Gpnmb cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Gpnmb
Entrez Gene ID	113955
Full Name	glycoprotein nmb
General protein information	Preferred Names glycoprotein nmb Names transmembrane glycoprotein NMB glycoprotein (transmembrane) nmb osteoactivin
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 4 Map Location: 4q24
Summary	may play a role in bone matrix production and mineralization; overexpressed in the osteopetrosis mutant op rat [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_133298.1	NP_579832.1	transmembrane glycoprotein NMB precursor

Pathways from BioSystems

Homologies

Bos taurus (cattle)	GPNMB	NP_001033154.1
Mus musculus (house mouse)	Gpnmb	NP_444340.3
Gallus gallus (chicken)	GPNMB	XP_425991.2
Danio rerio (zebrafish)	gpnmb	XP_691804.2
Rattus norvegicus (Norway rat)	Gpnmb	NP_579832.1
Canis lupus familiaris (dog)	GPNMB	XP_539472.2
Homo sapiens (human)	GPNMB	NP_001005340.1
Pan troglodytes (chimpanzee)	GPNMB	XP_001157101.2
	GPNMB	XP_001099643.2
Xenopus tropicalis (tropical clawed frog)	gpnmb	NP_001124514.1

Gene Ontology
Bibliography

Related articles in PubMed

Adverse left ventricular remodeling by glycoprotein nonmetastatic melanoma protein B in myocardial infarction.
J?rve A, M?hlstedt S, Qadri F, Nickl B, Schulz H, H?bner N, ?zcelik C, Bader M
FASEB journal : official publication of the Federation of American Societies for Experimental Biology31(2)556-568(2017 02)

Exploratory study on the effect of osteoactivin on muscle regeneration in a rat volumetric muscle loss model.
Ma J, Baker AR, Calabro A, Derwin KA
PloS one12(4)e0175853(2017)

Growth and repair factors, osteoactivin, matrix metalloproteinase and heat shock protein 72, increase with resolution of inflammation in musculotendinous tissues in a rat model of repetitive grasping.
Frara N, Abdelmagid SM, Tytell M, Amin M, Popoff SN, Safadi FF, Barbe MF
BMC musculoskeletal disorders1734(2016 Jan)

Beneficial impact of Gpnmb and its significance as a biomarker in nonalcoholic steatohepatitis.
Katayama A, Nakatsuka A, Eguchi J, Murakami K, Teshigawara S, Kanzaki M, Nunoue T, Hida K, Wada N, Yasunaka T, Ikeda F, Takaki A, Yamamoto K, Kiyonari H, Makino H, Wada J
Scientific reports516920(2015 Nov)

Role of microRNA-150 and glycoprotein nonmetastatic melanoma protein B in angiogenesis during hyperoxia-induced neonatal lung injury.
Narasaraju T, Shukla D, More S, Huang C, Zhang L, Xiao X, Liu L
American journal of respiratory cell and molecular biology52(2)253-61(2015 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

This is the first experimental study to show that GPNMB adversely influences myocardial remodeling.
Title: Adverse left ventricular remodeling by glycoprotein nonmetastatic melanoma protein B in myocardial infarction.

objective of this study is to investigate the potential regenerative effect of OA embedded and delivered via a cross-linked gelatin hydrogel within a volumetric tibialis anterior muscle defect in a rat model
Title: Exploratory study on the effect of osteoactivin on muscle regeneration in a rat volumetric muscle loss model.

A simultaneous increase in osteoactivin occurred with factors involved in tissue repair (MMPs and HSP72), in tissue regeneration after repetitive overuse.
Title: Growth and repair factors, osteoactivin, matrix metalloproteinase and heat shock protein 72, increase with resolution of inflammation in musculotendinous tissues in a rat model of repetitive grasping.

The GPNMB is a promising biomarker and therapeutic target for the development and progression of Nonalcoholic fatty liver disease in obesity.
Title: Beneficial impact of Gpnmb and its significance as a biomarker in nonalcoholic steatohepatitis.

Glycoprotein nonmetastatic melanoma protein B plays an important role in angiogenesis during hyperoxia injury
Title: Role of microRNA-150 and glycoprotein nonmetastatic melanoma protein B in angiogenesis during hyperoxia-induced neonatal lung injury.

