Cdc42bpa cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cdc42bpa
Entrez Gene ID	114116
Full Name	CDC42 binding protein kinase alpha
Synonyms	Mrck,Pk428
General protein information	Preferred Names CDC42 binding protein kinase alpha Names serine/threonine-protein kinase MRCK alpha MRCK alpha Ser-Thr protein kinase related to the myotonic dystrophy protein kinase myotonic dystrophy kinase-related CDC42-binding kinase alpha myotonic dystrophy protein kinase-like alpha mytonic dystrophy kinase-related Cdc42-binding kinase
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 13 Map Location: 13q26
Summary	catalyzes the phosphorylation of Ser19 of nonmuscle myosin light chain; binds GTP-Cdc42 and plays a role in cytoskeleton organization [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_053657.1	NP_446109.1	serine/threonine-protein kinase MRCK alpha

Pathways from BioSystems

Homologies

Homo sapiens (human)	CDC42BPA	NP_003598.2
	CDC42BPA	XP_002801950.1
Canis lupus familiaris (dog)	CDC42BPA	XP_005622674.1
Gallus gallus (chicken)	CDC42BPA	NP_001186372.1
Xenopus tropicalis (tropical clawed frog)	cdc42bpa	XP_002938889.2
Pan troglodytes (chimpanzee)	CDC42BPA	XP_003949757.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP012090	XP_320436.4
Rattus norvegicus (Norway rat)	Cdc42bpa	NP_446109.1
Danio rerio (zebrafish)	si:ch211-89p3.3	NP_001038559.1
Drosophila melanogaster (fruit fly)	gek	NP_523837.2
Caenorhabditis elegans (roundworm)	mrck-1	NP_504599.2
Mus musculus (house mouse)	Cdc42bpa	NP_001028457.1

Gene Ontology
Bibliography

Related articles in PubMed

Adaptor protein LRAP25 mediates myotonic dystrophy kinase-related Cdc42-binding kinase (MRCK) regulation of LIMK1 protein in lamellipodial F-actin dynamics.
Lee IC, Leung T, Tan I
The Journal of biological chemistry289(39)26989-7003(2014 Sep)

A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.
Blandin G, Marchand S, Charton K, Dani?le N, Gicquel E, Boucheteil JB, Bentaib A, Barrault L, Stockholm D, Bartoli M, Richard I
Skeletal muscle3(1)3(2013 Feb)

Chelerythrine perturbs lamellar actomyosin filaments by selective inhibition of myotonic dystrophy kinase-related Cdc42-binding kinase.
Tan I, Lai J, Yong J, Li SF, Leung T
FEBS letters585(9)1260-8(2011 May)

Large-scale proteomics and phosphoproteomics of urinary exosomes.
Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal of the American Society of Nephrology : JASN20(2)363-79(2009 Feb)

A tripartite complex containing MRCK modulates lamellar actomyosin retrograde flow.
Tan I, Yong J, Dong JM, Lim L, Leung T
Cell135(1)123-36(2008 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

the functional relevance of the LRAP25-MRCK complex in LIMK1-cofilin signaling and the importance of LRAP adaptors as key determinants of MRCK cellular localization and downstream specificities.
Title: Adaptor protein LRAP25 mediates myotonic dystrophy kinase-related Cdc42-binding kinase (MRCK) regulation of LIMK1 protein in lamellipodial F-actin dynamics.

Study reports that MRCK and myosin II-related MYO18A linked by the adaptor protein LRAP35a form a functional tripartite complex, which is responsible for the assembly of lamellar actomyosin bundles and of a subnuclear actomyosin network.
Title: A tripartite complex containing MRCK modulates lamellar actomyosin retrograde flow.

FGFR-mediated phosphorylation of ephexin1 enhances the guanine nucleotide exchange activity toward RhoA without affecting the activity to Rac1 or Cdc42.
Title: Regulation of ephexin1, a guanine nucleotide exchange factor of Rho family GTPases, by fibroblast growth factor receptor-mediated tyrosine phosphorylation.

The following Cdc42bpa gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cdc42bpa cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa10220	NM_053657.1 Latest version!	Rattus norvegicus CDC42 binding protein kinase alpha (Cdc42bpa), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	25	$1525.30 $2179.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cdc42bpa ( NM_053657.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_446109.1 Rattus norvegicus CDC42 binding protein kinase alpha (Cdc42bpa), mRNA.

