Cdkn1a cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cdkn1a
Entrez Gene ID	114851
Full Name	cyclin-dependent kinase inhibitor 1A
Synonyms	Cip1,UV96,Waf1
General protein information	Preferred Names cyclin-dependent kinase inhibitor 1A Names cyclin-dependent kinase inhibitor 1 cyclin-dependent kinase inhibitor 1A (P21) cyclin-dependent kinase inhibitor 1A (p21, Cip1)
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 20 Map Location: 20p12
Summary	a Cdk inhibitor; involved in negative regulation of the cell cycle [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_080782.3	NP_542960.1	cyclin-dependent kinase inhibitor 1
XM_006256128.3	XP_006256190.1	cyclin-dependent kinase inhibitor 1 isoform X1

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Cdkn1a	NP_542960.1
Pan troglodytes (chimpanzee)	CDKN1A	XP_003950884.1
Mus musculus (house mouse)	Cdkn1a	NP_031695.1
Homo sapiens (human)	CDKN1A	NP_001207706.1
Bos taurus (cattle)	CDKN1A	NP_001092428.1
	CDKN1A	XP_001116887.1
Canis lupus familiaris (dog)	CDKN1A	XP_005627336.1

Gene Ontology
Bibliography

Related articles in PubMed

Caveolin?1 regulates oxidative stress?induced senescence in nucleus pulposus cells primarily via the p53/p21 signaling pathway in?vitro.
Ding L, Zeng Q, Wu J, Li D, Wang H, Lu W, Jiang Z, Xu G
Molecular medicine reports16(6)9521-9527(2017 Dec)

Cyclin-Dependent Kinase Inhibitor p21WAF1/CIP1 Facilitates the Development of Cardiac Hypertrophy.
Tong YF, Wang Y, Ding YY, Li JM, Pan XC, Lu XL, Chen XH, Liu Y, Zhang HG
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology42(4)1645-1656(2017)

Involvement of Histone Lysine Methylation in p21 Gene Expression in Rat Kidney In Vivo and Rat Mesangial Cells In Vitro under Diabetic Conditions.
Li X, Li C, Li X, Cui P, Li Q, Guo Q, Han H, Liu S, Sun G
Journal of diabetes research20163853242(2016)

Cholesterol Retards Senescence in Bone Marrow Mesenchymal Stem Cells by Modulating Autophagy and ROS/p53/p21
Zhang M, Du Y, Lu R, Shu Y, Zhao W, Li Z, Zhang Y, Liu R, Yang T, Luo S, Gao M, Zhang Y, Zhang G, Liu J, Lu Y
Oxidative medicine and cellular longevity20167524308(2016)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The findings suggest that p21 facilitates the development of cardiac hypertrophy, and regulating the expression of p21 may be an approach to attenuate hypertrophic growth of cardiomyocytes.
Title: Cyclin-Dependent Kinase Inhibitor p21WAF1/CIP1 Facilitates the Development of Cardiac Hypertrophy.

Nurr1 was induced during intestinal regeneration after I/R injury. Nurr1 promoted proliferation of intestinal epithelial cells after H/R injury. Nurr1 inhibited p21 expression in a p53-independent manner. Nurr1 inhibited p21 gene transcription by binding to p21 promoter directly.
Title: Nurr1 promotes intestinal regeneration after ischemia/reperfusion injury by inhibiting the expression of p21 (Waf1/Cip1).

The aim of the present study was to examine the impacts and mechanisms of 12lipoxygenase (12LO) and its metabolites on the acetylation and methylation of histone3lysine (H3K) in the p21 gene. associated epigenetic changes, including increased histone H3K9Ac and H3K4Me1, and reduced H3K9M.e3 may involved in 12 (S)hydroxyeicosatetraenoic acid mediated p21 gene regulation.
Title: Role of histone modification in 12?lipoxygenase?associated p21 gene regulation.

p21 gene expression was upregulated in diabetic rats glomeruli.
Title: Involvement of Histone Lysine Methylation in p21 Gene Expression in Rat Kidney In Vivo and Rat Mesangial Cells In Vitro under Diabetic Conditions.

