Ifitm2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ifitm2
Entrez Gene ID	114709
Full Name	interferon induced transmembrane protein 2
Synonyms	Ifitm3l,Ifitml
General protein information	Preferred Names interferon induced transmembrane protein 2 Names interferon-induced transmembrane protein 2 interferon induced transmembrane protein 2 (1-8D) interferon induced transmembrane protein, like interferon-inducible protein 16
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q41
Summary	similar to the human interferon inducible 1-8 gene family that is activated during adrenal remodeling [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_030833.1	NP_110460.1	interferon-induced transmembrane protein 2

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	IFITM2	NP_001185696.1
Rattus norvegicus (Norway rat)	Ifitm2	NP_110460.1
Mus musculus (house mouse)	Ifitm2	NP_109619.1
Homo sapiens (human)	IFITM2	NP_006426.2
	IFITM3	XP_001106166.1

Gene Ontology
Bibliography

Related articles in PubMed

ZMPSTE24 defends against influenza and other pathogenic viruses.
Fu B, Wang L, Li S, Dorf ME
The Journal of experimental medicine214(4)919-929(2017 Apr)

IFITM proteins restrict viral membrane hemifusion.
Li K, Markosyan RM, Zheng YM, Golfetto O, Bungart B, Li M, Ding S, He Y, Liang C, Lee JC, Gratton E, Cohen FS, Liu SL
PLoS pathogens9(1)e1003124(2013 Jan)

Interferons induce the expression of IFITM1 and IFITM3 and suppress the proliferation of rat neonatal cardiomyocytes.
Lau SL, Yuen ML, Kou CY, Au KW, Zhou J, Tsui SK
Journal of cellular biochemistry113(3)841-7(2012 Mar)

Evolutionary dynamics of the interferon-induced transmembrane gene family in vertebrates.
Zhang Z, Liu J, Li M, Yang H, Zhang C
PloS one7(11)e49265(2012)

IFITM proteins restrict antibody-dependent enhancement of dengue virus infection.
Chan YK, Huang IC, Farzan M
PloS one7(3)e34508(2012)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Ifitm2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ifitm2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa07130	NM_030833.1 Latest version!	Rattus norvegicus interferon induced transmembrane protein 2 (Ifitm2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ifitm2 ( NM_030833.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_110460.1 Rattus norvegicus interferon induced transmembrane protein 2 (Ifitm2), mRNA.

Price & Availability↑

CloneID	ORa07130
Clone ID Related Accession (Same CDS sequence)	NM_030833.1
Accession Version	NM_030833.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 435bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-18
Organism	Rattus norvegicus(Norway rat)
Product	interferon-induced transmembrane protein 2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF164040.1. ##Evidence-Data-START## Transcript exon combination :: AF164040.1, FM086251.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01906347, SAMN01906351 [ECO:0000348] ##Evidence-Data-END##

ATGAGCCACA ATTCCCAAGC CTTCTTGCCC GCCAATGCCG GGCTTCCTCC AAGCTATGAG 
ACAATCAAAG AGGAGTACGG GGTGACTGAG CTGGGGGAAC CCAACAACTC AGCTGTCGTG 
AGGACCACCG TGATCAACAT GCCCAGAGAG GTCTCTGTGC CTGACCATGT GGTCTGGTCC 
CTGTTCAATA CGCTCTTCTT CAATGCCTGC TGCCTGGGCT TCATTGCCTA TGCCTACTCT 
GTGAAGTCCA GGGACAGGAA GATGGTGGGC GATGTGATTG GAGCCCAGGC CTACGCCTCC 
ACTGCCAAGT GCCTGAACAT CAGCTCCCTG ATCTTCAGTG TCCTCATGGT CATTATCTGC 
ATCATCATTT TCTCTACCAC CTCTGCGGTA GTCTTTCAGT CGCTTTCACA AAGAACGCCA 
CATTCTGGAT TCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_110460.1
CDS	60..494
Translation	MSHNSQAFLPANAGLPPSYETIKEEYGVTELGEPNNSAVVRTTVINMPREVSVPDHVVWSLFNTLFFNACCLGFIAYAYSVKSRDRKMVGDVIGAQAYASTAKCLNISSLIFSVLMVIICIIIFSTTSAVVFQSLSQRTPHSGF

Target ORF information:

RefSeq Version	NM_030833.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus interferon induced transmembrane protein 2 (Ifitm2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_030833.1

ORF Insert Sequence:

ATGAGCCACA ATTCCCAAGC CTTCTTGCCC GCCAATGCCG GGCTTCCTCC AAGCTATGAG 
ACAATCAAAG AGGAGTACGG GGTGACTGAG CTGGGGGAAC CCAACAACTC AGCTGTCGTG 
AGGACCACCG TGATCAACAT GCCCAGAGAG GTCTCTGTGC CTGACCATGT GGTCTGGTCC 
CTGTTCAATA CGCTCTTCTT CAATGCCTGC TGCCTGGGCT TCATTGCCTA TGCCTACTCT 
GTGAAGTCCA GGGACAGGAA GATGGTGGGC GATGTGATTG GAGCCCAGGC CTACGCCTCC 
ACTGCCAAGT GCCTGAACAT CAGCTCCCTG ATCTTCAGTG TCCTCATGGT CATTATCTGC 
ATCATCATTT TCTCTACCAC CTCTGCGGTA GTCTTTCAGT CGCTTTCACA AAGAACGCCA 
CATTCTGGAT TCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

ZMPSTE24 defends against influenza and other pathogenic viruses.
The Journal of experimental medicine214(4)919-929(2017 Apr)
Fu B,Wang L,Li S,Dorf ME

IFITM proteins restrict viral membrane hemifusion.
PLoS pathogens9(1)e1003124(2013 Jan)
Li K,Markosyan RM,Zheng YM,Golfetto O,Bungart B,Li M,Ding S,He Y,Liang C,Lee JC,Gratton E,Cohen FS,Liu SL

Interferons induce the expression of IFITM1 and IFITM3 and suppress the proliferation of rat neonatal cardiomyocytes.
Journal of cellular biochemistry113(3)841-7(2012 Mar)
Lau SL,Yuen ML,Kou CY,Au KW,Zhou J,Tsui SK

Evolutionary dynamics of the interferon-induced transmembrane gene family in vertebrates.
PloS one7(11)e49265(2012)
Zhang Z,Liu J,Li M,Yang H,Zhang C

IFITM proteins restrict antibody-dependent enhancement of dengue virus infection.
PloS one7(3)e34508(2012)
Chan YK,Huang IC,Farzan M