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CloneID	ORa10220
Clone ID Related Accession (Same CDS sequence)	NM_053657.1
Accession Version	NM_053657.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 5199bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	serine/threonine-protein kinase MRCK alpha
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF021935.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF021935.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGTCTGGAG AAGTGCGTTT GAGGCAGTTG GAACAGTTTA TTTTAGATGG GCCAGCTCAG 
ACCAATGGGC AGTGCTTCAG TGTGGAGACG TTACTGGACA TACTCATCTG TCTTTATGAT 
GAATGCAATA ATTCTCCATT GAGAAGAGAG AAGAACATTC TTGAATATCT AGAATGGGCT 
AAACCATTCA CTTCTAAAGT GAAGCAAATG CGCTTACATA GAGAAGACTT CGAAATATTA 
AAGGTGATTG GTCGAGGAGC TTTTGGTGAG GTTGCTGTAG TTAAACTGAA AAATGCAGAT 
AAAGTATTTG CCATGAAAAT TCTGAACAAG TGGGAAATGC TGAAAAGAGC TGAGACAGCG 
TGCTTTCGTG AAGAGAGGGA TGTGTTGGTA AATGGAGACA GTAAGTGGAT AACCACTCTG 
CACTATGCTT TTCAGGATGA CAATAACTTA TACCTGGTTA TGGATTATTA TGTTGGTGGG 
GATTTACTTA CTCTGCTCAG CAAATTTGAA GATCGATTGC CAGAAGAGAT GGCTCGGTTT 
TACTTGGCTG AGATGGTGAT AGCCATTGAC TCAGTTCACC AGCTCCACTA TGTTCACAGA 
GACATCAAAC CTGACAATAT ATTGATGGAT ATGAATGGAC ATATTCGTTT AGCAGATTTT 
GGTTCTTGTC TGAAGCTGAT GGAAGATGGA ACGGTCCAGT CCTCAGTGGC AGTTGGAACT 
CCAGACTACA TTTCCCCGGA AATCCTTCAG GCTATGGAGG ACGGGAAAGG CAGATATGGA 
CCAGAGTGTG ACTGGTGGTC CTTGGGAGTC TGCATGTATG AGATGCTTTA CGGAGAAACA 
CCATTCTATG CGGAATCTCT GGTGGAGACA TATGGAAAAA TTATGAATCA TAAAGAGAGG 
TTTCAGTTTC CAACCCAAGT GACTGATGTG TCTGAAAATG CTAAAGATCT TATTCGAAGA 
CTCATTTGTA GCAGAGAACA TCGACTTGGC CAGAATGGAA TAGAAGACTT TAAGAAACAT 
CCGTTTTTCA GTGGAATTGA TTGGGATAAC ATCCGAAACT GTGAAGCACC TTACATTCCA 
GAAGTTAGTA GTCCAACAGA CACGTCAAAT TTCGATGTGG ATGACGACTG TTTAAAAAAC 
TCTGAAACAA TGCCCCCACC AACACATACT GCATTTTCTG GCCATCATCT ACCATTTGTT 
GGGTTTACAT ATACTAGTAG CTGTGTTCTT TCTGATCGGA GCTGTTTAAG AGTCACAGCA 
GGTCCCACCT CACTGGATCT TGACGTCAAT GTCCAGAGGA CTCTAGATAA TAACTTAGCA 
ACTGAAGCTT ATGAAAGAAG AATTAAACGG CTAGAACAGG AAAAGCTTGA ACTTACTAGA 
