Flt4 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Flt4
Entrez Gene ID	114110
Full Name	fms-related tyrosine kinase 4
Synonyms	Vegfr3
General protein information	Preferred Names fms-related tyrosine kinase 4 Names vascular endothelial growth factor receptor 3 FLT-4 FMS-like tyrosine kinase 4 VEGFR-3 tyrosine-protein kinase receptor FLT4
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 10 Map Location: 10q21
Summary	VEGF receptor-related, cell surface associated kinase with growth promoting ability [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_053652.1	NP_446104.1	vascular endothelial growth factor receptor 3 precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	FLT4	NP_891555.2
Rattus norvegicus (Norway rat)	Flt4	NP_446104.1
Gallus gallus (chicken)	FLT4	XP_414600.3
Pan troglodytes (chimpanzee)	FLT4	XP_518160.4
	FLT4	XP_001107118.2
Bos taurus (cattle)	FLT4	XP_002688539.2
Danio rerio (zebrafish)	flt4	NP_571020.1
Xenopus tropicalis (tropical clawed frog)	LOC100493801	XP_002932350.2
Canis lupus familiaris (dog)	FLT4	XP_005626341.1
Mus musculus (house mouse)	Flt4	NP_032055.1

Gene Ontology
Bibliography

Related articles in PubMed

Developmental expression of vascular endothelial growth factor receptor 3 and vascular endothelial growth factor C in forebrain.
Ward MC, Cunningham AM
Neuroscience303544-57(2015 Sep)

Lymphatic function is required prenatally for lung inflation at birth.
Jakus Z, Gleghorn JP, Enis DR, Sen A, Chia S, Liu X, Rawnsley DR, Yang Y, Hess PR, Zou Z, Yang J, Guttentag SH, Nelson CM, Kahn ML
The Journal of experimental medicine211(5)815-26(2014 May)

Inhibition of VEGFR-3 activation in tumor-draining lymph nodes suppresses the outgrowth of lymph node metastases in the MT-450 syngeneic rat breast cancer model.
Quagliata L, Klusmeier S, Cremers N, Pytowski B, Harvey A, Pettis RJ, Thiele W, Sleeman JP
Clinical & experimental metastasis31(3)351-65(2014 Mar)

Structural and mechanistic insights into VEGF receptor 3 ligand binding and activation.
Lepp?nen VM, Tvorogov D, Kisko K, Prota AE, Jeltsch M, Anisimov A, Markovic-Mueller S, Stuttfeld E, Goldie KN, Ballmer-Hofer K, Alitalo K
Proceedings of the National Academy of Sciences of the United States of America110(32)12960-5(2013 Aug)

Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins.
Ghai R, Bugarcic A, Liu H, Norwood SJ, Skeldal S, Coulson EJ, Li SS, Teasdale RD, Collins BM
Proceedings of the National Academy of Sciences of the United States of America110(8)E643-52(2013 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The findings of this study suggest an important role for VEGFC/VEGFR3 signaling in neuronal proliferation in early forebrain development, and ongoing functions with niche neurogenesis, glial and ependymal function in the maturing postnatal brain.
Title: Developmental expression of vascular endothelial growth factor receptor 3 and vascular endothelial growth factor C in forebrain.

lymph node-specific antibody-mediated inhibition of VEGFR-3 activation in response to VEGF-C draining to the nodes from metastatic MT-450 tumors inhibited the outgrowth but not initiation of metastases in these nodes.
Title: Inhibition of VEGFR-3 activation in tumor-draining lymph nodes suppresses the outgrowth of lymph node metastases in the MT-450 syngeneic rat breast cancer model.

Expression of VEGFR-3 is enhanced in various cell types of the infarcted heart.
Title: Differential expression of vascular endothelial growth factor isoforms and receptor subtypes in the infarcted heart.

VEGFR-3 is involved in the recruitment of monocytic macrophages and in glial reactions during experimental autoimmune encephalomyelitis.
Title: Upregulation of vascular endothelial growth factor receptor-3 in the spinal cord of Lewis rats with experimental autoimmune encephalomyelitis.

VEGF-C/VEGFR-3 signaling modulated innate and adaptive immune responses in the development of obliterative bronchiolitis in rat tracheal allografts.
Title: Critical role of VEGF-C/VEGFR-3 signaling in innate and adaptive immune responses in experimental obliterative bronchiolitis.

