Clp1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Clp1
Entrez Gene ID	98985
Full Name	CLP1, cleavage and polyadenylation factor I subunit
Synonyms	AI462438,Heab
General protein information	Preferred Names CLP1, cleavage and polyadenylation factor I subunit Names polyribonucleotide 5'-hydroxyl-kinase Clp1 ATP/GTP-binding protein CLP1, cleavage and polyadenylation factor I subunit, homolog polyadenylation factor Clp1 polynucleotide kinase Clp1 pre-mRNA cleavage complex II protein Clp1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 2 Map Location: 2\|2 D

mRNA and Protein(s)

mRNA	Protein	Name
NM_133840.2	NP_598601.1	polyribonucleotide 5'-hydroxyl-kinase Clp1
NM_133840.3	NP_598601.1	polyribonucleotide 5'-hydroxyl-kinase Clp1

Pathways from BioSystems

Homologies

Homo sapiens (human)	CLP1	NP_006822.1
	CLP1	XP_001101762.1
Drosophila melanogaster (fruit fly)	cbc	NP_610876.1
Arabidopsis thaliana (thale cress)	CLPS3	NP_974220.1
Oryza sativa (rice)	Os02g0217500	NP_001046299.1
Gallus gallus (chicken)	CLP1	NP_001012292.1
Mus musculus (house mouse)	Clp1	NP_598601.1
Rattus norvegicus (Norway rat)	Clp1	NP_001009599.1
Danio rerio (zebrafish)	LOC565621	XP_693984.3
Anopheles gambiae (African malaria mosquito)	CLP1_ANOGA	XP_308174.2
Caenorhabditis elegans (roundworm)	clpf-1	NP_001040858.1
Xenopus tropicalis (tropical clawed frog)	clp1	NP_001008002.1
Canis lupus familiaris (dog)	CLP1	XP_005631257.1
Bos taurus (cattle)	CLP1	NP_001075182.1

Gene Ontology
Bibliography

Related articles in PubMed

Human CLP1 mutations alter tRNA biogenesis, affecting both peripheral and central nervous system function.
Karaca E, Weitzer S, Pehlivan D, Shiraishi H, Gogakos T, Hanada T, Jhangiani SN, Wiszniewski W, Withers M, Campbell IM, Erdin S, Isikay S, Franco LM, Gonzaga-Jauregui C, Gambin T, Gelowani V, Hunter JV, Yesil G, Koparir E, Yilmaz S, Brown M, Briskin D, Hafner M, Morozov P, Farazi TA, Bernreuther C, Glatzel M, Trattnig S, Friske J, Kronnerwetter C, Bainbridge MN, Gezdirici A, Seven M, Muzny DM, Boerwinkle E, Ozen M, , Clausen T, Tuschl T, Yuksel A, Hess A, Gibbs RA, Martinez J, Penninger JM, Lupski JR
Cell157(3)636-50(2014 Apr)

CLP1 links tRNA metabolism to progressive motor-neuron loss.
Hanada T, Weitzer S, Mair B, Bernreuther C, Wainger BJ, Ichida J, Hanada R, Orthofer M, Cronin SJ, Komnenovic V, Minis A, Sato F, Mimata H, Yoshimura A, Tamir I, Rainer J, Kofler R, Yaron A, Eggan KC, Woolf CJ, Glatzel M, Herbst R, Martinez J, Penninger JM
Nature495(7442)474-80(2013 Mar)

Expression of metanephric nephron-patterning genes in differentiating mesonephric tubules.
Georgas KM, Chiu HS, Lesieur E, Rumballe BA, Little MH
Developmental dynamics : an official publication of the American Association of Anatomists240(6)1600-12(2011 Jun)

CLP-1 associates with MyoD and HDAC to restore skeletal muscle cell regeneration.
Galatioto J, Mascareno E, Siddiqui MA
Journal of cell science123(Pt 21)3789-95(2010 Nov)