The following Gpnmb gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Gpnmb cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa00569	NM_133298.1 Latest version!	Rattus norvegicus glycoprotein nmb (Gpnmb), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$335.30 $479.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Gpnmb ( NM_133298.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_579832.1 Rattus norvegicus glycoprotein nmb (Gpnmb), mRNA.

Price & Availability↑

CloneID	ORa00569
Clone ID Related Accession (Same CDS sequence)	NM_133298.1
Accession Version	NM_133298.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1719bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Rattus norvegicus(Norway rat)
Product	transmembrane glycoprotein NMB precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF184983.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF184983.2, BC061725.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGAAAGTC TCTGCGGGGT CCTGGTATTT CTGCTGCTGG CTGCAGGACT GCCGCTCCAG 
GCGGCCAAGC GGTTCCGTGA TGTGCTGGGC CATGAGCAGT ATCCGGATCA CATGAGGGAG 
AACAACCAAT TACGTGGCTG GTCTTCAGAT GAAAATGAAT GGGATGAACA GCTGTATCCA 
GTGTGGAGGA GGGGAGAGGG CAGATGGAAG GACTCCTGGG AAGGAGGCCG TGTGCAGGCA 
GCCCTAACCA GTGATTCACC GGCCTTGGTG GGTTCCAATA TCACCTTCGT AGTGAACCTG 
GTGTTCCCCA GATGCCAGAA GGAAGATGCC AACGGCAATA TCGTCTATGA GAGGAACTGC 
AGAAGTGATT TGGAGCTGGC TTCTGACCCG TATGTCTACA ACTGGACCAC AGGGGCAGAC 
GATGAGGACT GGGAAGACAA CACCAGCCAA GGCCAGCACC TCAGGTTCCC CGACGGGAAG 
CCCTTCCCTC GCCCCCACGG ACGGAAGAAA TGGAACTTCG TCTACGTCTT CCACACACTT 
GGTCAGTATT TTCAAAAGCT GGGTCAGTGT TCAGCACGAG TTTCTATAAA CACAGTCAAC 
TTGACAGTTG GCCCTCAGGT CATGGAAGTG ATTGTCTTTC GAAGACACGG CCGGGCATAC 
ATTCCCATCT CCAAAGTGAA AGACGTGTAT GTGATAACAG ATCAGATCCC TATATTCGTG 
ACCATGTACC AGAAGAATGA CCGGAACTCG TCTGATGAAA CCTTCCTCAG AGACCTCCCC 
ATTTTCTTCG ATGTCCTCAT TCACGATCCC AGTCATTTCC TCAACTACTC TGCCATTTCC 
TACAAGTGGA ACTTTGGGGA CAACACTGGC CTGTTTGTCT CCAACAATCA CACTTTGAAT 
CACACGTATG TGCTCAATGG AACCTTCAAC TTTAACCTCA CCGTGCAAAC TGCAGTGCCG 
GGACCATGCC CCTCACCCAC ACCTTCGCCT TCTTCTTCGA CTTCTCCTTC GCCTGCATCT 
TCGCCTTCAC CCACATTATC AACACCTAGT CCCTCTTTAA TGCCTACTGG CTACAAATCC 
ATGGAGCTGA GTGACATTTC CAATGAAAAC TGCCGAATAA ACAGATATGG TTACTTCAGA 
GCCACCATCA CAATTGTAGA TGGAATCCTA GAAGTCAACA TCATCCAGGT AGCAGATGTC 
CCAATCCCCA CACTGCAGCC TGACAACTCA CTGATGGACT TCATTGTGAC CTGCAAAGGG 
GCCACTCCCA CGGAAGCCTG TACGATCATC TCTGACCCCA CCTGCCAGAT CGCCCAGAAC 
AGGGTGTGCA GCCCGGTGGC TGTGGATGAG CTGTGCCTCC TGTCCGTGAG GAGAGCCTTC 
AATGGGTCCG GCACGTACTG TGTGAATTTC ACTCTGGGAG ACGATGCAAG CCTGGCCCTC 
ACCAGCGCCC TGATCTCTAT CCCTGGCAAA GACCTAGGCT CCCCTCTGAG AACAGTGAAT 
GGTGTCCTGA TCTCCATTGG CTGCCTGGCC ATGTTTGTCA CCATGGTTAC CATCTTGCTG 
TACAAAAAAC ACAAGACGTA CAAGCCAATA GGAAACTGCA CCAGGAACGT GGTCAAGGGC 
AAAGGCCTGA GTGTTTTTCT CAGCCATGCA AAAGCCCCGT TCTCCCGAGG AGACCGGGAG 
AAGGATCCAC TGCTCCAGGA CAAGCCATGG ATGCTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_579832.1
CDS	115..1833
Translation	MESLCGVLVFLLLAAGLPLQAAKRFRDVLGHEQYPDHMRENNQLRGWSSDENEWDEQLYPVWRRGEGRWKDSWEGGRVQAALTSDSPALVGSNITFVVNLVFPRCQKEDANGNIVYERNCRSDLELASDPYVYNWTTGADDEDWEDNTSQGQHLRFPDGKPFPRPHGRKKWNFVYVFHTLGQYFQKLGQCSARVSINTVNLTVGPQVMEVIVFRRHGRAYIPISKVKDVYVITDQIPIFVTMYQKNDRNSSDETFLRDLPIFFDVLIHDPSHFLNYSAISYKWNFGDNTGLFVSNNHTLNHTYVLNGTFNFNLTVQTAVPGPCPSPTPSPSSSTSPSPASSPSPTLSTPSPSLMPTGYKSMELSDISNENCRINRYGYFRATITIVDGILEVNIIQVADVPIPTLQPDNSLMDFIVTCKGATPTEACTIISDPTCQIAQNRVCSPVAVDELCLLSVRRAFNGSGTYCVNFTLGDDASLALTSALISIPGKDLGSPLRTVNGVLISIGCLAMFVTMVTILLYKKHKTYKPIGNCTRNVVKGKGLSVFLSHAKAPFSRGDREKDPLLQDKPWML

