Csnk1a1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Csnk1a1
Entrez Gene ID	113927
Full Name	casein kinase 1, alpha 1
General protein information	Preferred Names casein kinase 1, alpha 1 Names casein kinase I isoform alpha CK1 CKI-alpha
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 18 Map Location: 18q12.1
Summary	splice variant isoforms CKI alpha and CKI alpha L both have casein kinase I activity but display differences in substrate kinetics [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_053615.1	NP_446067.1	casein kinase I isoform alpha

Pathways from BioSystems

Homologies

Bos taurus (cattle)	CSNK1A1	NP_777136.1
Gallus gallus (chicken)	CSNK1A1	NP_990384.1
Arabidopsis thaliana (thale cress)	ckl8	NP_199146.1
Arabidopsis thaliana (thale cress)	ADK1	NP_563695.2
Canis lupus familiaris (dog)	CSNK1A1	XP_005619366.1
Schizosaccharomyces pombe (fission yeast)	hhp2	NP_593184.1
Oryza sativa (rice)	Os02g0810400	NP_001048470.1
Oryza sativa (rice)	Os04g0514800	NP_001053309.1
Xenopus tropicalis (tropical clawed frog)	csnk1a1	NP_001001221.1
	CSNK1A1	XP_001106904.1
Rattus norvegicus (Norway rat)	Csnk1a1	NP_446067.1
Danio rerio (zebrafish)	LOC100334765	XP_002664490.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP000627	XP_001238805.2
Arabidopsis thaliana (thale cress)	CKL13	NP_171939.1
Arabidopsis thaliana (thale cress)	CKI1	NP_193170.1
Arabidopsis thaliana (thale cress)	ckl7	NP_199223.1
Pan troglodytes (chimpanzee)	CSNK1A1	XP_001163959.1
Drosophila melanogaster (fruit fly)	CkIalpha	NP_001162737.1
Arabidopsis thaliana (thale cress)	ckl10	NP_188976.1
Oryza sativa (rice)	Os02g0622100	NP_001047465.1
Homo sapiens (human)	CSNK1A1	NP_001020276.1
Mus musculus (house mouse)	Csnk1a1	NP_666199.1
Arabidopsis thaliana (thale cress)	CKL6	NP_567812.1

Gene Ontology
Bibliography

Related articles in PubMed

Bifurcating action of Smoothened in Hedgehog signaling is mediated by Dlg5.
Chong YC, Mann RK, Zhao C, Kato M, Beachy PA
Genes & development29(3)262-76(2015 Feb)

Phosphorylation of LRRK2 by casein kinase 1? regulates trans-Golgi clustering via differential interaction with ARHGEF7.
Chia R, Haddock S, Beilina A, Rudenko IN, Mamais A, Kaganovich A, Li Y, Kumaran R, Nalls MA, Cookson MR
Nature communications55827(2014 Dec)

Casein kinase 1 suppresses activation of REST in insulted hippocampal neurons and halts ischemia-induced neuronal death.
Kaneko N, Hwang JY, Gertner M, Pontarelli F, Zukin RS
The Journal of neuroscience : the official journal of the Society for Neuroscience34(17)6030-9(2014 Apr)

A novel mechanism of keratin cytoskeleton organization through casein kinase I? and FAM83H in colorectal cancer.
Kuga T, Kume H, Kawasaki N, Sato M, Adachi J, Shiromizu T, Hoshino I, Nishimori T, Matsubara H, Tomonaga T
Journal of cell science126(Pt 20)4721-31(2013 Oct)

The period of the circadian oscillator is primarily determined by the balance between casein kinase 1 and protein phosphatase 1.
Lee HM, Chen R, Kim H, Etchegaray JP, Weaver DR, Lee C
Proceedings of the National Academy of Sciences of the United States of America108(39)16451-6(2011 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

CK1 associates with and phosphorylates REST at two neighboring, but distinct, motifs within the C terminus of REST critical for binding of beta-TrCP and targeting of REST for proteasomal degradation.
Title: Casein kinase 1 suppresses activation of REST in insulted hippocampal neurons and halts ischemia-induced neuronal death.

