Oca2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Oca2
Entrez Gene ID	100365773
Full Name	pink-eyed dilution-like
Synonyms	Oca2,p
General protein information	Preferred Names pink-eyed dilution-like Names P protein oculocutaneous albinism II
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q22

mRNA and Protein(s)

mRNA	Protein	Name
NM_001271493.1	NP_001258422.1	P protein

Pathways from BioSystems

Homologies

	LOC712220	XP_002804735.1
Pan troglodytes (chimpanzee)	OCA2	XP_001162129.1
Mus musculus (house mouse)	Oca2	NP_068679.1
Bos taurus (cattle)	LOC524289	XP_002685246.1
Xenopus tropicalis (tropical clawed frog)	oca2	XP_002937026.2
Danio rerio (zebrafish)	oca2	XP_695807.5
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP009283	XP_320079.4
Homo sapiens (human)	OCA2	NP_000266.2
Canis lupus familiaris (dog)	LOC488683	XP_545800.3
Rattus norvegicus (Norway rat)	LOC100365773	NP_001258422.1
Gallus gallus (chicken)	OCA2	XP_425579.4

Gene Ontology
Bibliography

Related articles in PubMed

Localization to mature melanosomes by virtue of cytoplasmic dileucine motifs is required for human OCA2 function.
Sitaram A, Piccirillo R, Palmisano I, Harper DC, Dell'Angelica EC, Schiaffino MV, Marks MS
Molecular biology of the cell20(5)1464-77(2009 Mar)

The rat pink-eyed dilution (p) mutation: an identical intragenic deletion in pink-eye dilute-coat strains and several Wistar-derived albino strains.
Kuramoto T, Gohma H, Kimura K, Wedekind D, Hedrich HJ, Serikawa T
Mammalian genome : official journal of the International Mammalian Genome Society16(9)712-9(2005 Sep)

Increased frequency of DNA deletions in pink-eyed unstable mice carrying a mutation in the Werner syndrome gene homologue.
Lebel M
Carcinogenesis23(1)213-6(2002 Jan)

Slate--a new coat color mutant in the mouse.
PIERRO LJ, CHASE HB
The Journal of heredity5447-50(1963 Mar-Apr)

The Effects of Genotype and Cell Environment on Melanoblast Differentiation in the House Mouse.
Markert CL, Silvers WK
Genetics41(3)429-50(1956 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Oca2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Oca2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa41807	NM_001271493.1 Latest version!	Rattus norvegicus OCA2 melanosomal transmembrane protein (Oca2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$475.30 $679.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Oca2 ( NM_001271493.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001258422.1 Rattus norvegicus OCA2 melanosomal transmembrane protein (Oca2), mRNA.

Price & Availability↑

CloneID	ORa41807
Clone ID Related Accession (Same CDS sequence)	NM_001271493.1
Accession Version	NM_001271493.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2529bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-17
Organism	Rattus norvegicus(Norway rat)
Product	P protein
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AAHX01005530.1, AAHX01005531.1, AAHX01005533.1, AAHX01005535.1, AAHX01005539.1, AAHX01005540.1 and AAHX01005543.1. On Sep 29, 2012 this sequence version replaced XM_002725626.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: AB191343.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689601 [ECO:0000348] ##Evidence-Data-END##

