCTGCA CTTCAGGAAA GAAATTACAG CATTTACTTG 
AACCATACAA TGCTCCTAAA GGCAATACTC CTACACTGTG GGATCCCAGA GGATAAACTC 
AGTCAAGTCT ACGTTATTCT GTATGATGCT GTGACAGAGA AGCTGACTAG GAGGGAAGTA 
GAAGCTAAGT TCTGTAACCT GTCCTTGTCA TCTAATAGTC TGTGTCGACT CTATAAGTTC 
ATCGAGCAGA AGGGGGATTT GCAAGACCTA ACGCCGACCA TAAACTCACT AATAAAACAG 
AAAACAGGCA TTGCTCAGCT GGTGAAGTAT AGCTTAAAAG ACCTAGAGGA AGTTGTCGGG 
CTGCTGAAGA AACTTGGCGT GAAGTTGCAG GTCTCCATCA ACCTGGGCTT GGTTTACAAG 
GTGCAGCAGC ACAATGGCAT CATCTTCCAG TTCCTGGCAT TCAGCAAACG CAGGCAGAGG 
GTTGTGCCTG AGATCCTTGC AGCTGGTGGC AGATATGACC TGCTGATTCC CAAGTTCAGA 
GGCCCACAGG CTCTGGGGCC AGTGCCCACT GCTGTCGGTG TCAGCATAGC CATAGACAAG 
ATATTCGCCG CTGTCCTCAA CATGGGAGAG CCTGTTACAG TGAGCTCCTG TGACCTCCTG 
GTTGTCAGTG CTGGCCAGAT GTCCATGTCC AGGGCCATCA ACCTAACCCA GAAACTCTGG 
ACGGCCGGCA TCACTGCAGA GATCATGTAT GACTGGTCAC AGTCCCAGGA AGAGTTACAA 
GAATACTGCA GACATCACGA AATCACCTAT GTGGCCCTGG TCTCTGATAA AGAAGGAAGC 
CATGTCAAGG TCAAGTCCTT TGAGAAGGAG AGGCAAACAG AAAAACGTGT GTTGGAATCA 
GATCTTGTGG ACCATGTTAT GCAGAAACTA AGGACCAAAG TTGGTGACGA AAGGAATTTC 
AGAGACGCTT CTGATAATCT TGCCGTACAA ACTCTGAAGG GGTCGTTTTC TAATGCTTCA 
GGTTTGTTTG AAATCCATGG AACAACAGTA GTCCCCACTG TGAGTGTTAT ATCACCAGAA 
AAACTGTCGG CCAGCACCAG GAGGCGACAT GAGATTCAGG TGCAAACCCG ACTTCAGACT 
ACCCTTGCCA ATTTACATCA GAAAAGCAGT GAAATTGAAA TTTTGGCTGT GGATCTACCC 
AAGGAGACCA TCTTACAGTT TCTATCGCTA GAGTGGGACG CTGATGAACA GGCATTTAAC 
ACAACCGTGA AACAGCTGCT GTCACGCCTG CCAAAGCAAA GATACCTCAA ACTCGTCTGC 
GACGAAATCT ATAACATCAA AGTTGAGAAG AAGGTGTCGG TGTTGTTCCT GTACAGCTAC 
AGAGATGACT ACTACAGAAT CCTATTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

p58IPK is an inhibitor of the eIF2? kinase GCN2 and its localization and expression underpin protein synthesis and ER processing capacity.
The Biochemical journal465(2)213-25(2015 Jan)
Roobol A,Roobol J,Bastide A,Knight JR,Willis AE,Smales CM

Evolutionarily conserved IMPACT impairs various stress responses that require GCN1 for activating the eIF2 kinase GCN2.
Biochemical and biophysical research communications443(2)592-7(2014 Jan)
Cambiaghi TD,Pereira CM,Shanmugam R,Bolech M,Wek RC,Sattlegger E,Castilho BA

Vaccine activation of the nutrient sensor GCN2 in dendritic cells enhances antigen presentation.
Science (New York, N.Y.)343(6168)313-317(2014 Jan)
Ravindran R,Khan N,Nakaya HI,Li S,Loebbermann J,Maddur MS,Park Y,Jones DP,Chappert P,Davoust J,Weiss DS,Virgin HW,Ron D,Pulendran B

Gene expression analysis in response to lung toxicants: I. Sequencing and microarray development.
American journal of respiratory cell and molecular biology30(3)296-310(2004 Mar)
Shultz MA,Zhang L,Gu YZ,Baker GL,Fannuchi MV,Padua AM,Gurske WA,Morin D,Penn SG,Jovanovich SB,Plopper CG,Buckpitt AR

Activation of GCN2 in UV-irradiated cells inhibits translation.
Current biology : CB12(15)1279-86(2002 Aug)
Deng J,Harding HP,Raught B,Gingras AC,Berlanga JJ,Scheuner D,Kaufman RJ,Ron D,Sonenberg N

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Eif2ak4 cDNA ORF clone, Rattus norvegicus(Norway rat)

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Target ORF information:

ORF Insert Sequence:

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