AAACTTCAAG AGTCAACACA GACTGTTCAA GCCCTGCAGT ATTCAACTGT TGATGGTCCA 
CTAACGGCAA GCAAAGATTT AGAAATTAAA AGTCTGAAAG AAGAGATTGA AAAACTAAGA 
AAACAAGTAG CAGAAGTGAA TCATTTGGAA CAACAACTTG AAGAAGCTAA TTCTGTGAGA 
CGAGAACTAG ATGATGCTTT TAGGCAAATC AAAGCTTTTG AAAAACAAAT CAAAACTTTG 
CAGCAGGAAA GAGAAGAGCT AAATAAGGAA CTAGTCCAGG CTAGTGAGCG ATTAAAAAAC 
CAATCCAAAG AGCTGAAAGA CGCACACTGT CAGAGGAAAC TGGCCATGCA GGAGTTCATG 
GAGATCAATG AGCGACTAAC AGAATTGCAC ACCCAAAAGC AGAAACTTGC TCGCCATGTC 
CGAGATAAGG AAGAAGAGGT GGACCTGGTG ATGCAAAAAG CTGAGAGCTT AAGGCAGGAG 
CTTCGCAGAG CAGAAAGAGC CAAGAAAGAG CTGGAGGTTC ACACTGAAGC TCTAATTGCT 
GAAGCCTCAA AGGACCGGAA GCTCCGAGAG CAGAGCAGAC ATTATTCTAA ACAGCTGGAA 
AATGAATTGG AGGGACTGAA GCAAAAACAA ATTAGTTACT CACCAGGAAT ATGCAGCATA 
GAACACCAGC AAGAGATAAC TAAACTGAAA ACTGACTTGG AAAAGAAAAG TATCTTTTAT 
GAAGAAGAAA TCTCTAAAAG AGAAGGAATT CATGCAAGTG AGATTAAAAA TCTGAAGAAG 
GAGCTGCATG ACTCAGAAGG CCAGCAACTT GCTCTCAACA AAGAAATTAT GGTTTTAAAA 
GACAAATTGG AAAAAACCAG AAGGGAAAGT CAAAGTGAAA GGGAAGAATT TGAAAATGAG 
TTCAAGCAAC AATATGAACG GGAAAAAGTA TTATTAACTG AAGAGAATAA AAAGTTAACG 
AGTGAACTCG ATAAGCTAAC TTCGTTGTAT GAGAGCTTAA GTTTGCGCAA CCAGCACTTA 
GAAGAAGAGG TCAAAGATCT AGCAGATAAG AAGGAATCAG TTGCCCACTG GGAAGCCCAA 
ATCACAGAGA TAATCCAATG GGTGAGTGAT GAGAAGGACG CACGGGGCTA TCTTCAGGCC 
TTAGCTTCTA AAATGACTGA AGAATTAGAA GCGTTAAGGA ATTCCAGCCT GGGGACACGA 
GCGACAGATA TGCCCTGGAA AATGCGTCGT TTTGCAAAAC TGGACATGTC AGCTAGACTA 
GAGTTGCAAT CTGCCCTGGA TGCAGAAATC AGAGCTAAGC AGGCCATCCA GGAAGAGCTG 
AATAAAGTCA AAGCATCCAA CATCATAACA GAATGTAAAC TGAAAGATTC AGAGAAGAAG 
AACTTGGAAC TGTTGTCCGA AATCGAGCAG CTGATAAAGG ACACTGAAGA GCTTAGATCT 
GAAAAGGGTG TAGAGCACCG AGACTCACAG CACTCTTTCT TGGCATTTTT GAATACGCCT 
ACCGATGCTC TGGATCAATT TGAACGCTCT CCGTCCTGTA CTCCAGCTGG CAAAGGCAGA 
CGTATTGCAG ACTCTGCTCC GCTTCCAGTT CACACACCAA CTTTAAGGAA AAAGGGATGC 
CCAGCTTCAG CTGGTTTTCC ACCTAAGCGC AAGACTCATC AGTTTTTCGT GAAGTCTTTC 
ACTGCCCCTA CCAAGTGCCA TCAGTGTACC TCCTTGATGG TCGGTTTGAT AAGACAGGGC 
TGTTCCTGCG AAGTCTGTGG GTTCTCATGT CATATAACTT GTGTGAACAA AGCCCCGACC 