The following Flt4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Flt4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa13118	NM_053652.1 Latest version!	Rattus norvegicus fms-related tyrosine kinase 4 (Flt4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	25	$1000.30 $1429.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Flt4 ( NM_053652.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_446104.1 Rattus norvegicus fms-related tyrosine kinase 4 (Flt4), mRNA.

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CloneID	ORa13118
Clone ID Related Accession (Same CDS sequence)	NM_053652.1
Accession Version	NM_053652.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 4092bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-19
Organism	Rattus norvegicus(Norway rat)
Product	vascular endothelial growth factor receptor 3 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF402785.1. On Jan 12, 2005 this sequence version replaced XM_346389.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF402785.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689598, SAMEA2689599 [ECO:0000348] ##Evidence-Data-END##

ATGCAGCCGG GCGCTGCGCT GAACCGGCGC CTGTGGCTCT GCCTCGGACT CCTCCAAGGC 
CTGGCAAATG GCTACTCCAT GACCCCTCCA ACTCTGAACA TCACAGAGGA TTCATATGTC 
ATTGACACCG GGGACAGCCT ATCCATATCC TGCAGGGGGC AGCACCCCCT CGAGTGGACC 
TGGCGAGGGG CCCAAGAGGT ACTGACCACA GGTGGGAAGG ACAGCGAGGA CACGCAGGTT 
GTGCAAGACT GTGAAGGCAC AGAAGCTAGG CCCTACTGCA AGGTGCTGTC GCTGGCCCAG 
ACTCACGCCA ACAACACGGG CAGCTATTAC TGCTACTACA AGTATATCAA GGCCCGGATT 
GAGGGCACCA CAGCTGCCAG CACCTATGTG TTTGTAAGAG ACTTTGAACA GCCTTTCATC 
AACAAACCTG ACACGCTCCT GGTCAACAGG AAGGACTCGA TGTGGGTGCC CTGCTTGGTG 
TCCATTCCCG GCCTCAACAT CACACTGCGC TCGCAAAGTT CGGTGCTGCA CCCTGATGGG 
CAGGAGGTGT TGTGGGACGA CCGCCGGGGC ATGCGGGTGC CCACTCTACT GTTGCGTGAC 
GCCCTGTACC TGCAGTGCGA GACCACCTGG GGAGACCAGG ACTTCCTTTC CAATCCCTTC 
CTCGTGCACA TCACAGGCAA TGAGCTCTAT GACATCCAGC TGTACCCCAA GAAGTCACTG 
GAGCTGTTGG TTGGAGAGAA GCTGGTTTTG AACTGTACAG TATGGGCTGA GTTCGACTCT 
GGTGTCACCT TCGACTGGGA TTACCCAGGA AAGCAGGCAG AGCGTGCTAA GTGGGTACCT 
GAGCGGCGTT CCCAGCAGAC CCACACGGAA CTCTCCAGCA TCCTGACCAT CCACAATGTC 
AGCCAGCACG ACCTGGGCCC CTATGTGTGT GAGGCCAACA ATGGGATTCA GCAGTTCCGG 
GAAAGCACGG AGGTCATTGT GCACGAAAAG CCCTTCATCA GTGTCGAGTG GCTCAAAGGA 
CCTGTCCTGG AGGCCACAGC CGGTGACGAG ATGGTGAAGC TACCCGTGAA GCTTGCAGCT 
TATCCCCCAC CGGAGTTCCA ATGGTACAAG GACAGAAAGG CAGTGACTGG GCGCCACAAT 
