GPX2 cDNA ORF clone, Macaca mulatta(Rhesus monkey)

Gene
Clones
gRNAs

Summary

Gene Symbol	GPX2
Entrez Gene ID	708429
Full Name	glutathione peroxidase 2
Gene Type	protein-coding
Organism	Macaca mulatta(Rhesus monkey)
Summary	The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is predominantly expressed in the gastrointestinal tract and localized in the cytoplasm, and whose preferred substrate is hydrogen peroxide. It is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. [provided by RefSeq, Jul 2016].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001115137.2	NP_001108609.2	glutathione peroxidase 2

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Gpx2	NP_899653.2
Homo sapiens (human)	GPX2	NP_002074.2
Gallus gallus (chicken)	GPX2	NP_001264783.1
Bos taurus (cattle)	GPX2	NP_001156611.1
Xenopus tropicalis (tropical clawed frog)	gpx2	NP_001243244.1
Mus musculus (house mouse)	Gpx2	NP_109602.2
Pan troglodytes (chimpanzee)	GPX2	NP_001108606.1
	GPX2	NP_001108609.1
Canis lupus familiaris (dog)	GPX2	NP_001108607.1

Gene Ontology
Bibliography

Related articles in PubMed

A new rhesus macaque assembly and annotation for next-generation sequencing analyses.
Zimin AV, Cornish AS, Maudhoo MD, Gibbs RM, Zhang X, Pandey S, Meehan DT, Wipfler K, Bosinger SE, Johnson ZP, Tharp GK, Mar?ais G, Roberts M, Ferguson B, Fox HS, Treangen T, Salzberg SL, Yorke JA, Norgren RB Jr
Biology direct9(1)20(2014 Oct)

Analysis of the Macaca mulatta transcriptome and the sequence divergence between Macaca and human.
Magness CL, Fellin PC, Thomas MJ, Korth MJ, Agy MB, Proll SC, Fitzgibbon M, Scherer CA, Miner DG, Katze MG, Iadonato SP
Genome biology6(7)R60(2005)

Characterization of mammalian selenoproteomes.
Kryukov GV, Castellano S, Novoselov SV, Lobanov AV, Zehtab O, Guig? R, Gladyshev VN
Science (New York, N.Y.)300(5624)1439-43(2003 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following GPX2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GPX2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMb57577	NM_001115137.2 Latest version!	Macaca mulatta glutathione peroxidase 2 (GPX2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$104.30 $149.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

GPX2 ( NM_001115137.2 ) cDNA ORF clone, Macaca mulatta(Rhesus monkey) -> NP_001108609.2 Macaca mulatta glutathione peroxidase 2 (GPX2), mRNA.

Price & Availability↑

CloneID	OMb57577
Clone ID Related Accession (Same CDS sequence)	NM_001115137.2
Accession Version	NM_001115137.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 573bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-11
Organism	Macaca mulatta(Rhesus monkey)
Product	glutathione peroxidase 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from QNVO02000421.1, CO774353.1 and JV649196.1. On Jul 22, 2016 this sequence version replaced NM_001115137.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: CO774353.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4688316, SAMEA4688327 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## protein contains selenocysteine :: inferred from conservation ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCTTTCA TTGCCAAGTC CTTCTATGAC CTCAGTGCCA TCAGCCTGGA TGGGGAGAAG 
GTAGATTTCA ATACGTTCCG GGGCAGGGCC GTGCTGATTG AAAATGTGGC TTCACTCTGA 
GGCACAACCA CTCGGGACTT CACCCAGCTC AACGAGCTGC AATGCCGCTT TCCCAGGCGC 
CTGGTGGTCC TTGGCTTCCC TTGCAACCAA TTTGGACATC AGGAGAACTG TCAGAATGAG 
GAGATCCTGA ACAGTCTCAA GTATGTCCGT CCTGGGGGTG GATACCAGCC TACTTTCACC 
CTTGTCCAAA AATGTGAGGT GAATGGGCAG AATGAGCATC CTGTCTTCGC CTACCTGAAG 
GACAAGCTCC CCTACCCTCA TGATGACCCA TTTTCCCTCA TGACCGATCC CAAGCTCATC 
ATTTGGAGCC CCGTGCGCCG TTCAGATGTG GCCTGGAACT TTGAGAAGTT CCTCATAGGG 
CCGGAGGGAG AGCCCTTCCG ACGCTACAGC CGCACCTTCC CAACCATCAA CATTGAGCCT 
GACATCAAGC GCCTCCTTAA AGTTGCCATA TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001108609.2
CDS	178..750
Translation	MAFIAKSFYDLSAISLDGEKVDFNTFRGRAVLIENVASL*GTTTRDFTQLNELQCRFPRRLVVLGFPCNQFGHQENCQNEEILNSLKYVRPGGGYQPTFTLVQKCEVNGQNEHPVFAYLKDKLPYPHDDPFSLMTDPKLIIWSPVRRSDVAWNFEKFLIGPEGEPFRRYSRTFPTINIEPDIKRLLKVAI