Downregulation of cardiac lineage protein-1 confers cardioprotection through the upregulation of redox effectors.
Gurusamy N, Lekli I, Ahsan MK, Ray D, Mukherjee S, Mascareno E, Siddiqui MA, Das DK
FEBS letters584(1)187-93(2010 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

loss of CLP1 activity results in accumulation of a novel set of small RNA fragments derived from aberrant processing of tyrosine pre-transfer RNA; these tRNA fragments sensitize cells to oxidative-stress-induced p53 activation and p53-dependent cell death
Title: CLP1 links tRNA metabolism to progressive motor-neuron loss.

associates with MyoD and HDAC to restore skeletal muscle cell regeneration
Title: CLP-1 associates with MyoD and HDAC to restore skeletal muscle cell regeneration.

regulation of the CLP-1 levels is critical to cellular adaptation of the survival program that protects cardiomyocytes against stress
Title: Down-regulation of cardiac lineage protein (CLP-1) expression in CLP-1 +/- mice affords.

The following Clp1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Clp1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu14127	NM_133840.3 Latest version!	Mus musculus CLP1, cleavage and polyadenylation factor I subunit (Clp1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
View Old Accession Versions >>
OMu14127	NM_133840.2	Mus musculus CLP1, cleavage and polyadenylation factor I subunit (Clp1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Clp1 ( NM_133840.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_598601.1 Mus musculus CLP1, cleavage and polyadenylation factor I subunit (Clp1), mRNA.

Price & Availability↑

CloneID	OMu14127
Clone ID Related Accession (Same CDS sequence)	NM_133840.2 , NM_133840.3
Accession Version	NM_133840.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1278bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-05-27
Organism	Mus musculus(house mouse)
Product	polyribonucleotide 5'-hydroxyl-kinase Clp1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AL928914.15. On Nov 17, 2006 this sequence version replaced NM_133840.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: BC003237.1, AK169709.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849386, SAMN01164134 [ECO:0000348] ##Evidence-Data-END##

