Gene Symbol | BST-2A |
Entrez Gene ID | 100422799 |
Full Name | bone marrow stromal cell antigen 2A |
Gene Type | protein-coding |
Organism | Ovis aries(sheep) |
ORF » Species Summary » Ovis aries » BST-2A cDNA ORF clone
Gene Symbol | BST-2A |
Entrez Gene ID | 100422799 |
Full Name | bone marrow stromal cell antigen 2A |
Gene Type | protein-coding |
Organism | Ovis aries(sheep) |
mRNA | Protein | Name |
---|---|---|
XM_027969178.1 | XP_027824979.1 | bone marrow stromal cell antigen 2A isoform X1 |
NM_001178050.1 | NP_001171521.1 | bone marrow stromal cell antigen 2A |
XM_015095475.1 | XP_014950961.1 | bone marrow stromal cell antigen 2A isoform X1 |
The sheep tetherin paralog oBST2B blocks envelope glycoprotein incorporation into nascent retroviral virions.
Murphy L, Varela M, Desloire S, Ftaich N, Murgia C, Golder M, Neil S, Spencer TE, Wootton SK, Lavillette D, Terzian C, Palmarini M, Arnaud F
Journal of virology89(1)535-44(2015 Jan)
Interplay between ovine bone marrow stromal cell antigen 2/tetherin and endogenous retroviruses.
Arnaud F, Black SG, Murphy L, Griffiths DJ, Neil SJ, Spencer TE, Palmarini M
Journal of virology84(9)4415-25(2010 May)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
BST2B acts differently from BST2A by leading to a reduction in Jaagsiekte sheep retrovirus Env incorporation into viral particles, which ultimately results in the release of virions that are less infectious.
Title: The sheep tetherin paralog oBST2B blocks envelope glycoprotein incorporation into nascent retroviral virions.
Transfection assays found that ovine BST2 proteins (oBST2A and oBST2B) block release of viral particles produced by intact endogenous betaretroviruses loci and of related exogenous and pathogenic jaagsiekte sheep retrovirus.
Title: Interplay between ovine bone marrow stromal cell antigen 2/tetherin and endogenous retroviruses.
The following BST-2A gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the BST-2A cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OSm21027 | |
Clone ID Related Accession (Same CDS sequence) | NM_001178050.1 | |
Accession Version | NM_001178050.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 471bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-02-09 | |
Organism | Ovis aries(sheep) | |
Product | bone marrow stromal cell antigen 2A | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from GU376751.1. ##Evidence-Data-START## Transcript exon combination :: GU376751.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA104494976, SAMEA104494977 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGATGGACA AATTGGAAGG ATCTATGCTG ACTCGCTGCA AGCTACCGCT GTGGCTGGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001171521.1 |
CDS | 1..471 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001178050.1 |
1 | ATGATGGACA AATTGGAAGG ATCTATGCTG ACTCGCTGCA AGCTACCGCT GTGGCTGGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OSm22533 | |
Clone ID Related Accession (Same CDS sequence) | XM_027969178.1 | |
Accession Version | XM_027969178.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 471bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-02-05 | |
Organism | Ovis aries(sheep) | |
Product | bone marrow stromal cell antigen 2A isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_040256.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Ovis aries Annotation Release 103 Annotation Version :: 103 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGATGGACA AATTGGAAGG ATCTATGCTG ACTCGCTGCA AGCTACCGCT GTGGCTGGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_027824979.1 |
CDS | 202..672 |
Translation |
Target ORF information:
Target ORF information:
|
XM_027969178.1 |
1 | ATGATGGACA AATTGGAAGG ATCTATGCTG ACTCGCTGCA AGCTACCGCT GTGGCTGGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OSm49342 | |
Clone ID Related Accession (Same CDS sequence) | XM_015095475.1 | |
Accession Version | XM_015095475.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1068bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2015-12-16 | |
Organism | Ovis aries(sheep) | |
Product | bone marrow stromal cell antigen 2A isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NW_014639014.1) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Ovis aries Annotation Release 102 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.5 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## ##RefSeq-Attributes-START## ab initio :: 2% of CDS bases ##RefSeq-Attributes-END## |
1 | ATGATGGACA AATTGGAAGG ATCTATGCTG ACTCGCTGCA AGCTACCGCT GTGGCTGGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_014950961.1 |
CDS | 377..1444 |
Translation |
Target ORF information:
Target ORF information:
|
XM_015095475.1 |
1 | ATGATGGACA AATTGGAAGG ATCTATGCTG ACTCGCTGCA AGCTACCGCT GTGGCTGGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
The sheep tetherin paralog oBST2B blocks envelope glycoprotein incorporation into nascent retroviral virions. |
Interplay between ovine bone marrow stromal cell antigen 2/tetherin and endogenous retroviruses. |