FGF2 cDNA ORF clone, Ovis aries(sheep)

Gene
Clones
gRNAs

Summary

Gene Symbol	FGF2
Entrez Gene ID	443306
Full Name	fibroblast growth factor 2
Synonyms	FGF-2
Gene Type	protein-coding
Organism	Ovis aries(sheep)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001009769.1	NP_001009769.1	fibroblast growth factor 2 precursor

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Immunohistochemical localization of fibroblast growth factor-2 in the sheep ovary and its effects on pre-antral follicle apoptosis and development in vitro.
Santos JM, Menezes VG, Barberino RS, Macedo TJ, Lins TL, Gouveia BB, Barros VR, Santos LP, Gon?alves RJ, Matos MH
Reproduction in domestic animals = Zuchthygiene49(3)522-8(2014 Jun)

An investigation of growth factors and lactoferrin in naturally occurring ovine pulmonary adenomatosis.
Sozmen M, Beytut E
Journal of comparative pathology147(4)441-51(2012 Nov)

Compartmentalizing proximal FGFR1 signaling in ovine placental artery endothelial cell caveolae.
Feng L, Zhang HH, Wang W, Zheng J, Chen DB
Biology of reproduction87(2)40(2012 Aug)

Placental vascularity and growth factor expression in singleton, twin, and triplet pregnancies in the sheep.
Vonnahme KA, Evoniuk J, Johnson ML, Borowicz PP, Luther JS, Pant D, Redmer DA, Reynolds LP, Grazul-Bilska AT
Endocrine33(1)53-61(2008 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

this study demonstrated the presence of fibroblast growth factor 2 in ovine ovaries and that it inhibits apoptosis and promotes ovine follicle growth
Title: Immunohistochemical localization of fibroblast growth factor-2 in the sheep ovary and its effects on pre-antral follicle apoptosis and development in vitro.

These results suggest that bFGF, VEGF-C and PDGF-C have roles in the pathogenesis of ovine pulmonary adenomatosis.
Title: An investigation of growth factors and lactoferrin in naturally occurring ovine pulmonary adenomatosis.

proximal fibroblast growth factor (FGF2/FGFR1) signaling is compartmentalized in the placental endothelial caveolae via the FGFR substrate 2alpha that mediates formation of a FRS2alpha-GRB2-GAB1 complex
Title: Compartmentalizing proximal FGFR1 signaling in ovine placental artery endothelial cell caveolae.

Reduced fetal and placental weights in twins and/or triplet pregnancies are associated with an overall decrease in total placental vascularity, VEGF and FGF2 and/or FGFR protein expression.
Title: Placental vascularity and growth factor expression in singleton, twin, and triplet pregnancies in the sheep.

Exogenous human FGF-2 increased endogenous FGF-2 promoter activity and protein levels in ovine pulmonary arterial smooth muscle cells.
Title: Regulation of fibroblast growth factor-2 expression in pulmonary arterial smooth muscle cells involves increased reactive oxygen species generation.

The following FGF2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the FGF2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OSm00187	NM_001009769.1 Latest version!	Ovis aries fibroblast growth factor 2 (FGF2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$104.30 $149.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

FGF2 ( NM_001009769.1 ) cDNA ORF clone, Ovis aries(sheep) -> NP_001009769.1 Ovis aries fibroblast growth factor 2 (FGF2), mRNA.