Target ORF information:

RefSeq Version	NM_001115137.2
Organism	Macaca mulatta(Rhesus monkey)
Definition	Macaca mulatta glutathione peroxidase 2 (GPX2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001115137.2

ORF Insert Sequence:

ATGGCTTTCA TTGCCAAGTC CTTCTATGAC CTCAGTGCCA TCAGCCTGGA TGGGGAGAAG 
GTAGATTTCA ATACGTTCCG GGGCAGGGCC GTGCTGATTG AAAATGTGGC TTCACTCTGA 
GGCACAACCA CTCGGGACTT CACCCAGCTC AACGAGCTGC AATGCCGCTT TCCCAGGCGC 
CTGGTGGTCC TTGGCTTCCC TTGCAACCAA TTTGGACATC AGGAGAACTG TCAGAATGAG 
GAGATCCTGA ACAGTCTCAA GTATGTCCGT CCTGGGGGTG GATACCAGCC TACTTTCACC 
CTTGTCCAAA AATGTGAGGT GAATGGGCAG AATGAGCATC CTGTCTTCGC CTACCTGAAG 
GACAAGCTCC CCTACCCTCA TGATGACCCA TTTTCCCTCA TGACCGATCC CAAGCTCATC 
ATTTGGAGCC CCGTGCGCCG TTCAGATGTG GCCTGGAACT TTGAGAAGTT CCTCATAGGG 
CCGGAGGGAG AGCCCTTCCG ACGCTACAGC CGCACCTTCC CAACCATCAA CATTGAGCCT 
GACATCAAGC GCCTCCTTAA AGTTGCCATA TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A new rhesus macaque assembly and annotation for next-generation sequencing analyses.
Biology direct9(1)20(2014 Oct)
Zimin AV,Cornish AS,Maudhoo MD,Gibbs RM,Zhang X,Pandey S,Meehan DT,Wipfler K,Bosinger SE,Johnson ZP,Tharp GK,Mar?ais G,Roberts M,Ferguson B,Fox HS,Treangen T,Salzberg SL,Yorke JA,Norgren RB Jr

Analysis of the Macaca mulatta transcriptome and the sequence divergence between Macaca and human.
Genome biology6(7)R60(2005)
Magness CL,Fellin PC,Thomas MJ,Korth MJ,Agy MB,Proll SC,Fitzgibbon M,Scherer CA,Miner DG,Katze MG,Iadonato SP

Characterization of mammalian selenoproteomes.
Science (New York, N.Y.)300(5624)1439-43(2003 May)
Kryukov GV,Castellano S,Novoselov SV,Lobanov AV,Zehtab O,Guig? R,Gladyshev VN

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GPX2 cDNA ORF clone, Macaca mulatta(Rhesus monkey)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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