Nupr1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Stress Response Gene Nupr1 Alleviates Cyclosporin A Nephrotoxicity In Vivo.
Galichon P, Bataille A, Vandermeersch S, Wetzstein M, Xu-Dubois YC, Legouis D, Hertig A, Buob D, Placier S, Big? N, Lefevre G, Jouanneau C, Martin C, Iovanna JL, Rondeau E
Journal of the American Society of Nephrology : JASN28(2)545-556(2017 Feb)

Nupr1 Modulates Methamphetamine-Induced Dopaminergic Neuronal Apoptosis and Autophagy through CHOP-Trib3-Mediated Endoplasmic Reticulum Stress Signaling Pathway.
Xu X, Huang E, Tai Y, Zhao X, Chen X, Chen C, Chen R, Liu C, Lin Z, Wang H, Xie WB
Frontiers in molecular neuroscience10203(2017)

Nupr1/Chop signal axis is involved in mitochondrion-related endothelial cell apoptosis induced by methamphetamine.
Cai D, Huang E, Luo B, Yang Y, Zhang F, Liu C, Lin Z, Xie WB, Wang H
Cell death & disease7e2161(2016 Mar)

Nupr1 deletion protects against glucose intolerance by increasing beta cell mass.
Barbosa-Sampaio HC, Liu B, Drynda R, Rodriguez de Ledesma AM, King AJ, Bowe JE, Malicet C, Iovanna JL, Jones PM, Persaud SJ, Muller DS
Diabetologia56(11)2477-86(2013 Nov)

A role for the transcriptional regulator p8 in autophagy, is demonstrated.
Title: Deficiency of the transcriptional regulator p8 results in increased autophagy and apoptosis, and causes impaired heart function.

These results identify an unexpectedly broad involvement for p8 in key cellular events linked to cardiomyocyte hypertrophy and cardiac fibroblast matrix metalloproteases production, both of which occur in heart failure.
Title: Helix-loop-helix protein p8, a transcriptional regulator required for cardiomyocyte hypertrophy and cardiac fibroblast matrix metalloprotease induction.

TNFalpha-induced NF kappaB pathway contributes to the induction of p8 during pancreatitis and lipopolysaccharide-induced inflammation.
Title: Tumor necrosis factor alpha induces the expression of the nuclear protein p8 via a novel NF kappaB binding site within the promoter.

Astrocytes are sensitized to oxidative stress via a p38 mitogen-activated protein kinase-dependent p8 upregulation that leads in turn to decreased heme oxygenase 1 expression
Title: p8 Upregulation sensitizes astrocytes to oxidative stress.

strongly induced in ET-1-treated renal mesangial cells and in an animal model of diabetic nephropathy
Title: The pro-hypertrophic basic helix-loop-helix protein p8 is degraded by the ubiquitin/proteasome system in a protein kinase B/Akt- and glycogen synthase kinase-3-dependent manner, whereas endothelin induction of p8 mRNA and renal mesangial cell hypertrophy require NFAT4.