Taar1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Taar1
Entrez Gene ID	113914
Full Name	trace-amine-associated receptor 1
Synonyms	Tar1,Trar1,taR-1
General protein information	Preferred Names trace-amine-associated receptor 1 Names trace amine-associated receptor 1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1p12
Summary	G-protein coupled receptor that induces cAMP production in response to para-tyramine and other trace amines; also acts as a receptor for catecholamine metabolites and amphetamines [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_134328.1	NP_599155.1	trace amine-associated receptor 1

Pathways from BioSystems

Homologies

Homo sapiens (human)	TAAR1	NP_612200.1
Mus musculus (house mouse)	Taar1	NP_444435.1
Danio rerio (zebrafish)	taar1b	NP_001076373.1
Pan troglodytes (chimpanzee)	TAAR1	NP_001009145.1
Rattus norvegicus (Norway rat)	Taar1	NP_599155.1
Gallus gallus (chicken)	TAAR1	XP_004935797.1
Xenopus tropicalis (tropical clawed frog)	taar1	XP_002935857.1
	TAAR1	NP_001074234.1

Gene Ontology
Bibliography

Related articles in PubMed

Role of TAAR1 within the Subregions of the Mesocorticolimbic Dopaminergic System in Cocaine-Seeking Behavior.
Liu JF, Siemian JN, Seaman R Jr, Zhang Y, Li JX
The Journal of neuroscience : the official journal of the Society for Neuroscience37(4)882-892(2017 Jan)

The hallucinogen d-lysergic diethylamide (LSD) decreases dopamine firing activity through 5-HT
De Gregorio D, Posa L, Ochoa-Sanchez R, McLaughlin R, Maione S, Comai S, Gobbi G
Pharmacological research113(Pt A)81-91(2016 Nov)

Trace amine-associated receptor 1 activation silences GSK3? signaling of TAAR1 and D2R heteromers.
Harmeier A, Obermueller S, Meyer CA, Revel FG, Buchy D, Chaboz S, Dernick G, Wettstein JG, Iglesias A, Rolink A, Bettler B, Hoener MC
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology25(11)2049-61(2015 Nov)

Determinants involved in subtype-specific functions of rat trace amine-associated receptors 1 and 4.
St?ubert C, Bohnekamp J, Sch?neberg T
British journal of pharmacology168(5)1266-78(2013 Mar)

Distribution of exogenous [125I]-3-iodothyronamine in mouse in vivo: relationship with trace amine-associated receptors.
Chiellini G, Erba P, Carnicelli V, Manfredi C, Frascarelli S, Ghelardoni S, Mariani G, Zucchi R
The Journal of endocrinology213(3)223-30(2012 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

TAAR1 in different subregions of the mesocorticolimbic system contributes to reinstatement of cocaine-seeking behavior.
Title: Role of TAAR1 within the Subregions of the Mesocorticolimbic Dopaminergic System in Cocaine-Seeking Behavior.

Pretreatment with the trace amine-associate receptor 1 (TAAR1) antagonist EPPTB (5mg/kg, i.v.) blocked the inhibitory effect of LSD on VTA DA neurons.
Title: The hallucinogen d-lysergic diethylamide (LSD) decreases dopamine firing activity through 5-HT

Results demonstrate that betaArr2 signaling may be an important pathway for TAAR1 function and that the activation of the TAAR1-D2R complex negatively modulates GSK3b signaling
Title: Trace amine-associated receptor 1 activation silences GSK3? signaling of TAAR1 and D2R heteromers.

The different functionality of rat Taar subtypes 1 and 4 mainly correlates with receptor's cell surface expression rather than with specific amino acid residues involved in ligand binding specificity.
Title: Determinants involved in subtype-specific functions of rat trace amine-associated receptors 1 and 4.

Data show that TAARs were expressed only at trace amounts in most of the tissues, the exceptions being TAAR1 in stomach and testis and TAAR8a in intestine, spleen, and testis.
Title: Distribution of exogenous [125I]-3-iodothyronamine in mouse in vivo: relationship with trace amine-associated receptors.