ATGAGCGAGG AATCCAATGA TGACAAGAAG CCAACGACTA AGTTTGAACT AGAGCGAGAA 
ACAGAGCTTC GATTTGAGGT GGAGGCCTCT CAATCGGTTC AGTTGGAGTT GTTGGCTGGC 
ATGGCGGAGA TCTTTGGCAC AGAGCTGACC AGAAACAAGA AATTCACTTT TGATGCTGGT 
GCCAAGGTGG CTGTTTTCAC TTGGCATGGC TGTTCTCTGC AGTTGAGTGG CCGGACTGAG 
GTGGCTTATG TCTCTAAGGA CACCCCTATG TTGCTTTACC TCAACACTCA TACAGCCTTG 
GAGCAGATGC GGAGGCAGGC AGAAAAGGAA GAAGAGAGAG GTCCCCGAGT GATGGTAGTA 
GGTCCTACTG ATGTGGGCAA GTCCACTGTG TGTCGACTGC TACTCAACTA CGCAGTGCGT 
TTGGGCCGCC GTCCTACTTA CGTGGAGTTA GATGTAGGCC AGGGCTCTGT GTCCATCCCT 
GGTACCATGG GGGCCCTGTA CATTGAGCGT CCAGCAGATG TGGAAGAAGG TTTCTCCATC 
CAGGCCCCTC TTGTGTATCA TTTTGGCTCC ACCACGCCTG GCACCAACAT CAAGCTTTAC 
AATAAGATTA CATCTCGCTT AGCAGATGTG TTCAACCAAA GGTGTGAAGT GAACAGAAGG 
GCTTCTGTGA GTGGCTGTGT CATCAACACC TGTGGCTGGG TCAAGGGCTA TGGTTACCAA 
GCCCTGGTGC ACGCAGCGTC GGCCTTTGAG GTGGATGTGG TTGTGGTTCT GGATCAAGAG 
CGACTGTACA ACGAATTGAA AAGGGACCTG CCTCATTTTG TTCGAACTGT GTTGCTTCCA 
AAATCAGGGG GTGTGGTAGA ACGTTCCAAG GACTTCCGGC GGGAATGTAG AGATGAACGT 
ATCCGTGAGT ATTTCTATGG ATTTCGAGGC TGTTTCTATC CCCATGCCTT CAACGTCAAA 
TTTTCTGATG TGAAAATCTA CAAAGTTGGA GCACCCACCA TTCCAGATTC CTGTTTACCT 
CTGGGTATGT CTCAGGAAGA CAACCAGCTC AAGTTAGTGC CTGTCACCCC TGGTAGAGAT 
ATGGTGCACC ATCTCCTGAG TGTGAGCACT GCTGAGGGCA CAGAAGAGAA CCTTTCTGAG 
ACCAGTGTGG CTGGATTCAT TGTTGTGACC AGTGTGGATG TGGAACACCA AGTGTTTACT 
GTCCTGTCTC CAGCCCCCCG CCCATTGCCT AAGAACTTTC TTCTCATCAT GGATATCCGG 
TTCATGGATC TCAAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_598601.1
CDS	129..1406
Translation	MSEESNDDKKPTTKFELERETELRFEVEASQSVQLELLAGMAEIFGTELTRNKKFTFDAGAKVAVFTWHGCSLQLSGRTEVAYVSKDTPMLLYLNTHTALEQMRRQAEKEEERGPRVMVVGPTDVGKSTVCRLLLNYAVRLGRRPTYVELDVGQGSVSIPGTMGALYIERPADVEEGFSIQAPLVYHFGSTTPGTNIKLYNKITSRLADVFNQRCEVNRRASVSGCVINTCGWVKGYGYQALVHAASAFEVDVVVVLDQERLYNELKRDLPHFVRTVLLPKSGGVVERSKDFRRECRDERIREYFYGFRGCFYPHAFNVKFSDVKIYKVGAPTIPDSCLPLGMSQEDNQLKLVPVTPGRDMVHHLLSVSTAEGTEENLSETSVAGFIVVTSVDVEHQVFTVLSPAPRPLPKNFLLIMDIRFMDLK

Target ORF information:

RefSeq Version	NM_133840.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus CLP1, cleavage and polyadenylation factor I subunit (Clp1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_133840.2

ORF Insert Sequence:

ATGAGCGAGG AATCCAATGA TGACAAGAAG CCAACGACTA AGTTTGAACT AGAGCGAGAA 
ACAGAGCTTC GATTTGAGGT GGAGGCCTCT CAATCGGTTC AGTTGGAGTT GTTGGCTGGC 
ATGGCGGAGA TCTTTGGCAC AGAGCTGACC AGAAACAAGA AATTCACTTT TGATGCTGGT 
GCCAAGGTGG CTGTTTTCAC TTGGCATGGC TGTTCTCTGC AGTTGAGTGG CCGGACTGAG 
GTGGCTTATG TCTCTAAGGA CACCCCTATG TTGCTTTACC TCAACACTCA TACAGCCTTG 
GAGCAGATGC GGAGGCAGGC AGAAAAGGAA GAAGAGAGAG GTCCCCGAGT GATGGTAGTA 
GGTCCTACTG ATGTGGGCAA GTCCACTGTG TGTCGACTGC TACTCAACTA CGCAGTGCGT 
TTGGGCCGCC GTCCTACTTA CGTGGAGTTA GATGTAGGCC AGGGCTCTGT GTCCATCCCT 
GGTACCATGG GGGCCCTGTA CATTGAGCGT CCAGCAGATG TGGAAGAAGG TTTCTCCATC 
CAGGCCCCTC TTGTGTATCA TTTTGGCTCC ACCACGCCTG GCACCAACAT CAAGCTTTAC 
AATAAGATTA CATCTCGCTT AGCAGATGTG TTCAACCAAA GGTGTGAAGT GAACAGAAGG 
GCTTCTGTGA GTGGCTGTGT CATCAACACC TGTGGCTGGG TCAAGGGCTA TGGTTACCAA 
GCCCTGGTGC ACGCAGCGTC GGCCTTTGAG GTGGATGTGG TTGTGGTTCT GGATCAAGAG 
CGACTGTACA ACGAATTGAA AAGGGACCTG CCTCATTTTG TTCGAACTGT GTTGCTTCCA 
AAATCAGGGG GTGTGGTAGA ACGTTCCAAG GACTTCCGGC GGGAATGTAG AGATGAACGT 
ATCCGTGAGT ATTTCTATGG ATTTCGAGGC TGTTTCTATC CCCATGCCTT CAACGTCAAA 
TTTTCTGATG TGAAAATCTA CAAAGTTGGA GCACCCACCA TTCCAGATTC CTGTTTACCT 
CTGGGTATGT CTCAGGAAGA CAACCAGCTC AAGTTAGTGC CTGTCACCCC TGGTAGAGAT 
ATGGTGCACC ATCTCCTGAG TGTGAGCACT GCTGAGGGCA CAGAAGAGAA CCTTTCTGAG 
ACCAGTGTGG CTGGATTCAT TGTTGTGACC AGTGTGGATG TGGAACACCA AGTGTTTACT 
GTCCTGTCTC CAGCCCCCCG CCCATTGCCT AAGAACTTTC TTCTCATCAT GGATATCCGG 
TTCATGGATC TCAAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Clp1 ( NM_133840.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_598601.1 Mus musculus CLP1, cleavage and polyadenylation factor I subunit (Clp1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu14127
Clone ID Related Accession (Same CDS sequence)	NM_133840.2 , NM_133840.3
Accession Version	NM_133840.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1278bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-23
Organism	Mus musculus(house mouse)