CCACATGCTC TGGTGCTCAA AGAGGTGACC GAGGCCAGTG CAGGCGTCTA CACCCTCGCC 
CTGTGGAACT CTGCAGCCGG TCTGAGGCAG AATATCAGTC TGGAGCTGGT GGTGAATGTG 
CCGCCCCACA TCCATGAAAA GGAAGCTTCT TCACCCAGCA TCTACTCCCG CCACAGCCGC 
CAGACCCTCA CCTGCACCAC CTATGGGGTA CCCCAACCTC TCAGTGTTCA GTGGCACTGG 
AGGCCCTGGA CACCCTGTAA GACATTTGCC CAGCGCAGTC TCCGGAGGCG GCAGCCGCGG 
GATGGCATGC CACAGTGCCG AGACTGGAAG GAGGTGACCA CTCAGGACGC TGTGAACCCC 
ATCGAGAGCC TGGACACCTG GACCGAGTCT GTGGAGGGCA AGAACAAGAC GGTGAGCAAG 
CTGGTGATTC AGGATGCCAA TGTGTCAGCC ATGTACAAAT GCGTGGTCTT CAACAAAGTG 
GGCCAGGACG AGCGGCTCAT CTACTTCTAT GTGACCACCA TCCCTGACGG CTTCAGTATC 
GAATCAGAGC CATCCGAGGA TCCCTTAGAA GGCCAGTCCG TGCGCCTCAG CTGCCGGGCG 
GACAACTACA CGTATGAGCA TCTGCGCTGG TACCGGCTCA ACCTCTCCAC GCTGCACGAC 
GCTCAAGGGA ACCCCCTACT GCTCGACTGC AAGAACGTGC ACCTGTTTGC CACGCCCCTA 
GAGGCCAACC TAGAGGAGGC GGAGCCTGGG GCCCGCCACG CCACCCTCAG CTTGAATATC 
CCCCGAGTGG CGCCCGAGGA CGAGGGTGAC TACGTGTGTG AAGTGCAGGA TAGGCGCAGC 
CAGGACAAGC ACTGCCACAA GAAGTACCTG TCCGTGCAGG CCCTGGAAGC TCCTCGGCTC 
ACGCAGAACT TAACCGACCT CCTGGTGAAC GTGAGAACCT CCCTGGAGAT GCGATGTCCG 
GTAGCCGGAG CACATGTGCC CAGTATTGTG TGGTACAAAG ATGAAAGGCT CCTGGAGAAA 
GAGTCGGGAA TCGACCTGGC AGACTCCAAT CAGAGGCTGA GCATCCAACG CGTGCGCGAG 
GAGGACGCAG GTCGTTACCT GTGCAGTGTG TGCAATGCCA AGGGCTGCGT AAACTCCTCC 
GCCAGCGTGG CCGTAGAAGG CTCGGAAGAT AAAGGCAGCA TGGAGATTGT GATACTCATT 
GGCACTGGCG TCATCGCAGT CTTCTTCTGG GTCCTCCTCC TGCTCATCTT CTGTAACATG 
AAAAGGCCTG CCCATGCAGA CATCAAGACG GGCTACCTGT CCATCATCAT GGACCCCGGG 
GAGGTGCCTT TGGAGGAGCA GTGTGAATAC CTGTCCTATG ACGTCAGCCA GTGGGAGTTC 
CCCAGGGAAA GGTTGCACCT CGGGAGAGTC CTAGGCCATG GGGCTTTTGG GAAGGTGGTG 
GAAGCCTCAG CCTTTGGCAT CAATAAAGGC AGCAGCTGTG ATACCGTGGC GGTGAAGATG 
CTGAAAGAGG GCGCTACTGC CAGCGAACAC CGTGCCCTGA TGTCCGAGCT CAAGATCCTA 
ATTCACATCG GTAACCACCT CAATGTGGTC AACCTCCTAG GGGCGTGCAC CAAGCCCAAT 
GGCCCTCTCA TGGTGATCGT GGAGTTTTGC AAATACGGCA ACCTCTCCAA CTTCTTGCGT 
GTCAAGCGGG AGACGTTCGA CCCCTACGCA GAGAAGTCTC CCGAGCAACG CAGGCGCTTC 
CGCGCGATGG TAGAAGGCGC CAAGGCTGAT AGGAGGAGAC TTGGAAGCAC CGACAGAGCC 
CTGTTTACAA GGTTCCTGAT GGGCAAAGGA AGTGCACGGC GAGCCCCATT TGTCCAAGAA 
GCTGAGGACC TGTGGTTGAG CCCGCTGACC ATGGAGGACC TTGTCTGCTA CAGTTTCCAA 
GTGGCCCGGG GAATGGAGTT CCTGGCTTCC CGCAAGTGCA TTCACAGAGA CCTGGCTGCT 
CGGAACATTT TACTGTCAGA AAGTGACATA GTGAAGATCT GTGACTTTGG CCTCGCTCGG 
GACATCTACA AAGACCCTGA CTATGTCCGA AAGGGCAGCG CCCGACTGCC TCTGAAATGG 