Data show that Golgi apparatus casein kinase (G-CK) catalyzes the phosphorylation of rhBMP-15 and rhGDF-9.
Title: Golgi apparatus casein kinase phosphorylates bioactive Ser-6 of bone morphogenetic protein 15 and growth and differentiation factor 9.

These data indicate that CKIalpha, PIPKIalpha, and Star-PAP function together to modulate the production of specific Star-PAP messages.
Title: CKIalpha is associated with and phosphorylates star-PAP and is also required for expression of select star-PAP target messenger RNAs.

The following Csnk1a1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Csnk1a1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa10091	NM_053615.1 Latest version!	Rattus norvegicus casein kinase 1, alpha 1 (Csnk1a1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Csnk1a1 ( NM_053615.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_446067.1 Rattus norvegicus casein kinase 1, alpha 1 (Csnk1a1), mRNA.

Price & Availability↑

CloneID	ORa10091
Clone ID Related Accession (Same CDS sequence)	NM_053615.1
Accession Version	NM_053615.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 978bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	casein kinase I isoform alpha
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U77582.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U77582.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGCGAGCA GCAGCGGCTC CAAGGCCGAA TTTATCGTCG GTGGGAAATA CAAACTGGTG 
CGGAAGATCG GATCTGGTTC CTTCGGGGAC ATTTATCTAG CGATCAACAT CACCAATGGC 
GAGGAAGTGG CAGTGAAACT AGAATCCCAG AAGGCCAGGC ATCCCCAGTT GCTGTACGAG 
AGCAAACTGT ATAAGATTCT TCAAGGTGGG GTTGGCATCC CTCACATACG GTGGTATGGG 
CAAGGAAAAG ACTATAATGT GCTAGTCATG GATCTTCTGG GACCCAGCCT CGAAGACCTC 
TTCAATTTCT GTTCAAGAAG GTTCACTATG AAGACTGTAC TTATGTTAGC TGACCAGATG 
ATCAGTAGAA TTGAATATGT GCATACAAAG AATTTTATAC ACAGAGACAT TAAACCAGAT 
AACTTCCTAA TGGGTATTGG GCGTCACTGT AATAAGTTAT TCCTTATTGA TTTTGGTTTG 
GCCAAAAAGT ACAGAGACAA CAGGACAAGG CAACACATAC CATACAGGGA AGATAAAAAC 
CTCACTGGCA CTGCCCGGTA TGCCAGCATC AATGCACATC TTGGCATTGA GCAGAGTCGC 
CGAGATGACA TGGAATCTTT AGGATATGTT TTGATGTATT TTAATAGAAC CAGTCTGCCA 
TGGCAAGGGC TAAAGGCTGC AACAAAGAAA CAAAAATATG AAAAGATTAG TGAAAAGAAG 
ATGTCCACTC CTGTTGAAGT TTTGTGTAAG GGGTTTCCTG CAGAATTTGC CATGTACTTA 
AATTACTGTC GTGGGCTGCG CTTTGAGGAA GCTCCGGATT ACATGTATCT GAGGCAGCTG 
TTCCGCATCC TCTTCAGGAC CCTGAACCAC CAGTATGACT ACACGTTTGA TTGGACGATG 
TTAAAGCAGA AAGCAGCCCA GCAGGCAGCC TCTTCCAGTG GGCAGGGTCA GCAGGCCCAA 
ACCCCCACAG GTTTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_446067.1
CDS	1..978
Translation	MASSSGSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESKLYKILQGGVGIPHIRWYGQGKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQLFRILFRTLNHQYDYTFDWTMLKQKAAQQAASSSGQGQQAQTPTGF

Target ORF information:

RefSeq Version	NM_053615.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus casein kinase 1, alpha 1 (Csnk1a1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053615.1