ACTTGCCCAG TTCCTCCTGA GCAAACTAAA GGCCCACTCG GTATAGACCC CCAGAAGGGA 
GTAGGGACAG CGTATGAGGG CCATGTCCGG ATCCCTAAGC CGGCGGGAGT GAAGAAAGGG 
TGGCAGAGAG CACTGGCTGT GGTCTGTGAC TTCAAACTGT TTCTTTATGA TATCGCGGAG 
GGAAAAGCAT CGCAGCCCAG CTCCGTCATT AGTCAAGTGA TCGACATGAG AGATGAAGAA 
TTTTCCGTGA GTTCAGTCTT GGCTTCTGAT GTTATTCATG CAAGTCGAAA AGATATTCCC 
TGTATATTTA GAGTCACAGC CTCCCAGCTC TCAGCACCTA GTGACAAATG TTCCATCCTG 
ATGCTAGCCG ACAGCGAGAC TGAGAGGAGT AAGTGGGTGG GAGTGCTGAG TGAACTCCAC 
AAGGTTCTGA AGAAAAACAA GTTCAGAGAC CGCTCAGTGT ATGTCCCCAA AGAGGCTTAC 
GACAGCACTC TACCCCTCAT TAAAACAACG CAGGCCGCGG CAATCATAGA TCATGAGCGG 
GTAGCTTTGG GAAATGAAGA AGGATTATTT GTTGTGCATG TCACTAAAGA TGAGATTATT 
AGAGTTGGTG ATAATAAGAA AATTCATCAG ATTGAACTCA TTCCAAGTGA CCAGCTTGTT 
GCTGTGATCT CAGGCCGAAA TCGCCACGTC CGACTTTTCC CTATGTCAGC TTTGGATGGG 
CGAGAGACGG ATTTTTATAA ACTGGCAGAG ACTAAAGGGT GTCAAACCAT AGCTGCTGGG 
AAGGTGCGCC ATGGAGCTCT GTCCTGCCTG TGTGTGGCCA TGAAAAGACA GGTCCTCTGC 
TATGAACTGT TCCAAAGCAA GACCAGGCAC AGGAAGTTTA AGGAGATTCA AGTCCCATGT 
AATGTCCAGT GGATGGCCAT CTTCAGTGAA CATCTCTGTG TGGGATTCCA GTCAGGATTT 
CTCAGATACC CCCTGAATGG GGAAGGAAGT CCATGCAATA TGCTCCATTC AAATGACCAC 
ACACTGGCAT TCATTACACA CCAACCAATG GATGCTATCT GTGCCGTTGA GATCTCCAAC 
AAAGAGTATT TGCTGTGTTT TAGCAGCATT GGGATATACA CGGACTGCCA GGGCCGAAGA 
TCTAGACAGC AGGAACTGAT GTGGCCAGCA AATCCTTCCT CCTGTTGTTA CAATGCACCA 
TATCTCTCCA TTTACAGTGA AAATGCAGTT GATATCTTTG ATGTAAACTC CATGGAATGG 
ATACAGACGC TTCCTCTCAA GAAGGTTCGA CCTTTAAACA CTGAAGGATC ATTAAATCTT 
TTAGGGTTGG AGACCATTAG ATTAATATAT TTCAAAAATA AGATGGCAGA AGGGGATGAA 
CTTGTAGTTC CTGAAACATC AGATAATAGC CGAAAACAGA TGGTTAGAAA CATCAACAAC 
AAACGGCGTT ACTCCTTCCG GGTCCCAGAA GAAGAGAGGA TGCAGCAGAG AAGGGAGATG 
CTACGAGATC CAGAAATGAG AAATAAATTA ATTTCTAACC CAACTAATTT TAACCACATA 
GCACACATGG GTCCTGGAGA TGGAATACAG ATCCTAAAAG ACCTGCCCAT GAACCCACGG 
CCTCAGGAAA GCCGGACAGT ATTCAGTGGC TCCGTCAGTA TTCCCTCCAT CACCAAGTCC 
CGCCCTGAGC CAGGCCGCTC CATGAGTGCC AGCAGTGGCC TGTCTGCACG GTCATCAGCC 
CAGAATGGCA GTGCGCTAAA GAGGGAATTC TCTGGAGGAA GCTACAACAC GAAGCGACAG 