Target ORF information:

RefSeq Version	NM_133298.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus glycoprotein nmb (Gpnmb), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_133298.1

ORF Insert Sequence:

ATGGAAAGTC TCTGCGGGGT CCTGGTATTT CTGCTGCTGG CTGCAGGACT GCCGCTCCAG 
GCGGCCAAGC GGTTCCGTGA TGTGCTGGGC CATGAGCAGT ATCCGGATCA CATGAGGGAG 
AACAACCAAT TACGTGGCTG GTCTTCAGAT GAAAATGAAT GGGATGAACA GCTGTATCCA 
GTGTGGAGGA GGGGAGAGGG CAGATGGAAG GACTCCTGGG AAGGAGGCCG TGTGCAGGCA 
GCCCTAACCA GTGATTCACC GGCCTTGGTG GGTTCCAATA TCACCTTCGT AGTGAACCTG 
GTGTTCCCCA GATGCCAGAA GGAAGATGCC AACGGCAATA TCGTCTATGA GAGGAACTGC 
AGAAGTGATT TGGAGCTGGC TTCTGACCCG TATGTCTACA ACTGGACCAC AGGGGCAGAC 
GATGAGGACT GGGAAGACAA CACCAGCCAA GGCCAGCACC TCAGGTTCCC CGACGGGAAG 
CCCTTCCCTC GCCCCCACGG ACGGAAGAAA TGGAACTTCG TCTACGTCTT CCACACACTT 
GGTCAGTATT TTCAAAAGCT GGGTCAGTGT TCAGCACGAG TTTCTATAAA CACAGTCAAC 
TTGACAGTTG GCCCTCAGGT CATGGAAGTG ATTGTCTTTC GAAGACACGG CCGGGCATAC 
ATTCCCATCT CCAAAGTGAA AGACGTGTAT GTGATAACAG ATCAGATCCC TATATTCGTG 
ACCATGTACC AGAAGAATGA CCGGAACTCG TCTGATGAAA CCTTCCTCAG AGACCTCCCC 
ATTTTCTTCG ATGTCCTCAT TCACGATCCC AGTCATTTCC TCAACTACTC TGCCATTTCC 
TACAAGTGGA ACTTTGGGGA CAACACTGGC CTGTTTGTCT CCAACAATCA CACTTTGAAT 
CACACGTATG TGCTCAATGG AACCTTCAAC TTTAACCTCA CCGTGCAAAC TGCAGTGCCG 
GGACCATGCC CCTCACCCAC ACCTTCGCCT TCTTCTTCGA CTTCTCCTTC GCCTGCATCT 
TCGCCTTCAC CCACATTATC AACACCTAGT CCCTCTTTAA TGCCTACTGG CTACAAATCC 
ATGGAGCTGA GTGACATTTC CAATGAAAAC TGCCGAATAA ACAGATATGG TTACTTCAGA 
GCCACCATCA CAATTGTAGA TGGAATCCTA GAAGTCAACA TCATCCAGGT AGCAGATGTC 
CCAATCCCCA CACTGCAGCC TGACAACTCA CTGATGGACT TCATTGTGAC CTGCAAAGGG 
GCCACTCCCA CGGAAGCCTG TACGATCATC TCTGACCCCA CCTGCCAGAT CGCCCAGAAC 
AGGGTGTGCA GCCCGGTGGC TGTGGATGAG CTGTGCCTCC TGTCCGTGAG GAGAGCCTTC 
AATGGGTCCG GCACGTACTG TGTGAATTTC ACTCTGGGAG ACGATGCAAG CCTGGCCCTC 
ACCAGCGCCC TGATCTCTAT CCCTGGCAAA GACCTAGGCT CCCCTCTGAG AACAGTGAAT 
