Dao cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Dao
Entrez Gene ID	114027
Full Name	D-amino-acid oxidase
Synonyms	Dao1
General protein information	Preferred Names D-amino-acid oxidase Names D-amino-acid oxidase D-amino acid oxidase 1 DAAO DAMOX
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 12 Map Location: 12q16
Summary	catalyzes the conversion of d-amino acids to the corresponding alpha-keto acids; may be responsible for conversion of d-leucine to alpha-ketoisocaproic acid in the kidney [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_053626.1	NP_446078.1	D-amino-acid oxidase

Pathways from BioSystems

Homologies

	DAO	XP_001103664.1
Bos taurus (cattle)	DAO	NP_001193154.1
Danio rerio (zebrafish)	dao.2	NP_999897.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP001116	XP_322047.5
Danio rerio (zebrafish)	dao.1	NP_001028912.1
Xenopus tropicalis (tropical clawed frog)	dao	NP_001090631.1
Drosophila melanogaster (fruit fly)	CG11236	NP_609075.1
Kluyveromyces lactis	KLLA0A08492g	XP_451375.1
Homo sapiens (human)	DAO	NP_001908.3
Canis lupus familiaris (dog)	DAO	XP_543443.2
Mus musculus (house mouse)	Dao	NP_001273325.1
Rattus norvegicus (Norway rat)	Dao	NP_446078.1
Danio rerio (zebrafish)	dao.3	NP_991257.1

Gene Ontology
Bibliography

Related articles in PubMed

Diamine oxidase as a marker of intestinal mucosal injury and the effect of soluble dietary fiber on gastrointestinal tract toxicity after intravenous 5-fluorouracil treatment in rats.
Fukudome I, Kobayashi M, Dabanaka K, Maeda H, Okamoto K, Okabayashi T, Baba R, Kumagai N, Oba K, Fujita M, Hanazaki K
Medical molecular morphology47(2)100-7(2014 Jun)

Pathogenic effects of amyotrophic lateral sclerosis-linked mutation in D-amino acid oxidase are mediated by D-serine.
Paul P, Murphy T, Oseni Z, Sivalokanathan S, de Belleroche JS
Neurobiology of aging35(4)876-85(2014 Apr)

Study on the decrease of renal D-amino acid oxidase activity in the rat after renal ischemia by chiral ligand exchange capillary electrophoresis.
Zhang H, Qi L, Lin Y, Mao L, Chen Y
Amino acids42(1)337-45(2012 Jan)

Evidence for the interaction of D-amino acid oxidase with pLG72 in a glial cell line.
Sacchi S, Cappelletti P, Giovannardi S, Pollegioni L
Molecular and cellular neurosciences48(1)20-8(2011 Sep)

D-amino acid oxidase activity is inhibited by an interaction with bassoon protein at the presynaptic active zone.
Popiolek M, Ross JF, Charych E, Chanda P, Gundelfinger ED, Moss SJ, Brandon NJ, Pausch MH
The Journal of biological chemistry286(33)28867-75(2011 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Plasma DAO activity decreases in response to severe intestinal mucosal injury after 5-FU treatment.
Title: Diamine oxidase as a marker of intestinal mucosal injury and the effect of soluble dietary fiber on gastrointestinal tract toxicity after intravenous 5-fluorouracil treatment in rats.

Its toxic effect on motor neurons can be mediated by expression in motor neurons and it promotes autophagy.
Title: Pathogenic effects of amyotrophic lateral sclerosis-linked mutation in D-amino acid oxidase are mediated by D-serine.

The study showed that the operation of renal ischemia resulted in a 45.49 +/- 8.30% (n = 8) decrease in the DAAO-induced consumption of substrate, indicating a sharp decrease in renal DAAO activity following this acute renal injury.
Title: Study on the decrease of renal D-amino acid oxidase activity in the rat after renal ischemia by chiral ligand exchange capillary electrophoresis.

D-amino acid oxidase activity is inhibited by an interaction with bassoon protein at the presynaptic active zone.
Title: D-amino acid oxidase activity is inhibited by an interaction with bassoon protein at the presynaptic active zone.