The following Taar1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Taar1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa12836	NM_134328.1 Latest version!	Rattus norvegicus trace-amine-associated receptor 1 (Taar1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Taar1 ( NM_134328.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_599155.1 Rattus norvegicus trace-amine-associated receptor 1 (Taar1), mRNA.

Price & Availability↑

CloneID	ORa12836
Clone ID Related Accession (Same CDS sequence)	NM_134328.1
Accession Version	NM_134328.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 999bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Rattus norvegicus(Norway rat)
Product	trace amine-associated receptor 1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF421352.1. ##Evidence-Data-START## Transcript exon combination :: AF421352.1 [ECO:0000332] ##Evidence-Data-END##

ATGCATCTTT GCCACAATAG CGCGAATATT TCCCACACGA ACAGCAACTG GTCAAGGGAT 
GTCCGTGCTT CACTGTACAG CTTAATATCA CTCATAATTC TAACCACTCT GGTTGGCAAC 
TTAATAGTAA TCATTTCGAT ATCCCACTTC AAGCAACTTC ACACGCCCAC AAATTGGCTC 
CTTCATTCCA TGGCCGTTGT CGACTTTCTG CTGGGCTGTC TGGTCATGCC CTACAGCATG 
GTGAGAACAG TTGAGCACTG CTGGTACTTT GGGGAACTCT TCTGCAAACT TCACACCAGC 
ACTGATATCA TGCTGAGCTC GGCATCCATT CTCCACCTAG CCTTCATTTC CATTGACCGC 
TACTATGCTG TGTGCGACCC TTTAAGATAC AAAGCCAAGA TCAATCTCGC CGCCATTTTT 
GTGATGATCC TCATTAGCTG GAGCCTTCCT GCTGTTTTTG CATTTGGGAT GATCTTCCTG 
GAGCTGAACT TAGAAGGAGT TGAGGAGCAG TATCACAATC AGGTCTTCTG CCTGCGCGGC 
TGTTTTCCCT TCTTCAGTAA AGTATCTGGG GTACTGGCAT TCATGACGTC TTTCTATATA 
CCTGGATCTG TTATGTTATT TGTTTACTAT AGAATATATT TCATAGCTAA AGGACAAGCG 
AGGTCAATTA ATCGTGCAAA TCTTCAAGTT GGATTGGAAG GGGAAAGCAG AGCGCCACAA 
AGCAAGGAAA CAAAAGCCGC AAAAACCTTA GGGATCATGG TGGGCGTTTT CCTCCTGTGC 
TGGTGCCCGT TCTTTTTCTG CATGGTCCTG GACCCTTTCC TGGGCTATGT TATCCCACCC 
ACTCTGAATG ACACACTGAA TTGGTTCGGG TACCTGAACT CTGCCTTCAA CCCGATGGTT 
TATGCCTTTT TCTATCCCTG GTTCAGAAGA GCGTTGAAGA TGGTTCTCTT CGGTAAAATT 
TTCCAAAAAG ATTCATCTAG GTCTAAGTTA TTTTTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_599155.1
CDS	1..999
Translation	MHLCHNSANISHTNSNWSRDVRASLYSLISLIILTTLVGNLIVIISISHFKQLHTPTNWLLHSMAVVDFLLGCLVMPYSMVRTVEHCWYFGELFCKLHTSTDIMLSSASILHLAFISIDRYYAVCDPLRYKAKINLAAIFVMILISWSLPAVFAFGMIFLELNLEGVEEQYHNQVFCLRGCFPFFSKVSGVLAFMTSFYIPGSVMLFVYYRIYFIAKGQARSINRANLQVGLEGESRAPQSKETKAAKTLGIMVGVFLLCWCPFFFCMVLDPFLGYVIPPTLNDTLNWFGYLNSAFNPMVYAFFYPWFRRALKMVLFGKIFQKDSSRSKLFL

Target ORF information:

RefSeq Version	NM_134328.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus trace-amine-associated receptor 1 (Taar1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_134328.1

ORF Insert Sequence:

ATGCATCTTT GCCACAATAG CGCGAATATT TCCCACACGA ACAGCAACTG GTCAAGGGAT 
GTCCGTGCTT CACTGTACAG CTTAATATCA CTCATAATTC TAACCACTCT GGTTGGCAAC 
TTAATAGTAA TCATTTCGAT ATCCCACTTC AAGCAACTTC ACACGCCCAC AAATTGGCTC 
CTTCATTCCA TGGCCGTTGT CGACTTTCTG CTGGGCTGTC TGGTCATGCC CTACAGCATG 
GTGAGAACAG TTGAGCACTG CTGGTACTTT GGGGAACTCT TCTGCAAACT TCACACCAGC 
ACTGATATCA TGCTGAGCTC GGCATCCATT CTCCACCTAG CCTTCATTTC CATTGACCGC 
TACTATGCTG TGTGCGACCC TTTAAGATAC AAAGCCAAGA TCAATCTCGC CGCCATTTTT 
GTGATGATCC TCATTAGCTG GAGCCTTCCT GCTGTTTTTG CATTTGGGAT GATCTTCCTG 
GAGCTGAACT TAGAAGGAGT TGAGGAGCAG TATCACAATC AGGTCTTCTG CCTGCGCGGC 
TGTTTTCCCT TCTTCAGTAA AGTATCTGGG GTACTGGCAT TCATGACGTC TTTCTATATA 
CCTGGATCTG TTATGTTATT TGTTTACTAT AGAATATATT TCATAGCTAA AGGACAAGCG 
AGGTCAATTA ATCGTGCAAA TCTTCAAGTT GGATTGGAAG GGGAAAGCAG AGCGCCACAA 
AGCAAGGAAA CAAAAGCCGC AAAAACCTTA GGGATCATGG TGGGCGTTTT CCTCCTGTGC 
TGGTGCCCGT TCTTTTTCTG CATGGTCCTG GACCCTTTCC TGGGCTATGT TATCCCACCC 
ACTCTGAATG ACACACTGAA TTGGTTCGGG TACCTGAACT CTGCCTTCAA CCCGATGGTT 
TATGCCTTTT TCTATCCCTG GTTCAGAAGA GCGTTGAAGA TGGTTCTCTT CGGTAAAATT 
TTCCAAAAAG ATTCATCTAG GTCTAAGTTA TTTTTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Role of TAAR1 within the Subregions of the Mesocorticolimbic Dopaminergic System in Cocaine-Seeking Behavior.
The Journal of neuroscience : the official journal of the Society for Neuroscience37(4)882-892(2017 Jan)
Liu JF,Siemian JN,Seaman R Jr,Zhang Y,Li JX

The hallucinogen d-lysergic diethylamide (LSD) decreases dopamine firing activity through 5-HT
Pharmacological research113(Pt A)81-91(2016 Nov)
De Gregorio D,Posa L,Ochoa-Sanchez R,McLaughlin R,Maione S,Comai S,Gobbi G

Trace amine-associated receptor 1 activation silences GSK3? signaling of TAAR1 and D2R heteromers.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology25(11)2049-61(2015 Nov)
Harmeier A,Obermueller S,Meyer CA,Revel FG,Buchy D,Chaboz S,Dernick G,Wettstein JG,Iglesias A,Rolink A,Bettler B,Hoener MC

Determinants involved in subtype-specific functions of rat trace amine-associated receptors 1 and 4.
British journal of pharmacology168(5)1266-78(2013 Mar)
St?ubert C,Bohnekamp J,Sch?neberg T

Distribution of exogenous [125I]-3-iodothyronamine in mouse in vivo: relationship with trace amine-associated receptors.
The Journal of endocrinology213(3)223-30(2012 Jun)
Chiellini G,Erba P,Carnicelli V,Manfredi C,Frascarelli S,Ghelardoni S,Mariani G,Zucchi R

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Taar1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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