CCCATGCCCT CTCCCTCAGA AGGCTCTTTG TCATCAGGAG GCGTGGACCA AGGAAGTGAC 
GCCCCCGTGA GGGACTATGA TGGAGAGGAC TCTGATTCTC CAAGGCATTC CACAGCTTCC 
AACAGCTCTA ACCTGAGCAG CCCCCCAAGC CCCGTTTCAC CCCGAAAGAC CAAGAGCCTC 
TCCTTGGAGA GCACAGACCG TGGGAGCTGG GATCCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_446109.1
CDS	530..5728
Translation	MSGEVRLRQLEQFILDGPAQTNGQCFSVETLLDILICLYDECNNSPLRREKNILEYLEWAKPFTSKVKQMRLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNGDSKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEEMARFYLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERFQFPTQVTDVSENAKDLIRRLICSREHRLGQNGIEDFKKHPFFSGIDWDNIRNCEAPYIPEVSSPTDTSNFDVDDDCLKNSETMPPPTHTAFSGHHLPFVGFTYTSSCVLSDRSCLRVTAGPTSLDLDVNVQRTLDNNLATEAYERRIKRLEQEKLELTRKLQESTQTVQALQYSTVDGPLTASKDLEIKSLKEEIEKLRKQVAEVNHLEQQLEEANSVRRELDDAFRQIKAFEKQIKTLQQEREELNKELVQASERLKNQSKELKDAHCQRKLAMQEFMEINERLTELHTQKQKLARHVRDKEEEVDLVMQKAESLRQELRRAERAKKELEVHTEALIAEASKDRKLREQSRHYSKQLENELEGLKQKQISYSPGICSIEHQQEITKLKTDLEKKSIFYEEEISKREGIHASEIKNLKKELHDSEGQQLALNKEIMVLKDKLEKTRRESQSEREEFENEFKQQYEREKVLLTEENKKLTSELDKLTSLYESLSLRNQHLEEEVKDLADKKESVAHWEAQITEIIQWVSDEKDARGYLQALASKMTEELEALRNSSLGTRATDMPWKMRRFAKLDMSARLELQSALDAEIRAKQAIQEELNKVKASNIITECKLKDSEKKNLELLSEIEQLIKDTEELRSEKGVEHRDSQHSFLAFLNTPTDALDQFERSPSCTPAGKGRRIADSAPLPVHTPTLRKKGCPASAGFPPKRKTHQFFVKSFTAPTKCHQCTSLMVGLIRQGCSCEVCGFSCHITCVNKAPTTCPVPPEQTKGPLGIDPQKGVGTAYEGHVRIPKPAGVKKGWQRALAVVCDFKLFLYDIAEGKASQPSSVISQVIDMRDEEFSVSSVLASDVIHASRKDIPCIFRVTASQLSAPSDKCSILMLADSETERSKWVGVLSELHKVLKKNKFRDRSVYVPKEAYDSTLPLIKTTQAAAIIDHERVALGNEEGLFVVHVTKDEIIRVGDNKKIHQIELIPSDQLVAVISGRNRHVRLFPMSALDGRETDFYKLAETKGCQTIAAGKVRHGALSCLCVAMKRQVLCYELFQSKTRHRKFKEIQVPCNVQWMAIFSEHLCVGFQSGFLRYPLNGEGSPCNMLHSNDHTLAFITHQPMDAICAVEISNKEYLLCFSSIGIYTDCQGRRSRQQELMWPANPSSCCYNAPYLSIYSENAVDIFDVNSMEWIQTLPLKKVRPLNTEGSLNLLGLETIRLIYFKNKMAEGDELVVPETSDNSRKQMVRNINNKRRYSFRVPEEERMQQRREMLRDPEMRNKLISNPTNFNHIAHMGPGDGIQILKDLPMNPRPQESRTVFSGSVSIPSITKSRPEPGRSMSASSGLSARSSAQNGSALKREFSGGSYNTKRQPMPSPSEGSLSSGGVDQGSDAPVRDYDGEDSDSPRHSTASNSSNLSSPPSPVSPRKTKSLSLESTDRGSWDP