Price & Availability↑

CloneID	OSm00187
Clone ID Related Accession (Same CDS sequence)	NM_001009769.1
Accession Version	NM_001009769.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 468bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Ovis aries(sheep)
Product	fibroblast growth factor 2 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from L36136.1. ##Evidence-Data-START## Transcript exon combination :: DQ091182.1, L36136.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA104494983, SAMEA104495001 [ECO:0000348] ##Evidence-Data-END##

ATGGCCGCCG GGAGCATCAC CACGCTGCCA GCCCTGCCGG AGGACGGCGG CAGCAGCGCT 
TTCCCGCCCG GCCACTTTAA GGACCCCAAG CGGCTGTACT GCAAGAACGG GGGCTTCTTC 
CTGCGCATCC ACCCCGACGG CCGAGTGGAC GGGGTCCGCG AGAAGAGCGA CCCTCACATC 
AAACTACAAC TTCAAGCAGA AGAGAGAGGG GTTGTGTCTA TCAAAGGAGT GTGTGCAAAC 
CGTTACCTTG CTATGAAAGA AGATGGAAGA TTACTAGCTT CTAAATGTGT TACAGACGAG 
TGTTTCTTTT TTGAACGATT GGAGTCTAAT AACTACAATA CTTACCGGTC AAGGAAATAC 
TCCAGTTGGT ATGTGGCACT GAAACGAACT GGGCAGTATA AACTTGGACC CAAAACAGGA 
CCTGGGCAGA AAGCTATACT TTTTCTTCCA ATGTCTGCTA AGAGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001009769.1
CDS	1..468
Translation	MAAGSITTLPALPEDGGSSAFPPGHFKDPKRLYCKNGGFFLRIHPDGRVDGVREKSDPHIKLQLQAEERGVVSIKGVCANRYLAMKEDGRLLASKCVTDECFFFERLESNNYNTYRSRKYSSWYVALKRTGQYKLGPKTGPGQKAILFLPMSAKS

Target ORF information:

RefSeq Version	NM_001009769.1
Organism	Ovis aries(sheep)
Definition	Ovis aries fibroblast growth factor 2 (FGF2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001009769.1

ORF Insert Sequence:

ATGGCCGCCG GGAGCATCAC CACGCTGCCA GCCCTGCCGG AGGACGGCGG CAGCAGCGCT 
TTCCCGCCCG GCCACTTTAA GGACCCCAAG CGGCTGTACT GCAAGAACGG GGGCTTCTTC 
CTGCGCATCC ACCCCGACGG CCGAGTGGAC GGGGTCCGCG AGAAGAGCGA CCCTCACATC 
AAACTACAAC TTCAAGCAGA AGAGAGAGGG GTTGTGTCTA TCAAAGGAGT GTGTGCAAAC 
CGTTACCTTG CTATGAAAGA AGATGGAAGA TTACTAGCTT CTAAATGTGT TACAGACGAG 
TGTTTCTTTT TTGAACGATT GGAGTCTAAT AACTACAATA CTTACCGGTC AAGGAAATAC 
TCCAGTTGGT ATGTGGCACT GAAACGAACT GGGCAGTATA AACTTGGACC CAAAACAGGA 
CCTGGGCAGA AAGCTATACT TTTTCTTCCA ATGTCTGCTA AGAGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Immunohistochemical localization of fibroblast growth factor-2 in the sheep ovary and its effects on pre-antral follicle apoptosis and development in vitro.
Reproduction in domestic animals = Zuchthygiene49(3)522-8(2014 Jun)
Santos JM,Menezes VG,Barberino RS,Macedo TJ,Lins TL,Gouveia BB,Barros VR,Santos LP,Gon?alves RJ,Matos MH

An investigation of growth factors and lactoferrin in naturally occurring ovine pulmonary adenomatosis.
Journal of comparative pathology147(4)441-51(2012 Nov)
Sozmen M,Beytut E

Compartmentalizing proximal FGFR1 signaling in ovine placental artery endothelial cell caveolae.
Biology of reproduction87(2)40(2012 Aug)
Feng L,Zhang HH,Wang W,Zheng J,Chen DB

Placental vascularity and growth factor expression in singleton, twin, and triplet pregnancies in the sheep.
Endocrine33(1)53-61(2008 Feb)
Vonnahme KA,Evoniuk J,Johnson ML,Borowicz PP,Luther JS,Pant D,Redmer DA,Reynolds LP,Grazul-Bilska AT