Gene Symbol | TRIM5 |
Entrez Gene ID | 574288 |
Full Name | tripartite motif containing 5 |
Gene Type | protein-coding |
Organism | Macaca mulatta(Rhesus monkey) |
ORF » Species Summary » Macaca mulatta » TRIM5 cDNA ORF clone
Gene Symbol | TRIM5 |
Entrez Gene ID | 574288 |
Full Name | tripartite motif containing 5 |
Gene Type | protein-coding |
Organism | Macaca mulatta(Rhesus monkey) |
mRNA | Protein | Name |
---|---|---|
NM_001032910.1 | NP_001028082.1 | tripartite motif-containing protein 5 |
Pan troglodytes (chimpanzee) | TRIM5 | NP_001012668.1 |
Bos taurus (cattle) | LOC616948 | NP_001029970.1 |
Bos taurus (cattle) | LOC516599 | XP_002693251.1 |
Mus musculus (house mouse) | Trim12c | NP_783608.3 |
TRIM5 | NP_001028082.1 | |
Mus musculus (house mouse) | Trim5 | XP_997808.2 |
Rattus norvegicus (Norway rat) | Trim5 | NP_001014045.1 |
Homo sapiens (human) | TRIM5 | NP_149023.2 |
Na L, Tang YD, Wang C, Liu C, Wang X
The Journal of biological chemistry(2017 Dec)
Targeting the rhesus macaque TRIM5? gene to enhance the susceptibility of CD4
Wang X, Yu Q, Yuan Y, Teng Z, Li D, Zeng Y
Archives of virology162(3)793-798(2017 Mar)
Dynamic conformational changes in the rhesus TRIM5? dimer dictate the potency of HIV-1 restriction.
Lamichhane R, Mukherjee S, Smolin N, Pauszek RF 3rd, Bradley M, Sastri J, Robia SL, Millar D, Campbell EM
Virology500161-168(2017 01)
Crystal structure of the Trim5? Bbox2 domain from rhesus macaques describes a plastic oligomerisation interface.
Keown JR, Goldstone DC
Journal of structural biology195(3)282-285(2016 Sep)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
HIV-1 virus target the rhTRIM5alpha enhanced the susceptibility to HIV-1 infection.
Title: Targeting the rhesus macaque TRIM5? gene to enhance the susceptibility of CD4
L2 region of the TRIM5alpha dimer undergoes dynamic conformational changes, which results in the displacement of L2 regions by 25 angstroms relative to each other.
Title: Dynamic conformational changes in the rhesus TRIM5? dimer dictate the potency of HIV-1 restriction.
High resolution crystal structure of a Trim5Alpha dimeric Bbox domain.
Title: Crystal structure of the Trim5? Bbox2 domain from rhesus macaques describes a plastic oligomerisation interface.
These studies provide direct evidence that ubiquitin conjugation to rhTRIM5alpha-containing complexes is required for inhibition of HIV-1 Reverse Transcription and Capsid Destabilization.
Title: TRIM5?-Mediated Ubiquitin Chain Conjugation Is Required for Inhibition of HIV-1 Reverse Transcription and Capsid Destabilization.
Mutations in gag and pol are associated with escape of HIV-1 from rhTrim5alpha.
Title: Adaptation of HIV-1 to rhTrim5?-mediated restriction in vitro.
The following TRIM5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TRIM5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMb04765 | |
Clone ID Related Accession (Same CDS sequence) | NM_001032910.1 | |
Accession Version | NM_001032910.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1494bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-06-24 | |
Organism | Macaca mulatta(Rhesus monkey) | |
Product | tripartite motif-containing protein 5 | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY523632.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY523632.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4688321, SAMEA4688322 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGGCTTCTG GAATCCTGCT TAATGTAAAG GAGGAGGTGA CCTGTCCCAT CTGCCTGGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001028082.1 |
CDS | 271..1764 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001032910.1 |
1 | ATGGCTTCTG GAATCCTGCT TAATGTAAAG GAGGAGGTGA CCTGTCCCAT CTGCCTGGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
|
Targeting the rhesus macaque TRIM5? gene to enhance the susceptibility of CD4 |
Dynamic conformational changes in the rhesus TRIM5? dimer dictate the potency of HIV-1 restriction. |
Crystal structure of the Trim5? Bbox2 domain from rhesus macaques describes a plastic oligomerisation interface. |