ATGGCCCCCG AGAGCATCTT TGATAAGGTG TACACCACGC AGAGTGATGT GTGGTCCTTC 
GGCGTGCTGC TGTGGGAGAT CTTCTCATTG GGGGCCTCTC CATACCCTGG GGTACAGATC 
AATGAGGAAT TCTGCCAGCG GCTGAAAGAC GGCACACGAA TGAGGGCCCC AGAACTGGCC 
ACTCCTGCCA TACGCCACAT CATGCAGAGT TGCTGGTCTG GAGACCCTAA AGCGAGGCCT 
GCTTTCTCTG ACCTAGTGGA GATCCTGGGG GACCTGCTTC AGGGTGGAGG CTGGCAGGAG 
GAGGAGGAGG AATGCATGGC CCTGCACAGT TCTCAGAGCT CAGAGGAGGA TGGCTTCATG 
CAGGCATCCA CCACAGCTCT ACATATCACG GAGGCTGACG CTGAGAGCAG TCCACCCAGC 
ATGCATTGCC ACAGCCTGGC AGCCAGATAT TACAACTGTG TGTCCTTTCC TGGGCGCCTG 
GTCAGGGGGA CTAAGGCTCC AGGTTCCTCC AGGATGAAGA CGTTTGAAGA ATTGCCCATG 
ACCCCTACAA CCTACAAAGC CTCTGTGGAT AACCAAACAG ACAGCGGGAT GGTGCTGGCC 
TCAGAAGAGT TTGAGCAGAT AGAAAGCAGG CATAGACAAG AAGGCAGCTT CAGCCGTAAA 
GATCCTGGCC AGCACATGGA TATTTCCAGA GGACACCCGG ACCTCCAGGG GAGGCGGCGA 
CGGCCCACCC AGGGGGCACA AGGAGGCAAG GTGTTTTACA ACAACGAGTA TGGGGAGGTC 
TCCCAGCCGT GTACAGAAGG TGACTGCTGC CCGTCTGCTG GCTCCACCTT CTTCGCAGAC 
AGCAACTACT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_446104.1
CDS	1..4092
Translation	MQPGAALNRRLWLCLGLLQGLANGYSMTPPTLNITEDSYVIDTGDSLSISCRGQHPLEWTWRGAQEVLTTGGKDSEDTQVVQDCEGTEARPYCKVLSLAQTHANNTGSYYCYYKYIKARIEGTTAASTYVFVRDFEQPFINKPDTLLVNRKDSMWVPCLVSIPGLNITLRSQSSVLHPDGQEVLWDDRRGMRVPTLLLRDALYLQCETTWGDQDFLSNPFLVHITGNELYDIQLYPKKSLELLVGEKLVLNCTVWAEFDSGVTFDWDYPGKQAERAKWVPERRSQQTHTELSSILTIHNVSQHDLGPYVCEANNGIQQFRESTEVIVHEKPFISVEWLKGPVLEATAGDEMVKLPVKLAAYPPPEFQWYKDRKAVTGRHNPHALVLKEVTEASAGVYTLALWNSAAGLRQNISLELVVNVPPHIHEKEASSPSIYSRHSRQTLTCTTYGVPQPLSVQWHWRPWTPCKTFAQRSLRRRQPRDGMPQCRDWKEVTTQDAVNPIESLDTWTESVEGKNKTVSKLVIQDANVSAMYKCVVFNKVGQDERLIYFYVTTIPDGFSIESEPSEDPLEGQSVRLSCRADNYTYEHLRWYRLNLSTLHDAQGNPLLLDCKNVHLFATPLEANLEEAEPGARHATLSLNIPRVAPEDEGDYVCEVQDRRSQDKHCHKKYLSVQALEAPRLTQNLTDLLVNVRTSLEMRCPVAGAHVPSIVWYKDERLLEKESGIDLADSNQRLSIQRVREEDAGRYLCSVCNAKGCVNSSASVAVEGSEDKGSMEIVILIGTGVIAVFFWVLLLLIFCNMKRPAHADIKTGYLSIIMDPGEVPLEEQCEYLSYDVSQWEFPRERLHLGRVLGHGAFGKVVEASAFGINKGSSCDTVAVKMLKEGATASEHRALMSELKILIHIGNHLNVVNLLGACTKPNGPLMVIVEFCKYGNLSNFLRVKRETFDPYAEKSPEQRRRFRAMVEGAKADRRRLGSTDRALFTRFLMGKGSARRAPFVQEAEDLWLSPLTMEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSESDIVKICDFGLARDIYKDPDYVRKGSARLPLKWMAPESIFDKVYTTQSDVWSFGVLLWEIFSLGASPYPGVQINEEFCQRLKDGTRMRAPELATPAIRHIMQSCWSGDPKARPAFSDLVEILGDLLQGGGWQEEEEECMALHSSQSSEEDGFMQASTTALHITEADAESSPPSMHCHSLAARYYNCVSFPGRLVRGTKAPGSSRMKTFEELPMTPTTYKASVDNQTDSGMVLASEEFEQIESRHRQEGSFSRKDPGQHMDISRGHPDLQGRRRRPTQGAQGGKVFYNNEYGEVSQPCTEGDCCPSAGSTFFADSNY

