PDCD1 cDNA ORF clone, Macaca mulatta(Rhesus monkey)

CTLA-4
McGary CS, Deleage C, Harper J, Micci L, Ribeiro SP, Paganini S, Kuri-Cervantes L, Benne C, Ryan ES, Balderas R, Jean S, Easley K, Marconi V, Silvestri G, Estes JD, Sekaly RP, Paiardini M
Immunity47(4)776-788.e5(2017 Oct)

A new rhesus macaque assembly and annotation for next-generation sequencing analyses.
Zimin AV, Cornish AS, Maudhoo MD, Gibbs RM, Zhang X, Pandey S, Meehan DT, Wipfler K, Bosinger SE, Johnson ZP, Tharp GK, Mar?ais G, Roberts M, Ferguson B, Fox HS, Treangen T, Salzberg SL, Yorke JA, Norgren RB Jr
Biology direct9(1)20(2014 Oct)

T cells increase before zoster and PD-1 expression increases at the time of zoster in immunosuppressed nonhuman primates latently infected with simian varicella virus.
James SF, Traina-Dorge V, Deharo E, Wellish M, Palmer BE, Gilden D, Mahalingam R
Journal of neurovirology20(3)309-13(2014 Jun)

High production rates sustain in vivo levels of PD-1high simian immunodeficiency virus-specific CD8 T cells in the face of rapid clearance.
Petrovas C, Yamamoto T, Price DA, Rao SS, Klatt NR, Brenchley JM, Douek DC, Gostick E, Angermann BR, Grossman Z, Macallan DC, Meier-Schellersheim M, Koup RA
Journal of virology87(17)9836-44(2013 Sep)

Rhesus macaque lymph node PD-1(hi)CD4+ T cells express high levels of CXCR5 and IL-21 and display a CCR7(lo)ICOS+Bcl6+ T-follicular helper (Tfh) cell phenotype.
Onabajo OO, George J, Lewis MG, Mattapallil JJ
PloS one8(3)e59758(2013)

Data show that CTLA-4(+)PD-1(-) memory CD4(+) T cells, which share phenotypic markers with regulatory T cells, were enriched in SIV DNA in blood, lymph nodes (LN), spleen, and gut, and contained replication-competent and infectious virus.
Title: CTLA-4

Compared to before immunosuppression, PD-1 expression increased at reactivation. Increased T cells before zoster is likely due to virus reactivation.
Title: T cells increase before zoster and PD-1 expression increases at the time of zoster in immunosuppressed nonhuman primates latently infected with simian varicella virus.

A PD-1(high) phenotype is associated with accelerated in vivo CD8 T cell turnover in SIV-infections, especially within the SIV-specific CD8 T cell pool.
Title: High production rates sustain in vivo levels of PD-1high simian immunodeficiency virus-specific CD8 T cells in the face of rapid clearance.

High levels of PD-1 expression on CD4(+) T cells in lymph nodes of rhesus macaques can serve as a valuable marker to identify T follicular helper cells.
Title: Rhesus macaque lymph node PD-1(hi)CD4+ T cells express high levels of CXCR5 and IL-21 and display a CCR7(lo)ICOS+Bcl6+ T-follicular helper (Tfh) cell phenotype.

PD-1 can serve as a sensitive indicator of persistent, low-level virus replication
Title: Inhibitory TCR coreceptor PD-1 is a sensitive indicator of low-level replication of SIV and HIV-1.