Target ORF information:

RefSeq Version	NM_053657.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus CDC42 binding protein kinase alpha (Cdc42bpa), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053657.1

ORF Insert Sequence:

ATGTCTGGAG AAGTGCGTTT GAGGCAGTTG GAACAGTTTA TTTTAGATGG GCCAGCTCAG 
ACCAATGGGC AGTGCTTCAG TGTGGAGACG TTACTGGACA TACTCATCTG TCTTTATGAT 
GAATGCAATA ATTCTCCATT GAGAAGAGAG AAGAACATTC TTGAATATCT AGAATGGGCT 
AAACCATTCA CTTCTAAAGT GAAGCAAATG CGCTTACATA GAGAAGACTT CGAAATATTA 
AAGGTGATTG GTCGAGGAGC TTTTGGTGAG GTTGCTGTAG TTAAACTGAA AAATGCAGAT 
AAAGTATTTG CCATGAAAAT TCTGAACAAG TGGGAAATGC TGAAAAGAGC TGAGACAGCG 
TGCTTTCGTG AAGAGAGGGA TGTGTTGGTA AATGGAGACA GTAAGTGGAT AACCACTCTG 
CACTATGCTT TTCAGGATGA CAATAACTTA TACCTGGTTA TGGATTATTA TGTTGGTGGG 
GATTTACTTA CTCTGCTCAG CAAATTTGAA GATCGATTGC CAGAAGAGAT GGCTCGGTTT 
TACTTGGCTG AGATGGTGAT AGCCATTGAC TCAGTTCACC AGCTCCACTA TGTTCACAGA 
GACATCAAAC CTGACAATAT ATTGATGGAT ATGAATGGAC ATATTCGTTT AGCAGATTTT 
GGTTCTTGTC TGAAGCTGAT GGAAGATGGA ACGGTCCAGT CCTCAGTGGC AGTTGGAACT 
CCAGACTACA TTTCCCCGGA AATCCTTCAG GCTATGGAGG ACGGGAAAGG CAGATATGGA 
CCAGAGTGTG ACTGGTGGTC CTTGGGAGTC TGCATGTATG AGATGCTTTA CGGAGAAACA 
CCATTCTATG CGGAATCTCT GGTGGAGACA TATGGAAAAA TTATGAATCA TAAAGAGAGG 
TTTCAGTTTC CAACCCAAGT GACTGATGTG TCTGAAAATG CTAAAGATCT TATTCGAAGA 
CTCATTTGTA GCAGAGAACA TCGACTTGGC CAGAATGGAA TAGAAGACTT TAAGAAACAT 
CCGTTTTTCA GTGGAATTGA TTGGGATAAC ATCCGAAACT GTGAAGCACC TTACATTCCA 
GAAGTTAGTA GTCCAACAGA CACGTCAAAT TTCGATGTGG ATGACGACTG TTTAAAAAAC 
TCTGAAACAA TGCCCCCACC AACACATACT GCATTTTCTG GCCATCATCT ACCATTTGTT 
GGGTTTACAT ATACTAGTAG CTGTGTTCTT TCTGATCGGA GCTGTTTAAG AGTCACAGCA 
GGTCCCACCT CACTGGATCT TGACGTCAAT GTCCAGAGGA CTCTAGATAA TAACTTAGCA 
ACTGAAGCTT ATGAAAGAAG AATTAAACGG CTAGAACAGG AAAAGCTTGA ACTTACTAGA 
AAACTTCAAG AGTCAACACA GACTGTTCAA GCCCTGCAGT ATTCAACTGT TGATGGTCCA 
CTAACGGCAA GCAAAGATTT AGAAATTAAA AGTCTGAAAG AAGAGATTGA AAAACTAAGA 
AAACAAGTAG CAGAAGTGAA TCATTTGGAA CAACAACTTG AAGAAGCTAA TTCTGTGAGA 
CGAGAACTAG ATGATGCTTT TAGGCAAATC AAAGCTTTTG AAAAACAAAT CAAAACTTTG 
CAGCAGGAAA GAGAAGAGCT AAATAAGGAA CTAGTCCAGG CTAGTGAGCG ATTAAAAAAC 
CAATCCAAAG AGCTGAAAGA CGCACACTGT CAGAGGAAAC TGGCCATGCA GGAGTTCATG 
GAGATCAATG AGCGACTAAC AGAATTGCAC ACCCAAAAGC AGAAACTTGC TCGCCATGTC 
CGAGATAAGG AAGAAGAGGT GGACCTGGTG ATGCAAAAAG CTGAGAGCTT AAGGCAGGAG 
CTTCGCAGAG CAGAAAGAGC CAAGAAAGAG CTGGAGGTTC ACACTGAAGC TCTAATTGCT 
GAAGCCTCAA AGGACCGGAA GCTCCGAGAG CAGAGCAGAC ATTATTCTAA ACAGCTGGAA 