Target ORF information:

RefSeq Version	NM_053652.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus fms-related tyrosine kinase 4 (Flt4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053652.1

ORF Insert Sequence:

ATGCAGCCGG GCGCTGCGCT GAACCGGCGC CTGTGGCTCT GCCTCGGACT CCTCCAAGGC 
CTGGCAAATG GCTACTCCAT GACCCCTCCA ACTCTGAACA TCACAGAGGA TTCATATGTC 
ATTGACACCG GGGACAGCCT ATCCATATCC TGCAGGGGGC AGCACCCCCT CGAGTGGACC 
TGGCGAGGGG CCCAAGAGGT ACTGACCACA GGTGGGAAGG ACAGCGAGGA CACGCAGGTT 
GTGCAAGACT GTGAAGGCAC AGAAGCTAGG CCCTACTGCA AGGTGCTGTC GCTGGCCCAG 
ACTCACGCCA ACAACACGGG CAGCTATTAC TGCTACTACA AGTATATCAA GGCCCGGATT 
GAGGGCACCA CAGCTGCCAG CACCTATGTG TTTGTAAGAG ACTTTGAACA GCCTTTCATC 
AACAAACCTG ACACGCTCCT GGTCAACAGG AAGGACTCGA TGTGGGTGCC CTGCTTGGTG 
TCCATTCCCG GCCTCAACAT CACACTGCGC TCGCAAAGTT CGGTGCTGCA CCCTGATGGG 
CAGGAGGTGT TGTGGGACGA CCGCCGGGGC ATGCGGGTGC CCACTCTACT GTTGCGTGAC 
GCCCTGTACC TGCAGTGCGA GACCACCTGG GGAGACCAGG ACTTCCTTTC CAATCCCTTC 
CTCGTGCACA TCACAGGCAA TGAGCTCTAT GACATCCAGC TGTACCCCAA GAAGTCACTG 
GAGCTGTTGG TTGGAGAGAA GCTGGTTTTG AACTGTACAG TATGGGCTGA GTTCGACTCT 
GGTGTCACCT TCGACTGGGA TTACCCAGGA AAGCAGGCAG AGCGTGCTAA GTGGGTACCT 
GAGCGGCGTT CCCAGCAGAC CCACACGGAA CTCTCCAGCA TCCTGACCAT CCACAATGTC 
AGCCAGCACG ACCTGGGCCC CTATGTGTGT GAGGCCAACA ATGGGATTCA GCAGTTCCGG 
GAAAGCACGG AGGTCATTGT GCACGAAAAG CCCTTCATCA GTGTCGAGTG GCTCAAAGGA 
CCTGTCCTGG AGGCCACAGC CGGTGACGAG ATGGTGAAGC TACCCGTGAA GCTTGCAGCT 
TATCCCCCAC CGGAGTTCCA ATGGTACAAG GACAGAAAGG CAGTGACTGG GCGCCACAAT 
CCACATGCTC TGGTGCTCAA AGAGGTGACC GAGGCCAGTG CAGGCGTCTA CACCCTCGCC 
CTGTGGAACT CTGCAGCCGG TCTGAGGCAG AATATCAGTC TGGAGCTGGT GGTGAATGTG 
CCGCCCCACA TCCATGAAAA GGAAGCTTCT TCACCCAGCA TCTACTCCCG CCACAGCCGC 
CAGACCCTCA CCTGCACCAC CTATGGGGTA CCCCAACCTC TCAGTGTTCA GTGGCACTGG 
AGGCCCTGGA CACCCTGTAA GACATTTGCC CAGCGCAGTC TCCGGAGGCG GCAGCCGCGG 
GATGGCATGC CACAGTGCCG AGACTGGAAG GAGGTGACCA CTCAGGACGC TGTGAACCCC 
ATCGAGAGCC TGGACACCTG GACCGAGTCT GTGGAGGGCA AGAACAAGAC GGTGAGCAAG 
CTGGTGATTC AGGATGCCAA TGTGTCAGCC ATGTACAAAT GCGTGGTCTT CAACAAAGTG 
GGCCAGGACG AGCGGCTCAT CTACTTCTAT GTGACCACCA TCCCTGACGG CTTCAGTATC 
GAATCAGAGC CATCCGAGGA TCCCTTAGAA GGCCAGTCCG TGCGCCTCAG CTGCCGGGCG 
GACAACTACA CGTATGAGCA TCTGCGCTGG TACCGGCTCA ACCTCTCCAC GCTGCACGAC 
GCTCAAGGGA ACCCCCTACT GCTCGACTGC AAGAACGTGC ACCTGTTTGC CACGCCCCTA 
GAGGCCAACC TAGAGGAGGC GGAGCCTGGG GCCCGCCACG CCACCCTCAG CTTGAATATC 
CCCCGAGTGG CGCCCGAGGA CGAGGGTGAC TACGTGTGTG AAGTGCAGGA TAGGCGCAGC 
CAGGACAAGC ACTGCCACAA GAAGTACCTG TCCGTGCAGG CCCTGGAAGC TCCTCGGCTC 