GGTGTCCTGA TCTCCATTGG CTGCCTGGCC ATGTTTGTCA CCATGGTTAC CATCTTGCTG 
TACAAAAAAC ACAAGACGTA CAAGCCAATA GGAAACTGCA CCAGGAACGT GGTCAAGGGC 
AAAGGCCTGA GTGTTTTTCT CAGCCATGCA AAAGCCCCGT TCTCCCGAGG AGACCGGGAG 
AAGGATCCAC TGCTCCAGGA CAAGCCATGG ATGCTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Adverse left ventricular remodeling by glycoprotein nonmetastatic melanoma protein B in myocardial infarction.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology31(2)556-568(2017 02)
J?rve A,M?hlstedt S,Qadri F,Nickl B,Schulz H,H?bner N,?zcelik C,Bader M

Exploratory study on the effect of osteoactivin on muscle regeneration in a rat volumetric muscle loss model.
PloS one12(4)e0175853(2017)
Ma J,Baker AR,Calabro A,Derwin KA

Growth and repair factors, osteoactivin, matrix metalloproteinase and heat shock protein 72, increase with resolution of inflammation in musculotendinous tissues in a rat model of repetitive grasping.
BMC musculoskeletal disorders1734(2016 Jan)
Frara N,Abdelmagid SM,Tytell M,Amin M,Popoff SN,Safadi FF,Barbe MF

Beneficial impact of Gpnmb and its significance as a biomarker in nonalcoholic steatohepatitis.
Scientific reports516920(2015 Nov)
Katayama A,Nakatsuka A,Eguchi J,Murakami K,Teshigawara S,Kanzaki M,Nunoue T,Hida K,Wada N,Yasunaka T,Ikeda F,Takaki A,Yamamoto K,Kiyonari H,Makino H,Wada J

Role of microRNA-150 and glycoprotein nonmetastatic melanoma protein B in angiogenesis during hyperoxia-induced neonatal lung injury.
American journal of respiratory cell and molecular biology52(2)253-61(2015 Feb)
Narasaraju T,Shukla D,More S,Huang C,Zhang L,Xiao X,Liu L

- Most Popular Services
  - 人工遺伝子合成& DNA合成-納期保証
- Services & Products

見積依頼

Eメール

japanmarket@genscript.com

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

Gpnmb cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Most Popular Services

Services & Products

見積依頼

Eメール

電話

FAX

オンラインフォーム

サポート

会社情報

サポート

会社情報