| Gene Symbol | IGF2 |
| Entrez Gene ID | 443325 |
| Full Name | insulin like growth factor 2 |
| Synonyms | IGF-II |
| Gene Type | protein-coding |
| Organism | Ovis aries(sheep) |
ORF » Species Summary » Ovis aries » IGF2 cDNA ORF clone
| Gene Symbol | IGF2 |
| Entrez Gene ID | 443325 |
| Full Name | insulin like growth factor 2 |
| Synonyms | IGF-II |
| Gene Type | protein-coding |
| Organism | Ovis aries(sheep) |
| mRNA | Protein | Name |
|---|---|---|
| XM_012101544.2 | XP_011956934.1 | insulin-like growth factor II isoform X1 |
| XM_015102891.1 | XP_014958377.1 | insulin-like growth factor II isoform X2 |
| XM_027959249.1 | XP_027815050.1 | insulin-like growth factor II isoform X1 |
| XM_027959253.1 | XP_027815054.1 | insulin-like growth factor II isoform X2 |
| XM_015102891.2 | XP_014958377.1 | insulin-like growth factor II isoform X2 |
| XM_027959250.1 | XP_027815051.1 | insulin-like growth factor II isoform X1 |
| XM_027959252.1 | XP_027815053.1 | insulin-like growth factor II isoform X2 |
| NM_001009311.1 | NP_001009311.1 | insulin-like growth factor II preproprotein |
Periconceptional undernutrition modifies endocrine profiles and hepatic gene expression in sheep.
de Brun V, Meikle A, Casal A, Sequeira M, Contreras-Sol?s I, Carriquiry M, Forcada F, Sosa C, Abecia JA
Journal of animal physiology and animal nutrition99(4)710-8(2015 Aug)
Effects of different dietary intake on mRNA levels of MSTN, IGF-I, and IGF-II in the skeletal muscle of Dorper and Hu sheep hybrid F1 rams.
Xing HJ, Wang ZY, Zhong BS, Ying SJ, Nie HT, Zhou ZR, Fan YX, Wang F
Genetics and molecular research : GMR13(3)5258-68(2014 Jul)
Fertility in a high-altitude environment is compromised by luteal dysfunction: the relative roles of hypoxia and oxidative stress.
Parraguez VH, Urquieta B, P?rez L, Castellaro G, De los Reyes M, Torres-Rovira L, Aguado-Mart?nez A, Astiz S, Gonz?lez-Bulnes A
Reproductive biology and endocrinology : RB&E1124(2013 Mar)
Fetal growth restriction and the programming of heart growth and cardiac insulin-like growth factor 2 expression in the lamb.
Wang KC, Zhang L, McMillen IC, Botting KJ, Duffield JA, Zhang S, Suter CM, Brooks DA, Morrison JL
The Journal of physiology589(Pt 19)4709-22(2011 Oct)
Periconceptional undernutrition in normal and overweight ewes leads to increased adrenal growth and epigenetic changes in adrenal IGF2/H19 gene in offspring.
Zhang S, Rattanatray L, MacLaughlin SM, Cropley JE, Suter CM, Molloy L, Kleemann D, Walker SK, Muhlhausler BS, Morrison JL, McMillen IC
FASEB journal : official publication of the Federation of American Societies for Experimental Biology24(8)2772-82(2010 Aug)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
The mRNA expression levels of MSTN, IGF-1 and IGF-2 were significantly different in the same skeletal muscle under different dietary intake.
Title: Effects of different dietary intake on mRNA levels of MSTN, IGF-I, and IGF-II in the skeletal muscle of Dorper and Hu sheep hybrid F1 rams.
Data show that both short- and long-term exposure to high-altitude conditions decreased luteal growth and IGF-I and IGF-II gene expression but increased HIF-1 alpha and VEGF immunoexpression.
Title: Fertility in a high-altitude environment is compromised by luteal dysfunction: the relative roles of hypoxia and oxidative stress.
In PR fetal sheep, IGF-2, IGF-1R and IGF-2R mRNA expression was increased in the heart compared to controls.