AATGAATTGG AGGGACTGAA GCAAAAACAA ATTAGTTACT CACCAGGAAT ATGCAGCATA 
GAACACCAGC AAGAGATAAC TAAACTGAAA ACTGACTTGG AAAAGAAAAG TATCTTTTAT 
GAAGAAGAAA TCTCTAAAAG AGAAGGAATT CATGCAAGTG AGATTAAAAA TCTGAAGAAG 
GAGCTGCATG ACTCAGAAGG CCAGCAACTT GCTCTCAACA AAGAAATTAT GGTTTTAAAA 
GACAAATTGG AAAAAACCAG AAGGGAAAGT CAAAGTGAAA GGGAAGAATT TGAAAATGAG 
TTCAAGCAAC AATATGAACG GGAAAAAGTA TTATTAACTG AAGAGAATAA AAAGTTAACG 
AGTGAACTCG ATAAGCTAAC TTCGTTGTAT GAGAGCTTAA GTTTGCGCAA CCAGCACTTA 
GAAGAAGAGG TCAAAGATCT AGCAGATAAG AAGGAATCAG TTGCCCACTG GGAAGCCCAA 
ATCACAGAGA TAATCCAATG GGTGAGTGAT GAGAAGGACG CACGGGGCTA TCTTCAGGCC 
TTAGCTTCTA AAATGACTGA AGAATTAGAA GCGTTAAGGA ATTCCAGCCT GGGGACACGA 
GCGACAGATA TGCCCTGGAA AATGCGTCGT TTTGCAAAAC TGGACATGTC AGCTAGACTA 
GAGTTGCAAT CTGCCCTGGA TGCAGAAATC AGAGCTAAGC AGGCCATCCA GGAAGAGCTG 
AATAAAGTCA AAGCATCCAA CATCATAACA GAATGTAAAC TGAAAGATTC AGAGAAGAAG 
AACTTGGAAC TGTTGTCCGA AATCGAGCAG CTGATAAAGG ACACTGAAGA GCTTAGATCT 
GAAAAGGGTG TAGAGCACCG AGACTCACAG CACTCTTTCT TGGCATTTTT GAATACGCCT 
ACCGATGCTC TGGATCAATT TGAACGCTCT CCGTCCTGTA CTCCAGCTGG CAAAGGCAGA 
CGTATTGCAG ACTCTGCTCC GCTTCCAGTT CACACACCAA CTTTAAGGAA AAAGGGATGC 
CCAGCTTCAG CTGGTTTTCC ACCTAAGCGC AAGACTCATC AGTTTTTCGT GAAGTCTTTC 
ACTGCCCCTA CCAAGTGCCA TCAGTGTACC TCCTTGATGG TCGGTTTGAT AAGACAGGGC 
TGTTCCTGCG AAGTCTGTGG GTTCTCATGT CATATAACTT GTGTGAACAA AGCCCCGACC 
ACTTGCCCAG TTCCTCCTGA GCAAACTAAA GGCCCACTCG GTATAGACCC CCAGAAGGGA 
GTAGGGACAG CGTATGAGGG CCATGTCCGG ATCCCTAAGC CGGCGGGAGT GAAGAAAGGG 
TGGCAGAGAG CACTGGCTGT GGTCTGTGAC TTCAAACTGT TTCTTTATGA TATCGCGGAG 
GGAAAAGCAT CGCAGCCCAG CTCCGTCATT AGTCAAGTGA TCGACATGAG AGATGAAGAA 
TTTTCCGTGA GTTCAGTCTT GGCTTCTGAT GTTATTCATG CAAGTCGAAA AGATATTCCC 
TGTATATTTA GAGTCACAGC CTCCCAGCTC TCAGCACCTA GTGACAAATG TTCCATCCTG 
ATGCTAGCCG ACAGCGAGAC TGAGAGGAGT AAGTGGGTGG GAGTGCTGAG TGAACTCCAC 
AAGGTTCTGA AGAAAAACAA GTTCAGAGAC CGCTCAGTGT ATGTCCCCAA AGAGGCTTAC 
GACAGCACTC TACCCCTCAT TAAAACAACG CAGGCCGCGG CAATCATAGA TCATGAGCGG 
GTAGCTTTGG GAAATGAAGA AGGATTATTT GTTGTGCATG TCACTAAAGA TGAGATTATT 
AGAGTTGGTG ATAATAAGAA AATTCATCAG ATTGAACTCA TTCCAAGTGA CCAGCTTGTT 
GCTGTGATCT CAGGCCGAAA TCGCCACGTC CGACTTTTCC CTATGTCAGC TTTGGATGGG 
CGAGAGACGG ATTTTTATAA ACTGGCAGAG ACTAAAGGGT GTCAAACCAT AGCTGCTGGG 
AAGGTGCGCC ATGGAGCTCT GTCCTGCCTG TGTGTGGCCA TGAAAAGACA GGTCCTCTGC 
TATGAACTGT TCCAAAGCAA GACCAGGCAC AGGAAGTTTA AGGAGATTCA AGTCCCATGT 
AATGTCCAGT GGATGGCCAT CTTCAGTGAA CATCTCTGTG TGGGATTCCA GTCAGGATTT 
CTCAGATACC CCCTGAATGG GGAAGGAAGT CCATGCAATA TGCTCCATTC AAATGACCAC 
