Gene Symbol | SAMHD1 |
Entrez Gene ID | 709060 |
Full Name | SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 |
Gene Type | protein-coding |
Organism | Macaca mulatta(Rhesus monkey) |
ORF » Species Summary » Macaca mulatta » SAMHD1 cDNA ORF clone
Gene Symbol | SAMHD1 |
Entrez Gene ID | 709060 |
Full Name | SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 |
Gene Type | protein-coding |
Organism | Macaca mulatta(Rhesus monkey) |
mRNA | Protein | Name |
---|---|---|
XM_028827318.1 | XP_028683151.1 | deoxynucleoside triphosphate triphosphohydrolase SAMHD1 isoform X1 |
NM_001271642.1 | NP_001258571.1 | deoxynucleoside triphosphate triphosphohydrolase SAMHD1 |
Homo sapiens (human) | SAMHD1 | NP_056289.2 |
Rattus norvegicus (Norway rat) | Samhd1 | NP_001178672.1 |
Arabidopsis thaliana (thale cress) | AT5G40290 | NP_198845.1 |
Xenopus tropicalis (tropical clawed frog) | LOC100498574 | XP_002932931.2 |
Bos taurus (cattle) | SAMHD1 | NP_001069329.1 |
Arabidopsis thaliana (thale cress) | AT5G40270 | NP_568580.1 |
SAMHD1 | XP_001097562.2 | |
Canis lupus familiaris (dog) | SAMHD1 | XP_542986.3 |
Gallus gallus (chicken) | SAMHD1 | NP_001026016.1 |
Danio rerio (zebrafish) | samhd1 | NP_001153405.1 |
Pan troglodytes (chimpanzee) | SAMHD1 | XP_514624.3 |
Mus musculus (house mouse) | Samhd1 | NP_061339.3 |
The Expression of Functional Vpx during Pathogenic SIVmac Infections of Rhesus Macaques Suppresses SAMHD1 in CD4+ Memory T Cells.
Shingai M, Welbourn S, Brenchley JM, Acharya P, Miyagi E, Plishka RJ, Buckler-White A, Kwong PD, Nishimura Y, Strebel K, Martin MA
PLoS pathogens11(5)e1004928(2015 May)
A new rhesus macaque assembly and annotation for next-generation sequencing analyses.
Zimin AV, Cornish AS, Maudhoo MD, Gibbs RM, Zhang X, Pandey S, Meehan DT, Wipfler K, Bosinger SE, Johnson ZP, Tharp GK, Mar?ais G, Roberts M, Ferguson B, Fox HS, Treangen T, Salzberg SL, Yorke JA, Norgren RB Jr
Biology direct9(1)20(2014 Oct)
SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates.
Lahouassa H, Daddacha W, Hofmann H, Ayinde D, Logue EC, Dragin L, Bloch N, Maudet C, Bertrand M, Gramberg T, Pancino G, Priet S, Canard B, Laguette N, Benkirane M, Transy C, Landau NR, Kim B, Margottin-Goguet F
Nature immunology13(3)223-228(2012 Feb)
Evolutionary and functional analyses of the interaction between the myeloid restriction factor SAMHD1 and the lentiviral Vpx protein.
Laguette N, Rahm N, Sobhian B, Chable-Bessia C, M?nch J, Snoeck J, Sauter D, Switzer WM, Heneine W, Kirchhoff F, Delsuc F, Telenti A, Benkirane M
Cell host & microbe11(2)205-17(2012 Feb)
The ability of primate lentiviruses to degrade the monocyte restriction factor SAMHD1 preceded the birth of the viral accessory protein Vpx.
Lim ES, Fregoso OI, McCoy CO, Matsen FA, Malik HS, Emerman M
Cell host & microbe11(2)194-204(2012 Feb)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Data suggest that critical role of vpx (Simian immunodeficiency virus vpx protein) in vivo/in vitro is to promote degradation of SAMHD1 in memory CD4+ T-lymphocytes, generating high levels of plasma viremia and induction of immunodeficiency.
Title: The Expression of Functional Vpx during Pathogenic SIVmac Infections of Rhesus Macaques Suppresses SAMHD1 in CD4+ Memory T Cells.
Vpx prevented the SAMHD1-mediated decrease in dNTP concentration and induced the degradation of human and rhesus macaque SAMHD1 but had no effect on mouse SAMHD1
Title: SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates.
The following SAMHD1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SAMHD1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMb04467 | |
Clone ID Related Accession (Same CDS sequence) | NM_001271642.1 | |
Accession Version | NM_001271642.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1881bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-04-28 | |
Organism | Macaca mulatta(Rhesus monkey) | |
Product | deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JN936895.1. On Nov 2, 2012 this sequence version replaced XM_001097562.2. ##Evidence-Data-START## Transcript exon combination :: JN936895.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA27162418, SAMEA4688315 [ECO:0000350] ##Evidence-Data-END## |
1 | ATGCAGCAAG CCGACTCCGA CCAGCCCTCC AAGCGTCCCC GTTTCGATGA CAGCCCAAGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001258571.1 |
CDS | 1..1881 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGCAGCAAG CCGACTCCGA CCAGCCCTCC AAGCGTCCCC GTTTCGATGA CAGCCCAAGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMb61918 | |
Clone ID Related Accession (Same CDS sequence) | XM_028827318.1 | |
Accession Version | XM_028827318.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1683bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-04-25 | |
Organism | Macaca mulatta(Rhesus monkey) | |
Product | deoxynucleoside triphosphate triphosphohydrolase SAMHD1 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_041763.1) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Macaca mulatta Annotation Release 103 Annotation Version :: 103 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGGGTCCG GAGCAGGTGT GCTTCTTCCT CAGGCGCGGT GGCTTTGGAG AGCCGGCGCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_028683151.1 |
CDS | 397..2079 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGGGTCCG GAGCAGGTGT GCTTCTTCCT CAGGCGCGGT GGCTTTGGAG AGCCGGCGCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
The Expression of Functional Vpx during Pathogenic SIVmac Infections of Rhesus Macaques Suppresses SAMHD1 in CD4+ Memory T Cells. |
A new rhesus macaque assembly and annotation for next-generation sequencing analyses. |
SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates. |
Evolutionary and functional analyses of the interaction between the myeloid restriction factor SAMHD1 and the lentiviral Vpx protein. |
The ability of primate lentiviruses to degrade the monocyte restriction factor SAMHD1 preceded the birth of the viral accessory protein Vpx. |