Familial amyotrophic lateral sclerosis is associated with a mutation in D-amino acid oxidase
Title: Familial amyotrophic lateral sclerosis is associated with a mutation in D-amino acid oxidase.

The following Dao gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Dao cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa10122	NM_053626.1 Latest version!	Rattus norvegicus D-amino-acid oxidase (Dao), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Dao ( NM_053626.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_446078.1 Rattus norvegicus D-amino-acid oxidase (Dao), mRNA.

Price & Availability↑

CloneID	ORa10122
Clone ID Related Accession (Same CDS sequence)	NM_053626.1
Accession Version	NM_053626.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1041bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Rattus norvegicus(Norway rat)
Product	D-amino-acid oxidase
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB003400.1. On Jun 25, 2006 this sequence version replaced XM_001080433.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB003400.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGCGCGTGG CCGTGATTGG AGCGGGAGTC ATCGGACTGT CTACAGCCCT CTGCATTCAT 
GAACGTTACC ACCCAGCCCA ACCTCTGCAC ATGAAGATCT ATGCGGATCG CTTCACGCCG 
TTCACTACCA GCGATGTGGC TGCGGGACTC TGGCAGCCTT ATCTCTCTGA CCCCAGCAAC 
CCGCAGGAGG CGGAGTGGAA CCAGCAAACT TTCGATCACC TTCAGAGCTG CCTCCATTCT 
CCAAACGCTG AGAAAATGGG CTTGGCCCTA ATCTCAGGCT ACAACCTCTT CCGAGACGAA 
GTCCCGGACC CTTTCTGGAA AAGCACAGTT CTGGGATTCC GGAAGCTGAC CCCCAGCGAG 
TTGGACATGT TCCCTGATTA TAGCTATGGC TGGTTCAACA CGAGCCTCCT TCTTGAGGGG 
AAGAGCTACC TATCATGGCT GACTGAGAGG TTAACTGAGA GGGGAGTGAA GTTCATCCAT 
CGGAAGGTGG CATCTTTCGA AGAGGTGGTG AGAGGAGGCG TGGATGTGAT TATCAACTGC 
ACCGGGGTGT GGGCCGGGGC TCTGCAAGCA GACGCCTCCC TGCAGCCAGG CCGGGGCCAG 
ATCATCCAGG TGGAGGCCCC TTGGATAAAG CACTTCATCC TCACCCATGA TCCCAGCCTT 
GGCATCTACA ACTCTCCATA CATCATCCCA GGTTCCAAGA CAGTTACACT CGGAGGTGTA 
TTCCAGCTGG GGAACTGGAG CGAGCTAAAC AGCGTCCATG ACCACAACAC CATTTGGAAG 
AGCTGCTGTC AACTGGAGCC CACCCTGAAG AATGCAAGAA TCATGGGTGA ACTCACTGGC 
TTCCGGCCAG TCCGACCTCA GGTCCGGCTA GAAAGAGAAC GCCTTCGCTT TGGATCTTCA 
AGTGCAGAGG TCATCCATAA CTATGGTCAT GGAGGTTACG GGCTCACGAT TCACTGGGGT 
TGTGCAATGG AGGCAGCCAA CCTCTTTGGG AAAATTCTAG AAGAAAAGAA CTTGTCCAGG 
ATGCCTCCAT CCCACCTCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_446078.1
CDS	97..1137
Translation	MRVAVIGAGVIGLSTALCIHERYHPAQPLHMKIYADRFTPFTTSDVAAGLWQPYLSDPSNPQEAEWNQQTFDHLQSCLHSPNAEKMGLALISGYNLFRDEVPDPFWKSTVLGFRKLTPSELDMFPDYSYGWFNTSLLLEGKSYLSWLTERLTERGVKFIHRKVASFEEVVRGGVDVIINCTGVWAGALQADASLQPGRGQIIQVEAPWIKHFILTHDPSLGIYNSPYIIPGSKTVTLGGVFQLGNWSELNSVHDHNTIWKSCCQLEPTLKNARIMGELTGFRPVRPQVRLERERLRFGSSSAEVIHNYGHGGYGLTIHWGCAMEAANLFGKILEEKNLSRMPPSHL

Target ORF information:

RefSeq Version	NM_053626.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus D-amino-acid oxidase (Dao), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053626.1

ORF Insert Sequence:

ATGCGCGTGG CCGTGATTGG AGCGGGAGTC ATCGGACTGT CTACAGCCCT CTGCATTCAT 
GAACGTTACC ACCCAGCCCA ACCTCTGCAC ATGAAGATCT ATGCGGATCG CTTCACGCCG 
TTCACTACCA GCGATGTGGC TGCGGGACTC TGGCAGCCTT ATCTCTCTGA CCCCAGCAAC 
CCGCAGGAGG CGGAGTGGAA CCAGCAAACT TTCGATCACC TTCAGAGCTG CCTCCATTCT 
CCAAACGCTG AGAAAATGGG CTTGGCCCTA ATCTCAGGCT ACAACCTCTT CCGAGACGAA 
GTCCCGGACC CTTTCTGGAA AAGCACAGTT CTGGGATTCC GGAAGCTGAC CCCCAGCGAG 
TTGGACATGT TCCCTGATTA TAGCTATGGC TGGTTCAACA CGAGCCTCCT TCTTGAGGGG 
AAGAGCTACC TATCATGGCT GACTGAGAGG TTAACTGAGA GGGGAGTGAA GTTCATCCAT 
CGGAAGGTGG CATCTTTCGA AGAGGTGGTG AGAGGAGGCG TGGATGTGAT TATCAACTGC 
ACCGGGGTGT GGGCCGGGGC TCTGCAAGCA GACGCCTCCC TGCAGCCAGG CCGGGGCCAG 
ATCATCCAGG TGGAGGCCCC TTGGATAAAG CACTTCATCC TCACCCATGA TCCCAGCCTT 
GGCATCTACA ACTCTCCATA CATCATCCCA GGTTCCAAGA CAGTTACACT CGGAGGTGTA 
TTCCAGCTGG GGAACTGGAG CGAGCTAAAC AGCGTCCATG ACCACAACAC CATTTGGAAG 
AGCTGCTGTC AACTGGAGCC CACCCTGAAG AATGCAAGAA TCATGGGTGA ACTCACTGGC 
TTCCGGCCAG TCCGACCTCA GGTCCGGCTA GAAAGAGAAC GCCTTCGCTT TGGATCTTCA 
AGTGCAGAGG TCATCCATAA CTATGGTCAT GGAGGTTACG GGCTCACGAT TCACTGGGGT 
TGTGCAATGG AGGCAGCCAA CCTCTTTGGG AAAATTCTAG AAGAAAAGAA CTTGTCCAGG 
ATGCCTCCAT CCCACCTCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Diamine oxidase as a marker of intestinal mucosal injury and the effect of soluble dietary fiber on gastrointestinal tract toxicity after intravenous 5-fluorouracil treatment in rats.
Medical molecular morphology47(2)100-7(2014 Jun)
Fukudome I,Kobayashi M,Dabanaka K,Maeda H,Okamoto K,Okabayashi T,Baba R,Kumagai N,Oba K,Fujita M,Hanazaki K

Pathogenic effects of amyotrophic lateral sclerosis-linked mutation in D-amino acid oxidase are mediated by D-serine.
Neurobiology of aging35(4)876-85(2014 Apr)
Paul P,Murphy T,Oseni Z,Sivalokanathan S,de Belleroche JS

Study on the decrease of renal D-amino acid oxidase activity in the rat after renal ischemia by chiral ligand exchange capillary electrophoresis.
Amino acids42(1)337-45(2012 Jan)
Zhang H,Qi L,Lin Y,Mao L,Chen Y

Evidence for the interaction of D-amino acid oxidase with pLG72 in a glial cell line.
Molecular and cellular neurosciences48(1)20-8(2011 Sep)
Sacchi S,Cappelletti P,Giovannardi S,Pollegioni L

D-amino acid oxidase activity is inhibited by an interaction with bassoon protein at the presynaptic active zone.
The Journal of biological chemistry286(33)28867-75(2011 Aug)
Popiolek M,Ross JF,Charych E,Chanda P,Gundelfinger ED,Moss SJ,Brandon NJ,Pausch MH

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Dao cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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