ACACTGGCAT TCATTACACA CCAACCAATG GATGCTATCT GTGCCGTTGA GATCTCCAAC 
AAAGAGTATT TGCTGTGTTT TAGCAGCATT GGGATATACA CGGACTGCCA GGGCCGAAGA 
TCTAGACAGC AGGAACTGAT GTGGCCAGCA AATCCTTCCT CCTGTTGTTA CAATGCACCA 
TATCTCTCCA TTTACAGTGA AAATGCAGTT GATATCTTTG ATGTAAACTC CATGGAATGG 
ATACAGACGC TTCCTCTCAA GAAGGTTCGA CCTTTAAACA CTGAAGGATC ATTAAATCTT 
TTAGGGTTGG AGACCATTAG ATTAATATAT TTCAAAAATA AGATGGCAGA AGGGGATGAA 
CTTGTAGTTC CTGAAACATC AGATAATAGC CGAAAACAGA TGGTTAGAAA CATCAACAAC 
AAACGGCGTT ACTCCTTCCG GGTCCCAGAA GAAGAGAGGA TGCAGCAGAG AAGGGAGATG 
CTACGAGATC CAGAAATGAG AAATAAATTA ATTTCTAACC CAACTAATTT TAACCACATA 
GCACACATGG GTCCTGGAGA TGGAATACAG ATCCTAAAAG ACCTGCCCAT GAACCCACGG 
CCTCAGGAAA GCCGGACAGT ATTCAGTGGC TCCGTCAGTA TTCCCTCCAT CACCAAGTCC 
CGCCCTGAGC CAGGCCGCTC CATGAGTGCC AGCAGTGGCC TGTCTGCACG GTCATCAGCC 
CAGAATGGCA GTGCGCTAAA GAGGGAATTC TCTGGAGGAA GCTACAACAC GAAGCGACAG 
CCCATGCCCT CTCCCTCAGA AGGCTCTTTG TCATCAGGAG GCGTGGACCA AGGAAGTGAC 
GCCCCCGTGA GGGACTATGA TGGAGAGGAC TCTGATTCTC CAAGGCATTC CACAGCTTCC 
AACAGCTCTA ACCTGAGCAG CCCCCCAAGC CCCGTTTCAC CCCGAAAGAC CAAGAGCCTC 
TCCTTGGAGA GCACAGACCG TGGGAGCTGG GATCCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Adaptor protein LRAP25 mediates myotonic dystrophy kinase-related Cdc42-binding kinase (MRCK) regulation of LIMK1 protein in lamellipodial F-actin dynamics.
The Journal of biological chemistry289(39)26989-7003(2014 Sep)
Lee IC,Leung T,Tan I

A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.
Skeletal muscle3(1)3(2013 Feb)
Blandin G,Marchand S,Charton K,Dani?le N,Gicquel E,Boucheteil JB,Bentaib A,Barrault L,Stockholm D,Bartoli M,Richard I

Chelerythrine perturbs lamellar actomyosin filaments by selective inhibition of myotonic dystrophy kinase-related Cdc42-binding kinase.
FEBS letters585(9)1260-8(2011 May)
Tan I,Lai J,Yong J,Li SF,Leung T

Large-scale proteomics and phosphoproteomics of urinary exosomes.
Journal of the American Society of Nephrology : JASN20(2)363-79(2009 Feb)
Gonzales PA,Pisitkun T,Hoffert JD,Tchapyjnikov D,Star RA,Kleta R,Wang NS,Knepper MA

A tripartite complex containing MRCK modulates lamellar actomyosin retrograde flow.
Cell135(1)123-36(2008 Oct)
Tan I,Yong J,Dong JM,Lim L,Leung T

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Cdc42bpa cDNA ORF clone, Rattus norvegicus(Norway rat)

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gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

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