Cholesterol regulates bone marrow mesenchymal stem cell senescence by modulating cell cycle, autophagy, and the ROS/p53/p21(Cip1/Waf1) signaling pathway.
Title: Cholesterol Retards Senescence in Bone Marrow Mesenchymal Stem Cells by Modulating Autophagy and ROS/p53/p21

The following Cdkn1a gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cdkn1a cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa12533	NM_080782.3 Latest version!	Rattus norvegicus cyclin-dependent kinase inhibitor 1A (Cdkn1a), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
ORa12533	XM_006256128.3 Latest version!	Rattus norvegicus cyclin-dependent kinase inhibitor 1A (Cdkn1a), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cdkn1a ( NM_080782.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_542960.1 Rattus norvegicus cyclin-dependent kinase inhibitor 1A (Cdkn1a), mRNA.

Price & Availability↑

CloneID	ORa12533
Clone ID Related Accession (Same CDS sequence)	NM_080782.3 , XM_006256128.3
Accession Version	NM_080782.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 495bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-01
Organism	Rattus norvegicus(Norway rat)
Product	cyclin-dependent kinase inhibitor 1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC100620.1. On Aug 21, 2005 this sequence version replaced NM_080782.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC100620.1, DN947728.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00632251, SAMN00632253 [ECO:0000348] ##Evidence-Data-END##

ATGTCCGATC CTGGTGATGT CCGACCTGTT CCACACAGGA GCAAAGTATG CCGTCGTCTG 
TTCGGTCCCG TGGACAGTGA GCAGTTGAGC CGCGATTGCG ATGCGCTCAT GGCGAGCTGT 
CTCCAGGAGG CCCGAGAACG GTGGAACTTT GACTTCGCCA CTGAGACGCC ACTGGAGGGC 
AACTACGTCT GGGAGCGTGT TCGGAGCCCA GGGCTGCCCA AGATCTACCT GAGCCCTGGG 
TCCCGCCGCC GTGATGACCT GGGAGGGGAC AAGAGGCCCA GTACCTCCTC GGCCCTGCTG 
CAGGGGCCAG GGCCAGCTCC GGAGGACCAC GTGGCCTTGT CGCTGTCTTG CACTCTGGTG 
TCTCACGCCC CTGAGAGGCC TGAAGACTCC CCGGGCGGGA CCGGGACATC TCAGGGCCGA 
AAACGGAGGC AGACCAGCCT AACAGATTTC TATCACTCCA AGCGCCGATT GGTCTTCTGC 
AAGAGAAAGC CCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_542960.1
CDS	42..536
Translation	MSDPGDVRPVPHRSKVCRRLFGPVDSEQLSRDCDALMASCLQEARERWNFDFATETPLEGNYVWERVRSPGLPKIYLSPGSRRRDDLGGDKRPSTSSALLQGPGPAPEDHVALSLSCTLVSHAPERPEDSPGGTGTSQGRKRRQTSLTDFYHSKRRLVFCKRKP

Target ORF information:

RefSeq Version	NM_080782.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus cyclin-dependent kinase inhibitor 1A (Cdkn1a), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_080782.3

ORF Insert Sequence:

ATGTCCGATC CTGGTGATGT CCGACCTGTT CCACACAGGA GCAAAGTATG CCGTCGTCTG 
TTCGGTCCCG TGGACAGTGA GCAGTTGAGC CGCGATTGCG ATGCGCTCAT GGCGAGCTGT 
CTCCAGGAGG CCCGAGAACG GTGGAACTTT GACTTCGCCA CTGAGACGCC ACTGGAGGGC 
AACTACGTCT GGGAGCGTGT TCGGAGCCCA GGGCTGCCCA AGATCTACCT GAGCCCTGGG 
TCCCGCCGCC GTGATGACCT GGGAGGGGAC AAGAGGCCCA GTACCTCCTC GGCCCTGCTG 
CAGGGGCCAG GGCCAGCTCC GGAGGACCAC GTGGCCTTGT CGCTGTCTTG CACTCTGGTG 
TCTCACGCCC CTGAGAGGCC TGAAGACTCC CCGGGCGGGA CCGGGACATC TCAGGGCCGA 
AAACGGAGGC AGACCAGCCT AACAGATTTC TATCACTCCA AGCGCCGATT GGTCTTCTGC 
AAGAGAAAGC CCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Cdkn1a ( XM_006256128.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006256190.1 Rattus norvegicus cyclin-dependent kinase inhibitor 1A (Cdkn1a), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa12533
Clone ID Related Accession (Same CDS sequence)	NM_080782.3 , XM_006256128.3
Accession Version	XM_006256128.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 495bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	cyclin-dependent kinase inhibitor 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005119.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006256128.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCCGATC CTGGTGATGT CCGACCTGTT CCACACAGGA GCAAAGTATG CCGTCGTCTG 
TTCGGTCCCG TGGACAGTGA GCAGTTGAGC CGCGATTGCG ATGCGCTCAT GGCGAGCTGT 
CTCCAGGAGG CCCGAGAACG GTGGAACTTT GACTTCGCCA CTGAGACGCC ACTGGAGGGC 
AACTACGTCT GGGAGCGTGT TCGGAGCCCA GGGCTGCCCA AGATCTACCT GAGCCCTGGG 
TCCCGCCGCC GTGATGACCT GGGAGGGGAC AAGAGGCCCA GTACCTCCTC GGCCCTGCTG 
CAGGGGCCAG GGCCAGCTCC GGAGGACCAC GTGGCCTTGT CGCTGTCTTG CACTCTGGTG 
TCTCACGCCC CTGAGAGGCC TGAAGACTCC CCGGGCGGGA CCGGGACATC TCAGGGCCGA 
AAACGGAGGC AGACCAGCCT AACAGATTTC TATCACTCCA AGCGCCGATT GGTCTTCTGC 
AAGAGAAAGC CCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006256190.1
CDS	121..615
Translation	MSDPGDVRPVPHRSKVCRRLFGPVDSEQLSRDCDALMASCLQEARERWNFDFATETPLEGNYVWERVRSPGLPKIYLSPGSRRRDDLGGDKRPSTSSALLQGPGPAPEDHVALSLSCTLVSHAPERPEDSPGGTGTSQGRKRRQTSLTDFYHSKRRLVFCKRKP

Target ORF information:

RefSeq Version	XM_006256128.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus cyclin-dependent kinase inhibitor 1A (Cdkn1a), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006256128.3

ORF Insert Sequence:

ATGTCCGATC CTGGTGATGT CCGACCTGTT CCACACAGGA GCAAAGTATG CCGTCGTCTG 
TTCGGTCCCG TGGACAGTGA GCAGTTGAGC CGCGATTGCG ATGCGCTCAT GGCGAGCTGT 
CTCCAGGAGG CCCGAGAACG GTGGAACTTT GACTTCGCCA CTGAGACGCC ACTGGAGGGC 
AACTACGTCT GGGAGCGTGT TCGGAGCCCA GGGCTGCCCA AGATCTACCT GAGCCCTGGG 
TCCCGCCGCC GTGATGACCT GGGAGGGGAC AAGAGGCCCA GTACCTCCTC GGCCCTGCTG 
CAGGGGCCAG GGCCAGCTCC GGAGGACCAC GTGGCCTTGT CGCTGTCTTG CACTCTGGTG 
TCTCACGCCC CTGAGAGGCC TGAAGACTCC CCGGGCGGGA CCGGGACATC TCAGGGCCGA 
AAACGGAGGC AGACCAGCCT AACAGATTTC TATCACTCCA AGCGCCGATT GGTCTTCTGC 
AAGAGAAAGC CCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Caveolin?1 regulates oxidative stress?induced senescence in nucleus pulposus cells primarily via the p53/p21 signaling pathway in?vitro.
Molecular medicine reports16(6)9521-9527(2017 Dec)
Ding L,Zeng Q,Wu J,Li D,Wang H,Lu W,Jiang Z,Xu G

Cyclin-Dependent Kinase Inhibitor p21WAF1/CIP1 Facilitates the Development of Cardiac Hypertrophy.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology42(4)1645-1656(2017)
Tong YF,Wang Y,Ding YY,Li JM,Pan XC,Lu XL,Chen XH,Liu Y,Zhang HG

Involvement of Histone Lysine Methylation in p21 Gene Expression in Rat Kidney In Vivo and Rat Mesangial Cells In Vitro under Diabetic Conditions.
Journal of diabetes research20163853242(2016)
Li X,Li C,Li X,Cui P,Li Q,Guo Q,Han H,Liu S,Sun G

Cholesterol Retards Senescence in Bone Marrow Mesenchymal Stem Cells by Modulating Autophagy and ROS/p53/p21
Oxidative medicine and cellular longevity20167524308(2016)
Zhang M,Du Y,Lu R,Shu Y,Zhao W,Li Z,Zhang Y,Liu R,Yang T,Luo S,Gao M,Zhang Y,Zhang G,Liu J,Lu Y

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Cdkn1a cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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