ATGCACCTTG AGAACAAAGA CATCAGGCTG GCCTCAGCCA TGCTGGAAGT AGAGCTACAC 
CAGACATCTG CTCTGTCAGT TCCAACTTGC CCAGACCCAG GACGGCCGCT GACAGTCAAA 
CCCACTGCCA GTAACTATGA GCTCGGCCAG GCAGACCCCT GCATCCCACA TGCTGGTGAG 
GCTGCTGGGA AGAGCCCCTG TGTTCCTGAA CATGCAGAAT TTGGCTCATT CCTTATGAAG 
GGGAGGACTC ATTCGCCTTT GTCTCAGTTC AGCTCCAGCT TAAAAGACCT TTCTTTTAAG 
GAAGACACTC CTCTGCTGTG GAATTCCCCA CAAAAGAAAA GGTCTCAGTT CATGCCTGTT 
CATCACCCAG AATTCATAGC TACTGAAGAT TCATGGGAAA GCGGCCTGAC TGTCTGGGAG 
CAAAAATGCA TGCTGGGTAA AGAAGTTGCA GATTTGTCTG CATTGGCCTC CTCAGAGAAA 
GGGGATCTTG CAGGCGGTGT CCACCTTAGA GCCCAGGTCT CCAAGCTTGG ATGCTGTGTG 
CGCTGGATGA AGATCACAGG CTTGTTTGTT TTCGTGGTGC TGTGCTCTAT TTTATTCAGC 
CTGTATCCAG ATCAAGGAAA GCTATGGCAG CTGTTGGCCG TGTCTCCGCT GGAAAACTAC 
TCTGTGACCC TCAGTGGCCG CGCTGACTCC ATAATTCTTC AGCTGGACCT GGCAGGGGCC 
TTAATGCCTG GCGGACCAAG TGGTTCAGGG AAAGAAGAAC ATGTCATGGT GGTGGTGACT 
CAGACAGACG CCGTGGGCAA CAGATGGCGG CGACCACAGC AGGTCACTCA CAATTGGACT 
GTCCCTTTAA ATCCAAGAAG CGAGCACGTG GTGGTGAGCA GAACCTTTGA GATAGTGAGC 
AGGGAGGCTG TTTCTATCAG CATCCAGGCC TCTCTACAAC AGACTCGCCT TGTTCCTCTC 
TTGCTGGCCC ATCAGTTCCT TGGGGCAAGT GTTGAAGCAC AAGTGGCAAG CGCGGTGGCC 
ATCCTCACAG GGGTTTATAC TCTGATCATA TTTGAGATTG TTCACAGAAC CCTGGCAGCC 
ATGTTGGGAG CTCTTGCAGC ACTAGCAGCT TTGGCTGTGG TTGGAGATAG ACCCAGCCTG 
ACCCACGTGG TGGAGTGGAT TGATTTTGAG ACTCTGGCCC TGCTGTTTGG CATGATGATC 
TTGGTAGCTA TATTTTCAGA AACAGGATTT TTTGATTACT GTGCTGTAAA GGCATACCAG 
CTTTCTCGAG GAAGAGTGTG GGCCATGATA ATCATGCTTT GTCTCATGGC TGCCATCCTT 
TCTGCCTTCT TAGACAATGT CACCACGATG CTCCTTTTTA CCCCTGTCAC CATAAGGTTA 
TGTGAGGTGC TCAACCTTGA TCCAAGACAA GTCCTCATTG CAGAAGTGAT CTTCACAAAC 
ATTGGAGGAG CCGCCACTGC TATTGGGGAC CCACCAAATG TTATCATTGT GTCCAATCAG 
GAGTTAAGGA AAATGGGTCT GGACTTCGCT GGTTTCACAG CACACATGTT CCTGGGAATT 
TGCCTTGTTC TCCTGGTTTC CTTTCCCCTC CTCAGACTCC TGTATTGGAA CAAAAAGCTT 
TATAACAAGG AGCCTAGTGA GATCGTCGAG CTGAAGCATG AGATTCATGT CTGGCGTTTG 