ORF Insert Sequence:

ATGGCGAGCA GCAGCGGCTC CAAGGCCGAA TTTATCGTCG GTGGGAAATA CAAACTGGTG 
CGGAAGATCG GATCTGGTTC CTTCGGGGAC ATTTATCTAG CGATCAACAT CACCAATGGC 
GAGGAAGTGG CAGTGAAACT AGAATCCCAG AAGGCCAGGC ATCCCCAGTT GCTGTACGAG 
AGCAAACTGT ATAAGATTCT TCAAGGTGGG GTTGGCATCC CTCACATACG GTGGTATGGG 
CAAGGAAAAG ACTATAATGT GCTAGTCATG GATCTTCTGG GACCCAGCCT CGAAGACCTC 
TTCAATTTCT GTTCAAGAAG GTTCACTATG AAGACTGTAC TTATGTTAGC TGACCAGATG 
ATCAGTAGAA TTGAATATGT GCATACAAAG AATTTTATAC ACAGAGACAT TAAACCAGAT 
AACTTCCTAA TGGGTATTGG GCGTCACTGT AATAAGTTAT TCCTTATTGA TTTTGGTTTG 
GCCAAAAAGT ACAGAGACAA CAGGACAAGG CAACACATAC CATACAGGGA AGATAAAAAC 
CTCACTGGCA CTGCCCGGTA TGCCAGCATC AATGCACATC TTGGCATTGA GCAGAGTCGC 
CGAGATGACA TGGAATCTTT AGGATATGTT TTGATGTATT TTAATAGAAC CAGTCTGCCA 
TGGCAAGGGC TAAAGGCTGC AACAAAGAAA CAAAAATATG AAAAGATTAG TGAAAAGAAG 
ATGTCCACTC CTGTTGAAGT TTTGTGTAAG GGGTTTCCTG CAGAATTTGC CATGTACTTA 
AATTACTGTC GTGGGCTGCG CTTTGAGGAA GCTCCGGATT ACATGTATCT GAGGCAGCTG 
TTCCGCATCC TCTTCAGGAC CCTGAACCAC CAGTATGACT ACACGTTTGA TTGGACGATG 
TTAAAGCAGA AAGCAGCCCA GCAGGCAGCC TCTTCCAGTG GGCAGGGTCA GCAGGCCCAA 
ACCCCCACAG GTTTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Bifurcating action of Smoothened in Hedgehog signaling is mediated by Dlg5.
Genes & development29(3)262-76(2015 Feb)
Chong YC,Mann RK,Zhao C,Kato M,Beachy PA

Phosphorylation of LRRK2 by casein kinase 1? regulates trans-Golgi clustering via differential interaction with ARHGEF7.
Nature communications55827(2014 Dec)
Chia R,Haddock S,Beilina A,Rudenko IN,Mamais A,Kaganovich A,Li Y,Kumaran R,Nalls MA,Cookson MR

Casein kinase 1 suppresses activation of REST in insulted hippocampal neurons and halts ischemia-induced neuronal death.
The Journal of neuroscience : the official journal of the Society for Neuroscience34(17)6030-9(2014 Apr)
Kaneko N,Hwang JY,Gertner M,Pontarelli F,Zukin RS

A novel mechanism of keratin cytoskeleton organization through casein kinase I? and FAM83H in colorectal cancer.
Journal of cell science126(Pt 20)4721-31(2013 Oct)
Kuga T,Kume H,Kawasaki N,Sato M,Adachi J,Shiromizu T,Hoshino I,Nishimori T,Matsubara H,Tomonaga T

The period of the circadian oscillator is primarily determined by the balance between casein kinase 1 and protein phosphatase 1.
Proceedings of the National Academy of Sciences of the United States of America108(39)16451-6(2011 Sep)
Lee HM,Chen R,Kim H,Etchegaray JP,Weaver DR,Lee C

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Csnk1a1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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