ACGCAGAACT TAACCGACCT CCTGGTGAAC GTGAGAACCT CCCTGGAGAT GCGATGTCCG 
GTAGCCGGAG CACATGTGCC CAGTATTGTG TGGTACAAAG ATGAAAGGCT CCTGGAGAAA 
GAGTCGGGAA TCGACCTGGC AGACTCCAAT CAGAGGCTGA GCATCCAACG CGTGCGCGAG 
GAGGACGCAG GTCGTTACCT GTGCAGTGTG TGCAATGCCA AGGGCTGCGT AAACTCCTCC 
GCCAGCGTGG CCGTAGAAGG CTCGGAAGAT AAAGGCAGCA TGGAGATTGT GATACTCATT 
GGCACTGGCG TCATCGCAGT CTTCTTCTGG GTCCTCCTCC TGCTCATCTT CTGTAACATG 
AAAAGGCCTG CCCATGCAGA CATCAAGACG GGCTACCTGT CCATCATCAT GGACCCCGGG 
GAGGTGCCTT TGGAGGAGCA GTGTGAATAC CTGTCCTATG ACGTCAGCCA GTGGGAGTTC 
CCCAGGGAAA GGTTGCACCT CGGGAGAGTC CTAGGCCATG GGGCTTTTGG GAAGGTGGTG 
GAAGCCTCAG CCTTTGGCAT CAATAAAGGC AGCAGCTGTG ATACCGTGGC GGTGAAGATG 
CTGAAAGAGG GCGCTACTGC CAGCGAACAC CGTGCCCTGA TGTCCGAGCT CAAGATCCTA 
ATTCACATCG GTAACCACCT CAATGTGGTC AACCTCCTAG GGGCGTGCAC CAAGCCCAAT 
GGCCCTCTCA TGGTGATCGT GGAGTTTTGC AAATACGGCA ACCTCTCCAA CTTCTTGCGT 
GTCAAGCGGG AGACGTTCGA CCCCTACGCA GAGAAGTCTC CCGAGCAACG CAGGCGCTTC 
CGCGCGATGG TAGAAGGCGC CAAGGCTGAT AGGAGGAGAC TTGGAAGCAC CGACAGAGCC 
CTGTTTACAA GGTTCCTGAT GGGCAAAGGA AGTGCACGGC GAGCCCCATT TGTCCAAGAA 
GCTGAGGACC TGTGGTTGAG CCCGCTGACC ATGGAGGACC TTGTCTGCTA CAGTTTCCAA 
GTGGCCCGGG GAATGGAGTT CCTGGCTTCC CGCAAGTGCA TTCACAGAGA CCTGGCTGCT 
CGGAACATTT TACTGTCAGA AAGTGACATA GTGAAGATCT GTGACTTTGG CCTCGCTCGG 
GACATCTACA AAGACCCTGA CTATGTCCGA AAGGGCAGCG CCCGACTGCC TCTGAAATGG 
ATGGCCCCCG AGAGCATCTT TGATAAGGTG TACACCACGC AGAGTGATGT GTGGTCCTTC 
GGCGTGCTGC TGTGGGAGAT CTTCTCATTG GGGGCCTCTC CATACCCTGG GGTACAGATC 
AATGAGGAAT TCTGCCAGCG GCTGAAAGAC GGCACACGAA TGAGGGCCCC AGAACTGGCC 
ACTCCTGCCA TACGCCACAT CATGCAGAGT TGCTGGTCTG GAGACCCTAA AGCGAGGCCT 
GCTTTCTCTG ACCTAGTGGA GATCCTGGGG GACCTGCTTC AGGGTGGAGG CTGGCAGGAG 
GAGGAGGAGG AATGCATGGC CCTGCACAGT TCTCAGAGCT CAGAGGAGGA TGGCTTCATG 
CAGGCATCCA CCACAGCTCT ACATATCACG GAGGCTGACG CTGAGAGCAG TCCACCCAGC 
ATGCATTGCC ACAGCCTGGC AGCCAGATAT TACAACTGTG TGTCCTTTCC TGGGCGCCTG 
GTCAGGGGGA CTAAGGCTCC AGGTTCCTCC AGGATGAAGA CGTTTGAAGA ATTGCCCATG 
ACCCCTACAA CCTACAAAGC CTCTGTGGAT AACCAAACAG ACAGCGGGAT GGTGCTGGCC 
TCAGAAGAGT TTGAGCAGAT AGAAAGCAGG CATAGACAAG AAGGCAGCTT CAGCCGTAAA 
GATCCTGGCC AGCACATGGA TATTTCCAGA GGACACCCGG ACCTCCAGGG GAGGCGGCGA 
CGGCCCACCC AGGGGGCACA AGGAGGCAAG GTGTTTTACA ACAACGAGTA TGGGGAGGTC 
TCCCAGCCGT GTACAGAAGG TGACTGCTGC CCGTCTGCTG GCTCCACCTT CTTCGCAGAC 
AGCAACTACT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Developmental expression of vascular endothelial growth factor receptor 3 and vascular endothelial growth factor C in forebrain.
Neuroscience303544-57(2015 Sep)
Ward MC,Cunningham AM