ACAGCCCAGC GCATCAGTCC AGCCAGCCGT GAGGAGACAG CTGTGCGTGG CTTGCTGCTG 
GAGAAAGTGC TTGCCCTGGA GCATCTGCTG GCTCAAAGGC TGCATACTTT CCACAGACAA 
ATTTCACAGG AAGACAAAAA TTGGGAGACC AATATCCAAG AGCTACAAAG AAAGCATAGG 
ATATCAGACA GGAGTCTGCT TGTCAAGTGC CTGACGGTGC TGGGATTTGT CATCTCCATG 
TTTTTTCTCA ACTCCTTTGT CCCTGGCATT CACCTTGATC TTGGATGGAT TGCTATTCTG 
GGTGCCATCT GGTTGCTAAT TTTAGCTGAT ATTCATGACT TTGAGATCAT TCTACACAGA 
GTAGAGTGGG CGACTCTCCT CTTCTTTGCA GCACTCTTTG TGCTGATGGA GGCATTGACA 
CATCTTCACT TAGTAGAATA TGTTGGAGAA CAGACTGCCC TGCTAATAAA GATGGTTCCA 
GAAGATCAGC GCTTTGCAGC TGCCATTGTC CTAATAGTGT GGGTCTCAGC CTTGGCATCG 
TCCTTGATTG ACAACATCCC ATTCACTGCT ACAATGATTC CTGTCCTCCT GAACCTGAGC 
CAAGACCCTG AAATTAGTTT GCCTGCACTG CCTCTCATGT ATGCCCTGGC CCTTGGTGCC 
TGCCTGGGAG GTAACGGGAC ACTGATAGGA GCATCTGCAA ATGTTGTTTG CGCAGGAATC 
GCAGAGCAGC ATGGGTATGG ATTCTCTTTC ATGGAATTTT TCAGGTTGGG CTTCCCCATG 
ATGCTCATGT CCTGCACCAT TGGGATGTGC TATCTCCTGA TTGCTCATGT TGTGGTGGGA 
TGGAATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001258422.1
CDS	126..2654
Translation	MHLENKDIRLASAMLEVELHQTSALSVPTCPDPGRPLTVKPTASNYELGQADPCIPHAGEAAGKSPCVPEHAEFGSFLMKGRTHSPLSQFSSSLKDLSFKEDTPLLWNSPQKKRSQFMPVHHPEFIATEDSWESGLTVWEQKCMLGKEVADLSALASSEKGDLAGGVHLRAQVSKLGCCVRWMKITGLFVFVVLCSILFSLYPDQGKLWQLLAVSPLENYSVTLSGRADSIILQLDLAGALMPGGPSGSGKEEHVMVVVTQTDAVGNRWRRPQQVTHNWTVPLNPRSEHVVVSRTFEIVSREAVSISIQASLQQTRLVPLLLAHQFLGASVEAQVASAVAILTGVYTLIIFEIVHRTLAAMLGALAALAALAVVGDRPSLTHVVEWIDFETLALLFGMMILVAIFSETGFFDYCAVKAYQLSRGRVWAMIIMLCLMAAILSAFLDNVTTMLLFTPVTIRLCEVLNLDPRQVLIAEVIFTNIGGAATAIGDPPNVIIVSNQELRKMGLDFAGFTAHMFLGICLVLLVSFPLLRLLYWNKKLYNKEPSEIVELKHEIHVWRLTAQRISPASREETAVRGLLLEKVLALEHLLAQRLHTFHRQISQEDKNWETNIQELQRKHRISDRSLLVKCLTVLGFVISMFFLNSFVPGIHLDLGWIAILGAIWLLILADIHDFEIILHRVEWATLLFFAALFVLMEALTHLHLVEYVGEQTALLIKMVPEDQRFAAAIVLIVWVSALASSLIDNIPFTATMIPVLLNLSQDPEISLPALPLMYALALGACLGGNGTLIGASANVVCAGIAEQHGYGFSFMEFFRLGFPMMLMSCTIGMCYLLIAHVVVGWN