Product	polyribonucleotide 5'-hydroxyl-kinase Clp1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL928914.15. On Apr 26, 2018 this sequence version replaced NM_133840.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: BC003237.1, AK169709.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849386, SAMN01164134 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGCGAGG AATCCAATGA TGACAAGAAG CCAACGACTA AGTTTGAACT AGAGCGAGAA 
ACAGAGCTTC GATTTGAGGT GGAGGCCTCT CAATCGGTTC AGTTGGAGTT GTTGGCTGGC 
ATGGCGGAGA TCTTTGGCAC AGAGCTGACC AGAAACAAGA AATTCACTTT TGATGCTGGT 
GCCAAGGTGG CTGTTTTCAC TTGGCATGGC TGTTCTCTGC AGTTGAGTGG CCGGACTGAG 
GTGGCTTATG TCTCTAAGGA CACCCCTATG TTGCTTTACC TCAACACTCA TACAGCCTTG 
GAGCAGATGC GGAGGCAGGC AGAAAAGGAA GAAGAGAGAG GTCCCCGAGT GATGGTAGTA 
GGTCCTACTG ATGTGGGCAA GTCCACTGTG TGTCGACTGC TACTCAACTA CGCAGTGCGT 
TTGGGCCGCC GTCCTACTTA CGTGGAGTTA GATGTAGGCC AGGGCTCTGT GTCCATCCCT 
GGTACCATGG GGGCCCTGTA CATTGAGCGT CCAGCAGATG TGGAAGAAGG TTTCTCCATC 
CAGGCCCCTC TTGTGTATCA TTTTGGCTCC ACCACGCCTG GCACCAACAT CAAGCTTTAC 
AATAAGATTA CATCTCGCTT AGCAGATGTG TTCAACCAAA GGTGTGAAGT GAACAGAAGG 
GCTTCTGTGA GTGGCTGTGT CATCAACACC TGTGGCTGGG TCAAGGGCTA TGGTTACCAA 
GCCCTGGTGC ACGCAGCGTC GGCCTTTGAG GTGGATGTGG TTGTGGTTCT GGATCAAGAG 
CGACTGTACA ACGAATTGAA AAGGGACCTG CCTCATTTTG TTCGAACTGT GTTGCTTCCA 
AAATCAGGGG GTGTGGTAGA ACGTTCCAAG GACTTCCGGC GGGAATGTAG AGATGAACGT 
ATCCGTGAGT ATTTCTATGG ATTTCGAGGC TGTTTCTATC CCCATGCCTT CAACGTCAAA 
TTTTCTGATG TGAAAATCTA CAAAGTTGGA GCACCCACCA TTCCAGATTC CTGTTTACCT 
CTGGGTATGT CTCAGGAAGA CAACCAGCTC AAGTTAGTGC CTGTCACCCC TGGTAGAGAT 
ATGGTGCACC ATCTCCTGAG TGTGAGCACT GCTGAGGGCA CAGAAGAGAA CCTTTCTGAG 
ACCAGTGTGG CTGGATTCAT TGTTGTGACC AGTGTGGATG TGGAACACCA AGTGTTTACT 
GTCCTGTCTC CAGCCCCCCG CCCATTGCCT AAGAACTTTC TTCTCATCAT GGATATCCGG 
TTCATGGATC TCAAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_598601.1
CDS	148..1425
Translation	MSEESNDDKKPTTKFELERETELRFEVEASQSVQLELLAGMAEIFGTELTRNKKFTFDAGAKVAVFTWHGCSLQLSGRTEVAYVSKDTPMLLYLNTHTALEQMRRQAEKEEERGPRVMVVGPTDVGKSTVCRLLLNYAVRLGRRPTYVELDVGQGSVSIPGTMGALYIERPADVEEGFSIQAPLVYHFGSTTPGTNIKLYNKITSRLADVFNQRCEVNRRASVSGCVINTCGWVKGYGYQALVHAASAFEVDVVVVLDQERLYNELKRDLPHFVRTVLLPKSGGVVERSKDFRRECRDERIREYFYGFRGCFYPHAFNVKFSDVKIYKVGAPTIPDSCLPLGMSQEDNQLKLVPVTPGRDMVHHLLSVSTAEGTEENLSETSVAGFIVVTSVDVEHQVFTVLSPAPRPLPKNFLLIMDIRFMDLK