Lymphatic function is required prenatally for lung inflation at birth.
The Journal of experimental medicine211(5)815-26(2014 May)
Jakus Z,Gleghorn JP,Enis DR,Sen A,Chia S,Liu X,Rawnsley DR,Yang Y,Hess PR,Zou Z,Yang J,Guttentag SH,Nelson CM,Kahn ML

Inhibition of VEGFR-3 activation in tumor-draining lymph nodes suppresses the outgrowth of lymph node metastases in the MT-450 syngeneic rat breast cancer model.
Clinical & experimental metastasis31(3)351-65(2014 Mar)
Quagliata L,Klusmeier S,Cremers N,Pytowski B,Harvey A,Pettis RJ,Thiele W,Sleeman JP

Structural and mechanistic insights into VEGF receptor 3 ligand binding and activation.
Proceedings of the National Academy of Sciences of the United States of America110(32)12960-5(2013 Aug)
Lepp?nen VM,Tvorogov D,Kisko K,Prota AE,Jeltsch M,Anisimov A,Markovic-Mueller S,Stuttfeld E,Goldie KN,Ballmer-Hofer K,Alitalo K

Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins.
Proceedings of the National Academy of Sciences of the United States of America110(8)E643-52(2013 Feb)
Ghai R,Bugarcic A,Liu H,Norwood SJ,Skeldal S,Coulson EJ,Li SS,Teasdale RD,Collins BM

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Flt4 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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