Target ORF information:

RefSeq Version	NM_001271493.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus OCA2 melanosomal transmembrane protein (Oca2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001271493.1

ORF Insert Sequence:

ATGCACCTTG AGAACAAAGA CATCAGGCTG GCCTCAGCCA TGCTGGAAGT AGAGCTACAC 
CAGACATCTG CTCTGTCAGT TCCAACTTGC CCAGACCCAG GACGGCCGCT GACAGTCAAA 
CCCACTGCCA GTAACTATGA GCTCGGCCAG GCAGACCCCT GCATCCCACA TGCTGGTGAG 
GCTGCTGGGA AGAGCCCCTG TGTTCCTGAA CATGCAGAAT TTGGCTCATT CCTTATGAAG 
GGGAGGACTC ATTCGCCTTT GTCTCAGTTC AGCTCCAGCT TAAAAGACCT TTCTTTTAAG 
GAAGACACTC CTCTGCTGTG GAATTCCCCA CAAAAGAAAA GGTCTCAGTT CATGCCTGTT 
CATCACCCAG AATTCATAGC TACTGAAGAT TCATGGGAAA GCGGCCTGAC TGTCTGGGAG 
CAAAAATGCA TGCTGGGTAA AGAAGTTGCA GATTTGTCTG CATTGGCCTC CTCAGAGAAA 
GGGGATCTTG CAGGCGGTGT CCACCTTAGA GCCCAGGTCT CCAAGCTTGG ATGCTGTGTG 
CGCTGGATGA AGATCACAGG CTTGTTTGTT TTCGTGGTGC TGTGCTCTAT TTTATTCAGC 
CTGTATCCAG ATCAAGGAAA GCTATGGCAG CTGTTGGCCG TGTCTCCGCT GGAAAACTAC 
TCTGTGACCC TCAGTGGCCG CGCTGACTCC ATAATTCTTC AGCTGGACCT GGCAGGGGCC 
TTAATGCCTG GCGGACCAAG TGGTTCAGGG AAAGAAGAAC ATGTCATGGT GGTGGTGACT 
CAGACAGACG CCGTGGGCAA CAGATGGCGG CGACCACAGC AGGTCACTCA CAATTGGACT 
GTCCCTTTAA ATCCAAGAAG CGAGCACGTG GTGGTGAGCA GAACCTTTGA GATAGTGAGC 
AGGGAGGCTG TTTCTATCAG CATCCAGGCC TCTCTACAAC AGACTCGCCT TGTTCCTCTC 
TTGCTGGCCC ATCAGTTCCT TGGGGCAAGT GTTGAAGCAC AAGTGGCAAG CGCGGTGGCC 
ATCCTCACAG GGGTTTATAC TCTGATCATA TTTGAGATTG TTCACAGAAC CCTGGCAGCC 
ATGTTGGGAG CTCTTGCAGC ACTAGCAGCT TTGGCTGTGG TTGGAGATAG ACCCAGCCTG 
ACCCACGTGG TGGAGTGGAT TGATTTTGAG ACTCTGGCCC TGCTGTTTGG CATGATGATC 
TTGGTAGCTA TATTTTCAGA AACAGGATTT TTTGATTACT GTGCTGTAAA GGCATACCAG 
CTTTCTCGAG GAAGAGTGTG GGCCATGATA ATCATGCTTT GTCTCATGGC TGCCATCCTT 
TCTGCCTTCT TAGACAATGT CACCACGATG CTCCTTTTTA CCCCTGTCAC CATAAGGTTA 
TGTGAGGTGC TCAACCTTGA TCCAAGACAA GTCCTCATTG CAGAAGTGAT CTTCACAAAC 
ATTGGAGGAG CCGCCACTGC TATTGGGGAC CCACCAAATG TTATCATTGT GTCCAATCAG 
GAGTTAAGGA AAATGGGTCT GGACTTCGCT GGTTTCACAG CACACATGTT CCTGGGAATT 
TGCCTTGTTC TCCTGGTTTC CTTTCCCCTC CTCAGACTCC TGTATTGGAA CAAAAAGCTT 
TATAACAAGG AGCCTAGTGA GATCGTCGAG CTGAAGCATG AGATTCATGT CTGGCGTTTG 
ACAGCCCAGC GCATCAGTCC AGCCAGCCGT GAGGAGACAG CTGTGCGTGG CTTGCTGCTG 
GAGAAAGTGC TTGCCCTGGA GCATCTGCTG GCTCAAAGGC TGCATACTTT CCACAGACAA 
ATTTCACAGG AAGACAAAAA TTGGGAGACC AATATCCAAG AGCTACAAAG AAAGCATAGG 
ATATCAGACA GGAGTCTGCT TGTCAAGTGC CTGACGGTGC TGGGATTTGT CATCTCCATG 
TTTTTTCTCA ACTCCTTTGT CCCTGGCATT CACCTTGATC TTGGATGGAT TGCTATTCTG 
GGTGCCATCT GGTTGCTAAT TTTAGCTGAT ATTCATGACT TTGAGATCAT TCTACACAGA 
GTAGAGTGGG CGACTCTCCT CTTCTTTGCA GCACTCTTTG TGCTGATGGA GGCATTGACA 
CATCTTCACT TAGTAGAATA TGTTGGAGAA CAGACTGCCC TGCTAATAAA GATGGTTCCA 
GAAGATCAGC GCTTTGCAGC TGCCATTGTC CTAATAGTGT GGGTCTCAGC CTTGGCATCG 
TCCTTGATTG ACAACATCCC ATTCACTGCT ACAATGATTC CTGTCCTCCT GAACCTGAGC 
CAAGACCCTG AAATTAGTTT GCCTGCACTG CCTCTCATGT ATGCCCTGGC CCTTGGTGCC 
TGCCTGGGAG GTAACGGGAC ACTGATAGGA GCATCTGCAA ATGTTGTTTG CGCAGGAATC 
GCAGAGCAGC ATGGGTATGG ATTCTCTTTC ATGGAATTTT TCAGGTTGGG CTTCCCCATG 
ATGCTCATGT CCTGCACCAT TGGGATGTGC TATCTCCTGA TTGCTCATGT TGTGGTGGGA 
TGGAATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Localization to mature melanosomes by virtue of cytoplasmic dileucine motifs is required for human OCA2 function.
Molecular biology of the cell20(5)1464-77(2009 Mar)
Sitaram A,Piccirillo R,Palmisano I,Harper DC,Dell'Angelica EC,Schiaffino MV,Marks MS

The rat pink-eyed dilution (p) mutation: an identical intragenic deletion in pink-eye dilute-coat strains and several Wistar-derived albino strains.
Mammalian genome : official journal of the International Mammalian Genome Society16(9)712-9(2005 Sep)
Kuramoto T,Gohma H,Kimura K,Wedekind D,Hedrich HJ,Serikawa T

Increased frequency of DNA deletions in pink-eyed unstable mice carrying a mutation in the Werner syndrome gene homologue.
Carcinogenesis23(1)213-6(2002 Jan)
Lebel M

Slate--a new coat color mutant in the mouse.
The Journal of heredity5447-50(1963 Mar-Apr)
PIERRO LJ,CHASE HB

The Effects of Genotype and Cell Environment on Melanoblast Differentiation in the House Mouse.
Genetics41(3)429-50(1956 May)
Markert CL,Silvers WK

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Oca2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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