Target ORF information:

RefSeq Version	NM_133840.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus CLP1, cleavage and polyadenylation factor I subunit (Clp1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_133840.3

ORF Insert Sequence:

ATGAGCGAGG AATCCAATGA TGACAAGAAG CCAACGACTA AGTTTGAACT AGAGCGAGAA 
ACAGAGCTTC GATTTGAGGT GGAGGCCTCT CAATCGGTTC AGTTGGAGTT GTTGGCTGGC 
ATGGCGGAGA TCTTTGGCAC AGAGCTGACC AGAAACAAGA AATTCACTTT TGATGCTGGT 
GCCAAGGTGG CTGTTTTCAC TTGGCATGGC TGTTCTCTGC AGTTGAGTGG CCGGACTGAG 
GTGGCTTATG TCTCTAAGGA CACCCCTATG TTGCTTTACC TCAACACTCA TACAGCCTTG 
GAGCAGATGC GGAGGCAGGC AGAAAAGGAA GAAGAGAGAG GTCCCCGAGT GATGGTAGTA 
GGTCCTACTG ATGTGGGCAA GTCCACTGTG TGTCGACTGC TACTCAACTA CGCAGTGCGT 
TTGGGCCGCC GTCCTACTTA CGTGGAGTTA GATGTAGGCC AGGGCTCTGT GTCCATCCCT 
GGTACCATGG GGGCCCTGTA CATTGAGCGT CCAGCAGATG TGGAAGAAGG TTTCTCCATC 
CAGGCCCCTC TTGTGTATCA TTTTGGCTCC ACCACGCCTG GCACCAACAT CAAGCTTTAC 
AATAAGATTA CATCTCGCTT AGCAGATGTG TTCAACCAAA GGTGTGAAGT GAACAGAAGG 
GCTTCTGTGA GTGGCTGTGT CATCAACACC TGTGGCTGGG TCAAGGGCTA TGGTTACCAA 
GCCCTGGTGC ACGCAGCGTC GGCCTTTGAG GTGGATGTGG TTGTGGTTCT GGATCAAGAG 
CGACTGTACA ACGAATTGAA AAGGGACCTG CCTCATTTTG TTCGAACTGT GTTGCTTCCA 
AAATCAGGGG GTGTGGTAGA ACGTTCCAAG GACTTCCGGC GGGAATGTAG AGATGAACGT 
ATCCGTGAGT ATTTCTATGG ATTTCGAGGC TGTTTCTATC CCCATGCCTT CAACGTCAAA 
TTTTCTGATG TGAAAATCTA CAAAGTTGGA GCACCCACCA TTCCAGATTC CTGTTTACCT 
CTGGGTATGT CTCAGGAAGA CAACCAGCTC AAGTTAGTGC CTGTCACCCC TGGTAGAGAT 
ATGGTGCACC ATCTCCTGAG TGTGAGCACT GCTGAGGGCA CAGAAGAGAA CCTTTCTGAG 
ACCAGTGTGG CTGGATTCAT TGTTGTGACC AGTGTGGATG TGGAACACCA AGTGTTTACT 
GTCCTGTCTC CAGCCCCCCG CCCATTGCCT AAGAACTTTC TTCTCATCAT GGATATCCGG 
TTCATGGATC TCAAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Human CLP1 mutations alter tRNA biogenesis, affecting both peripheral and central nervous system function.
Cell157(3)636-50(2014 Apr)
Karaca E,Weitzer S,Pehlivan D,Shiraishi H,Gogakos T,Hanada T,Jhangiani SN,Wiszniewski W,Withers M,Campbell IM,Erdin S,Isikay S,Franco LM,Gonzaga-Jauregui C,Gambin T,Gelowani V,Hunter JV,Yesil G,Koparir E,Yilmaz S,Brown M,Briskin D,Hafner M,Morozov P,Farazi TA,Bernreuther C,Glatzel M,Trattnig S,Friske J,Kronnerwetter C,Bainbridge MN,Gezdirici A,Seven M,Muzny DM,Boerwinkle E,Ozen M,,Clausen T,Tuschl T,Yuksel A,Hess A,Gibbs RA,Martinez J,Penninger JM,Lupski JR

CLP1 links tRNA metabolism to progressive motor-neuron loss.
Nature495(7442)474-80(2013 Mar)
Hanada T,Weitzer S,Mair B,Bernreuther C,Wainger BJ,Ichida J,Hanada R,Orthofer M,Cronin SJ,Komnenovic V,Minis A,Sato F,Mimata H,Yoshimura A,Tamir I,Rainer J,Kofler R,Yaron A,Eggan KC,Woolf CJ,Glatzel M,Herbst R,Martinez J,Penninger JM

Expression of metanephric nephron-patterning genes in differentiating mesonephric tubules.
Developmental dynamics : an official publication of the American Association of Anatomists240(6)1600-12(2011 Jun)
Georgas KM,Chiu HS,Lesieur E,Rumballe BA,Little MH

CLP-1 associates with MyoD and HDAC to restore skeletal muscle cell regeneration.
Journal of cell science123(Pt 21)3789-95(2010 Nov)
Galatioto J,Mascareno E,Siddiqui MA

Downregulation of cardiac lineage protein-1 confers cardioprotection through the upregulation of redox effectors.
FEBS letters584(1)187-93(2010 Jan)
Gurusamy N,Lekli I,Ahsan MK,Ray D,Mukherjee S,Mascareno E,Siddiqui MA,Das DK

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Clp1 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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