Title: Fetal growth restriction and the programming of heart growth and cardiac insulin-like growth factor 2 expression in the lamb.
weight loss in both normal and overweight mothers during the periconceptional period results in epigenetic modification of IGF2 in the adrenal gland, adrenal overgrowth, and increased vulnerability to stress in offspring
Title: Periconceptional undernutrition in normal and overweight ewes leads to increased adrenal growth and epigenetic changes in adrenal IGF2/H19 gene in offspring.
investigation whether the ovine H19-IGF2 and IGF2R loci are imprinted and analysis of their DNA methylation status in cloned lambs [IGF2, H19, & IGF2R]
Title: Conservation of IGF2-H19 and IGF2R imprinting in sheep: effects of somatic cell nuclear transfer.
The following IGF2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the IGF2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OSm21560 | |
| Clone ID Related Accession (Same CDS sequence) | XM_015102891.1 , XM_027959253.1 , XM_015102891.2 , XM_027959252.1 , NM_001009311.1 | |
| Accession Version | NM_001009311.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 540bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-12-24 | |
| Organism | Ovis aries(sheep) | |
| Product | insulin-like growth factor II preproprotein | |
| Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from X55638.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X55638.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA104495026 [ECO:0000348] ##Evidence-Data-END## | |
1 | ATGGGGATCA CAGCAGGAAA GTCGATGCTG GCGCTTCTTG CCTTCTTGGC CTTCGCCTCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_001009311.1 |
| CDS | 283..822 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_001009311.1 |
1 | ATGGGGATCA CAGCAGGAAA GTCGATGCTG GCGCTTCTTG CCTTCTTGGC CTTCGCCTCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OSm21560 | |
| Clone ID Related Accession (Same CDS sequence) | XM_015102891.1 , XM_027959253.1 , XM_015102891.2 , XM_027959252.1 , NM_001009311.1 | |
| Accession Version | XM_015102891.1 | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 540bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2015-12-16 | |
| Organism | Ovis aries(sheep) | |
| Product | insulin-like growth factor II isoform X2 | |
| Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NW_014639030.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Ovis aries Annotation Release 102 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.5 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## | |
1 | ATGGGGATCA CAGCAGGAAA GTCGATGCTG GCGCTTCTTG CCTTCTTGGC CTTCGCCTCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | XP_014958377.1 |
| CDS | 177..716 |
| Translation |
Target ORF information:
Target ORF information:
|
XM_015102891.1 |
1 | ATGGGGATCA CAGCAGGAAA GTCGATGCTG GCGCTTCTTG CCTTCTTGGC CTTCGCCTCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OSm21560 | |
| Clone ID Related Accession (Same CDS sequence) | XM_015102891.1 , XM_027959253.1 , XM_015102891.2 , XM_027959252.1 , NM_001009311.1 | |
| Accession Version | XM_027959253.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 540bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-02-05 | |
| Organism | Ovis aries(sheep) | |
| Product | insulin-like growth factor II isoform X2 | |
| Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_040272.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Ovis aries Annotation Release 103 Annotation Version :: 103 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## | |
1 | ATGGGGATCA CAGCAGGAAA GTCGATGCTG GCGCTTCTTG CCTTCTTGGC CTTCGCCTCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | XP_027815054.1 |
| CDS | 512..1051 |
| Translation |
Target ORF information:
Target ORF information:
|
XM_027959253.1 |
1 | ATGGGGATCA CAGCAGGAAA GTCGATGCTG GCGCTTCTTG CCTTCTTGGC CTTCGCCTCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OSm21560 | |
| Clone ID Related Accession (Same CDS sequence) | XM_015102891.1 , XM_027959253.1 , XM_015102891.2 , XM_027959252.1 , NM_001009311.1 | |
| Accession Version | XM_015102891.2 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 540bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-02-05 | |
| Organism | Ovis aries(sheep) | |
| Product | insulin-like growth factor II isoform X2 | |
| Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_040272.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Feb 6, 2019 this sequence version replaced XM_015102891.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Ovis aries Annotation Release 103 Annotation Version :: 103 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## | |
1 | ATGGGGATCA CAGCAGGAAA GTCGATGCTG GCGCTTCTTG CCTTCTTGGC CTTCGCCTCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | XP_014958377.1 |
| CDS | 930..1469 |
| Translation |
Target ORF information:
Target ORF information:
|
XM_015102891.2 |
1 | ATGGGGATCA CAGCAGGAAA GTCGATGCTG GCGCTTCTTG CCTTCTTGGC CTTCGCCTCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OSm21560 | |
| Clone ID Related Accession (Same CDS sequence) | XM_015102891.1 , XM_027959253.1 , XM_015102891.2 , XM_027959252.1 , NM_001009311.1 | |
| Accession Version | XM_027959252.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 540bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-02-05 | |
| Organism | Ovis aries(sheep) | |
| Product | insulin-like growth factor II isoform X2 | |
| Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_040272.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Ovis aries Annotation Release 103 Annotation Version :: 103 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## | |
1 | ATGGGGATCA CAGCAGGAAA GTCGATGCTG GCGCTTCTTG CCTTCTTGGC CTTCGCCTCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | XP_027815053.1 |
| CDS | 119..658 |
| Translation |
Target ORF information:
Target ORF information:
|
XM_027959252.1 |
1 | ATGGGGATCA CAGCAGGAAA GTCGATGCTG GCGCTTCTTG CCTTCTTGGC CTTCGCCTCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OSm21789 | |
| Clone ID Related Accession (Same CDS sequence) | XM_012101544.2 , XM_027959249.1 , XM_027959250.1 | |
| Accession Version | XM_012101544.2 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 708bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2015-12-16 | |
| Organism | Ovis aries(sheep) | |
| Product | insulin-like growth factor II isoform X1 | |
| Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NW_014639030.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Dec 17, 2015 this sequence version replaced XM_012101544.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Ovis aries Annotation Release 102 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.5 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## | |
1 | ATGGTTTCCC CAGACCCTCA AATGACCGTG GTGGCCCCCG GGGCTGAACC CGAATCTACG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | XP_011956934.1 |
| CDS | 1124..1831 |
| Translation |
Target ORF information:
Target ORF information:
|
XM_012101544.2 |
1 | ATGGTTTCCC CAGACCCTCA AATGACCGTG GTGGCCCCCG GGGCTGAACC CGAATCTACG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OSm21789 | |
| Clone ID Related Accession (Same CDS sequence) | XM_012101544.2 , XM_027959249.1 , XM_027959250.1 | |
| Accession Version | XM_027959249.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 708bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-02-05 | |
| Organism | Ovis aries(sheep) | |
| Product | insulin-like growth factor II isoform X1 | |
| Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_040272.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Ovis aries Annotation Release 103 Annotation Version :: 103 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## | |
1 | ATGGTTTCCC CAGACCCTCA AATGACCGTG GTGGCCCCCG GGGCTGAACC CGAATCTACG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | XP_027815050.1 |
| CDS | 70..777 |
| Translation |
Target ORF information:
Target ORF information:
|
XM_027959249.1 |
1 | ATGGTTTCCC CAGACCCTCA AATGACCGTG GTGGCCCCCG GGGCTGAACC CGAATCTACG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OSm21789 | |
| Clone ID Related Accession (Same CDS sequence) | XM_012101544.2 , XM_027959249.1 , XM_027959250.1 | |
| Accession Version | XM_027959250.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 708bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-02-05 | |
| Organism | Ovis aries(sheep) | |
| Product | insulin-like growth factor II isoform X1 | |
| Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_040272.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Ovis aries Annotation Release 103 Annotation Version :: 103 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## | |
1 | ATGGTTTCCC CAGACCCTCA AATGACCGTG GTGGCCCCCG GGGCTGAACC CGAATCTACG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | XP_027815051.1 |
| CDS | 547..1254 |
| Translation |
Target ORF information:
Target ORF information:
|
XM_027959250.1 |
1 | ATGGTTTCCC CAGACCCTCA AATGACCGTG GTGGCCCCCG GGGCTGAACC CGAATCTACG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Periconceptional undernutrition modifies endocrine profiles and hepatic gene expression in sheep. |
Effects of different dietary intake on mRNA levels of MSTN, IGF-I, and IGF-II in the skeletal muscle of Dorper and Hu sheep hybrid F1 rams. |
Fertility in a high-altitude environment is compromised by luteal dysfunction: the relative roles of hypoxia and oxidative stress. |
Fetal growth restriction and the programming of heart growth and cardiac insulin-like growth factor 2 expression in the lamb. |
Periconceptional undernutrition in normal and overweight ewes leads to increased adrenal growth and epigenetic changes in adrenal IGF2/H19 gene in offspring. |